2023

Bouchahda, Mohamed, Ulusakarya, Ayhan, Thirot-Bidault, Anne, Attari, Amal, Bossevot, Rachel, Tuligenga, Richard, Hammel, Pascal, Adam, René and Lévi, Francis A. (2023) Multicentre, interventional, single-arm study protocol of telemonitored circadian rhythms and patient-reported outcomes for improving mFOLFIRINOX safety in patients with pancreatic cancer (MultiDom, NCT04263948). BMJ Open, 13 (6). e069973. doi:10.1136/bmjopen-2022-069973 ISSN 2044-6055.

2022

Ducreux, Michel and Lévi, Francis A. (2022) Hepatic artery infusion therapy : the European experience. In: Vauthey, J. N. and Kawaguchi, Y. and Adam, R., (eds.) Colorectal Liver Metastasis. Cham: Springer, pp. 329-340. ISBN 9783031093227

Faraut, Brice, Cordina-Duverger, Emilie, Aristizabal, Guillen, Drogou, Catherine, Gauriau, Caroline, Sauvet, Fabien, Lévi, Francis A., Léger, Damien and Guénel, Pascal (2022) Immune disruptions and night shift work in hospital healthcare professionals : the intricate effects of social jet-lag and sleep debt. Frontiers in Immunology, 13 . 939829. doi:10.3389/fimmu.2022.939829 ISSN 1664-3224.

Innominato, Pasquale F., Karaboué, Abdoulaye, Bouchahda, Mohammed, Bjarnason, Georg A. and Lévi, Francis A. (2022) The future of precise cancer chronotherapeutics. The Lancet Oncology, 23 (6). e242. doi:10.1016/S1470-2045(22)00188-7

Spitschan, Manuel, Santhi, Nayantara, Ahluwalia, Amrita, Fischer, Dorothee, Hunt, Lilian, Karp, Natasha, Lévi, Francis A., Pineda-Torra, Ines, Vidafar, Parisa and White, Rhiannon (2022) Science forum : sex differences and sex bias in human circadian and sleep physiology research. eLife, 11 . e65419. doi:10.7554/elife.65419 ISSN 2050-084X.

Karaboué, Abdoulaye, Collon, Thierry, Pavese, Ida, Bodiguel, Viviane, Cucherousset, Joel, Zakine, Elda, Innominato, Pasquale F., Bouchahda, Mohamed, Adam, René and Lévi, Francis A. (2022) Time-dependent efficacy of checkpoint inhibitor nivolumab : results from a pilot study in patients with metastatic non-small-cell lung cancer. Cancers, 14 (4). e896. doi:10.3390/cancers14040896 ISSN 2072-6694.

2021

Dulong, S., Huang, Qi, Innominato, P. F., Karaboue, A., Bouchahda, M., Pruvost, A., Théodoro, F., Agrofoglio, L. A., Adam, R., Finkenstädt, Bärbel and Lévi, Francis A. (2021) Circadian and chemotherapy-related changes in urinary modified nucleosides excretion in patients with metastatic colorectal cancer. Scientific Reports, 11 (1). 24015. doi:10.1038/s41598-021-03247-2 ISSN 2045-2322.

Lévi, Francis A. (2021) Daytime versus evening infusions of immune checkpoint inhibitors. The Lancet, 22 (12). pp. 1648-1650. doi:10.1016/S1470-2045(21)00607-0

Innominato, Pasquale F., Komarzynski, Sandra, Dallmann, Robert, Wreglesworth, Nicholas, Bouchahda, Mohamed, Karaboué, Abdoulaye, Ulusakarya, Ayhan, Subbe, Christian, Spiegel, David and Lévi, Francis A. (2021) Impact of assessment frequency of patient-reported outcomes : an observational study using an eHealth platform in cancer patients. Supportive Care In Cancer, 29 . pp. 6167-6170. doi:10.1007/s00520-021-06262-1 ISSN 0941-4355.

Innominato, Pasquale F., Karaboué, Abdoulaye, Focan, Christian, Chollet, Philippe, Giacchetti, Sylvie, Bouchahda, Mohamed, Ulusakarya, Ayhan, Torsello, Angela, Adam, René, Lévi, Francis A. and Garufi, Carlo (2021) Efficacy and safety of chronomodulated irinotecan, oxaliplatin, 5‐fluorouracil and leucovorin combination as first‐ or second‐line treatment against metastatic colorectal cancer : results from the International EORTC 05011 Trial. International Journal of Cancer, 148 (10). pp. 2512-2521. doi:10.1002/ijc.33422 ISSN 0020-7136.

