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Investigating the evolutionary origins and cell biology of Negativicutes.
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Brown, Richard Francis (2016) Investigating the evolutionary origins and cell biology of Negativicutes. PhD thesis, University of Warwick.
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Official URL: http://webcat.warwick.ac.uk/record=b3067395~S15
Abstract
The Negativicutes are a class of bacteria within the predominantly Grampositive phylum Firmicutes that possess a diderm Gram-negative cell envelope along with lipopolysaccharides. Remarkably, some members of this class of Gram-negative bacteria can form endospores. The evolutionary origins of this enigmatic class were investigated through bioinformatics analyses, which defined and characterised their Gram-negative and Gram-positive toolkits, while analyses of Gram-negative signature proteins provided insights into the origins of the Gram-negative toolkit. The genome of Sporomusa sphaeroides, a sporulating species from the Negativicutes, was sequenced and annotated for the first time. In addition, the transcriptional landscapes of Veillonella parvula and Sporomusa sphaeroides during logarithmic and stationary phase growth were investigated using RNA-Seq, expanding the repertoire of known genome features, including non-coding RNAs within these species.
Item Type: | Thesis (PhD) | ||||
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Subjects: | Q Science > QH Natural history | ||||
Library of Congress Subject Headings (LCSH): | Phylogeny -- Molecular aspects, Gram's stain, Stains and staining (Microscopy), Gram-negative bacteria, Cytology | ||||
Official Date: | October 2016 | ||||
Dates: |
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Institution: | University of Warwick | ||||
Theses Department: | Warwick Medical School | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Pallen, Mark J. ; Denham, Emma | ||||
Format of File: | |||||
Extent: | xvii, 214 leaves : illustrations, charts | ||||
Language: | eng |
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