2023

Grammatopoulos, Dimitris K., Li, Weizi, Young, Lawrence S. and Anderson, Neil R. (2023) UK diagnostics in the era of ‘permacrisis’ : is it fit for purpose and able to respond to the challenges ahead? Clinical Chemistry and Laboratory Medicine (CCLM), 61 (11). e225-e226. doi:10.1515/cclm-2023-0450

2022

Yap, Lee Fah, Wong, Anna Kang Chee, Paterson, Ian C. and Young, Lawrence S. (2022) Functional implications of Epstein-Barr virus lytic genes in carcinogenesis. Cancers, 14 (23). 5780. doi:10.3390/cancers14235780 ISSN 2072-6694.

Grammatopoulos, Dimitris K., Young, Lawrence S. and Anderson, Neil. (2022) Transforming the UK's diagnostics agenda after COVID-19. The Lancet, 399 (10335). 1606. doi:10.1016/S0140-6736(22)00169-6

Velapasamy, S., Lo, K. W, Chung, G. T. Y., Tsang, C. M., Dawson, C. W., Young, L. S., Tsao, S. W., Paterson, I. and Yap, L. F. (2022) Disruption of TGF-β signalling supports EBV infection in epithelial cells : role in the pathogenesis of nasopharyngeal carcinoma. Journal of Pathology . ISSN 0022-3417. (In Press)

2021

Stewart, Stuart, Newson, Louise, Briggs, Tracy A., Grammatopoulos, Dimitris, Young, Lawrence S. and Gill, Paramjit (2021) Long COVID risk - a signal to address sex hormones and women's health. The Lancet Regional Health - Europe, 11 . 100242. doi:10.1016/j.lanepe.2021.100242

2020

Zhang, Wen-Ying, Banerjee, Samya, Imberti, Cinzia, Clarkson, Guy J., Wang, Qian, Zhong, Qian, Young, Lawrence S., Romero-Canelón, Isolda, Zeng, Musheng, Habtemariam, Abraha and Sadler, Peter J. (2020) Strategies for conjugating iridium(III) anticancer complexes to targeting peptides via copper-free click chemistry. Inorganica Chimica Acta, 503 . 119396. doi:10.1016/j.ica.2019.119396 ISSN 0020-1693.

Elmetwali, Taha, Salman, Asmaa, Wei, Wenbin, Hussain, Syed A., Young, Lawrence S. and Palmer, Daniel H. (2020) CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation. Scientific Reports, 10 (1). 342. doi:10.1038/s41598-019-57293-y ISSN 2045-2322.

2019

Song, Hualong, Rogers, Nicola J., Allison, Simon J., Brabec, Viktor, Bridgewater, Hannah, Kostrhunova, Hana, Markova, Lenka, Phillips, Roger M., Pinder, Emma C., Shepherd, Samantha L., Young, Lawrence S., Zajac, Juraj and Scott, Peter (2019) Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification. Chemical Science, 10 (37). pp. 8547-8557. doi:10.1039/C9SC02651G ISSN 2041-6520.

2018

Lo, Angela Kwok-Fung, Lung, Raymond Wai-Ming, Dawson, Christopher W., Young, Lawrence S., Ko, Chuen-Wai, Yeung, Walter Wai, Kang, Wei, To, Ka-Fai and Lo, Kwok-Wai (2018) Activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated lipogenesis by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma. Journal of Pathology, 246 (2). pp. 180-190. doi:10.1002/path.5130 ISSN 0022-3417.

Velapasamy, Sharmila, Dawson, Christopher W., Young, Lawrence S., Paterson, Ian C. and Yap, Lee Fah (2018) The dynamic roles of TGF-β signalling in EBV-associated cancers. Cancers, 10 (8). 247. doi:10.3390/cancers10080247 ISSN 2072-6694.

