Jochimsen, Thies H., Zeisig, Vilia, Schulz, Jessica, Werner, Peter, Patt, Marianne, Patt, Jörg, Dreyer, Antje Y., Boltze, Johannes, Barthel, Henryk, Sabri, Osama and Sattler, Bernhard (2016) Fully automated calculation of image-derived input function in simultaneous PET/MRI in a sheep model. EJNMMI Physics, 3 (1). 2. doi:10.1186/s40658-016-0139-2 ISSN 2197-7364.
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Abstract
Background
Obtaining the arterial input function (AIF) from image data in dynamic positron emission tomography (PET) examinations is a non-invasive alternative to arterial blood sampling. In simultaneous PET/magnetic resonance imaging (PET/MRI), high-resolution MRI angiographies can be used to define major arteries for correction of partial-volume effects (PVE) and point spread function (PSF) response in the PET data. The present study describes a fully automated method to obtain the image-derived input function (IDIF) in PET/MRI. Results are compared to those obtained by arterial blood sampling.
Methods
To segment the trunk of the major arteries in the neck, a high-resolution time-of-flight MRI angiography was postprocessed by a vessel-enhancement filter based on the inertia tensor. Together with the measured PSF of the PET subsystem, the arterial mask was used for geometrical deconvolution, yielding the time-resolved activity concentration averaged over a major artery. The method was compared to manual arterial blood sampling at the hind leg of 21 sheep (animal stroke model) during measurement of blood flow with O15-water. Absolute quantification of activity concentration was compared after bolus passage during steady state, i.e., between 2.5- and 5-min post injection. Cerebral blood flow (CBF) values from blood sampling and IDIF were also compared.
Results
The cross-calibration factor obtained by comparing activity concentrations in blood samples and IDIF during steady state is 0.98 ± 0.10. In all examinations, the IDIF provided a much earlier and sharper bolus peak than in the time course of activity concentration obtained by arterial blood sampling. CBF using the IDIF was 22 % higher than CBF obtained by using the AIF yielded by blood sampling.
Conclusions
The small deviation between arterial blood sampling and IDIF during steady state indicates that correction of PVE and PSF is possible with the method presented. The differences in bolus dynamics and, hence, CBF values can be explained by the different sampling locations (hind leg vs. major neck arteries) with differences in delay/dispersion. It will be the topic of further work to test the method on humans with the perspective of replacing invasive blood sampling by an IDIF using simultaneous PET/MRI.
| Item Type: | Journal Article |
|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
| Journal or Publication Title: | EJNMMI Physics |
| Publisher: | Springer |
| ISSN: | 2197-7364 |
| Official Date: | 13 February 2016 |
| Dates: | Date Event 13 February 2016 Published 29 January 2016 Accepted |
| Volume: | 3 |
| Number: | 1 |
| Article Number: | 2 |
| DOI: | 10.1186/s40658-016-0139-2 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| URI: | https://wrap.warwick.ac.uk/119159/ |
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