Journal Article

Phillpott, Mason, Daga, Sunil, Higgins, Rob, Lowe, David Philip, Krishnan, Nithya S., Zehnder, Daniel, Briggs, David and Khovanova, N. A. (2022) Dynamic behaviour of donor specific antibodies in the early period following HLA incompatible kidney transplantation. Transplant International, 35 . 10128. doi:10.3389/ti.2022.10128 ISSN 1432-2277.

Shaikhina, Torgyn, Lowe, David Philip, Daga, Sunil, Briggs, David, Higgins, Rob and Khovanova, N. A. (2019) Decision tree and random forest models for outcome prediction in antibody incompatible kidney transplantation. Biomedical Signal Processing and Control, 52 . pp. 456-462. doi:10.1016/j.bspc.2017.01.012 ISSN 1746-8094.

Daga, Sunil, Moyse, Harry, Briggs, David, Lowe, David Philip, Evans, Neil D., Jones, James, Buchli, Rico, McMurtrey, Curtis, Mulder, Arend, Hildebrand, William, Claas, Frans, Higgins, Rob, Mitchell, Daniel A. and Zehnder, Daniel (2018) Direct quantitative measurement of the kinetics of HLA-specific antibody interactions with isolated HLA proteins. Human Immunology, 79 (2). pp. 122-128. doi:10.1016/j.humimm.2017.10.012 ISSN 0198-8859.

Zhang, Yan, Briggs, David, Lowe, David Philip, Mitchell, Daniel A., Daga, Sunil, Krishnan, Nithya, Higgins, Rob and Khovanova, N. A. (2017) A new data-driven model for post-transplant antibody dynamics in high risk kidney transplantation. Mathematical Biosciences, 284 . pp. 3-11. doi:10.1016/j.mbs.2016.04.008 ISSN 0025-5564.

Zhang, Yan, Lowe, David Philip, Briggs, David, Higgins, Rob and Khovanova, N. A. (2015) Novel data-driven stochastic model for antibody dynamics in kidney transplantation. IFAC-PapersOnLine, 48 (20). pp. 249-254. doi:10.1016/j.ifacol.2015.10.147 ISSN 2405-8963.

Khovanova, N. A., Daga, Sunil, Shaikhina, Torgyn, Krishnan, Nithya, Jones, James, Zehnder, Daniel, Mitchell, Daniel A., Higgins, Rob, Briggs, David and Lowe, David Philip (2015) Subclass analysis of donor HLA-specific IgG in antibody-incompatible renal transplantation reveals a significant association of IgG4 with rejection and graft failure. Transplant International, 28 (12). pp. 1-11. doi:10.1111/tri.12648 ISSN 0934-0874.

Shaikhina, Torgyn, Lowe, David Philip, Daga, Sunil, Briggs, David, Higgins, Rob and Khovanova, N. A. (2015) Machine learning for predictive modelling based on small data in biomedical engineering. IFAC-PapersOnLine, 48 (20). pp. 469-474. doi:10.1016/j.ifacol.2015.10.185 ISSN 2405-8963.

Higgins, Rob, Lowe, David Philip, Daga, Sunil, Hathaway, Mark, Williams, C, Lam, F. T., Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Fletcher, Simon, Krishnan, Nithya, Hart, Pat, Zehnder, Daniel and Briggs, David (2015) Pregnancy-induced HLA antibodies respond more vigorously after renal transplantation than antibodies induced by prior transplantation. Human Immunology, 76 (8). pp. 546-552. doi:10.1016/j.humimm.2015.06.013 ISSN 0198-8859.

Lowe, David Philip, Daga, Sunil, Briggs, David, Khovanova, N. A., Mitchell, Daniel A., Higgins, Rob and Krishnan, N. (2015) Meeting report : 3rd international transplant conference: how much risk can you take? International Journal of Immunogenetics, Volume 42 (Number 2). pp. 59-68. doi:10.1111/iji.12184 ISSN 1744-3121.

