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Antifreeze protein mimetic metallohelices with potent ice recrystallization inhibition activity
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Mitchell, Daniel E., Clarkson, Guy J., Fox, David J., Vipond, Rebecca A. (Ann), Scott, Peter and Gibson, Matthew I. (2017) Antifreeze protein mimetic metallohelices with potent ice recrystallization inhibition activity. Journal of the American Chemical Society, 139 (29). pp. 9835-9838. doi:10.1021/jacs.7b05822 ISSN 0002-7863.
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Official URL: http://doi.org/10.1021/jacs.7b05822
Abstract
Antifreeze proteins are produced by extremophile species to control ice formation and growth, and they have potential applications in many fields. There are few examples of synthetic materials which can reproduce their potent ice recrystallization inhibition property. We report that self-assembled enantiomerically pure, amphipathic metallohelicies inhibited ice growth at just 20 μM. Structure-property relationships and calculations support the hypothesis that amphipathicity is the key motif for activity. This opens up a new field of metallo-organic antifreeze protein mimetics and provides insight into the origins of ice-growth inhibition.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QP Physiology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Antifreeze proteins, Amphiphiles, Ice crystals -- Growth -- Prevention | ||||||||
Journal or Publication Title: | Journal of the American Chemical Society | ||||||||
Publisher: | American Chemical Society | ||||||||
ISSN: | 0002-7863 | ||||||||
Official Date: | 26 July 2017 | ||||||||
Dates: |
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Volume: | 139 | ||||||||
Number: | 29 | ||||||||
Page Range: | pp. 9835-9838 | ||||||||
DOI: | 10.1021/jacs.7b05822 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 28 July 2017 | ||||||||
Date of first compliant Open Access: | 12 October 2017 | ||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), European Research Council (ERC) | ||||||||
Grant number: | EP/F500378/1 (EPSRC), CRYOMAT 638661 (ERC) |
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