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Number of items: 546.
Advantage West Midlands (AWM)
Fu, Ying, Romero, Maria, Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni and Sadler, P. J. (2016) Os2-Os4 switch controls DNA knotting and anticancer activity. Angewandte Chemie International Edition, 55 (31). pp. 8909-8912. doi:10.1002/anie.201602995 ISSN 1433-7851.
Fu, Ying, Sanchez-Cano, Carlos, Soni, Rina, Romero-Canelón, Isolda, Hearn, Jessica M., Liu, Zhe, Wills, Martin and Sadler, P. J. (2016) The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Transactions, 45 (20). pp. 8367-8378. doi:10.1039/c6dt01242f ISSN 1477-9226.
Romero-Canelón, Isolda, Mos, Magdalena and Sadler, P. J. (2015) Enhancement of selectivity of an organometallic anticancer agent by redox modulation. Journal of Medicinal Chemistry, 58 (19). pp. 7874-7880. doi:10.1021/acs.jmedchem.5b00655 ISSN 0022-2623.
Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2015) Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design. Nature Communications, 6 . pp. 1-9. 6582. doi:10.1038/ncomms7582 ISSN 2041-1723.
Soldevila-Barreda, Joan J. and Sadler, P. J. (2015) Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology, Volume 25 . pp. 172-183. doi:10.1016/j.cbpa.2015.01.024 ISSN 1367-5931.
Liu, Zhe , Romero-Canelón, Isolda, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2014) Potent half-sandwich iridium(III) anticancer complexes containing C∧N-Chelated and pyridine ligands. Organometallics, 33 (19). pp. 5324-5333. doi:10.1021/om500644f ISSN 0276-7333.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Sánchez, Ana M., Dove, Andrew P., Procter, Richard J., Soldevila-Barreda, Joan J., Kirby, Nigel, Hands-Portman, Ian, Smith, Corinne J., O'Reilly, Rachel K., Beanland, R. and Sadler, P. J. (2014) Fabrication of crystals from single metal atoms. Nature Communications, Volume 5 . Article number 3851 . doi:10.1038/ncomms4851 ISSN 2041-1723.
Rijt, Sabine H. van, Romero-Canelón, Isolda, Fu, Ying, Shnyder, Steve D. and Sadler, P. J. (2014) Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells. Metallomics, 6 (5). pp. 1014-1022. doi:10.1039/c4mt00034j ISSN 1756-5901.
Liu, Zhe and Sadler, P. J. (2014) Organoiridium complexes : anticancer agents and catalysts. Accounts of chemical research, 47 (4). pp. 1174-1185. doi:10.1021/ar400266c ISSN 0001-4842.
Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505 ISSN 1433-7851.
Fu, Ying, Soni, Rina, Romero, Maria, Pizarro, Ana M., Salassa, Luca, Clarkson, Guy J., Hearn, Jessica M., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2013) Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity. Chemistry - A European Journal, Volume 19 (Number 45). pp. 15199-15209. doi:10.1002/chem.201302183 ISSN 0947-6539.
Smith, Nicola A. and Sadler, P. J. (2013) Photoactivatable metal complexes : from theory to applications in biotechnology and medicine. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Volume 371 (Number 1995). p. 20120519. doi:10.1098/rsta.2012.0519 ISSN 1364-503X.
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Betanzos-Lara, Soledad, Novakova, Olga, Deeth, Robert J., Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor), Sadler, P. J. and Habtemariam, Abraha (2012) Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity. JBIC Journal of Biological Inorganic Chemistry, 17 (7). pp. 1033-1051. doi:10.1007/s00775-012-0917-9 ISSN 0949-8257.
Unterkofler, S., McQuitty, Ruth J., Euser, T. G., Farrer, Nicola J., Sadler, P. J. and Russell, P. St.J. (2012) Microfluidic integration of photonic crystal fibers for online photochemical reaction analysis. Optics Letters, Volume 37 (Number 11). pp. 1952-1954. doi:10.1364/OL.37.001952 ISSN 0146-9592.
Noffke, Anna Louise, Habtemariam, Abraha, Pizarro, Ana M. and Sadler, P. J. (2012) Designing organometallic compounds for catalysis and therapy. Chemical Communications, Vol.48 (No.43). pp. 5219-5246. doi:10.1039/c2cc30678f ISSN 1359-7345.
