Foo, Mathias, Sawlekar, Rucha, Kulkarni, Vishwesh V. and Bates, Declan (2016) Biologically inspired design of feedback control systems implemented using DNA strand displacement reactions. In: 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Orlando, Florida, 16-20 Aug 2016. Published in: 2016 IEEE 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) ISSN 1558-4615.
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Abstract
The use of abstract chemical reaction networks (CRNs) as a modelling and design framework for the implementation of computing and control circuits using enzyme-free, entropy driven DNA strand displacement (DSD) reactions is starting to garner widespread attention in the area of synthetic biology. Previous work in this area has demonstrated the theoretical plausibility of using this approach to design biomolecular feedback control systems based on classical proportional-integral (PI) controllers, which may be constructed from CRNs implementing gain, summation and integrator operators. Here, we propose an alternative design approach that utilises the abstract chemical reactions involved in cellular signalling cycles to implement a biomolecular controller - termed a signalling-cycle (SC) controller. We compare the performance of the PI and SC controllers in closed-loop with a nonlinear second-order chemical process. Our results show that the SC controller outperforms the PI controller in terms of both performance and robustness, and also requires fewer abstract chemical reactions to implement, highlighting its potential usefulness in the construction of biomolecular control circuits.
| Item Type: | Conference Item (Paper) |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QA Mathematics T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) T Technology > TK Electrical engineering. Electronics Nuclear engineering |
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering |
| Journal or Publication Title: | 2016 IEEE 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) |
| Publisher: | IEEE |
| ISSN: | 1558-4615 |
| Official Date: | 18 October 2016 |
| Dates: | Date Event 18 October 2016 Available 16 August 2016 Completion 20 May 2016 Accepted 29 April 2016 Submitted |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Date of first compliant deposit: | 1 December 2016 |
| Date of first compliant Open Access: | 1 December 2016 |
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) |
| Conference Paper Type: | Paper |
| Title of Event: | 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) |
| Type of Event: | Conference |
| Location of Event: | Orlando, Florida |
| Date(s) of Event: | 16-20 Aug 2016 |
| Related URLs: | |
| URI: | https://wrap.warwick.ac.uk/84226/ |
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