The Library
Electronic nose technology as a point-of-care solution for the detection of colorectal cancer
Tools
Westenbrink, Eric W. (2016) Electronic nose technology as a point-of-care solution for the detection of colorectal cancer. PhD thesis, University of Warwick.
|
PDF
WRAP_Theses_Westenbrink_2016.pdf - Requires a PDF viewer. Download (7Mb) | Preview |
Official URL: http://webcat.warwick.ac.uk/record=b3062874~S1
Abstract
This thesis presents a comparative study of electronic nose technologies for the detection of colorectal cancer from healthy and disease controls using gases/volatiles in urine headspace. A review is made of the clinical features of lower gastro-intestinal diseases and the sensing technologies available to electronic noses. The literature surrounding the detection of cancers and other diseases by sensing of gases and volatiles is also reviewed. An investigation into the common volatile components of urine headspace is conducted experimentally using a gas chromatograph – mass spectrometer (451 Scion SQ, Bruker Corp), resulting in 10 candidate chemicals with links to gut bacteria and diet. A humidity generation unit was developed and integrated with a volatile testing rig to aid in assessing the response of different electronic nose technologies to volatile chemical groups.
Four electronic nose systems were tested in parallel studies using urine headspace samples from patients of colorectal cancer (CRC) and irritable bowel syndrome (IBS), as well as healthy volunteers. This involved pre-classified multivariate analysis techniques followed by K-Nearest-Neighbour validation for sensitivity and specificity. A commercial electronic nose based on metal oxide sensors (Fox 4000, AlphaMOS Ltd) analysed 93 urine samples giving a sensitivity and specificity to colorectal cancer of 54% and 48%. A field asymmetric ion mobility spectrometer that is commercially available (Lonestar, Owlstone Ltd) was tested using 133 samples of CRC and volunteer samples, yielding 88% disease sensitivity and 60% specificity. A new electronic nose system was developed using state-of-the-art ampere-metric and optical sensors and tested against 92 urine samples, giving a respective sensitivity and specificity to CRC against IBS controls of 78% and 79%. A final instrument was developed that includes a micro-packed GC column and an array of micro-hotplate metal oxide sensors, which analysed 49 samples to give a 92% sensitivity and 77% specificity to CRC against IBS.
Item Type: | Thesis (PhD) | ||||
---|---|---|---|---|---|
Subjects: | T Technology > TP Chemical technology | ||||
Library of Congress Subject Headings (LCSH): | Chemical detectors., Olfactory sensors., Odors., Scientific apparatus and instruments -- Computer simulation., Colon (Anatomy) -- Cancer -- Detection. | ||||
Official Date: | September 2016 | ||||
Dates: |
|
||||
Institution: | University of Warwick | ||||
Theses Department: | School of Engineering | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Covington, James A.,1973- ; Arasaradnam, Ramesh | ||||
Extent: | xx, 251 leaves : illustrations, charts. | ||||
Language: | eng |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year