Mukherjee, Arindam, Bilton, Paul R., Mackay, Logan, Janoschka, Adam, Zhu, Haizhong, Rea, Dean, Langridge-Smith, Pat R. R., Campopiano, Dominic J., Teschner, Thomas, Trautwein, Alfred, Schünemann, Volker and Sadler, P. J. (2012) Ferric ion (hydr)oxo clusters in the “Venus flytrap” cleft of FbpA : Mössbauer, calorimetric and mass spectrometric studies. JBIC Journal of Biological Inorganic Chemistry, Vol.17 (No.4). pp. 573-588. doi:10.1007/s00775-012-0878-z ISSN 0949-8257.
Tai, Hui-Chung, Brodbeck, Ralf, Kasparkova, Jana, Farrer, Nicola J., Brabec, V. (Viktor), Sadler, P. J. and Deeth, Robert J. (2012) Combined theoretical and computational study of interstrand DNA guanine–guanine cross-linking bytrans-[Pt(pyridine)2] derived from the photoactivated prodrugtrans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]. Inorganic Chemistry, Vol.51 (No.12). pp. 6830-6841. doi:10.1021/ic3005745 ISSN 0020-1669.
Romero-Canelón, Isolda, Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2012) Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes. Metallomics, Volume 4 (Number 12). pp. 1271-1279. doi:10.1039/c2mt20189e ISSN 1756-5901.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha, Novakova, Olga, Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor) and Sadler, P. J. (2012) Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics, Vol.31 (No.9). pp. 3466-3479. doi:10.1021/om201177y ISSN 0276-7333.
Fu, Y. (Ying), Romero, Maria, Habtemariam, Abraha, Snowden, Michael E., Song, Lijiang, Clarkson, Guy J., Qamar, Bushra, Pizarro, Ana M., Unwin, Patrick R. and Sadler, P. J. (2012) The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes. Chemical Science, Vol.3 (No.8). pp. 2485-2494. doi:10.1039/c2sc20220d ISSN 2041-6520.
Ronconi, Luca, Pizarro, Ana M., McQuitty, Ruth J. and Sadler, P. J. (2011) Insights into the acid-base properties of PtIV-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry - A European Journal, Volume 17 (Number 43). pp. 12051-12058. doi:10.1002/chem.201002792 ISSN 0947-6539.
Farrer, Nicola J., Gierth, Peter and Sadler, P. J. (2011) Probing platinum azido complexes by 14N and 15N NMR spectroscopy. Chemistry - A European Journal, Vol.17 (No.43). pp. 12059-12066. doi:10.1002/chem.201101409 ISSN 0947-6539.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics, Vol.30 (No.17). pp. 4702-4710. doi:10.1021/om2005468 ISSN 0276-7333.
Shnyder, Steve D., Fu, Y. (Ying), Habtemariam, Abraha, Rijt, Sabine H. van, Cooper, Patricia A., Loadman, Paul M. and Sadler, P. J. (2011) Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex. MedChemComm, Vol.2 (No.7). pp. 666-668. doi:10.1039/c1md00075f ISSN 2040-2503.
Betanzos-Lara, Soledad, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic cis-Dichlorido ruthenium(II) ammine complexes. European Journal of Inorganic Chemistry, Volume 2011 (Number 21). pp. 3257-3264. doi:10.1002/ejic.201100250 ISSN 1434-1948.
Liu, Zhe , Salassa, Luca, Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorganic Chemistry, Vol.50 (No.12). pp. 5777-5783. doi:10.1021/ic200607j ISSN 0020-1669.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Fletcher, Sally A., Kisova, Anna, Vrana, Oldrich, Salassa, Luca, Bruijnincx, Pieter C. A., Clarkson, Guy J., Brabec, V. (Viktor) and Sadler, P. J. (2011) Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry, Vol.54 (No.8). pp. 3011-3026. doi:10.1021/jm2000932 ISSN 0022-2623.
Kisova, Anna, Zerzankova, Lenka, Habtemariam, Abraha, Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2011) Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Molecular Pharmaceutics, Vol.8 (No.3). pp. 949-957. doi:10.1021/mp200105d ISSN 1543-8384.
Rijt, Sabine H. van, Kostrhunova, Hana, Brabec, V. (Viktor) and Sadler, P. J. (2011) Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity. Bioconjugate Chemistry, Vol.22 (No.2). pp. 218-226. doi:10.1021/bc100369p ISSN 1043-1802.
