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IL-1 beta-dependent activation of NF-kappa B mediates PGE(2) release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase
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UNSPECIFIED (2003) IL-1 beta-dependent activation of NF-kappa B mediates PGE(2) release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. FEBS LETTERS, 547 (1-3). pp. 75-79. doi:10.1016/S0014-5793(03)00672-0 ISSN 0014-5793.
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Official URL: http://dx.doi.org/10.1016/S0014-5793(03)00672-0
Abstract
Prostaglandin (PG) E-2 release is induced in pulmonary A549 cells by the NF-kappaB-activating stimuli interleukin-1beta (IL-1beta) and phorbol 12-myristate 13-acetate (PMA). Adenoviral over-expression of IkappaBalphaDeltaN, a dominant NF-kappaB inhibitor, prevents NF-kappaB-dependent transcription and was used to qualify the role of NF-kappaB in the release of PGE(2). IkappaBalphaDeltaN repressed IL-1beta-induced, but not PMA-induced, cycloxygenase-2 (COX-2) and microsomal prostaglandin E synthase (mPGES) expression. These data conclusively demonstrate a substantial role for NF-kappabeta in the co-ordinate induction of COX-2, mPGES and in the corresponding release of PGE(2) by IL-1beta. However, other pathways are primarily responsible for PGE(2) release induced by PMA. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
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Journal or Publication Title: | FEBS LETTERS | ||||
Publisher: | ELSEVIER SCIENCE BV | ||||
ISSN: | 0014-5793 | ||||
Official Date: | 17 July 2003 | ||||
Dates: |
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Volume: | 547 | ||||
Number: | 1-3 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 75-79 | ||||
DOI: | 10.1016/S0014-5793(03)00672-0 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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