The Library
Investigation of effect of fullerenol on viscoelasticity properties of human hepatocellular carcinoma by AFM-Based creep tests
Tools
Tools
Tools
Zhu, Xinyao, Wang, Zuobin and Liu, Xianping (2017) Investigation of effect of fullerenol on viscoelasticity properties of human hepatocellular carcinoma by AFM-Based creep tests. Journal of Materials Research, 32 (13). pp. 2521-2531. doi:10.1557/jmr.2017.229
|
PDF
WRAP-investigation-effect-viscoelasticity-human-tests-Zhu-2017.pdf - Accepted Version - Requires a PDF viewer. Download (1426Kb) | Preview |
Official URL: https://doi.org/10.1557/jmr.2017.229
Abstract
Cellular elasticity is frequently measured to investigate the biomechanical effects of drug treatment, diseases and aging. In light of cellular viscosity property exhibited by filament actin networks, this study investigates the viscoelasticity alterations of human hepatocellular carcinoma (SMMC-7721) cell subjected to fullerenol treatment by means of creep tests realized by AFM indentation. An SMMC-7721 cell was first modeled as a sphere and then a flattened layer with finite thickness. Both Sneddon’s solutions and Dimitriadis model have been modified to adapt for viscoelastic situation, which are used to fit the same indentation depth – time curves obtained by creep tests. We find that the SMMC-7721 cell’s creep behavior is well described by the two modified models, and the divergence of parameters determined by the two models is justified. By fullerenol treatment, the SMMC-7721 cell exhibits a significant decrease of elastic modulus and viscosity, which is presumably due to the disruption of actin filaments. This work represents a new attempt to understand the alternation of the viscoelastic properties of cancerous cells under the treatment of fullerenol, which has the significance of comprehensively elucidating the biomechanical effects of anticancer agents (such as fullerenol) on cancer cells.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | T Technology > TJ Mechanical engineering and machinery | ||||||||
| Divisions: | Faculty of Science > Engineering | ||||||||
| Journal or Publication Title: | Journal of Materials Research | ||||||||
| Publisher: | Cambridge University Press | ||||||||
| ISSN: | 0884-2914 | ||||||||
| Official Date: | 14 July 2017 | ||||||||
| Dates: |
|
||||||||
| Date of first compliant deposit: | 26 May 2017 | ||||||||
| Volume: | 32 | ||||||||
| Number: | 13 | ||||||||
| Page Range: | pp. 2521-2531 | ||||||||
| DOI: | 10.1557/jmr.2017.229 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Copyright Holders: | JMR | ||||||||
| Funder: | Horizon 2020 (European Commission) (H2020) | ||||||||
| Grant number: | 644971 |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
