2020

Challis, Gregory L., Nakou, Ioanna, Jenner, Matthew, Dashti, Yousef, Romero-Canelón, Isolda, Masschelein, Joleen and Mahenthiralingam, Eshwar (2020) Genomics-driven discovery of a novel glutarimide antibiotic from Burkholderia gladioli reveals an unusual polyketide synthase chain release mechanism. Angewandte Chemie International Edition, 59 (51). pp. 23145-23153. doi:10.1002/anie.202009007

2019

Hai, Yang, Jenner, Matthew and Tang, Yi (2019) Complete stereoinversion of L-tryptophan by a fungal single module nonribosomal peptide synthetase. Journal of the American Chemical Society, 141 (41). pp. 16222-16226. doi:10.1021/jacs.9b08898

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Füllöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11 . 913-923 . doi:10.1038/s41557-019-0335-5

Jenner, Matthew, Jian, Xinyun, Dashti, Yousef, Masschelein, Joleen, Hobson, Christian, Roberts, Douglas M., Jones, Cerith, Harris, Simon, Parkhill, Julian, Raja, Huzefa A., Oberlies, Nicholas H., Pearce, Cedric J., Mahenthiralingam, Eshwar and Challis, Gregory L. (2019) An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics. Chemical Science, 10 (21). pp. 5489-5494. doi:10.1039/C8SC04897E

Mullins, Alex J., Murray, James A. H., Bull, Matthew J., Jenner, Matthew, Jones, Cerith, Webster, Gordon, Green, Angharad E., Neill, Daniel R., Connor, Thomas R., Parkhill, Julian, Challis, Gregory L. and Mahenthiralingam, Eshwar (2019) Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria. Nature microbiology, 4 . pp. 996-1005. doi:10.1038/s41564-019-0383-z

2018

Kosol, Simone, Jenner, Matthew, Lewandowski, Józef R. and Challis, Gregory L. (2018) Protein–protein interactions in trans-AT polyketide synthases. Natural Product Reports, 35 (10). pp. 1097-1109. doi:10.1039/C8NP00066B

Jenner, Matthew, Kosol, Simone, Griffiths, Daniel, Prasongpholchai, Panward, Manzi, Lucio, Barrow, Andrew S., Moses, John E., Oldham, Neil J., Lewandowski, Józef R. and Challis, Gregory L. (2018) Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases. Nature Chemical Biology, 14 . pp. 270-275. doi:10.1038/nchembio.2549

Menon, Binuraj R. K. and Jenner, Matthew (2018) Biosynthesis : reprogramming assembly lines. Nature Chemistry, 10 (3). pp. 245-247. doi:10.1038/nchem.2941

2017

Song, Lijiang, Jenner, Matthew, Masschelein, Joleen, Jones, Cerith, Bull, Matthew J., Harris, Simon R., Hartkoorn, Ruben C., Vocat, Anthony, Romero-Canelón, Isolda, Coupland, Paul, Webster, Gordon, Dunn, Matthew, Weiser, Rebecca, Paisey, Christopher, Cole, Stewart T., Parkhill, Julian, Mahenthiralingam, Eshwar and Challis, Gregory L. (2017) Discovery and biosynthesis of Gladiolin : a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. Journal of the American Chemical Society, 139 (23). pp. 7974-7981. doi:10.1021/jacs.7b03382

2016

Asiani, Karishma R., Williams, Huw, Bird, Louise, Jenner, Matthew, Searle, Mark S., Hobman, Jon L., Scott, David J. and Soultanas, Panos (2016) SilE is an intrinsically disordered periplasmic ‘molecular sponge' involved in bacterial silver resistance. Molecular Microbiology, 101 (5). pp. 731-742. doi:10.1111/mmi.13399

Jenner, Matthew, Afonso, Jose P., Kohlhaas, Christoph, Karbaum, Petra, Frank, Sarah, Piel, Jörn and Oldham, Neil J. (2016) Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins. Chemical Communications, 52 (30). pp. 5262-5265. doi:10.1039/c6cc01453d

Jenner, M., Masschelein, Joleen, Dashti, Y., Jones, C., Harris, S., Parkhill, J., Pearce, C., Mahenthiralingham, E. and Challis, G. L. (2016) Biosynthesis of a 'fungal' peptide antibiotic by Burkholderia gladioli. Planta Medica, 81 (S 01). S1-S381. doi:10.1055/s-0036-1597080

Rowe, R. A., Jones, C., Bull, M. J., Jenner, M., Song, L., Dashti, Y., Harris, S. R., Parkhill, J., Connor, T. R., Challis, G. L. and Mahenthiralingam, E. (2016) Characterisation of vietnamycin : a novel Burkholderia antibiotic targeting mupirocin-resistant methicillin-resistant Staphylococcus aureus (MRSA). Planta Medica, 81 (S 01). S1-S381. doi:10.1055/s-0036-1596684

Jones, C., Bull, M. J., Jenner, M., Song, L., Dashti, Y., Harris, S. R., Parkhill, J., Connor, T. R., Challis, G. L. and Mahenthiralingam, E. (2016) Genome mining and characterisation of multiple bioactive compounds from a Burkholderia gladioli isolate collection. Planta Medica, 81 (S 01). S1-S381. doi:10.1055/s-0036-1596149

2014

Jenner, Matthew, Afonso, José Pedro, Bailey, Hannah R., Frank, Sarah, Kampa, Annette, Piel, Jörn and Oldham, Neil J. (2014) Acyl-chain elongation drives ketosynthase substrate selectivity intrans-acyltransferase polyketide synthases. Angewandte Chemie International Edition, 54 (6). pp. 1817-1821. doi:10.1002/anie.201410219