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Self-assembled selenium nanoparticles and their application in the rapid diagnostic detection of small cell lung cancer biomarkers
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Zhao, Yilin, Sun, Qiufeng, Zhang, Xi, Baeyens, Jan and Su, Haijia (2017) Self-assembled selenium nanoparticles and their application in the rapid diagnostic detection of small cell lung cancer biomarkers. Soft Matter, 481 (4). pp. 481-489. doi:10.1039/c7sm01687e ISSN 1744-683X.
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Official URL: http://doi.org/10.1039/c7sm01687e
Abstract
By coupling molecular imprinting, chitosan biosorption and TiO2 photocatalysis, selenium nanoparticles (Se NPs) were self-assembled in a controlled manner on the molecular imprinting sites of zeolite-chitosan-TiO2 microspheres. Se NPs with different sizes and areal densities were individually synthesized by controlling the rapid adsorption of molecular-imprinted nanocomposites and photocatalytic reaction of TiO2 nanoparticles. In order to improve the sensitivity and specificity of rapid diagnostic detection, Se NPs were self-assembled again into high-order and spherically stable structures with an average size of 80 nm by well-defined monomer units, after separation from zeolite-chitosan-TiO2 microspheres with a stabilizer of 0.3% (v/v) bovine serum albumin. Due to their biological activity, spherical-shaped Se NPs were used for dot-blot immunoassays with multiple native antigens for rapid serodiagnosis of human lung cancer. The sensitivity of the dot immunoassays for detecting progastrin-releasing peptide (ProGRP) was 75 pg mL-1. The detection time of colloidal Se dot immunoassays for ProGRP was only 5 min. No positive results were observed with other commonly potential interfering substances, including carcinoembryonic antigen, α-fetoprotein antigen and BSA. The research presents a simple and green method for the reuse of SeO32- and the controlled synthesis of Se NPs for biological and medical applications by bioaffinity adsorption and photoreduction.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Soft Matter | ||||||||
Publisher: | Royal Society of Chemistry | ||||||||
ISSN: | 1744-683X | ||||||||
Official Date: | 27 November 2017 | ||||||||
Dates: |
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Volume: | 481 | ||||||||
Number: | 4 | ||||||||
Page Range: | pp. 481-489 | ||||||||
DOI: | 10.1039/c7sm01687e | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | ** From PubMed via Jisc Publications Router. | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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