Kumar, Swati, Needham, Russell J., Abraham, Kristin, Bridgewater, Hannah E., Garbutt, Lauren A, Xandri-Monje, Helena, Dallmann, Robert, Perrier, Sébastien, Sadler, Peter J. and Lévi, Francis A. (2021) Dose and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice. Metallomics, 13 (2). mfaa003. doi:10.1093/mtomcs/mfaa003 ISSN 1756-5901.

2020

Lévi, Francis A., Komarzynski, Sandra, Huang, Qi, Young, Teresa, Ang, Yeng, Fuller, Claire, Bolborea, Matei, Brettschneider, Julia, Fursse, Joanna, Finkenstädt, Bärbel, White, David Pollard and Innominato, Pasquale F. (2020) Tele-monitoring of cancer patients’ rhythms during daily life identifies actionable determinants of circadian and sleep disruption. Cancers, 12 (7). 1938. doi:10.3390/cancers12071938 ISSN 2072-6694.

Innominato, Pasquale F., Ballesta, Annabelle, Huang, Qi, Focan, Christian, Chollet, Philippe, Karaboué, Abdoulaye, Giacchetti, Sylvie, Bouchahda, Mohamed, Adam, René, Garufi, Carlo and Lévi, Francis A. (2020) Sex-dependent least toxic timing of irinotecan combined with chronomodulated chemotherapy for metastatic colorectal cancer : randomized multicenter. Cancer Medicine, 9 (12). pp. 4148-4159. doi:10.1002/cam4.3056 ISSN 2045-7634.

Hill, Roger, Innominato, Pasquale F., Lévi, Francis A. and Ballesta, Annabelle (2020) Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy. PLoS Computational Biology, 16 (1). e1007218. doi:10.1371/journal.pcbi.1007218 ISSN 1553-7358.

Hadj-Amar, Beniamino, Finkenstädt, Bärbel, Fiecas, Mark, Lévi, Francis A. and Huckstepp, Robert T. R. (2020) Bayesian model search for nonstationary periodic time series. Journal of the American Statistical Association, 115 (531). pp. 1320-1335. doi:10.1080/01621459.2019.1623043 ISSN 0162-1459.

2019

Gurnani, Pratik, Sanchez-Cano, Carlos, Abraham, Kristin, Xandri-Monje, Helena, Cook, Alexander B., Hartlieb, Matthias, Lévi, Francis A., Dallmann, Robert and Perrier, Sébastien (2019) RAFT emulsion polymerization as a platform to generate well-defined biocompatible latex nanoparticles. Macromolecular Bioscience, 18 (10). 1800213. doi:10.1002/mabi.201800213 ISSN 1616-5187.

Komarzynski, Sandra, Huang, Qi, Lévi, Francis A., Palesh, Oxana G., Ulusakarya, Ayhan, Bouchahda, Mohamed, Haydar, Mazen, Wreglesworth, Nicholas I, Morère, Jean-François, Adam, René and Innominato, Pasquale F. (2019) The day after : correlates of patient-reported outcomes with actigraphy-assessed sleep in cancer patients at home (inCASA project). Sleep, 42 (10). zsz146. doi:10.1093/sleep/zsz146 ISSN 0161-8105.

Komarzynski, Sandra, Bolborea, Matei, Huang, Qi, Finkenstädt, Bärbel and Lévi, Francis A. (2019) Predictability of individual circadian phase during daily routine for medical applications of circadian clocks. JCI Insight, 4 (18). e130423. doi:10.1172/jci.insight.130423 ISSN 2379-3708.

Cederroth, Christopher R., Albrecht, Urs, Bass, Joseph, Brown, Steven A., Dyhrfjeld-Johnsen, Jonas, Gachon, Frederic, Green, Carla B., Hastings, Michael H., Helfrich-Förster, Charlotte, Hogenesch, John B., Lévi, Francis A., Loudon, Andrew, Lundkvist, Gabriella B., Meijer, Johanna H., Rosbash, Michael, Takahashi, Joseph S., Young, Michael and Canlon, Barbara (2019) Medicine in the fourth dimension. Cell Metabolism, 30 (2). pp. 238-250. doi:10.1016/j.cmet.2019.06.019 ISSN 1550-4131.