Liu, Hong-Ke and Sadler, P. J. (2011) Metal complexes as DNA intercalators. Accounts of Chemical Research, Vol.44 (No.5). pp. 349-359. doi:10.1021/ar100140e ISSN 0001-4842.
Fu, Y. (Ying), Habtemariam, Abraha, Basri, Aida M. B. H., Braddick, Darren, Clarkson, Guy J. and Sadler, P. J. (2011) Structure–activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity. Dalton Transactions (No.40). pp. 10553-10562. doi:10.1039/c1dt10937e ISSN 1477-9226.
Salassa, Luca, Ruiu, Tiziana, Garino, Claudio, Pizarro, Ana M., Bardelli, Fabrizio, Gianolio, Diego, Westendorf, Aron, Bednarski, Patrick J., Lamberti, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) EXAFS, DFT, light-induced nucleobase binding, and cytotoxicity of the photoactive complex cis-[Ru(bpy)2(CO)Cl]+. Organometallics, Vol.29 (No.4). pp. 6703-6710. doi:10.1021/om100734y ISSN 0276-7333.
Fu, Y. (Ying), Habtemariam, Abraha, Pizarro, Ana M., Rijt, Sabine H. van, Healey, David J., Cooper, Patricia A., Shnyder, Steven D., Clarkson, Guy J. and Sadler, P. J. (2010) Organometallic osmium arene complexes with potent cancer cell cytotoxicity. Journal of Medicinal Chemistry, Vol.53 (No.22). pp. 8192-8196. doi:10.1021/jm100560f ISSN 0022-2623.
Ruiu, Tiziana, Garino, Claudio, Salassa, Luca, Pizarro, Ana M., Nervi, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) Spectroscopic and computational study of ligand photodissociation from [Ru(dipyrido[3,2-a:2',3'-c]phenazine)(4-aminopyridine)(4)](2+). European Journal of Inorganic Chemistry, Vol.2010 (No.8). pp. 1186-1195. doi:10.1002/ejic.200900990 ISSN 1434-1948.
Rijt, Sabine H. van, Mukherjee, Arindam, Pizarro, Ana M. and Sadler, P. J. (2010) Cytotoxicity, hydrophobicity, uptake, and distribution of osmium(II) anticancer complexes in ovarian cancer cells. Journal of Medicinal Chemistry, Vol.53 (No.2). pp. 840-849. doi:10.1021/jm901556u ISSN 0022-2623.
Rijt, Sabine H. van, Hebden, Andrew J., Amaresekera, Thakshila, Deeth, Robert J., Clarkson, Guy J., Parsons, S. (Simon), McGowan, Patrick C. and Sadler, P. J. (2009) Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes. Journal of Medicinal Chemistry, Vol.52 (No.23). pp. 7753-7764. doi:10.1021/jm900731j ISSN 0022-2623.
Rijt, Sabine H. van and Sadler, P. J. (2009) Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discovery Today, Vol.14 (No.23-24). pp. 1089-1097. doi:10.1016/j.drudis.2009.09.003 ISSN 1359-6446.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2009) Photocontrolled nucleobase binding to an organometallic Ru-II arene complex. Chemical Communications (No.43). pp. 6622-6624. doi:10.1039/b914153g ISSN 1359-7345.
Akademie věd České republiky [Academy of Sciences of the Czech Republic]
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha, Novakova, Olga, Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor) and Sadler, P. J. (2012) Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics, Vol.31 (No.9). pp. 3466-3479. doi:10.1021/om201177y ISSN 0276-7333.
Akademie věd České republiky [Academy of Sciences of the Czech Republic] (ASCR)
Kisova, Anna, Zerzankova, Lenka, Habtemariam, Abraha, Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2011) Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Molecular Pharmaceutics, Vol.8 (No.3). pp. 949-957. doi:10.1021/mp200105d ISSN 1543-8384.
Rijt, Sabine H. van, Kostrhunova, Hana, Brabec, V. (Viktor) and Sadler, P. J. (2011) Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity. Bioconjugate Chemistry, Vol.22 (No.2). pp. 218-226. doi:10.1021/bc100369p ISSN 1043-1802.