McMurtrey, Curtis, Lowe, David Philip, Buchli, Rico, Daga, Sunil, Royer, Derek, Humphrey, Alisha, Cate, Steven, Osborn, Sean, Mojsilovic, Aleksandar, VanGundy, Rodney, Bardet, Wilfried, Duty, Andrew, Mojsilovic, Danijela, Jackson, Kenneth, Stastny, Peter, Briggs, David, Zehnder, Daniel, Higgins, Rob and Hildebrand, William (2014) Profiling antibodies to class II HLA in transplant patient sera. Human Immunology, Volume 75 (Number 3). pp. 261-270. doi:10.1016/j.humimm.2013.11.015 ISSN 0198-8859.

Evans, Neil D., Moyse, Harry, Lowe, David Philip, Briggs, D., Higgins, Rob, Mitchell, Daniel A., Zehnder, Daniel and Chappell, M. J. (Michael J.) (2013) Structural identifiability of surface binding reactions involving heterogeneous analyte : application to surface plasmon resonance experiments. Automatica, Volume 49 (Number 1). pp. 48-57. doi:10.1016/j.automatica.2012.09.015 ISSN 0005-1098.

Krishnan, Nithya S., Zehnder, Daniel, Daga, Sunil, Lowe, David Philip, Lam, F. T., Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Hamer, Rizwan, Briggs, David, Dr., Raymond, Neil T. and Higgins, Rob (2013) Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation. PLoS One, Volume 8 (Number 7). Article number e68663. doi:10.1371/journal.pone.0068663 ISSN 1932-6203.

Lowe, David Philip, Higgins, Rob, Zehnder, Daniel and Briggs, D. C. (2013) Significant IgG subclass heterogeneity in HLA-specific antibodies : implications for pathogenicity, prognosis, and the rejection response. Human Immunology, Volume 74 (Number 5). pp. 666-672. doi:10.1016/j.humimm.2013.01.008 ISSN 0198-8859.

Hamer, Rizwan, Molostvov, Guerman, Lowe, David Philip, Satchell, Simon, Mathieson, Peter, Ilyas, Rebecca, Mitchell, Daniel A., Lam, For T., Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Fletcher, Simon, Briggs, David, Krishnan, Nithya, Higgins, Rob and Zehnder, Daniel (2012) Human leukocyte antigen-specific antibodies and gamma-interferon stimulate human microvascular and glomerular endothelial cells to produce complement factor C4. Transplantation, Vol.93 (No.9). pp. 867-873. doi:10.1097/TP.0b013e31824b3762 ISSN 0041-1337.

Sinha, Devan, Lambie, Mark, Krishnan, Nithya, McSorley, Kath, Hamer, Rizwan, Lowe, David Philip, Briggs, David, Fletcher, Simon, Zehnder, Daniel and Higgins, Rob (2012) Cryofiltration in the treatment of cryoglobulinemia and HLA antibody-incompatible transplantation. Therapeutic Apheresis and Dialysis, Vol.16 (No.1). pp. 91-96. doi:10.1111/j.1744-9987.2011.01004.x ISSN 1744-9979.

Higgins, Rob, Lowe, David Philip, Hathaway, Mark, Williams, Clare, Lam, For T., Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Fletcher, Simon, Chen, Klaus, Krishnan, Nithya, Hamer, Rizwan, Daga, Sunil, Edey, Matthew, Zehnder, Daniel and Briggs, David (2011) Human leukocyte antigen antibody-incompatible renal transplantation : excellent medium-term outcomes with negative cytotoxic crossmatch. Transplantation, Vol.92 (No.8). pp. 900-906. doi:10.1097/TP.0b013e31822dc38d ISSN 0041-1337.

Higgins, Rob, Lowe, David Philip, Hathaway, Mark, Lam, For T., Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Fletcher, Simon, Chen, Klaus, Krishnan, Nithya, Hamer, Rizwan, Zehnder, Daniel and Briggs, David (2010) Double filtration plasmapheresis in antibody-incompatible kidney transplantation. Therapeutic Apheresis and Dialysis, Vol.14 (No.4). pp. 392-399. doi:10.1111/j.1744-9987.2010.00821.x ISSN 1744-9979.

Hamer, Rizwan, Roche, Laura, Smillie, David, Harmer, Andrea, Mitchell, Daniel A., Molostvov, Guerman, Lam, For T., Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Fletcher, Simon, Briggs, David, Lowe, David Philip, Zehnder, Daniel and Higgins, Rob (2010) Soluble CD30 and Cd27 levels in patients undergoing HLA antibody-incompatible renal transplantation. Transplant Immunology, Vol.23 (No.4). pp. 161-165. doi:10.1016/j.trim.2010.06.004 ISSN 0966-3274.

