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Enzymatically-stable oxetane-based dipeptide hydrogels
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McDougall, Laura, Draper, Emily Rose, Beadle, Jonathan D., Shipman, Michael, Raubo, Piotr, Jamieson, Andrew George and Adams, Dave (2018) Enzymatically-stable oxetane-based dipeptide hydrogels. Chemical Communications, 54 (14). pp. 1793-1796. doi:10.1039/C7CC09701H ISSN 1359-7345.
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WRAP-enzymatically-stable-oxetane-based-hydrogels-Shipman-2018.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution. Download (1433Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/C7CC09701H
Abstract
Low molecular weight gelators that are not easily degraded by enzymes have a range of potential applications. Here, we report new Fmoc-protected dipeptides in which the amide carbonyl group has been replaced by an oxetane ring. Remarkably one of these peptidomimetics, but not the corresponding dipeptide, is an effective gelator, forming hydrogels at a concentration of 3 mg/mL. On assembly, there is a lack of beta-sheet structure, implying that there is no requirement for this motif in such a gel. Furthermore, the modified dipeptide is also stable to proteolysis compared to the parent dipeptide.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Colloids, Enzymes, Proteolysis | ||||||||
Journal or Publication Title: | Chemical Communications | ||||||||
Publisher: | Royal Society of Chemistry | ||||||||
ISSN: | 1359-7345 | ||||||||
Official Date: | 18 February 2018 | ||||||||
Dates: |
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Volume: | 54 | ||||||||
Number: | 14 | ||||||||
Page Range: | pp. 1793-1796 | ||||||||
DOI: | 10.1039/C7CC09701H | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 26 January 2018 | ||||||||
Date of first compliant Open Access: | 29 January 2018 |
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