Morris, Mhairi, Laverick, Louise, Wei, Wenbin, Davis, Alexandra, O’Neill, Samantha, Wood, Liam, Wright, Jack, Dawson, Christopher and Young, Lawrence (2018) The EBV-encoded oncoprotein, LMP1, induces an Epithelial-to-Mesenchymal Transition (EMT) via Its CTAR1 domain through integrin-mediated ERK-MAPK signalling. Cancers, 10 (5). p. 130. doi:10.3390/cancers10050130 ISSN 2072-6694.

Lung, Raymond W-M., Hau, Pok-Man, Yu, Ken H-O., Yip, Kevin Y., Tong, Joanna H-M., Chak, Wing-Po, Chan, Anthony W-H., Lam, Ka-Hei, Lo, Angela Kwok-Fung, Tin, Edith K-Y., Chau, Shuk-Ling, Pang, Jesse C-S., Kwan, Johnny S-H., Busson, Pierre, Young, Lawrence S., Yap, Lee-Fah, Tsao, Sai-Wah, To, Ka-Fai and Lo, Kwok-Wai (2018) EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma. The Journal of Pathology, 244 (4). pp. 394-407. doi:10.1002/path.5018 ISSN 0022-3417.

2016

Young, Lawrence S., Yap, Lee Fah and Murray, Paul G. (2016) Epstein–Barr virus : more than 50 years old and still providing surprises. Nature Reviews Cancer, 16 (12). pp. 789-802. doi:10.1038/nrc.2016.92 ISSN 1474-175X.

Leonard, Sarah M., Pereira, Merlin, Roberts, Sally, Cuschieri, Kate, Nuovo, Gerard, Athavale, Ramanand, Young, Lawrence, Ganesan, Raji and Woodman, Ciarán B. (2016) Evidence of disrupted high-risk human papillomavirus DNA in morphologically normal cervices of older women. Scientific Reports, 6 . 20847. doi:10.1038/srep20847 ISSN 2045-2322.

Morris, Mhairi A., Dawson, Christopher W., Laverick, Louise, Davis, Alexandra M., Dudman, Joe P. R., Raveenthiraraj, Sathuwarman, Ahmad, Zeeshan, Yap, Lee-Fah and Young, Lawrence S. (2016) The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling. Scientific Reports, 6 . 19533. doi:10.1038/srep19533 ISSN 2045-2322.

Dyer, Nigel, Young, Lawrence S. and Ott, Sascha (2016) Artifacts in the data of Hu et al. Nature Genetics, 48 (1). pp. 2-3. doi:10.1038/ng.3392

2015

Young, Lawrence S. (2015) Pathogens best paper awards for 2015. Pathogens, 4 (2). pp. 387-389. 00387. doi:10.3390/pathogens4020387 ISSN 2076-0817.

Palser, Anne L., Grayson, Nicholas E., White, Robert E., Corton, Craig, Correia, Samantha, Ba abdullah, Mohammed M., Watson, Simon J., Cotten, Matthew, Arrand, John R., Murray, Paul G., Allday, Martin J., Rickinson, Alan B., Young, Lawrence S., Farrell, Paul J. and Kellam, Paul (2015) Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection. Journal of Virology, Volume 89 (Number 10). pp. 5222-5237. doi:10.1128/JVI.03614-14 ISSN 0022-538X.

Lo, Angela Kwok-Fung, Dawson, Christopher W., Young, Lawrence S., Ko, Chuen-Wai, Hau, Pok-Man and Lo, Kwok-Wai (2015) Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells. The Journal of Pathology, 237 (2). pp. 238-248. doi:10.1002/path.4575 ISSN 0022-3417.

2014

Elmetwali, Taha, Young, Lawrence S. and Palmer, Daniel H. (2014) Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-κB activation via a negative feedback loop. Cell Death and Disease , Volume 5 (Number 5). Article number e1213. doi:10.1038/cddis.2014.172 ISSN 2041-4889.