Higgins, Rob, Zehnder, Daniel, Chen, Klaus, Lowe, David Philip, McKinnell, Joanna, Lam, For T., Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Fletcher, Simon, Krishnan, Nithya, Hamer, Rizwan and Briggs, David (2010) The histological development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation. Nephrology, Dialysis, Transplantation, Vol.25 (No.4). pp. 1306-1312. doi:10.1093/ndt/gfp610 ISSN 0931-0509.

Higgins, Rob, Lowe, David Philip, Hathaway, Mark, Lam, For, Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Fletcher, Simon, Chen, Klaus, Krishnan, Nithya, Hamer, Rizwan, Zehnder, Daniel and Briggs, David (2009) Rises and falls in donor-specific and third-party HLA antibody levels after antibody incompatible transplantation. Transplantation, Vol.87 (No.6). pp. 882-888. doi:10.1097/TP.0b013e31819a6788 ISSN 0041-1337.

Higgins, Rob, Hathaway, Mark, Lowe, David Philip, Lam, For, Kashi, Habib, Tan, Lam Chin, Imray, C. (Chris), Fletcher, Simon, Zehnder, Daniel, Chen, Klaus, Krishnan, Nithya, Hamer, Rizwan and Briggs, David (2007) Blood levels of donor-specific human leukocyte antigen antibodies after renal transplantation : resolution of rejection in the presence of circulating donor-specific antibody. Transplantation, Vol.84 (No.7). pp. 876-884. doi:10.1097/01.tp.0000284729.39137.6e ISSN 0041-1337.

James, C. J. and Lowe, David Philip (2003) Extracting multisource brain activity from a single electromagnetic channel. Artificial Intelligence in Medicine, Vol. 28 (No. 1). pp. 89-104. doi:10.1016/S0933-3657(03)00037-X ISSN 09333657.

Conference Item

Khovanova, N. A., Lowe, David Philip, Daga, Sunil, Shaikhina, Torgyn, Mitchell, Daniel A., Zehnder, Daniel, Briggs, David and Higgins, Rob (2015) Assessment of IgG subclass significance for early graft rejection and long-term survival in HLA-antibody incompatible renal transplantation : multivariate approach. In: 2015 American Transplant Congress, Philadelphia, USA, 2 - 6 May 2015. Published in: American Journal Transplant, 15 (Supplement 3). p. 338.

Shaikhina, Torgyn, Khovanova, N. A., Daga, Sunil, Krishnan, Nithya, Lowe, David Philip, Mitchell, Daniel A., Briggs, David and Higgins, Rob (2015) Decision trees for small data sets : prediction of acute antibody mediated rejection in early post-transplant period in antibody incompatible transplantation. In: Joint British Transplantation Society and Nederlandse Transplantatie Vereniging Congress, Bournemouth, UK, 11th - 13th Mar 2015

Khovanova, N. A., Lowe, David Philip, Daga, Sunil, Shaikhina, Torgyn, Krishnan, Nithya, Mitchell, Daniel A., Zehnder, Daniel, Briggs, David and Higgins, Rob (2015) IgG4 subclass associates with early graft rejection and decreased allograft survival times in antibody incompatible transplantation. In: Joint British Transplantation Society and Nederlandse Transplantatie Vereniging Congress, Bournemouth, UK, 11- 13 Mar 2015 (Unpublished)

Shaikhina, Torgyn, Khovanova, N. A., Daga, Sunil, Krishnan, Nithya, Lowe, David Philip, Mitchell, Daniel A., Briggs, David and Higgins, Rob (2015) Prediction of acute antibody mediated rejection in antibody incompatible renal transplantation using machine learning for wide data. In: 2015 American Transplant Congress, Philadelphia, USA, 2 - 6 May 2015. Published in: American Journal Transplant, 15 (Supplement 3). p. 1364.

