Fairbanks, Emma L., Brennan, Marnie L., Mertens, Peter P. C., Tildesley, Michael J. and Daly, Janet M. (2022) Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search. Transboundary and Emerging Diseases, 69 (4). pp. 671-681. doi:10.1111/tbed.14420 ISSN 1865-1674.
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Abstract
African horse sickness (AHS) is a vector-borne disease transmitted by Culicoides spp., endemic to sub-Saharan Africa. There have been many examples of historic and recent outbreaks in the Middle East, Asia and Europe. However, not much is known about infection dynamics and outbreak potential in these naive populations. In order to better inform a previously published ordinary differential equation model, we performed a systematic literature search to identify studies documenting experimental infection of naive (control) equids in vaccination trials. Data on the time until the onset of viraemia, clinical signs and death after experimental infection of a naive equid and duration of viraemia were extracted. The time to viraemia was 4.6 days and the time to clinical signs was 4.9 days, longer than the previously estimated latent period of 3.7 days. The infectious periods of animals that died/were euthanized or survived were found to be 3.9 and 8.7 days, whereas previous estimations were 4.4 and 6 days, respectively. The case fatality was also found to be higher than previous estimations. The updated parameter values (along with other more recently published estimates from literature) resulted in an increase in the number of host deaths, decrease in the duration of the outbreak and greater prevalence in vectors.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine S Agriculture > SF Animal culture |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
| SWORD Depositor: | Library Publications Router |
| Library of Congress Subject Headings (LCSH): | African horse sickness virus, African horse sickness virus -- Mathematical models, Insects as carriers of disease, African horse sickness -- Epidemiology -- Mathematical models |
| Journal or Publication Title: | Transboundary and Emerging Diseases |
| Publisher: | Wiley |
| ISSN: | 1865-1674 |
| Official Date: | July 2022 |
| Dates: | Date Event July 2022 Published 18 December 2021 Available 29 September 2021 Accepted |
| Volume: | 69 |
| Number: | 4 |
| Page Range: | pp. 671-681 |
| DOI: | 10.1111/tbed.14420 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 1 February 2022 |
| Date of first compliant Open Access: | 1 February 2022 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID 1944283 [BBSRC] Biotechnology and Biological Sciences Research Council |
| Related URLs: | |
| URI: | https://wrap.warwick.ac.uk/161807/ |
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