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‘Something in the way she moves’ : the functional significance of flexibility in the multiple roles of protein disulfide isomerase (PDI)
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Freedman, R. B., Desmond, Jasmine L., Byrne, Lee J., Heal, Jack W., Howard, Mark J., Sanghera, Narinder, Walker, Kelly L., Wallis, A. Katrine, Wells, Stephen A., Williamson, Richard A. and Römer, Rudolf A. (2017) ‘Something in the way she moves’ : the functional significance of flexibility in the multiple roles of protein disulfide isomerase (PDI). Biochimica et Biophysica Acta - Proteins and Proteomics, 1865 (11 Part A). pp. 1383-1394. doi:10.1016/j.bbapap.2017.08.014 ISSN 1570-9639.
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Official URL: https://doi.org/10.1016/j.bbapap.2017.08.014
Abstract
Protein disulfide isomerase (PDI) has diverse functions in the endoplasmic reticulum as catalyst of redox transfer, disulfide isomerization and oxidative protein folding, as molecular chaperone and in multi-subunit complexes. It interacts with an extraordinarily wide range of substrate and partner proteins, but there is only limited structural information on these interactions. Extensive evidence on the flexibility of PDI in solution is not matched by any detailed picture of the scope of its motion. A new rapid method for simulating the motion of large proteins provides detailed molecular trajectories for PDI demonstrating extensive changes in the relative orientation of its four domains, great variation in the distances between key sites and internal motion within the core ligand-binding domain. The review shows that these simulations are consistent with experimental evidence and provide insight into the functional capabilities conferred by the extensive flexible motion of PDI.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | Q Science > QH Natural history Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Science > Centre for Scientific Computing |
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Library of Congress Subject Headings (LCSH): | Protein disulfide isomerase, Endoplasmic reticulum | |||||||||||||||
Journal or Publication Title: | Biochimica et Biophysica Acta - Proteins and Proteomics | |||||||||||||||
Publisher: | Elsevier BV | |||||||||||||||
ISSN: | 1570-9639 | |||||||||||||||
Official Date: | November 2017 | |||||||||||||||
Dates: |
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Volume: | 1865 | |||||||||||||||
Number: | 11 Part A | |||||||||||||||
Page Range: | pp. 1383-1394 | |||||||||||||||
DOI: | 10.1016/j.bbapap.2017.08.014 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
Date of first compliant deposit: | 30 August 2017 | |||||||||||||||
Date of first compliant Open Access: | 24 August 2018 | |||||||||||||||
RIOXX Funder/Project Grant: |
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