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Mathematical models of microbial growth and metabolism : a whole-organism perspective
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Nev, Olga and Berg, Hugo van den (2017) Mathematical models of microbial growth and metabolism : a whole-organism perspective. Science Progress, 100 (4). pp. 343-362. ISSN 0036-8504.
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Official URL: https://doi.org/10.3184/003685017X15063357842583
Abstract
We review the principles underpinning the development of mathematical models of the metabolic activities of micro-organisms. Such models are important to understand and chart the substantial contributions made by micro-organisms to geochemical cycles, and also to optimise the performance of bioreactors that exploit the biochemical capabilities of these organisms. We advocate an approach based on the principle of dynamic allocation. We survey the biological background that motivates this approach, including nutrient assimilation, the regulation of gene expression, and the principles of microbial growth. In addition, we discuss the classic models of microbial growth as well as contemporary approaches. The dynamic allocation theory generalises these classic models in a natural manner and is readily amenable to the additional information provided by transcriptomics and proteomics approaches. Finally, we touch upon these organising principles in the context of the transition from the free-living unicellular mode of life to multicellularity.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QR Microbiology | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | ||||||
Library of Congress Subject Headings (LCSH): | Microbial growth -- Mathematical models, Microbial metabolism | ||||||
Journal or Publication Title: | Science Progress | ||||||
Publisher: | Science Reviews 2000 Ltd. | ||||||
ISSN: | 0036-8504 | ||||||
Official Date: | 1 November 2017 | ||||||
Dates: |
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Volume: | 100 | ||||||
Number: | 4 | ||||||
Page Range: | pp. 343-362 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Date of first compliant deposit: | 14 June 2017 | ||||||
Date of first compliant Open Access: | 22 January 2018 | ||||||
RIOXX Funder/Project Grant: |
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