Makura, Caroline BT, Nirantharakumar, Krishnarajah, Girling, Alan J, Saravanan, Ponnusamy and Narendran, Parth (2013) Effects of physical activity on the development and progression of microvascular complications in type 1 diabetes : retrospective analysis of the DCCT study. BMC Endocrine Disorders, Volume 13 (Number 1). Article number 37. doi:10.1186/1472-6823-13-37 ISSN 1472-6823.
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Abstract
Background: To examine the effects of physical activity on the development and progression of microvascular complications in patients with type 1 diabetes.
Methods: A retrospective analysis of data from the Diabetes Control and Complications trial was undertaken. Physical activity data was collected at baseline for each of 1441 recruits, converted to metabolic equivalent of task values, and categorised according to the American College of Sports Medicine recommendations. The rates of development/progression of diabetic retinopathy, nephropathy and neuropathy were compared in those who achieved over twice recommended, up to twice recommended, and less than recommended metabolic equivalent of task levels of activity. The DCCT study had a mean duration of follow up of 6.5 years ending in 1993.
Results: A total of 271 subjects had a sustained three-step progression in diabetic retinopathy. The rates of development or progression of retinopathy showed no significant association with physical activity level. The number of outcomes for nephropathy and neuropathy were small and there was no significant association with physical activity level.
Conclusions: We found no evidence that physical activity improves microvascular outcomes in type 1 diabetes. However we demonstrate no evidence of harm. We suggest that physical activity continues to play an important role in the management of type 1 diabetes.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Diabetes , Diabetes -- Complications, Diabetes -- Research , Exercise -- Physiological aspects, Exercise therapy |
| Journal or Publication Title: | BMC Endocrine Disorders |
| Publisher: | BioMed Central Ltd. |
| ISSN: | 1472-6823 |
| Official Date: | October 2013 |
| Dates: | Date Event October 2013 Published |
| Volume: | Volume 13 |
| Number: | Number 1 |
| Page Range: | Article number 37 |
| DOI: | 10.1186/1472-6823-13-37 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 26 December 2015 |
| Date of first compliant Open Access: | 26 December 2015 |
| Funder: | National Institutes of Health (U.S.) (NIH), National Center for Research Resources (U.S.) (NCRR) |
| URI: | https://wrap.warwick.ac.uk/58452/ |
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