Muthuri, Stella G., Zhang, Weiya, Maciewicz, Rose A., Muir, Kenneth (Kenneth R.) and Doherty, Michael (2015) Beer and wine consumption and risk of knee or hip osteoarthritis : a case control study. Arthritis Research & Therapy, Volume 17 (Number 1). Article number 06411623. doi:10.1186/s13075-015-0534-4 ISSN 1478-6354.
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Abstract
Introduction:
The aim of this study was to investigate the association between alcoholic and non-alcoholic beverages and knee or hip osteoarthritis (OA).
Methods:
We conducted a case–control study of Caucasian men and women aged 45 to 86 years of age from Nottingham, UK. Cases had clinically severe symptoms and radiographic knee or hip OA; controls had no symptoms and no radiographic knee or hip OA. Exposure information was sought using interview-based questionnaires and a semi-quantitative food frequency questionnaire to assess beverage consumption at ages 21 to 50 years. Odds ratios (ORs), adjusted ORs (aORs), 95% confidence intervals (CI) and P values were estimated using logistic regression models.
Results:
A total of 1,001 knee OA, 993 hip OA and 933 control participants were included in the study. Increasing beer consumption was associated with an increasing risk of OA (P for trend ≤0.001). Compared to those who did not consume beer, aORs for people who consumed 20 or more servings of beer were 1.93 (95% CI 1.26 to 2.94) and 2.15 (95% CI 1.45 to 3.19) for knee OA and hip OA, respectively. In contrast, increasing levels of wine consumption were associated with decreased likelihood of knee OA (P for trend <0.001). Compared to those who did not consume wine, aOR for knee OA among those who consumed 4 to 6 glasses of wine per week and ≥7 glasses of wine per week was 0.55 (95% CI 0.34 to 0.87) and 0.48 (95% CI 0.29 to 0.80), respectively. No association was identified between non-alcoholic beverages and knee or hip OA.
Conclusions:
Beer consumption appears to be a risk factor for knee and hip OA whereas consumption of wine has a negative association with knee OA. The mechanism behind these findings is speculative but warrants further study.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Osteoarthritis, Beer, Wine |
| Journal or Publication Title: | Arthritis Research & Therapy |
| Publisher: | BioMed Central Ltd. |
| ISSN: | 1478-6354 |
| Official Date: | 5 February 2015 |
| Dates: | Date Event 5 February 2015 Published 21 January 2015 Accepted 10 April 2014 Submitted |
| Volume: | Volume 17 |
| Number: | Number 1 |
| Number of Pages: | 14 |
| Article Number: | Article number 06411623 |
| DOI: | 10.1186/s13075-015-0534-4 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 29 December 2015 |
| Date of first compliant Open Access: | 29 December 2015 |
| Funder: | AstraZeneca (Firm) |
| Adapted As: | |
| URI: | https://wrap.warwick.ac.uk/66861/ |
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