Novakova, Olga, Malina, J. (Jaroslav), Suchankova, Tereza, Kasparkova, Jana, Bugarcic, Tijana, Sadler, P. J. and Brabec, V. (Viktor) (2010) Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru-II complexes containing terphenyl arenes. Chemistry - A European Journal, Vol.16 (No.19). pp. 5744-5754. doi:10.1002/chem.200903078 ISSN 0947-6539.
Bugarcic, Tijana, Habtemariam, Abraha, Stepankova, Jana, Heringova, Pavla, Kasparkova, Jana, Deeth, Robert J., Johnstone, Russell D. L., Prescimone, Alessandro, Parkin, Andrew, Parsons, S. (Simon), Brabec, V. (Viktor) and Sadler, P. J. (2008) The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes. Inorganic Chemistry, Vol.47 (No.24). pp. 11470-11486. doi:10.1021/ic801361m ISSN 0020-1669.
Bugarcic, Tijana, Novakova, Olga, Halamikova, Anna, Zerzankova, Lenka, Vrana, Oldrich, Kasparkova, Jana, Habtemariam, Abraha, Parsons, S. (Simon), Sadler, P. J. and Brabec, V. (Viktor) (2008) Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes. Journal of Medicinal Chemistry, Vol.51 (No.17). pp. 5310-5319. doi:10.1021/jm8003043 ISSN 0022-2623.
Castellano-Castillo, Maria, Kostrhunova, Hana, Marini, Victoria, Kasparkova, Jana, Sadler, P. J., Malinge, Jean-Marc and Brabec, V. (Viktor) (2008) Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes. Journal of Biological Inorganic Chemistry, Vol.13 (No.6). pp. 993-999. doi:10.1007/s00775-008-0386-3 ISSN 0949-8257.
Kostrhunova, Hana, Florian, Jakub, Novakova, Olga, Peacock, Anna F. A., Sadler, P. J. and Brabec, V. (Viktor) (2008) DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media. Journal of Medicinal Chemistry, Vol.51 (No.12). pp. 3635-3643. doi:10.1021/jm701538w ISSN 0022-2623.
Australian Research Council (ARC)
Diakos, Connie I., Messerle, Barbara A., del Socorro Murdoch, P., Parkinson, J. A. (John A.), Sadler, P. J., Fenton, Ronald R. and Hambley, Trevor W. (2009) Identification by NMR spectroscopy of the two stereoisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz=3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A.T-rich 14-mer DNA duplex. Inorganic Chemistry, Vol.48 (No.7). pp. 3047-3056. doi:10.1021/ic802207m ISSN 0020-1669.
BP (Firm)
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) Allosteric inhibition of cobalt binding to albumin by fatty acids : implications for the detection of myocardial ischemia. Journal of Medicinal Chemistry, Vol.55 (No.9). pp. 4425-4430. doi:10.1021/jm3003137 ISSN 0022-2623.
Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Fu, Ying, Romero, Maria, Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni and Sadler, P. J. (2016) Os2-Os4 switch controls DNA knotting and anticancer activity. Angewandte Chemie International Edition, 55 (31). pp. 8909-8912. doi:10.1002/anie.201602995 ISSN 1433-7851.
Smith, Nichola A., Zhang, Pingyu, Greenough, Simon E., Horbury, Michael D., Clarkson, Guy J., McFeely, Daniel, Habtemariam, Abraha, Salassa, Luca, Stavros, Vasilios G., Dowson, Christopher G. and Sadler, P. J. (2016) Combatting AMR : photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chemical Science, 8 (1). pp. 395-404. doi:10.1039/C6SC03028A ISSN 2041-6520.
Chellan , Prinessa and Sadler, P. J. (2015) The elements of life and medicines. Philosophical Transactions of the Royal Society A : Mathematical, Physical and Engineering Sciences, Volume 373 (Number 2037). Article number 20140182. doi:10.1098/rsta.2014.0182 ISSN 1364-503X.
Liu, Zhe and Sadler, P. J. (2014) Organoiridium complexes : anticancer agents and catalysts. Accounts of chemical research, 47 (4). pp. 1174-1185. doi:10.1021/ar400266c ISSN 0001-4842.
Liu, Zhe , Romero-Canelón, Isolda, Qamar, Bushra, Hearn, Jessica M., Habtemariam, Abraha, Barry, Nicolas P. E., Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2014) The potent oxidant anticancer activity of organoiridium catalysts. Angewandte Chemie International Edition, Volume 53 (Number 15). pp. 3941-3946. doi:10.1002/anie.201311161 ISSN 1433-7851.
