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A new model for ancient DNA decay based on paleogenomic meta-analysis
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Kistler, Logan, Ware, Roselyn, Smith, Oliver, Collins, Matthew and Allaby, Robin G. (2017) A new model for ancient DNA decay based on paleogenomic meta-analysis. Nucleic Acids Research, 45 (11). pp. 6310-6320. doi:10.1093/nar/gkx361 ISSN 0305-1048.
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Official URL: http://dx.doi.org/10.1093/nar/gkx361
Abstract
The persistence of DNA over archaeological and paleontological timescales in diverse environments has led to a revolutionary body of paleogenomic research, yet the dynamics of DNA degradation are still poorly understood. We analyzed 185 paleogenomic datasets and compared DNA survival with environmental variables and sample ages. We find cytosine deamination follows a conventional thermal age model, but we find no correlation between DNA fragmentation and sample age over the timespans analyzed, even when controlling for environmental variables. We propose a model for ancient DNA decay wherein fragmentation rapidly reaches a threshold, then subsequently slows. The observed loss of DNA over time may be due to a bulk diffusion process in many cases, highlighting the importance of tissues and environments creating effectively closed systems for DNA preservation. This model of DNA degradation is largely based on mammal bone samples due to published genomic dataset availability. Continued refinement to the model to reflect diverse biological systems and tissue types will further improve our understanding of ancient DNA breakdown dynamics.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QH Natural history | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Library of Congress Subject Headings (LCSH): | Genomics, DNA, Archaeology, Paleontology | ||||||||
Journal or Publication Title: | Nucleic Acids Research | ||||||||
Publisher: | Oxford University Press | ||||||||
ISSN: | 0305-1048 | ||||||||
Official Date: | 20 June 2017 | ||||||||
Dates: |
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Volume: | 45 | ||||||||
Number: | 11 | ||||||||
Page Range: | pp. 6310-6320 | ||||||||
DOI: | 10.1093/nar/gkx361 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 15 May 2017 | ||||||||
Date of first compliant Open Access: | 16 May 2017 | ||||||||
Funder: | Natural Environment Research Council (Great Britain) (NERC) | ||||||||
Grant number: | NE/L012030/1 |
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