Koh, Mark Jean-Ann, Giam, Yoke Chin, Liew, Hui Min, Foong, Alice Yee-Wah, Ho, Chong Jin, Wong, Sharon Mun Yee, Tang, Mark Boon Yang, Ho, Madeline Sheun Ling, Tan, Lucinda Siyun, Mason, James and Cork, Michael J. (2017) Comparison of the simple patient-centric atopic dermatitis scoring system PEST with SCORAD in young children using a ceramide dominant therapeutic moisturizer. Dermatology and Therapy, 7 (3). pp. 383-393. doi:10.1007/s13555-017-0186-1 ISSN 2193-8210.

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Abstract

Introduction:
Patient eczema severity time (PEST) is a new atopic dermatitis (AD) scoring system based on patients’ own perception of their disease. Conventional scales such as SCORing of atopic dermatitis (SCORAD) reflect the clinician’s observations during the clinic visit. Instead, the PEST score captures eczema severity, relapse and recovery as experienced by the patient or caregiver on a daily basis, promoting patient engagement, compliance with treatment and improved outcomes. This study aims to determine the correlation between carer-assessed PEST and clinician-assessed SCORAD in paediatric AD patients after 12 weeks of treatment using a ceramide-dominant therapeutic moisturizer.

Methods:
Prospective, open-label, observational, multi-centre study in which children with AD aged 6 months to 6 years were treated with a ceramide dominant therapeutic moisturizer twice daily for 12 weeks; 58 children with mild-to-moderate AD were included. Correlation between the 7-day averaged PEST and SCORAD scores for assessment of AD severity was measured within a general linear model. PEST and SCORAD were compared in week 4 and week 12.

Results:
At week 12, a moderate correlation was found between the SCORAD and PEST scores (r = 0.51). The mean change in SCORAD and PEST scores from baseline to week 12 was −11.46 [95% confidence interval (CI) −14.99 to −7.92, p < 0.0001] and −1.33 (95% CI −0.71 to −0.10, p < 0.0001) respectively. PEST demonstrated greater responsiveness to change (33.3% of scale) compared to SCORAD (13.8% of scale).

Conclusion:
The PEST score correlates well with the SCORAD score and may have improved sensitivity when detecting changes in the severity of AD. The ceramide-dominant therapeutic moisturizer used was safe and effective in the management of AD in young children.

Item Type:	Journal Article
Subjects:	R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services R Medicine > RL Dermatology
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH):	Eczema in children -- Treatment, Atopic dermatitis
Journal or Publication Title:	Dermatology and Therapy
Publisher:	Springer Healthcare Communications Ltd.
ISSN:	2193-8210
Official Date:	September 2017
Dates:	Date Event September 2017 Published 14 June 2017 Available 14 June 2017 Accepted
Volume:	7
Number:	3
Page Range:	pp. 383-393
DOI:	10.1007/s13555-017-0186-1
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	19 June 2017
Date of first compliant Open Access:	20 June 2017
Funder:	Hyphens Pharma Pte Ltd

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