Okyar, Alper, Kumar, Swati, Filipski, Elisabeth, Piccolo, Enza, Ozturk, Narin, Xandri-Monje, Helena, Pala-Kara, Zeliha, Abraham, Kristin, Gato de Jesus Gomes, Ana Rita, Orman, Mehmet N., Li, Robert Xiao-Mei, Dallmann, Robert, Lévi, Francis A. and Ballesta, Annabelle (2019) Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling. Scientific Reports, 9 . 10505. doi:10.1038/s41598-019-46977-0 ISSN 2045-2322.

(2019) Carcinogenicity of night shift work. The Lancet Oncology, 124 . doi:10.1016/S1470-2045(19)30455-3 ISSN 1470-2045.

Labrèche, France, Guénel, Pascal, Lévi, Francis A., Doré, Jean-Francois, Costa, Giovanni, Lasfargues, Gérard and Gronfier, Claude (2019) Night shift work increases cancer risk of women—Letter. Cancer Epidemiology Biomarkers & Prevention, 28 (2). p. 422. doi:10.1158/1055-9965.EPI-18-0104

Vlachou, Denise, Bjarnason, Georg A., Giacchetti, Sylvie, Lévi, Francis A. and Rand, D. A. (David A.) (2019) TimeTeller : a new tool for precision circadian medicine and cancer prognosis. Working Paper. Cold Spring Harbor: bioRXiv. (Unpublished)

2018

Innominato, Pasquale F., Komarzynski, Sandra, Palesh, Oxana G., Dallmann, Robert, Bjarnason, Georg A., Giacchetti , Syvie, Ulusakarya , Ayhan, Bouchahda, Mohamed, Haydar, Mazen, Ballesta, Annabelle, Karaboué, Abdoulaye, Wreglesworth, Nicholas I., Spiegel, David and Lévi, Francis A. (2018) Circadian rest-activity rhythm as an objective biomarker of patient-reported outcomes in patients with advanced cancer. Cancer Medicine, 7 (9). pp. 4396-4405. doi:10.1002/cam4.1711 ISSN 2045-7634.

Komarzynski, Sandra, Huang, Qi, Innominato, Pasquale F., Maurice, Monique, Arbaud, Alexandre, Beau, Jacques, Bouchahda, Mohamed, Ulusakarya, Ayhan, Beaumatin, Nicolas, Breda, Gabrièle, Finkenstädt, Bärbel and Lévi, Francis A. (2018) Relevance of a mobile internet platform for capturing inter- and intrasubject variabilities in circadian coordination during daily routine : pilot study. Journal of Medical Internet Research, 20 (6). e204. doi:10.2196/jmir.9779 ISSN 1438-8871.

Innominato, Pasquale F., Komarzynski, Sandra, Karaboué, Abdoulaye, Ulusakarya, Ayhan, Bouchahda, Mohamed, Haydar, Mazen, Bossevot-Desmaris, Rachel, Mocquery, Magali, Plessis, Virginie and Lévi, Francis A. (2018) Home-based e-Health platform for multidimensional telemonitoring of symptoms, body weight, sleep, and circadian activity : relevance for chronomodulated administration of irinotecan, fluorouracil-leucovorin, and oxaliplatin at home—results From a pilot study. JCO Clinical Cancer Informatics . doi:10.1200/CCI.17.00125 ISSN 2473-4276.

Ozturk, Narin, Ozturk, Dilek, Pala-Kara, Zeliha, Kaptan, Engin, Sancar-Bas, Serap, Ozsoy, Nurten, Cinar, Suzan, Deniz, Gunnur, Li, Xiao-Mei, Giacchetti, Sylvie, Lévi, Francis A. and Okyar, Alper (2018) The immune system as a chronotoxicity target of the anticancer mTOR inhibitor everolimus. Chronobiology International, 35 (5). pp. 705-718. doi:10.1080/07420528.2018.1432632 ISSN 0742-0528.

