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Optimal management of nutrient reserves in microorganisms under time-varying environmental conditions
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Nev, Olga and Berg, Hugo van den (2017) Optimal management of nutrient reserves in microorganisms under time-varying environmental conditions. Journal of Theoretical Biology, 429 . pp. 124-141. ISSN 0022-5193.
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Official URL: https://doi.org/10.1016/j.jtbi.2017.06.015
Abstract
Intracellular reserves are a conspicuous feature of many bacteria; such internal stores are often present in the form of inclusions in which polymeric storage compounds are accumulated. Such reserves tend to increase in times of plenty and be used up in times of scarcity. Mathematical models that describe the dynamical nature of reserve build-up and use are known as “cell quota,” “dynamic energy/nutrient budget,” or “variable-internal-stores” models. Here we present a stoichiometrically consistent macro-chemical model that accounts for variable stores as well as adaptive allocation of building blocks to various types of catalytic machinery. The model posits feedback loops linking expression of assimilatory machinery to reserve density. The precise form of the “regulatory law” at the heart of such a loop expresses how the cell manages internal stores. We demonstrate how this “regulatory law” can be recovered from experimental data using several empirical data sets. We find that stores should be expected to be negiglibly small in stable growth-sustaining environments, but prominent in environments characterised by marked fluctuations on time scales commensurate with the inherent dynamic time scale of the organismal system.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QR Microbiology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Research Centres > Molecular Organisation and Assembly in Cells (MOAC) |
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Library of Congress Subject Headings (LCSH): | Microbial growth -- Mathematical models, Cells -- Adaptation | ||||||||
Journal or Publication Title: | Journal of Theoretical Biology | ||||||||
Publisher: | Elsevier | ||||||||
ISSN: | 0022-5193 | ||||||||
Official Date: | 21 September 2017 | ||||||||
Dates: |
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Volume: | 429 | ||||||||
Page Range: | pp. 124-141 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 16 June 2017 | ||||||||
Date of first compliant Open Access: | 22 January 2018 | ||||||||
RIOXX Funder/Project Grant: |
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