Barnett, James P., Dr., Blindauer, Claudia A., Kassaar, Omar, Khazaipoul, Siavash, Martin, Esther M., Sadler, P. J. and Stewart, Alan J. S. (2013) Allosteric modulation of zinc speciation by fatty acids. Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 830 (Number 12). doi:10.1016/j.bbagen.2013.05.028 ISSN 0304-4165.
Hearn, Jessica M., Romero-Canelón, Isolda, Qamar, Bushra, Liu, Zhe , Hands-Portman, Ian and Sadler, P. J. (2013) Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis. ACS Chemical Biology, Volume 8 (Number 6). pp. 1335-1343. doi:10.1021/cb400070a ISSN 1554-8929.
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) Allosteric inhibition of cobalt binding to albumin by fatty acids : implications for the detection of myocardial ischemia. Journal of Medicinal Chemistry, Vol.55 (No.9). pp. 4425-4430. doi:10.1021/jm3003137 ISSN 0022-2623.
Booyjzsen, Claire, Scarff, Charlotte A., Moreton, Ben, Portman, Ian J., Scrivens, James H., Costantini, Giovanni and Sadler, P. J. (2012) Fibrillation of transferrin. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1820 (No.3). pp. 427-436. doi:10.1016/j.bbagen.2011.11.004 ISSN 0304-4165.
Lu, Jin, Stewart, Alan J, Sleep, Darrell, Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) A molecular mechanism for modulating plasma Zn speciation by fatty acids. Journal of the American Chemical Society, Vol.134 (No.3). pp. 1454-1457. doi:10.1021/ja210496n ISSN 1520-5126.
Ross, Allison, Soares, Dinesh C., Covelli, Danielle, Pannecouque, Christophe, Budd, Laura, Collins, Anna, Robertson, N. (Neil), Parsons, S. (Simon), De Clercq, Erik, Kennepohl, Pierre and Sadler, P. J. (2010) Oxovanadium(IV) cyclam and bicyclam complexes : potential CXCR4 receptor antagonists. Inorganic Chemistry, Vol.49 (No.3). pp. 1122-1132. doi:10.1021/ic9020614 ISSN 0020-1669.
Shi, Yanbo, Harvey, Ian, Campopiano, Dominic and Sadler, P. J. (2010) Niobium uptake and release by bacterial ferric ion binding protein. Bioinorganic Chemistry and Applications . doi:10.1155/2010/307578 ISSN 1565-3633.
Newstead, Simon, Fowler, Philip W., Bilton, Paul R., Carpenter, Elisabeth P., Sadler, P. J., Campopiano, Dominic J., Sansom, M. S. P. (Mark S. P.) and Iwata, So (2009) Insights into how nucleotide-binding domains power ABC transport. Structure, Vol.17 (NO.9). pp. 1213-1222. doi:10.1016/j.str.2009.07.009 ISSN 0969-2126.
Blindauer, Claudia A., Harvey, Ian, Bunyan, Kerry E., Stewart, Alan J., Sleep, Darrell, Harrison, David J., Berezenko, Stephen and Sadler, P. J. (2009) Structure, properties, and engineering of the major zinc binding site on human albumin. Journal of Biological Chemistry, Vol.284 (No.34). pp. 23116-23124. doi:10.1074/jbc.M109.003459 ISSN 0021-9258.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2009) Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design. Advances in Inorganic Chemistry, Vol.61 . pp. 1-62. doi:10.1016/S0898-8838(09)00201-3 ISSN 0898-8838.
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317 ISSN 0300-5127.
Dougan, Sarah J., Habtemariam, Abraha, McHale, Sarah E., Parsons, S. (Simon) and Sadler, P. J. (2008) Catalytic organometallic anticancer complexes. Proceedings of the National Academy of Sciences of the United States of America, Vol.105 (No.33). pp. 11628-11633. doi:10.1073/pnas.0800076105 ISSN 0027-8424.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2008) New trends for metal complexes with anticancer activity. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 197-206. doi:10.1016/j.cbpa.2007.11.013 ISSN 1367-5931.
