Wu, Xin-Rui, Wu, Kai-Min, Deng, Yue-Ting, Huang, Shu-Yi, Yang, Liu, Dong, Qiang, Feng, Jian-Feng, Cheng, Wei and Yu, Jin-Tai (2022) Association of kidney function with risk of incident dementia : a prospective cohort study of 275,167 UK Biobank participants. Journal of Alzheimer's Disease, 90 (3). pp. 1249-1261. doi:10.3233/jad-220609 ISSN 1875-8908.
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Abstract
Background:Previous studies have reported inconsistent associations between chronic kidney disease (CKD) and dementia. Objective:To evaluate whether CKD is a risk factor for dementia and compare the performance of different measures of calculating estimated glomerular filtration rate (eGFR). Methods:275,167 participants from UK Biobank were included and eGFR at baseline was calculated using serum creatinine (eGFRcr), cystatin C (eGFRcys), and creatinine-cystatin C equations (eGFRcr-cys). Restricted cubic splines and Cox regression models were performed to assess the relationship of eGFR with all-cause dementia, Alzheimer’s disease (AD), and vascular dementia (VaD). Results:We observed a U-shaped relationship between each eGFR and risk of all-cause dementia and VaD, with eGFRcys and eGFRcr-cys showing a closer linkage (peGFRcys <0.0001, peGFRcrhboxcys<0.0001 and peGFRcr = 0.0001). Lower and supranormal eGFR were related to increased risk of all-cause dementia. Compared to the reference category of 90–104 ml/min/1.73 m2, adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of all-cause dementia for eGFRcr-cys 30–59, <30, and ≥105 ml/min/1.73 m2 were 1.26 (95% CI [1.05–1.50], p = 0.012), 2.62 (95% CI [1.54–4.47], p < 0.001), and 1.41 (95% CI [1.17–1.70], p < 0.001). No statistically significant association was observed between eGFR with risk of AD. Conclusion:This prospective study identified impaired kidney function as a critical risk factor for dementia and noted the application of cystatin C strengthened the relationship between CKD and dementia, underlining the significant value of preserving kidney function to reduce the risk of dementia and considering cystatin C measurement as part of clinical practice.
Item Type: | Journal Article |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science |
SWORD Depositor: | Library Publications Router |
Journal or Publication Title: | Journal of Alzheimer's Disease |
Publisher: | IOS Press |
ISSN: | 1875-8908 |
Official Date: | 8 October 2022 |
Dates: | Date Event 8 October 2022 Published 9 September 2022 Accepted |
Volume: | 90 |
Number: | 3 |
Page Range: | pp. 1249-1261 |
DOI: | 10.3233/jad-220609 |
Status: | Peer Reviewed |
Publication Status: | Published |
Access rights to Published version: | Restricted or Subscription Access |
URI: | https://wrap.warwick.ac.uk/170354/ |
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