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MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins.
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Hunter, Chris J., Remenyi, Judit, Correa, Sonia A., Privitera, Lucia, Reyskens, Kathleen M. S. E., Martin, Kirsty J., Toth, Rachel, Frenguelli, Bruno G. and Arthur, J. Simon C. (2017) MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins. FEBS Open Bio, 7 (6). pp. 821-834. doi:10.1002/2211-5463.12232 ISSN 2211-5463.
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Official URL: http://dx.doi.org/10.1002/2211-5463.12232
Abstract
The immediate early gene activity-regulated cytoskeletal protein (Arc)/Arg3.1 and the neurotrophin brain-derived neurotrophic factor (BDNF) play important roles in synaptic plasticity and learning and memory in the mammalian brain. However, the mechanisms by which BDNF regulates the expression of Arc/Arg3.1 are unclear. In this study, we show that BDNF acts via the ERK1/2 pathway to activate the nuclear kinase mitogen- and stress-activated protein kinase 1 (MSK1). MSK1 then induces Arc/Arg3.1 expression via the phosphorylation of histone H3 at the Arc/Arg3.1 promoter. MSK1 can also phosphorylate the transcription factor cyclic-AMP response element-binding protein (CREB) on Ser133. However, this is not required for BDNF-induced Arc.Arg3.1 transcription as a Ser133Ala knockin mutation had no effect on Arc/Arg3.1 induction. In parallel, ERK1/2 directly activates Arc/Arg3.1 mRNA transcription via at least one serum response element on the promoter, which bind a complex of the Serum Response Factor (SRF) and a Ternary Complex Factor (TCF).
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QP Physiology | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Neuroplasticity, Neurotrophic functions, Protein kinases, Genetic transcription -- Regulation | |||||||||||||||
| Journal or Publication Title: | FEBS Open Bio | |||||||||||||||
| Publisher: | John Wiley & Sons Ltd. | |||||||||||||||
| ISSN: | 2211-5463 | |||||||||||||||
| Official Date: | 11 May 2017 | |||||||||||||||
| Dates: |
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| Volume: | 7 | |||||||||||||||
| Number: | 6 | |||||||||||||||
| Page Range: | pp. 821-834 | |||||||||||||||
| DOI: | 10.1002/2211-5463.12232 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Funder: | Wellcome Trust (London, England), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Medical Research Council (Great Britain) (MRC), WPH Charitable Trust | |||||||||||||||
| RIOXX Funder/Project Grant: |
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