2012

Hu, Chunfang, Wei, Wenbin, Chen, Xiaoyi, Woodman, Ciaran B. J., Yao, Yunhong, Nicholls, J. M. (John M.), Joab, Irène, Sihota, Sim K., Shao, Jian-Yong, Derkaoui, K. Dalia, Amari, Aicha, Maloney, Stephanie L., Bell, Andrew I., Murray, Paul G., Dawson, Christopher W., Young, Lawrence S. and Arrand, J. R. (John R.) (2012) A global view of the oncogenic landscape in nasopharyngeal carcinoma : an integrated analysis at the genetic and expression levels. PLoS One, Vol.7 (No.7). e41055. doi:10.1371/journal.pone.0041055 ISSN 1932-6203.

Leonard, S. M., Wei, W., Collins, S. I., Pereira, M., Diyaf, A., Constandinou-Williams, C., Young, Lawrence S., Roberts, S. and Woodman, Ciaran B. J. (2012) Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women. Carcinogenesis, Vol.33 (No.7). pp. 1286-1293. doi:10.1093/carcin/bgs157 ISSN 0143-3334.

Dawson, Christopher W., Port, Rebecca J. and Young, Lawrence S. (2012) The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC). Seminars in Cancer Biology, Vol.22 (No.2). pp. 144-153. doi:10.1016/j.semcancer.2012.01.004 ISSN 1044-579X.

Sivachandran, N., Dawson, C. W., Young, Lawrence S., Liu, F.-F., Middeldorp, J. and Frappier, L. (2012) Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinoma. Journal of Virology, Vol.86 (No.1). pp. 60-68. doi:10.1128/JVI.05623-11 ISSN 0022-538X.

2011

Steele, J. C., Rao, A., Marsden, J. R., Armstrong, C. J., Berhane, S., Billingham, L. J., Graham, N., Roberts, C., Ryan, G., Uppal, H., Walker, C., Young, Lawrence S. and Steven, N. M. (2011) Phase I/II trial of a dendritic cell vaccine transfected with DNA encoding melan A and gp100 for patients with metastatic melanoma. Gene Therapy, Vol.18 (No.6). pp. 584-593. doi:10.1038/gt.2011.1 ISSN 0969-7128.

Ma, Y. T., Collins, S. I., Young, Lawrence S., Murray, Paul G. and Woodman, Ciaran B. J. (2011) Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study. British Journal of Cancer, Vol.104 (No.9). pp. 1500-1504. doi:10.1038/bjc.2011.113 ISSN 0007-0920.

2010

Owen, Thomas J., O'Neil, John D., Dawson, Christopher W., Hu, Chunfang, Chen, Xiaoyi, Yao, Yunhong, Wood, Victoria H. J., Mitchell, Louise E., White, Robert J., Young, Lawrence S. and Arrand, J. R. (2010) Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors. Molecular Cancer, Vol.9 (No.1). p. 241. doi:10.1186/1476-4598-9-241 ISSN 1476-4598.

Lo, Angela K. F., Dawson, Christopher W., Lo, Kwok W., Yu, Yanxing and Young, Lawrence S. (2010) Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition. Molecular Cancer, Vol.9 (No.1). p. 155. doi:10.1186/1476-4598-9-155 ISSN 1476-4598.

Cader, Fathima Zumla, Kearns, Pamela, Young, Lawrence S., Murray, Paul and Vockerodt, Martina (2010) The contribution of the Epstein-Barr virus to the pathogenesis of childhood lymphomas. Cancer Treatment Reviews, Vol.36 (No.4). pp. 348-353. doi:10.1016/j.ctrv.2010.02.011 ISSN 0305-7372.

Elmetwali, Taha, Searle, Peter F., McNeish, Iain, Young, Lawrence S. and Palmer, Daniel H. (2010) CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus. Molecular Cancer, Vol.9 (No.1). p. 52. doi:10.1186/1476-4598-9-52 ISSN 1476-4598.