Huang, Qi, Cohen, Dwayne, Komarzynski, Sandra, Li, Xiao-Mei, Innominato, Pasquale F., Lévi, Francis A. and Finkenstädt, Bärbel (2018) Hidden Markov models for monitoring circadian rhythmicity in telemetric activity data. Journal of The Royal Society Interface, 15 (139). doi:10.1098/rsif-2017-0885 ISSN 1742-5689.

Zhang, Yuan, Giacchetti, Sylvie, Parouchev, Alexandre, Hadadi, Eva, Li, Xiaomei, Dallmann, Robert, Xandri-Monje, Helena, Portier, Lucie, Adam, René, Lévi, Francis A., Dulong, Sandrine and Chang, Yunhua (2018) Dosing time dependent in vitro pharmacodynamics of Everolimus despite a defective circadian clock. Cell Cycle, 17 (1). pp. 33-42. doi:10.1080/15384101.2017.1387695 ISSN 1538-4101.

2017

Palesh, Oxana, Haitz, Karyn, Lévi, Francis A., Bjarnason, Georg A., Deguzman, Carl, Alizeh, Igbal, Ulusakarya, Ayhan, Packer, Mary Melissa and Innominato, Pasquale F. (2017) Relationship between subjective and actigraphy-measured sleep in 237 patients with metastatic colorectal cancer. Quality of Life Research, 26 (10). pp. 2783-2791. doi:10.1007/s11136-017-1617-2 ISSN 0962-9343.

Lévi, Francis A., Karaboué, Abdoulaye, Saffroy, Raphaël, Desterke, Christophe, Boige, Valerie, Smith, Denis, Hebbar, Mohamed, Innominato, Pasquale, Taieb, Julien, Carvalho, Carlos, Guimbaud, Rosine, Focan, Christian, Bouchahda, Mohamed, Adam, René, Ducreux, Michel, Milano, Gérard and Lemoine, Antoinette (2017) Pharmacogenetic determinants of outcomes on triplet hepatic artery infusion and intravenous cetuximab for liver metastases from colorectal cancer (European trial OPTILIV, NCT00852228). British Journal of Cancer, 117 (7). pp. 965-973. doi:10.1038/bjc.2017.278 ISSN 0007-0920.

Garufi, C., Levi, F., Karaboué, A., Torsello, A., Focan, C., Chollet, P. and Innominato, P. (2017) 513PEfficacy and tolerability of chronomodulated FOLFIRINOX (chronoIFLO) as 1st or 2nd line treatment in patients (pts) with metastatic colorectal cancer (MCC) : final results from an international trial (EORTC 05011). Annals of Oncology, 28 (5). doi:10.1093/annonc/mdx393.039 ISSN 0923-7534.

Innominato, P., Komarzynski , S., Bouchahda, M., Ulusakarya, A., Haydar, M., Karaboué, A. and Levi, F. (2017) Multidimensional telemonitoring of cancer patients (pts) receiving chronomodulated (chrono) Irinotecan (I), 5-fluorouracil (F), leucovorin (L) and oxaliplatin (O; chronoIFLO4) combination at home. Annals of Oncology, 28 (5). doi:10.1093/annonc/mdx388.019 ISSN 0923-7534.

Levi, F., Garufi, C., Karaboué, A., Focan, C., Chollet, P., Li, X-M. and Innominato, P. (2017) Sex-related differences in circadian-dependent tolerance of Irinotecan (I) added to chronomodulated (chrono) 5-Fluorouracil (F), Leucovorin (L) and Oxaliplatin (O): Final results from international randomised time-finding study in patients with metastatic colorectal cancer (MCC). Annals of Oncology, 28 (5). doi:10.1093/annonc/mdx393.048 ISSN 0923-7534.

Mteyrek, Ali, Filipski, Elisabeth, Guettier, Catherine, Oklejewicz, Malgorzata, van der Horst, Gijsbertus T.J., Okyar, Alper and Lévi, Francis A. (2017) Critical cholangiocarcinogenesis control by cryptochrome clock genes. International Journal of Cancer, 140 (11). pp. 2473-2483. doi:10.1002/ijc.30663 ISSN 0020-7136.

Ballesta, Annabelle, Innominato, Pasquale F., Dallmann, Robert, Rand, D. A. (David A.) and Lévi, Francis A. (2017) Systems chronotherapeutics. Pharmacological Reviews, 69 (2). pp. 161-199. doi:10.1124/pr.116.013441 ISSN 0031-6997.

