Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Chiral metallohelices enantioselectively target hybrid human telomeric G-quadruplex DNA

Tools
- Tools
+ Tools

Zhao, Andong, Howson, Suzanne E., Zhao, Chuanqi, Ren, Jinsong, Scott, Peter, Wang, Chunyu and Qu, Xiaogang (2017) Chiral metallohelices enantioselectively target hybrid human telomeric G-quadruplex DNA. Nucleic Acids Research, 45 (9). pp. 5026-5035. doi:10.1093/nar/gkx244 ISSN 0305-1048.

[img]
Preview
PDF
WRAP-chiral-metallohelices-enantioselectively-target-hybrid-Scott-2017.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons: Attribution-Noncommercial 4.0.

Download (2176Kb) | Preview
Official URL: https://doi.org/10.1093/nar/gkx244

Request Changes to record.

Abstract

The design and synthesis of metal complexes that can specifically target DNA secondary structure has attracted considerable attention. Chiral metallosupramolecular complexes (e.g. helicates) in particular display unique DNA-binding behavior, however until recently few examples which are both water-compatible and enantiomerically pure have been reported. Herein we report that one metallohelix enantiomer , available from a diastereoselective synthesis with no need for resolution, can enantioselectively stabilize human telomeric hybrid G-quadruplex and strongly inhibit telomerase activity with IC 50 of 600 nM. In contrast, no such a preference is observed for the mirror image complex . More intriguingly, neither of the two enantiomers binds specifically to human telomeric antiparallel G-quadruplex. To the best of our knowledge, this is the first example of one pair of enantiomers with contrasting selectivity for human telomeric hybrid G-quadruplex. Further studies show that can discriminate human telomeric G-quadruplex from other telomeric G-quadruplexes.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Enantiomers, Chirality, Telomerase, Quadruplex nucleic acids
Journal or Publication Title: Nucleic Acids Research
Publisher: Oxford University Press
ISSN: 0305-1048
Official Date: 19 May 2017
Dates:
DateEvent
19 May 2017Published
8 April 2017Available
30 March 2017Accepted
Volume: 45
Number: 9
Page Range: pp. 5026-5035
DOI: 10.1093/nar/gkx244
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): ** From PubMed via Jisc Publications Router. ** History: ** received: 22-12-2016 ** accepted: 30-03-2017
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 19 October 2017
Date of first compliant Open Access: 23 October 2017
Funder: China. Guo jia ke xue ji shu bu [Ministry of Science and Technology] (CMST), Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC)
Grant number: 2012CB720602 (CMST), 21210002, 21431007, 21533008, 21572216 (NSFC)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us