Constandinou-Williams, C., Collins, S. I., Roberts, S., Young, Lawrence S., Woodman, Ciaran B. J. and Murray, Paul G. (2010) Is human papillomavirus viral load a clinically useful predictive marker? A longitudinal study. Cancer Epidemiology Biomarkers & Prevention, Vol.19 (No.3). pp. 832-837. doi:10.1158/1055-9965.EPI-09-0838 ISSN 1055-9965.

Elmetwali, Taha, Young, Lawrence S. and Palmer, Daniel H. (2010) CD40 ligand-induced carcinoma cell death : a balance between activation of TNFR-associated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals. Journal of Immunology, Vol.184 (No.2). pp. 1111-1120. doi:10.4049/jimmunol.0900528 ISSN 0022-1767.

Valentine, Robert, Dawson, Christopher W., Hu, Chunfang, Shah, Khilan M., Owen, Thomas J., Date, Kathryn L., Maia, Sonia P., Shao, Jianyong, Arrand, J. R. (John R.), Young, Lawrence S. and O'Neil, John D. (2010) Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation. Molecular Cancer, Vol.9 (No.1). p. 1. doi:10.1186/1476-4598-9-1 ISSN 1476-4598.

Collins, Stuart, Rollason, Terry P., Young, Lawrence S. and Woodman, Ciaran B. J. (2010) Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women : a longitudinal study. European Journal of Cancer Care, Vol.46 (No.2). pp. 405-411. doi:10.1016/j.ejca.2009.09.015 ISSN 0961-5423.

2009

Shah, K. M., Stewart, S. E., Wei, W., Woodman, Ciaran B. J., O'Neil, J. D., Dawson, Christopher W. and Young, Lawrence S. (2009) The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation. Oncogene, Vol.28 (No.44). pp. 3903-3914. doi:10.1038/onc.2009.249 ISSN 0950-9232.

Shah, K. M. and Young, Lawrence S. (2009) Epstein-Barr virus and carcinogenesis : beyond Burkitt’s lymphoma. Clinical Microbiology and Infection, Vol.15 (No.11). pp. 982-988. doi:10.1111/j.1469-0691.2009.03033.x ISSN 1198-743X.

Morris, Mhairi A., Dawson, Christopher W. and Young, Lawrence S. (2009) Role of the Epstein–Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma. Future Oncology, Vol.5 (No.6). pp. 811-825. doi:10.2217/fon.09.53 ISSN 1479-6694.

Patel, Prashant, Young, J Graham, Mautner, Vivien, Ashdown, Daniel, Bonney, Sarah, Pineda, Robert G., Collins, Stuart I., Searle, Peter F., Hull, Diana, Peers, Elizabeth, Chester, John, Wallace, D. Michael, Doherty, Alan, Leung, Hing, Young, Lawrence S. and James, Nicholas D. (2009) A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1984. Molecular Therapy, Vol.17 (No.7). pp. 1292-1299. doi:10.1038/mt.2009.80 ISSN 1525-0016.

Collins, S. I., Constandinou-Williams, C., Wen, K., Young, Lawrence S., Roberts, S., Murray, Paul G. and Woodman, Ciaran B. J. (2009) Disruption of the E2 Gene is a common and early event in the natural history of cervical human papillomavirus infection : a longitudinal cohort study. Cancer Research, Vol.69 (No.9). pp. 3828-3832. doi:10.1158/0008-5472.CAN-08-3099 ISSN 0008-5472.

Schreck, Sabine, Friebel, Daniela, Buettner, Maike, Distel, Luitpold, Grabenbauer, Gerhard, Young, Lawrence S. and Niedobitek, Gerald (2009) Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma. Hematological Oncology, Vol.27 (No.1). pp. 31-39. doi:10.1002/hon.878 ISSN 0278-0232.

