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Environmental and genetic determinants of vitamin D status among older adults in London, UK
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Jolliffe, David A., Hanifa, Yasmeen, Witt, Karolina D., Venton, Timothy R., Rowe, Marion, Timms, Peter M., Hyppönen, Elina, Walton, Robert T., Griffiths, Christopher J. and Martineau, Adrian R. (2016) Environmental and genetic determinants of vitamin D status among older adults in London, UK. The Journal of Steroid Biochemistry and Molecular Biology, 164 . pp. 30-35. doi:10.1016/j.jsbmb.2016.01.005 ISSN 0960-0760.
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Official URL: http://dx.doi.org/10.1016/j.jsbmb.2016.01.005
Abstract
Despite the high prevalence of vitamin D deficiency among older adults in the UK, studies investigating the determinants of vitamin D status in this group are lacking. We conducted a cross-sectional study in 222 older adults living in sheltered accommodation in London, UK, who were screened for participation in a clinical trial of vitamin D supplementation for the prevention of acute respiratory infection. Details of potential demographic and lifestyle determinants of vitamin D status were collected by questionnaire and blood samples were taken for analysis of serum 25-hydroxyvitamin D (25[OH]D) concentration and DNA extraction. Fifteen single nucleotide polymorphisms (SNP) in 6 genes (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, VDR) previously reported to associate with circulating 25(OH)D concentration were typed using Taqman allelic discrimination assays. Linear regression was used to identify environmental and genetic factors independently associated with serum 25(OH)D concentration. Mean serum 25(OH)D concentration was 42.7 nmol/L (SD 22.0); 144/222 (64.9%) participants had serum 25(OH)D concentrations <50 nmol/L. The following factors were independently associated with lower serum 25(OH)D concentration: non-white ethnicity (−8.6 nmol/L, 95% CI −14.9 to −2.3, P = 0.008); lack of vitamin D supplement consumption (−17.1 nmol/L, 95% CI −23.3 to −10.9, P < 0.001) vs. taking a daily supplement; sampling in Q1/January–March (−12.2 nmol/L, 95% CI −21.5 to −2.9, P = 0.01), and sampling in Q4/October–December (−10.3 nmol/L, 95% CI −20.2 to −0.4, P = 0.04) vs. sampling in Q3/July–September. None of the 15 SNP investigated independently associated with serum 25(OH)D concentration after correcting for multiple comparisons. In conclusion, vitamin D deficiency was highly prevalent among the older adults in this study; non-White ethnicity, lack of vitamin D supplement consumption and sampling in winter and spring independently associated with lower vitamin D status.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | The Journal of Steroid Biochemistry and Molecular Biology | ||||||||
Publisher: | Pergamon Press | ||||||||
ISSN: | 0960-0760 | ||||||||
Official Date: | November 2016 | ||||||||
Dates: |
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Volume: | 164 | ||||||||
Page Range: | pp. 30-35 | ||||||||
DOI: | 10.1016/j.jsbmb.2016.01.005 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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