Lévi, Francis A., Karaboué, Abdoulaye, Etienne-Grimaldi, Marie-Christine, Paintaud, Gilles, Focan, Christian, Innominato, Pasquale F., Bouchahda, Mohamed, Milano, Gérard and Chatelut, Etienne (2017) Pharmacokinetics of Irinotecan, Oxaliplatin and 5-Fluorouracil during hepatic artery chronomodulated infusion : a translational European OPTILIV study. Clinical Pharmacokinetics, 56 (2). pp. 165-177. doi:10.1007/s40262-016-0431-2 ISSN 0312-5963.

2016

Innominato, Pasquale F., Komarzynski, Sandra, Mohammad-Djafari, Ali, Arbaud, Alexandre, Ulusakarya, Ayhan, Bouchahda, Mohamed, Haydar, Mazen, Bossevot-Desmaris, Rachel, Plessis, Virginie, Mocquery, Magali, Bouchoucha, Davina, Afshar, Mehran, Beau, Jacques, Karaboué, Abdoulaye, Morère, Jean-François, Fursse, Joanna, Rovira Simon, Jordi and Lévi, Francis A. (2016) Clinical relevance of the first domomedicine platform securing multidrug chronotherapy delivery in metastatic cancer patients at home : the inCASA European project. Journal of Medical Internet Research, 18 (11). e305. doi:10.2196/jmir.6303 ISSN 1438-8871.

(2016) Early tumour response as a survival predictor in previously- treated patients receiving triplet hepatic artery infusion and intravenous cetuximab for unresectable liver metastases from wild-type KRAS colorectal cancer. European Journal of Cancer Care, 68 . pp. 163-172. doi:10.1016/j.ejca.2016.09.011 ISSN 0961-5423.

Bishehsari, Faraz, Lévi, Francis A., Turek, Fred W. and Keshavarzian, Ali (2016) Circadian rhythms in gastrointestinal health and diseases. Gastroenterology, 151 (3). e1-e5. doi:10.1053/j.gastro.2016.07.036 ISSN 0016-5085.

Mteyrek, Ali, Filipski, Elisabeth, Guettier, Catherine, Okyar, Alper and Lévi, Francis A. (2016) Clock gene Per2 as a controller of liver carcinogenesis. Oncotarget, 2016 (7). pp. 85832-85847. doi:10.18632/oncotarget.11037 ISSN 1949-2553.

Dallmann, Robert, Okyar, Alper and Lévi, Francis A. (2016) Dosing-time makes the poison : circadian regulation and pharmacotherapy. Trends in Molecular Medicine, 22 (5). pp. 430-445. doi:10.1016/j.molmed.2016.03.004 ISSN 1471-4914.

Ortiz-Tudela, Elisabet, Innominato, Pasquale F., Rol, Maria Angeles, Lévi, Francis A. and Madrid, Juan Antonio (2016) Relevance of internal time and circadian robustness for cancer patients. BMC Cancer, 16 (1). 285. doi:10.1186/s12885-016-2319-9 ISSN 1471-2407.

Schott, B., Stegmaier, J., Arbaud, A., Reischl, M., Mikut, R. and Lévi, Francis A. (2016) Robust individual circadian parameter estimation for biosignal-based personalisation of cancer chronotherapy. In: Workshop Biosignalverarbeitung 2016, Berlin, Germany, 7-8 Apr 2016. Published in: Biosignal processing workshop 2016: Innovations in the acquisition and analysis of bioelectric and biomagnetic signals, Berlin, April 7-8, 2016 pp. 67-70.

(2016) Conversion to resection of liver metastases from colorectal cancer with hepatic artery infusion of combined chemotherapy and systemic cetuximab in multicenter trial OPTILIV. Annals of Oncology, 27 (2). pp. 267-274. doi:10.1093/annonc/mdv548 ISSN 0923-7534.

2015

Natale, Vincenzo, Innominato, Pasquale F., Boreggiani, Michele, Tonetti, Lorenzo, Filardi, Marco, Parganiha, Arti, Fabbri, Marco, Martoni, Monica and Lévi, Francis A. (2015) The difference between in bed and out of bed activity as a behavioral marker of cancer patients : a comparative actigraphic study. Chronobiology International, 32 (7). pp. 925-933. doi:10.3109/07420528.2015.1053909 ISSN 0742-0528.

