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The role of parafacial neurons in the control of breathing during exercise
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Korsak, Alla, Sheikhbahaei , Shahriar , Machhada , Asif , Gourine , Alexander V. and Huckstepp, Robert T. R. (2018) The role of parafacial neurons in the control of breathing during exercise. Scientific Reports, 8 . 400 . doi:10.1038/s41598-017-17412-z ISSN 2045-2322.
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WRAP-role-parafacial-neurons-control-breathing-during-exercise-Huckstepp-2018.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (3727Kb) | Preview |
Official URL: http://doi.org/10.1038/s41598-017-17412-z
Abstract
Neuronal cell groups residing within the retrotrapezoid nucleus (RTN) and C1 area of the rostral ventrolateral medulla oblongata contribute to the maintenance of resting respiratory activity and arterial blood pressure, and play an important role in the development of cardiorespiratory responses to metabolic challenges (such as hypercapnia and hypoxia). In rats, acute silencing of neurons within the parafacial region which includes the RTN and the rostral aspect of the C1 circuit (pFRTN/C1), transduced to express HM4D (Gi-coupled) receptors, was found to dramatically reduce exercise capacity (by 60%), determined by an intensity controlled treadmill running test. In a model of simulated exercise (electrical stimulation of the sciatic or femoral nerve in urethane anaesthetised spontaneously breathing rats) silencing of the pFRTN/C1 neurons had no effect on cardiovascular changes, but significantly reduced the respiratory response during steady state exercise. These results identify a neuronal cell group in the lower brainstem which is critically important for the development of the respiratory response to exercise and, determines exercise capacity.
Item Type: | Journal Article | ||||||||||||
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Subjects: | Q Science > QP Physiology | ||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||
Library of Congress Subject Headings (LCSH): | Respiration -- Physiological aspects, Exercise, Neurosciences | ||||||||||||
Journal or Publication Title: | Scientific Reports | ||||||||||||
Publisher: | Nature Publishing Group | ||||||||||||
ISSN: | 2045-2322 | ||||||||||||
Official Date: | 10 January 2018 | ||||||||||||
Dates: |
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Volume: | 8 | ||||||||||||
Article Number: | 400 | ||||||||||||
DOI: | 10.1038/s41598-017-17412-z | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
Date of first compliant deposit: | 12 January 2018 | ||||||||||||
Date of first compliant Open Access: | 15 January 2018 | ||||||||||||
RIOXX Funder/Project Grant: |
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