Freeman, Karoline, Saunders, Mark P., Uthman, Olalekan A., Taylor-Phillips, Sian, Connock, M., Court, Rachel A., Gurung, T., Sutcliffe, P. (Paul) and Clarke, Aileen (2016) Is monitoring of plasma 5-fluorouracil levels in metastatic / advanced colorectal cancer clinically effective? A systematic review. BMC Cancer, 16 (1). doi:10.1186/s12885-016-2581-x ISSN 1471-2407.
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Abstract
Background:
Pharmacokinetic guided dosing of 5-fluorouracil chemotherapies to bring plasma 5-fluorouracil into a desired therapeutic range may lead to fewer side effects and better patient outcomes. High performance liquid chromatography and a high throughput nanoparticle immunoassay (My5-FU) have been used in conjunction with treatment algorithms to guide dosing. The objective of this study was to assess accuracy, clinical effectiveness and safety of plasma 5-fluorouracil guided dose regimen(s) versus standard regimens based on body surface area in colorectal cancer.
Methods:
We undertook a systematic review. MEDLINE; MEDLINE In-Process & Other Non-Indexed Citations; EMBASE; Cochrane Library; Science Citation Index and Conference Proceedings (Web of Science); and NIHR Health Technology Assessment Programme were searched from inception to January 2014. We reviewed evidence on accuracy of My5-FU for estimating plasma 5-fluorouracil and on the clinical effectiveness of pharmacokinetic dosing compared to body surface area dosing. Estimates of individual patient data for overall survival and progression-free survival were reconstructed from published studies. Survival and adverse events data were synthesised and examined for consistency across studies.
Results:
My5-FU assays were found to be consistent with reference liquid chromatography tandem mass spectrometry. Comparative studies pointed to gains in overall survival and in progression-free survival with pharmacokinetic dosing, and were consistent across multiple studies.
Conclusions:
Although our analyses are encouraging, uncertainties remain because evidence is mainly from outmoded 5-fluorouracil regimens; a randomised controlled trial is urgently needed to investigate new dose adjustment methods in modern treatment regimens.
Item Type: | Journal Article |
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Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology |
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
Library of Congress Subject Headings (LCSH): | Colon (Anatomy) -- Cancer -- Chemotherapy, Rectum -- Cancer -- Chemotherapy, Pharmacokinetics |
Journal or Publication Title: | BMC Cancer |
Publisher: | BioMed Central Ltd. |
ISSN: | 1471-2407 |
Official Date: | 25 July 2016 |
Dates: | Date Event 25 July 2016 Published 19 July 2016 Accepted 2 December 2016 Submitted |
Volume: | 16 |
Number: | 1 |
DOI: | 10.1186/s12885-016-2581-x |
Status: | Peer Reviewed |
Publication Status: | Published |
Access rights to Published version: | Open Access (Creative Commons open licence) |
Date of first compliant deposit: | 29 July 2016 |
Date of first compliant Open Access: | 1 August 2016 |
Funder: | National Institute for Health Research (Great Britain) (NIHR), University Hospitals Birmingham NHS Foundation Trust |
Grant number: | 13/111/01 (NIHR) |
URI: | https://wrap.warwick.ac.uk/80530/ |
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