Dulong, S., Ballesta, A., Okyar, A. and Lévi, Francis A. (2015) Identification of circadian determinants of cancer chronotherapy through in vitro chronopharmacology and mathematical modeling. Molecular Cancer Therapeutics, 14 (9). pp. 2154-2164. doi:10.1158/1535-7163.MCT-15-0129 ISSN 1535-7163.

Feillet, Céline‏, Horst, Gijsbertus Theodorus Johannes van der‏, Lévi, Francis A., Rand, D. A. and Delaunay, Franck (2015) Coupling between the circadian clock and cell cycle oscillators : implication for healthy cells and malignant growth. Frontiers in Neurology, Volume 6 . Article number 96. doi:10.3389/fneur.2015.00096 ISSN 1664-2295.

Sallam, Hatem, El-Serafi, Ahmed T., Filipski, Elisabeth, Terelius, Ylva, Lévi, Francis A. and Hassan, Moustapha (2015) The effect of circadian rhythm on pharmacokinetics and metabolism of the Cdk inhibitor, roscovitine, in tumor mice model. Chronobiology International, 32 (5). pp. 608-614. doi:10.3109/07420528.2015.1022782 ISSN 0742-0528.

Innominato, Pasquale F., Spiegel, David, Ulusakarya, Ayhan, Giacchetti, Sylvie, Bjarnason, Georg A., Lévi, Francis A. and Palesh, Oxana (2015) Subjective sleep and overall survival in chemotherapy-naïve patients with metastatic colorectal cancer. Sleep Medicine, 16 (3). pp. 391-398. doi:10.1016/j.sleep.2014.10.022 ISSN 1389-9457.

2014

Feillet, C., Krusche, Peter, Tamanini, F., Janssens, R. C., Downey, Mike J., Martin, P., Teboul, M., Saito, S., Lévi, Francis A., Bretschneider, Till, van der Horst, G. T. J., Delaunay, F. and Rand, D. A. (David A.) (2014) Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle. Proceedings of the National Academy of Sciences of the United States of America, Volume 111 (Number 27). pp. 9828-9833. doi:10.1073/pnas.1320474111 ISSN 0027-8424.

Lévi, Francis A., Dugué, Pierre-Antoine, Innominato, Pasquale F., Karaboué, Abdoulaye, Dispersyn, Garance, Parganiha, Arti, Giacchetti, Sylvie, Moreau, Thierry, Focan, Christian, Waterhouse, Jim and Spiegel, David (2014) Wrist actimetry circadian rhythm as a robust predictor of colorectal cancer patients survival. Chronobiology International, 31 (8). pp. 891-900. doi:10.3109/07420528.2014.924523 ISSN 0742-0528.

Ortiz-Tudela, Elisabet, Iurisci, Ida, Beau, Jacques, Karaboue, Abdoulaye, Moreau, Thierry, Rol, Maria Angeles, Madrid, Juan Antonio, Lévi, Francis A. and Innominato, Pasquale F. (2014) The circadian rest-activity rhythm, a potential safety pharmacology endpoint of cancer chemotherapy. International Journal of Cancer, Volume 134 (Number 11). pp. 2717-2725. doi:10.1002/ijc.28587 ISSN 0020-7136.

Innominato, Pasquale F., Roche, Véronique P., Palesh, Oxana G., Ulusakarya, Ayhan, Spiegel, David and Lévi, Francis A. (2014) The circadian timing system in clinical oncology. Annals of Medicine, Volume 46 (Number 4). pp. 191-207. doi:10.3109/07853890.2014.916990 ISSN 0785-3890.

Roche, Véronique Pasquale, Mohamad-Djafari, Ali, Innominato, Pasquale Fabio, Karaboué, Abdoulaye, Gorbach, Alexander and Lévi, Francis A. (2014) Thoracic surface temperature rhythms as circadian biomarkers for cancer chronotherapy. Chronobiology International, Volume 31 (Number 3). pp. 409-420. doi:10.3109/07420528.2013.864301 ISSN 0742-0528.