Liang, Xiangyang, Parkinson, J. A. (John A.), Weishäupl, Michael, Gould, Robert O., Paisey, Stephen J., Park, Hye-seo, Hunter, Tina M., Blindauer, Claudia A., Parsons, S. (Simon) and Sadler, P. J. (2002) Structure and dynamics of metallomacrocycles : recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society, Vol.124 (No.31). pp. 9105-9112. doi:10.1021/ja0260723 ISSN 0002-7863.
Birmingham Science City
Fu, Ying, Romero, Maria, Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni and Sadler, P. J. (2016) Os2-Os4 switch controls DNA knotting and anticancer activity. Angewandte Chemie International Edition, 55 (31). pp. 8909-8912. doi:10.1002/anie.201602995 ISSN 1433-7851.
Fu, Ying, Sanchez-Cano, Carlos, Soni, Rina, Romero-Canelón, Isolda, Hearn, Jessica M., Liu, Zhe, Wills, Martin and Sadler, P. J. (2016) The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Transactions, 45 (20). pp. 8367-8378. doi:10.1039/c6dt01242f ISSN 1477-9226.
Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2015) Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design. Nature Communications, 6 . pp. 1-9. 6582. doi:10.1038/ncomms7582 ISSN 2041-1723.
Soldevila-Barreda, Joan J. and Sadler, P. J. (2015) Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology, Volume 25 . pp. 172-183. doi:10.1016/j.cbpa.2015.01.024 ISSN 1367-5931.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f ISSN 0301-7249.
Liu, Zhe , Romero-Canelón, Isolda, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2014) Potent half-sandwich iridium(III) anticancer complexes containing C∧N-Chelated and pyridine ligands. Organometallics, 33 (19). pp. 5324-5333. doi:10.1021/om500644f ISSN 0276-7333.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Sánchez, Ana M., Dove, Andrew P., Procter, Richard J., Soldevila-Barreda, Joan J., Kirby, Nigel, Hands-Portman, Ian, Smith, Corinne J., O'Reilly, Rachel K., Beanland, R. and Sadler, P. J. (2014) Fabrication of crystals from single metal atoms. Nature Communications, Volume 5 . Article number 3851 . doi:10.1038/ncomms4851 ISSN 2041-1723.
Rijt, Sabine H. van, Romero-Canelón, Isolda, Fu, Ying, Shnyder, Steve D. and Sadler, P. J. (2014) Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells. Metallomics, 6 (5). pp. 1014-1022. doi:10.1039/c4mt00034j ISSN 1756-5901.
Liu, Zhe and Sadler, P. J. (2014) Organoiridium complexes : anticancer agents and catalysts. Accounts of chemical research, 47 (4). pp. 1174-1185. doi:10.1021/ar400266c ISSN 0001-4842.
Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505 ISSN 1433-7851.
Smith, Nicola A. and Sadler, P. J. (2013) Photoactivatable metal complexes : from theory to applications in biotechnology and medicine. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Volume 371 (Number 1995). p. 20120519. doi:10.1098/rsta.2012.0519 ISSN 1364-503X.
Hearn, Jessica M., Romero-Canelón, Isolda, Qamar, Bushra, Liu, Zhe , Hands-Portman, Ian and Sadler, P. J. (2013) Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis. ACS Chemical Biology, Volume 8 (Number 6). pp. 1335-1343. doi:10.1021/cb400070a ISSN 1554-8929.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics, Vol.30 (No.17). pp. 4702-4710. doi:10.1021/om2005468 ISSN 0276-7333.
Liu, Zhe , Salassa, Luca, Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorganic Chemistry, Vol.50 (No.12). pp. 5777-5783. doi:10.1021/ic200607j ISSN 0020-1669.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Fletcher, Sally A., Kisova, Anna, Vrana, Oldrich, Salassa, Luca, Bruijnincx, Pieter C. A., Clarkson, Guy J., Brabec, V. (Viktor) and Sadler, P. J. (2011) Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry, Vol.54 (No.8). pp. 3011-3026. doi:10.1021/jm2000932 ISSN 0022-2623.
Salassa, Luca, Ruiu, Tiziana, Garino, Claudio, Pizarro, Ana M., Bardelli, Fabrizio, Gianolio, Diego, Westendorf, Aron, Bednarski, Patrick J., Lamberti, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) EXAFS, DFT, light-induced nucleobase binding, and cytotoxicity of the photoactive complex cis-[Ru(bpy)2(CO)Cl]+. Organometallics, Vol.29 (No.4). pp. 6703-6710. doi:10.1021/om100734y ISSN 0276-7333.