Shaikhina, Torgyn, Daga, Sunil, Krishnan, Nithya, Lowe, David Philip, Mitchell, Daniel A., Briggs, David, Higgins, Rob and Khovanova, N. A. (2014) Decision trees in renal transplantation : prediction of acute antibody mediated rejection in the early post-transplant period. In: Third International Transplantation conference : how much risk can you take (and what to do if it all goes pear shaped)., University of Warwick, UK, 31 Oct - 01 Nov 2014 (Unpublished)

Khovanova, N. A., Lowe, David Philip, Daga, Sunil, Shaikhina, Torgyn, Krishnan, Nithya, Zehnder, Daniel, Briggs, David and Higgins, Rob (2014) Presence and levels of non-complement fixing IgG4 subclass associates with early graft rejection and decreased allograft survival times in antibody incompatible transplantation. In: Third International Transplantation conference : How much risk can you take and what to do if it all goes pear shaped., University of Warwick, UK, 31 Oct -1 Nov 2014 (Unpublished)

Lowe, David Philip, Khovanova, N. A., Zehnder, Daniel, Higgins, Rob and Briggs, D. (2012) Increased presence of complement fixing IgG isotypes and its association with acute rejection in antibody incompatible transplantation. In: The 23rd British Society for Histocompatibility and Immunogenetics Conference, Liverpool, U.K., May 28 - Jun 3, 2012. Published in: Tissue Antigens, Vol.79 (No.6). p. 505. doi:10.1111/j.1399-0039.2012.01877.x ISSN 0001-2815.

Moyse, Harry, Lowe, David Philip, Briggs, D., Higgins, Rob, Bentall, A., Ball, S., Mitchell, Daniel A., Chappell, M. J. (Michael J.), Zehnder, Daniel and Evans, Neil D. (2012) Estimation of antibody binding affinities with surface plasmon resonance experiments in incompatible blood type renal transplants. In: 8th IFAC Symposium on Biological and Medical Systems, Budapest, Hungary, 29-31 Aug 2012. Published in: Biological and Medical Systems, Volume 8 (Number 1). pp. 97-102. ISBN 9783902823106. doi:10.3182/20120829-3-HU-2029.00088 ISSN 1474-6670.

Higgins, Rob, Zehnder, Daniel, Hamer, Rizwan, Krishnan, Nithya, McSorley, Kath, Lowe, David Philip, Briggs, D. (David) and Fletcher, S. (Simon) (2011) Cryofiltration : novel approach to removal of alloantibodies prior to renal transplantation. In: American Transplant Congress, Philadelphia, PA, 2011. Published in: American Journal of Transplantation, Volume 11 (Supplement 2). p. 293. doi:DOI: 10.1111/j.1600-6143.2011.03534.x ISSN 1600-6135.

Higgins, Rob, Lowe, David Philip, Briggs, D. (David), Fletcher, S. (Simon), Krishnan, Nithya, Lam, For T., Kashi, Habib, Imray, C. (Chris), Tan, L. C. and Zehnder, Daniel (2011) Medium term outcomes in HLA antibody incompatible renal transplantation ; importance of CDC crossmatch status. In: American Transplant Congress, Philadelphia, PA, 2011. Published in: American Journal of Transplantation, Volume 11 (Supplement 2). p. 484. ISSN 1600-6135.

Higgins, Rob, Lowe, David Philip, Nicol, A., Collins, C., Krishnan, Nithya, Hathaway, M. (Mark), Zehnder, Daniel, Hamer, Rizwan, Edey, Matthew and Briggs, D. (David) (2011) Towards clonal deletion ; fine timing of the donor specific HLA antibody response after renal transplantation in pre-sensitised subjects. In: American Transplant Congress, Philadelphia, PA, 2011. Published in: American Journal of Transplantation, Volume 11 (Supplement 2). p. 484. ISSN 1600-6135.

Thesis

Lowe, David Philip (2013) Characterisation of HLA-specific antibodies. PhD thesis, University of Warwick.

Dataset

Shaikhina, Torgyn, Lowe, David Philip, Daga, Sunil, Briggs, David, Higgins, Rob and Khovanova, N. A. (2017) Data for Decision tree and random forest models for outcome prediction in antibody incompatible kidney transplantation. [Dataset]

Zhang, Yan, Briggs, David, Lowe, David Philip, Mitchell, Daniel A., Daga, Sunil, Krishnan, Nithya, Higgins, Rob and Khovanova, N. A. (2016) Data for A new data-driven model for post-transplant antibody dynamics in high risk kidney transplantation. [Dataset]