Filipski, Elisabeth, Berland, Elodie, Ozturk, Narin, Guettier, Catherine, van der Horst, Gijsbertus T. J., Lévi, Francis A. and Okyar, Alper (2014) Optimization of irinotecan chronotherapy with P-glycoprotein inhibition. Toxicology and Applied Pharmacology, 274 (3). pp. 471-479. doi:10.1016/j.taap.2013.12.018 ISSN 0041008X.

2013

Li, X. -M., Mohammad-Djafari, A., Dumitru, M., Dulong, S., Filipski, E., Siffroi-Fernandez, S., Mteyrek, A., Scaglione, F., Guettier, C., Delaunay, F. and Lévi, Francis A. (2013) A circadian clock transcription model for the personalization of cancer chronotherapy. Cancer Research, Volume 73 (Number 24). pp. 7176-7188. doi:10.1158/0008-5472.CAN-13-1528 ISSN 0008-5472.

Costa, Maria J. (Maria João), Finkenstädt, Bärbel, Gould, Peter D., Foreman, Julia, Halliday, Karen J., Hall, Anthony, Roche, Véronique, Lévi, Francis A. and Rand, D. A. (David A.) (2013) Inference on periodicity of circadian time series. Biostatistics, Volume 14 (Number 4). pp. 792-806. doi:10.1093/biostatistics/kxt020 ISSN 1465-4644.

2012

Innominato, Pasquale F., Giacchetti, Sylvie, Bjarnason, Georg A., Focan, Christian, Garufi, Carlo, Coudert, Bruno, Iacobelli, Stefano, Tampellini, Marco, Durando, Xavier, Mormont, Marie-Christine, Waterhouse, Jim and Lévi, Francis A. (2012) Prediction of overall survival through circadian rest-activity monitoring during chemotherapy for metastatic colorectal cancer. International Journal of Cancer, Volume 131 (Number 11). pp. 2684-2692. doi:10.1002/ijc.27574 ISSN 0020-7136.

Giacchetti, S., Dugue, P. A., Innominato, P. F., Bjarnason, G. A., Focan, C., Garufi, C., Tumolo, S., Coudert, B., Iacobelli, S., Smaaland, R., Tampellini, M., Adam, R., Moreau, T. and Lévi, Francis A. (2012) Sex moderates circadian chemotherapy effects on survival of patients with metastatic colorectal cancer : a meta-analysis. Annals of Oncology, Volume 23 (Number 12). pp. 3110-3116. doi:10.1093/annonc/mds148 ISSN 0923-7534.

2011

Ballesta, Annabelle, Dulong, Sandrine, Abbara, Chadi, Cohen, Boris, Okyar, Alper, Clairambault, Jean and Lévi, Francis A. (2011) A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery. PLoS Computational Biology, 7 (9). pp. 1-12. Article number e1002143. doi:10.1371/journal.pcbi.1002143 ISSN 1553-7358.

Lévi, Francis A., Mosekilde, E. and Rand, D. A. (David A.) (2011) Advancing systems medicine and therapeutics through biosimulation. Interface Focus, Vol.1 (No.1). pp. 3-6. doi:10.1098/rsfs.2010.0019 ISSN 2042-8898.

2010

Lévi, Francis A., Okyar, Alper, Dulong, Sandrine, Innominato, Pasquale F. and Clairambault, Jean (2010) Circadian timing in cancer treatments. Annual Review of Pharmacology and Toxicology, Volume 50 (Number 1). pp. 377-421. doi:10.1146/annurev.pharmtox.48.113006.094626 ISSN 0362-1642.

2007

Lévi, Francis A. and Schibler, Ueli (2007) Circadian rhythms : mechanisms and therapeutic implications. Annual Review of Pharmacology and Toxicology, Volume 47 (Number 1). pp. 593-628. doi:10.1146/annurev.pharmtox.47.120505.105208 ISSN 0362-1642.

2001

Lévi, Francis A. (2001) Circadian chronotherapy for human cancers. The Lancet. Oncology, Volume 2 (Number 5). pp. 307-315. doi:10.1016/s1470-2045(00)00326-0 ISSN 1470-2045.

1997

Lévi, Francis A., Zidani, Rachid and Misset, Jean-Louis (1997) Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. The Lancet, Volume 350 (Number 9079). pp. 681-686. doi:10.1016/s0140-6736(97)03358-8 ISSN 0140-6736.