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Poly(oligo(ethylene glycol) vinyl acetate)s : a versatile class of thermoresponsive and biocompatible polymers
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Hedir, Guillaume, Arno, Maria Chiara, Langlais, Marvin, Husband, Jonathan, O'Reilly, Rachel K. and Dove, Andrew P. (2017) Poly(oligo(ethylene glycol) vinyl acetate)s : a versatile class of thermoresponsive and biocompatible polymers. Angewandte Chemie International Edition, 56 (31). pp. 9178-9182. doi:10.1002/anie.201703763 ISSN 1433-7851.
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Official URL: http://dx.doi.org/10.1002/anie.201703763
Abstract
Polymers with a thermally-triggered phase transition are important in the design of materials for biological applications where their behavior can be used to trigger release or (dis)assembly events. Despite their advantages, a system with tuneable thermal response, end-group reactive sites, low toxicity and controlled main-chain degradability has not been realised, yet would represent a significant advance. We report the versatile new poly(oligo(ethylene glycol) vinyl acetate)s with excellent control over their molecular properties obtained through RAFT/MADIX polymerization. Furthermore, we demonstrate structure-controlled thermal transitions, conjugation to human lysozyme through the retained end group and moreover show that this class of polymers can uniquely be copolymerized with 2-methylene-1,3-dioxepane (MDO) to generate polymers in which the degradability and cloud point can be independently tuned to create materials that display the same cloud point but degrade differently.
Item Type: | Journal Article | ||||||||||||||||||||||||
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Subjects: | T Technology > TP Chemical technology | ||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Vinyl acetate, Addition polymerization | ||||||||||||||||||||||||
Journal or Publication Title: | Angewandte Chemie International Edition | ||||||||||||||||||||||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||||||||||||||||||
ISSN: | 1433-7851 | ||||||||||||||||||||||||
Official Date: | 30 June 2017 | ||||||||||||||||||||||||
Dates: |
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Volume: | 56 | ||||||||||||||||||||||||
Number: | 31 | ||||||||||||||||||||||||
Page Range: | pp. 9178-9182 | ||||||||||||||||||||||||
DOI: | 10.1002/anie.201703763 | ||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||
Date of first compliant deposit: | 20 November 2017 | ||||||||||||||||||||||||
Date of first compliant Open Access: | 19 June 2018 | ||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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