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Sex- and gamete-specific patterns of X chromosome segregation in a trioecious nematode
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Tandonnet, Sophie, Farrell, Maureen C., Koutsovoulos, Georgios D., Blaxter, Mark L., Parihar, Manish, Sadler, Penny L., Shakes, Diane C. and Pires da Silva, André (2018) Sex- and gamete-specific patterns of X chromosome segregation in a trioecious nematode. Current Biology, 28 (1). pp. 93-99. doi:10.1016/j.cub.2017.11.037 ISSN 0960-9822.
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Official URL: http://dx.doi.org/10.1016/j.cub.2017.11.037
Abstract
Three key steps in meiosis allow diploid organisms to produce haploid gametes: (1) homologous chromosomes (homologs) pair and undergo crossovers; (2) homologs segregate to opposite poles; and (3) sister chromatids segregate to opposite poles. The XX/XO sex determination system found in many nematodes [1] facilitates the study of meiosis because variation is easily recognized [2, 3, 4]. Here we show that meiotic segregation of X chromosomes in the trioecious nematode Auanema rhodensis [5] varies according to sex (hermaphrodite, female, or male) and type of gametogenesis (oogenesis or spermatogenesis). In this species, XO males exclusively produce X-bearing sperm [6, 7]. The unpaired X precociously separates into sister chromatids, which co-segregate with the autosome set to generate a functional haplo-X sperm. The other set of autosomes is discarded into a residual body. Here we explore the X chromosome behavior in female and hermaphrodite meioses. Whereas X chromosomes segregate following the canonical pattern during XX female oogenesis to yield haplo-X oocytes, during XX hermaphrodite oogenesis they segregate to the first polar body to yield nullo-X oocytes. Thus, crosses between XX hermaphrodites and males yield exclusively male progeny. During hermaphrodite spermatogenesis, the sister chromatids of the X chromosomes separate during meiosis I, and homologous X chromatids segregate to the functional sperm to create diplo-X sperm. Given these intra-species, intra-individual, and intra-gametogenesis variations in the meiotic program, A. rhodensis is an ideal model for studying the plasticity of meiosis and how it can be modulated.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QL Zoology | |||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Nematodes -- Reproduction, Nematodes -- Genetics, Intersexuality in animals, Meiosis, Gametes, Spermatogenesis, Chromosomes | |||||||||||||||||||||
Journal or Publication Title: | Current Biology | |||||||||||||||||||||
Publisher: | Cell Press | |||||||||||||||||||||
ISSN: | 0960-9822 | |||||||||||||||||||||
Official Date: | 8 January 2018 | |||||||||||||||||||||
Dates: |
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Volume: | 28 | |||||||||||||||||||||
Number: | 1 | |||||||||||||||||||||
Page Range: | pp. 93-99 | |||||||||||||||||||||
DOI: | 10.1016/j.cub.2017.11.037 | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 6 December 2017 | |||||||||||||||||||||
Date of first compliant Open Access: | 10 January 2018 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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