Toleman, Michelle S., Herbert, Katharine, McCarthy, Noel D. and Church, David N. (2016) Vaccination of chemotherapy patients — effect of guideline implementation. Supportive Care In Cancer, 24 (5). pp. 2317-2321. doi:10.1007/s00520-015-3037-6 ISSN 0941-4355.
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Abstract
PURPOSE:
Despite substantial morbidity and mortality of influenza and pneumococcal infections in cancer patients treated with chemotherapy, vaccination against both illnesses is infrequent. We evaluated the impact of implementation of clinical guidelines on vaccination of chemotherapy patients treated in our institute.
METHODS:
We performed a prospective audit before (2012) and after (2013-2014) the introduction of immunisation guidelines for chemotherapy patients in a UK tertiary cancer centre.
RESULTS:
Guideline implementation was associated with a significant increase in the rate of pneumococcal vaccination compared to the 2012 baseline (47 vs. 25 %, P = 0.0018), though this was not sustained the following year (34 %, P = 0.13, vs. baseline). Influenza vaccine coverage was high (∼70 %) throughout. There was a marked disparity between patients aged ≤65 and those >65 years in the rate of pneumococcal vaccination in both 2013 and 2014 (38 vs. 68 % and 17 vs. 53 %, respectively, both P < 0.001), and, to a lesser extent, in the rate of influenza vaccination in the same period (64 vs. 82 %, P < 0.1, and 63 vs. 85 %, P = 0.009, respectively).
CONCLUSIONS:
The implementation of clinical vaccine guidelines was associated with a significant increase in pneumococcal vaccination, though continued effort appears required to deliver persistent improvement. Initiatives to increase vaccination uptake in patients aged ≤65 are merited.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Cancer -- Patients, Chemotherapy, Influenza -- Vaccination, Pneumonia, Pneumococcal -- Vaccination |
| Journal or Publication Title: | Supportive Care In Cancer |
| Publisher: | Springer |
| ISSN: | 0941-4355 |
| Official Date: | May 2016 |
| Dates: | Date Event May 2016 Published 26 November 2015 Available 7 May 2015 Accepted |
| Volume: | 24 |
| Number: | 5 |
| Page Range: | pp. 2317-2321 |
| DOI: | 10.1007/s00520-015-3037-6 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Date of first compliant deposit: | 19 October 2016 |
| Date of first compliant Open Access: | 26 November 2016 |
| Funder: | Academy of Medical Sciences (Great Britain), Health Foundation (Great Britain) (HF), Cancer Research UK (CRUK), Wellcome Trust (London, England) |
| URI: | https://wrap.warwick.ac.uk/76170/ |
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