Bose, Shikha, Yap, Lee-Fah, Fung, Matthew, Starzcynski, Jane, Saleh, Amyza, Morgan, Susan, Dawson, Christopher W., Chukwuma, Marilyn B., Maina, Esther, Buettner, Maike, Wei, Wenbin, Arrand, J. R. (John R.), Lim, Paul V. H., Young, Lawrence S., Teo, Soo Hwang, Stankovic, Tatjana, Woodman, Ciaran B. J. and Murray, Paul G. (2009) The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. Journal of Pathology, Vol.217 (No.3). pp. 345-352. doi:10.1002/path.2487 ISSN 0022-3417.

Palmer, Daniel H., Midgley, Rachel S., Mirza, Noweeda, Torr, Elizabeth E., Ahmed, Forhad, Steele, Jane C., Steven, Neil M., Kerr, David J., Young, Lawrence S. and Adams, David H. (2009) A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma. Hepatology, Vol.49 (No.1). pp. 124-132. doi:10.1002/hep.22626 ISSN 0270-9139.

2008

O'Neil, J. D., Owen, T. J., Wood, V. H. J., Date, K. L., Valentine, R., Chukwuma, M. B., Arrand, J. R. (John R.), Dawson, C. W. and Young, Lawrence S. (2008) Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro. Journal of General Virology, Vol.89 (No.11). pp. 2833-2842. doi:10.1099/vir.0.2008/003392-0 ISSN 0022-1317.

Morris, M. A., Dawson, C. W., Wei, W., O'Neil, J. D., Stewart, S. E., Jia, J., Bell, A. I., Young, Lawrence S. and Arrand, J. R. (John R.) (2008) Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes. Journal of General Virology, Vol.89 (No.11). pp. 2806-2820. doi:10.1099/vir.0.2008/003970-0 ISSN 0022-1317.

Morris, M., Young, Lawrence S. and Dawson, Christopher W. (2008) DNA tumour viruses promote tumour cell invasion and metastasis by deregulating the normal processes of cell adhesion and motility. European Journal of Cell Biology, Vol.87 (No.8-9). pp. 677-697. doi:10.1016/j.ejcb.2008.03.005 ISSN 0171-9335.

Vockerodt, M., Morgan, S. L., Kuo, M., Wei, W., Chukwuma, M. B., Arrand, J. R. (John R.), Kube, D., Gordon, J., Young, Lawrence S., Woodman, Ciaran B. J. and Murray, Paul G. (2008) The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype. Journal of Pathology, Vol.216 (No.1). pp. 83-92. doi:10.1002/path.2384 ISSN 0022-3417.

Young, J. G., Green, N. K., Mautner, V., Searle, P. F., Young, Lawrence S. and James, Nicholas D. (2008) Combining gene and immunotherapy for prostate cancer. Prostate Cancer and Prostatic Diseases, Vol.11 (No.2). pp. 187-193. doi:10.1038/sj.pcan.4501008 ISSN 1365-7852.

(2008) Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin's Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells. American Journal of Pathology, Vol.173 (No.1). pp. 195-204. doi:10.2353/ajpath.2008.070845 ISSN 0002-9440.

Flavell, Joanne R., Baumforth, Karl R. N., Wood, Victoria H. J., Davies, Gillian L., Wei, Wenbin, Reynolds, Gary M., Morgan, Susan, Boyce, Andrew, Kelly, Gemma L., Young, Lawrence S. and Murray, Paul G. (2008) Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells. Blood, Vol.111 (No.1). pp. 292-301. doi:10.1182/blood-2006-11-059881 ISSN 0006-4971.

Dawson, Christopher W., Laverick, L., Morris, M. A., Tramoutanis, G. and Young, Lawrence S. (2008) Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. Journal of Virology, Vol.82 (No.7). pp. 3654-3664. doi:10.1128/JVI.01888-07 ISSN 0022-538X.

1996

Herod, J. J., Eliopoulos, A. G., Warwick, Jane, Niedobitek, G., Young, Lawrence S. and Kerr, D. J. (1996) The prognostic significance of Bcl-2 and p53 expression in ovarian carcinoma. Cancer Research, Volume 56 (Number 9). pp. 2178-84. ISSN 0008-5472.