Journal Article

Challis, Gregory L., Nakou, Ioanna, Jenner, Matthew, Dashti, Yousef, Romero-Canelón, Isolda, Masschelein, Joleen and Mahenthiralingam, Eshwar (2020) Genomics-driven discovery of a novel glutarimide antibiotic from Burkholderia gladioli reveals an unusual polyketide synthase chain release mechanism. Angewandte Chemie International Edition, 59 (51). pp. 23145-23153. doi:10.1002/anie.202009007 ISSN 1433-7851.

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Füllöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11 . 913-923 . doi:10.1038/s41557-019-0335-5 ISSN 1755-4330.

Masschelein, Joleen, Sydor, Paulina K., Hobson, Christian, Howe, Rhiannon, Jones, Cerith, Roberts, Douglas M., Zhong, Ling Yap, Parkhill, Julian, Mahenthiralingam, Eshwar and Challis, Gregory L. (2019) A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis. Nature Chemistry, 11 . 906-912 . doi:10.1038/s41557-019-0309-7 ISSN 1755-4330.

Zhou, Shanshan, Song, Lijiang, Masschelein, Joleen, Sumang, Felaine A. M., Papa, Irene A., Zulaybar, Teofila O., Custodio, Aileen B., Zabala, Daniel, Alcantara, Edwin P., Emmanuel de los Santos, L. C. and Challis, Gregory L. (2019) Pentamycin biosynthesis in Philippine Streptomyces sp. S816 : cytochrome P450-catalyzed installation of the C-14 hydroxyl group. ACS Chemical Biology, 14 (6). pp. 1305-1309. doi:10.1021/acschembio.9b00270 ISSN 1554-8929.

Jenner, Matthew, Jian, Xinyun, Dashti, Yousef, Masschelein, Joleen, Hobson, Christian, Roberts, Douglas M., Jones, Cerith, Harris, Simon, Parkhill, Julian, Raja, Huzefa A., Oberlies, Nicholas H., Pearce, Cedric J., Mahenthiralingam, Eshwar and Challis, Gregory L. (2019) An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics. Chemical Science, 10 (21). pp. 5489-5494. doi:10.1039/C8SC04897E ISSN 2041-6520.

Song, Lijiang, Jenner, Matthew, Masschelein, Joleen, Jones, Cerith, Bull, Matthew J., Harris, Simon R., Hartkoorn, Ruben C., Vocat, Anthony, Romero-Canelón, Isolda, Coupland, Paul, Webster, Gordon, Dunn, Matthew, Weiser, Rebecca, Paisey, Christopher, Cole, Stewart T., Parkhill, Julian, Mahenthiralingam, Eshwar and Challis, Gregory L. (2017) Discovery and biosynthesis of Gladiolin : a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. Journal of the American Chemical Society, 139 (23). pp. 7974-7981. doi:10.1021/jacs.7b03382 ISSN 0002-7863.

Awodi, U. R., Ronan, Jade L., Masschelein, Joleen, Emmanuel de los Santos, L. C. and Challis, Gregory L. (2017) Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis. Chemical Science, 8 (1). pp. 411-415. doi:10.1039/C6SC02803A ISSN 2041-6520.

Uytterhoeven, Birgit, Appermans, Kenny, Song, Lijiang, Masschelein, Joleen, Lathouwers, Thomas , Michiels, Chris W. and Lavigne, Rob (2016) Systematic analysis of the kalimantacin assembly line NRPS module using an adapted targeted mutagenesis approach. Microbiology Open, 5 (2). pp. 279-286. doi:10.1002/mbo3.326 ISSN 2045-8827.

Jenner, M., Masschelein, Joleen, Dashti, Y., Jones, C., Harris, S., Parkhill, J., Pearce, C., Mahenthiralingham, E. and Challis, G. L. (2016) Biosynthesis of a 'fungal' peptide antibiotic by Burkholderia gladioli. Planta Medica, 81 (S 01). S1-S381. doi:10.1055/s-0036-1597080 ISSN 0032-0943.

Masschelein, Joleen, Sydor, P. K., Griffiths, D. E., Valentic, T. R., Gallo, A., Jones, C., Song, L., Tsai, S. C., Lewandowski, J. R., Mahenthiralingam, E. and Challis, G. L. (2016) Dissection and rational engineering of the biosynthetic pathway to enacyloxin, a promising anti-Gram-negative antibiotic. Planta Medica, 81 (S 01). S1-S381. doi:10.1055/s-0036-1596129 ISSN 0032-0943.

Dataset

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Fülöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Data for Structural basis for chain release from the enacyloxin polyketide synthase. [Dataset]