2019

Cummings, Matthew, Peters, Anna D. , Whitehead, George F. S. , Menon, Binuraj R. K., Micklefield, Jason and Webb, Simon J. (2019) Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli. PLoS Biology, 17 (7). e3000347. doi:10.1371/journal.pbio

2018

Bennett, Matthew R., Thompson, Mark L., Shepherd, Sarah A., Dunstan, Mark S., Herbert, Abigail J., Smith, Duncan R. M., Cronin, Victoria A., Menon, Binuraj R. K., Levy, Colin and Micklefield, Jason (2018) Structure and biocatalytic scope of coclaurine N-methyltransferase. Angewandte Chemie International Edition . doi:10.1002/anie.201805060 (In Press)

Menon, Binuraj R. K. and Jenner, Matthew (2018) Biosynthesis : reprogramming assembly lines. Nature Chemistry, 10 (3). pp. 245-247. doi:10.1038/nchem.2941

2017

Menon, Binuraj R. K., Brandenburger, Eileen, Sharif, Humera H., Klemstein, Ulrike, Shepherd, Sarah A., Greaney, Michael F. and Micklefield, Jason (2017) RadH : a versatile halogenase for integration into synthetic pathways. Angewandte Chemie International Edition, 56 (39). pp. 11841-11845. doi:10.1002/anie.201706342

Latham, Jonathan, Brandenburger, Eileen, Shepherd, Sarah A., Menon, Binuraj R. K. and Micklefield, Jason (2017) Development of halogenase enzymes for use in synthesis. Chemical Reviews . doi:10.1021/acs.chemrev.7b00032

2016

Ortmayer, Mary, Lafite, Pierre, Menon, Binuraj R. K., Tralau, Tewes, Fisher, Karl, Denkhaus, Lukas, Scrutton, Nigel S., Rigby, Stephen E. J., Munro, Andrew W., Hay, Sam and Leys, David (2016) An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme. Nature, 539 (7630). pp. 593-597. doi:10.1038/nature20159

Menon, Binuraj R. K., Latham, Jonathan, Dunstan, Mark S., Brandenburger, Eileen, Klemstein, Ulrike, Leys, David, Karthikeyan, Chinnan, Greaney, Michael F., Shepherd, Sarah A. and Micklefield, Jason (2016) Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes. Organic and Biomolecular Chemistry, 14 (39). pp. 9354-9361. doi:10.1039/C6OB01861K

Menon, Binuraj R. K., Hardman, Samantha J. O., Scrutton, Nigel S. and Heyes, Derren J. (2016) Multiple active site residues are important for photochemical efficiency in the light-activated enzyme protochlorophyllide oxidoreductase (POR). Journal of Photochemistry and Photobiology B: Biology , 161 . pp. 236-243. doi:10.1016/j.jphotobiol.2016.05.029

Latham, Jonathan, Henry, Jean-Marc, Sharif, Humera H., Menon, Binuraj R. K., Shepherd, Sarah A., Greaney, Michael F. and Micklefield, Jason (2016) Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C–H activation. Nature Communications, 7 . 11873. doi:10.1038/ncomms11873

Shepherd, Sarah A., Menon, Binuraj R. K., Fisk, Heidi, Struck, Anna-Winona, Levy, Colin, Leys, David and Micklefield, Jason (2016) A structure-guided switch in the regioselectivity of a tryptophan halogenase. Chembiochem, 17 (9). pp. 821-824. doi:10.1002/cbic.201600051

2015

Menon, Navya, Pásztor, András, Menon, Binuraj R. K., Kallio, Pauli, Fisher, Karl, Akhtar, M. Kalim, Leys, David, Jones, Patrik R. and Scrutton, Nigel S. (2015) A microbial platform for renewable propane synthesis based on a fermentative butanol pathway. Biotechnology for Biofuels, 8 (1). 61. doi:10.1186/s13068-015-0231-1

Menon, Binuraj R. K., Menon, Navya, Fisher, Karl, Rigby, Stephen E. J., Leys, David and Scrutton, Nigel S. (2015) Glutamate 338 is an electrostatic facilitator of C-Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase. FEBS Journal, 282 (7). pp. 1242-1255. doi:10.1111/febs.13215

Shepherd, Sarah A., Karthikeyan, Chinnan, Latham, Jonathan, Struck, Anna-Winona, Thompson, Mark L., Menon, Binuraj R. K., Styles, Matthew Q., Levy, Colin, Leys, David and Micklefield, Jason (2015) Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes. Chemical Science, 6 (6). pp. 3454-3460. doi:10.1039/C5SC00913H

2014

Menon, Binuraj R. K., Fisher, Karl, Rigby, Stephen E. J., Scrutton, Nigel S. and Leys, David (2014) A conformational sampling model for radical catalysis in pyridoxal phosphate- and cobalamin-dependent enzymes. Journal of Biological Chemistry, 289 (49). pp. 34161-34174. doi:10.1074/jbc.M114.590471

2009

Menon, Binuraj R. K., Waltho, Jonathan P., Scrutton, Nigel S. and Heyes, Derren J. (2009) Cryogenic and laser photoexcitation studies identify multiple roles for active site residues in the light-driven enzyme protochlorophyllide oxidoreductase. Journal of Biological Chemistry, 284 (27). pp. 18160-18166. doi:10.1074/jbc.M109.020719

Menon, Binuraj R. K., Davison, Paul A., Hunter, C. Neil, Scrutton, Nigel S. and Heyes, Derren J. (2009) Mutagenesis alters the catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase. Journal of Biological Chemistry, 285 (3). pp. 2113-2119. doi:10.1074/jbc.M109.071522

2008

Heyes, Derren J., Menon, Binuraj R. K. , Sakuma, Michiyo and Scrutton, Nigel S. (2008) Conformational events during ternary enzyme−substrate complex formation are rate limiting in the catalytic cycle of the light-driven enzyme protochlorophyllide oxidoreductase. Biochemistry, 47 (41). pp. 10991-10998. doi:10.1021/bi801521c