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Interactions between myeloma and endothelial cells and the effects of thalidomide and its analogues
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UNSPECIFIED (2002) Interactions between myeloma and endothelial cells and the effects of thalidomide and its analogues. In: 7th Annual Meeting of the European-Haematology-Association, FLORENCE, ITALY, JUN 06-09, 2002. Published in: 7TH ANNUAL MEETING OF THE EUROPEAN HAEMATOLOGY ASSOCIATION pp. 263-266. ISBN 88-323-2606-X.
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Abstract
Modelling the situation observed in vivo, we examined the effects of thalidomide and its analogues in co-cultures of myeloma and endothelial cells. It was found that myeloma cells in co-culture had significantly lower levels of CC-10004- and CC-1088-induced apoptosis than those cultured alone. Interestingly, basal apoptosis was also lower in RPMI-8226/S co-cultured with endothelial cells compared to myeloma cell culture. Our data suggest that myeloma/endothelial cell interactions in co-culture have a significant protective effect on both basal and drug-induced levels of apoptosis in myeloma cells.
Item Type: | Conference Item (UNSPECIFIED) | ||||
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Subjects: | R Medicine > RB Pathology | ||||
Journal or Publication Title: | 7TH ANNUAL MEETING OF THE EUROPEAN HAEMATOLOGY ASSOCIATION | ||||
Publisher: | MEDIMOND S R L | ||||
ISBN: | 88-323-2606-X | ||||
Official Date: | 2002 | ||||
Dates: |
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Number of Pages: | 4 | ||||
Page Range: | pp. 263-266 | ||||
Publication Status: | Published | ||||
Title of Event: | 7th Annual Meeting of the European-Haematology-Association | ||||
Location of Event: | FLORENCE, ITALY | ||||
Date(s) of Event: | JUN 06-09, 2002 |
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