Venkataraman, Hema, Ram, Uma, Craik, Sam, Arungunasekaran, Anuradhai, Seshadri, Suresh and Saravanan, Ponnusamy (2017) Increased fetal adiposity prior to diagnosis of gestational diabetes in South Asians : more evidence for the ‘thin–fat’ baby. Diabetologia, 60 (3). pp. 399-405. doi:10.1007/s00125-016-4166-2 ISSN 1432-0428.
Preview |
PDF
WRAP-increased-fetal-adiposity-prior-diagnosis-gestational-diabetes-Saravanan-2017.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1MB) | Preview |
Abstract
Aims/hypothesis
Gestational diabetes mellitus (GDM) is associated with an increased future risk of obesity in the offspring. Increased adiposity has been observed in the newborns of women with GDM. Our aim was to examine early fetal adiposity in women with GDM.
Methods
Obstetric and sonographic data was collated for 153 women with GDM and 178 controls from a single centre in Chennai, India. Fetal head circumference (HC), abdominal circumference (AC), femur length (FL) and biparietal diameter (BPD) were recorded at 11, 20 and 32 weeks. Anterior abdominal wall thickness (AAWT) as a marker of abdominal adiposity at 20 and 32 weeks was compared between groups. Adjustments were made for maternal age, BMI, parity, gestational weight gain, fetal sex and gestational age.
Results
Fetuses of women with GDM had significantly higher AAWT at 20 weeks (β 0.26 [95% CI 0.15, 0.37] mm, p < 0.0001) despite lower measures of HC, FL, BPD and AC. AAWT remained higher in the fetuses of women with GDM at 32 weeks (β 0.48 [0.30, 0.65] mm, p < 0.0001) despite similar measures for HC, FL, BPD and AC between groups. Both groups had similar birthweights at term. There was an independent relationship between fasting plasma glucose levels and AAWT after adjustment as described above.
Conclusions/interpretation
A ‘thin but fat’ phenotype signifying a disproportionate increase in adiposity despite smaller or similar lean body mass was observed in the fetuses of mothers with GDM, even at 20 weeks, thus pre-dating the biochemical diagnosis of GDM. Increased AAWT may serve as an early marker of GDM.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RG Gynecology and obstetrics |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| SWORD Depositor: | Library Publications Router |
| Library of Congress Subject Headings (LCSH): | Diabetes in pregnancy, Birth weight, Newborn infants -- Metabolism, Ethnicity -- Health aspects |
| Journal or Publication Title: | Diabetologia |
| Publisher: | Springer |
| ISSN: | 1432-0428 |
| Official Date: | March 2017 |
| Dates: | Date Event March 2017 Published 2 December 2016 Available 7 November 2016 Accepted |
| Volume: | 60 |
| Number: | 3 |
| Page Range: | pp. 399-405 |
| DOI: | 10.1007/s00125-016-4166-2 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 4 June 2018 |
| Date of first compliant Open Access: | 4 June 2018 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID |
| Related URLs: | |
| URI: | https://wrap.warwick.ac.uk/95687/ |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |