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Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa
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Yindom, L.-M., Leligdowicz, A., Martin, M. P., Gao, X., Qi, Y., Zaman, S. M. A., Van Der Loeff, M. S., Van Tienen, C., Jaye, A., Aveika, A., Worwui, A., Diatta, M., Vincent, T., Whittle, H. C., Rowland-Jones, S. L., Walton, Robert T. and Carrington, M. (2010) Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa. Journal of Virology, 84 (16). pp. 8202-8208. ISSN 0022-538X.
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Official URL: https://doi.org/10.1128/JVI.00116-10
Abstract
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HLA-B*0801 is associated with susceptibility to infection. Interestingly, previous data indicate that HLA-B*1503 is associated with low viral loads in HIV-1 clade B infection but has no significant effect on viral load in clade C infection. In general, alleles strongly associated with HIV-1 disease showed no effect in HIV-2 disease. These data emphasize the unique nature of the effects of HLA and HLA/KIR combinations on HIV-2 immune responses relative to HIV-1, which could be related to their distinct clinical course.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Journal of Virology | ||||||
Publisher: | American Society for Microbiology | ||||||
ISSN: | 0022-538X | ||||||
Official Date: | 2 June 2010 | ||||||
Dates: |
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Volume: | 84 | ||||||
Number: | 16 | ||||||
Page Range: | pp. 8202-8208 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Reuse Statement (publisher, data, author rights): | cited By 21 | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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