Cappuccio, Francesco, D'Elia, Lanfranco, Strazzullo, Pasquale and Miller, Michelle A. (2010) Sleep duration and all-cause mortality : a systematic review and meta-analysis of prospective studies. Sleep, Vol.33 (No.5). pp. 585-592. ISSN 0161-8105.
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Abstract
Background: Increasing evidence suggests an association between both short and long duration of habitual sleep with adverse health outcomes.
Objectives: To assess whether the population longitudinal evidence supports the presence of a relationship between duration of sleep and all-cause mortality, to investigate both short and long sleep duration and to obtain an estimate of the risk.
Methods: We performed a systematic search of publications using MEDLINE (1966-2009), EMBASE (from 1980), the Cochrane Library, and manual searches without language restrictions. We included studies if they were prospective, had follow-up >3 years, had duration of sleep at baseline, and all-cause mortality prospectively. We extracted relative risks (RR) and 95% confidence intervals (CI) and pooled them using a random effect model. We carried out sensitivity analyses and assessed heterogeneity and publication bias.
Results: Overall, the 16 studies analyzed provided 27 independent cohort samples. They included 1,382,999 male and female participants (follow-up range 4 to 25 years), and 112,566 deaths. Sleep duration was assessed by questionnaire and outcome through death certification. In the pooled analysis, short duration of sleep was associated with a greater risk of death (RR: 1.12; 95% CI 1.06 to 1.18; P <0.01) with no evidence of publication bias (P = 0.74) but heterogeneity between studies (P = 0.02). Long duration of sleep was also associated with a greater risk of death (1.30; [1.22 to 1.38]; P < 0.0001) with no evidence of publication bias (P = 0.18) but significant heterogeneity between studies (P < 0.0001).
Conclusion: Both short and long duration of sleep are significant predictors of death in prospective population studies.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Sleep, Systematic reviews (Medical research), Meta-analysis, Mortality |
| Journal or Publication Title: | Sleep |
| Publisher: | American Academy of Sleep Medicine |
| ISSN: | 0161-8105 |
| Official Date: | 1 May 2010 |
| Dates: | Date Event 1 May 2010 Published |
| Volume: | Vol.33 |
| Number: | No.5 |
| Number of Pages: | 8 |
| Page Range: | pp. 585-592 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Seventh Framework Programme (European Commission) (FP7) |
| Grant number: | FP7-HEALTH-2007-201550 (FP7) |
| URI: | https://wrap.warwick.ac.uk/5980/ |
Data sourced from Thomson Reuters' Web of Knowledge
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