Fu, Y. (Ying), Habtemariam, Abraha, Pizarro, Ana M., Rijt, Sabine H. van, Healey, David J., Cooper, Patricia A., Shnyder, Steven D., Clarkson, Guy J. and Sadler, P. J. (2010) Organometallic osmium arene complexes with potent cancer cell cytotoxicity. Journal of Medicinal Chemistry, Vol.53 (No.22). pp. 8192-8196. doi:10.1021/jm100560f ISSN 0022-2623.
Rijt, Sabine H. van and Sadler, P. J. (2009) Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discovery Today, Vol.14 (No.23-24). pp. 1089-1097. doi:10.1016/j.drudis.2009.09.003 ISSN 1359-6446.
Brazil. Coordenação do Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Silva Sousa, Eduardo Henrique, Ridnour, Lisa A., Gouveia, Florêncio S., Silva da Silva, Carlos Daniel, Wink, David A., de França Lopes, Luiz Gonzaga and Sadler, P. J. (2016) Thiol-Activated HNO release from a ruthenium antiangiogenesis complex and HIF-1α inhibition for cancer therapy. ACS Chemical Biology, 11 (7). pp. 2057-2065. doi:10.1021/acschembio.6b00222 ISSN 1554-8929.
British Columbia Knowledge Development Fund (BCKDF)
Sriskandakumar, Thamayanthy, Petzold, Holm, Bruijnincx, Pieter C. A., Habtemariam, Abraha, Sadler, P. J. and Kennepohl, Pierre (2009) Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT. Journal of the American Chemical Society, Vol.131 (No.37). pp. 13355-13361. doi:10.1021/ja903405z ISSN 0002-7863.
British Heart Foundation
Barnett, James P., Dr., Blindauer, Claudia A., Kassaar, Omar, Khazaipoul, Siavash, Martin, Esther M., Sadler, P. J. and Stewart, Alan J. S. (2013) Allosteric modulation of zinc speciation by fatty acids. Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 830 (Number 12). doi:10.1016/j.bbagen.2013.05.028 ISSN 0304-4165.
British Petroleum Company (BP)
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317 ISSN 0300-5127.
Bruker Daltonics
Wootton, Christopher, Millett, Adam J., Lopez-Clavijo, Andrea F., Chiu, Cookson, Barrow, Mark P., Clarkson, Guy J., Sadler, P. J. and O'Connor, Peter B. (2019) Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation. Analyst, 144 (5). pp. 1575-1581. doi:10.1039/C8AN02094A ISSN 0003-2654.
Bruker Analytische Meßtechnik GmbH
Banerjee, Samya, Soldevila-Barreda, Joan J., Wolny, Juliusz A., Wootton, Christopher, Habtemariam, Abraha, Romero-Canelón, Isolda, Chen, Feng, Clarkson, Guy J., Prokes, Ivan, Song, Lijiang, O'Connor, Peter B., Schünemann, Volker and Sadler, P. J. (2018) New activation mechanism for half-sandwich organometallic anticancer complexes. Chemical Science, 9 (12). pp. 3177-3185. doi:10.1039/c7sc05058e ISSN 2041-6539.
Canada Foundation for Innovation (CFI)
Sriskandakumar, Thamayanthy, Petzold, Holm, Bruijnincx, Pieter C. A., Habtemariam, Abraha, Sadler, P. J. and Kennepohl, Pierre (2009) Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT. Journal of the American Chemical Society, Vol.131 (No.37). pp. 13355-13361. doi:10.1021/ja903405z ISSN 0002-7863.
Cancer Council NSW
Diakos, Connie I., Messerle, Barbara A., del Socorro Murdoch, P., Parkinson, J. A. (John A.), Sadler, P. J., Fenton, Ronald R. and Hambley, Trevor W. (2009) Identification by NMR spectroscopy of the two stereoisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz=3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A.T-rich 14-mer DNA duplex. Inorganic Chemistry, Vol.48 (No.7). pp. 3047-3056. doi:10.1021/ic802207m ISSN 0020-1669.
Catalonia (Spain)
Barragán, Flavia, Carrion-Salip, Dolors, Gómez-Pinto, Irene, González-Cantó, Alejandro, Sadler, P. J., de Llorens, Rafael, Moreno, Virtudes, González, Carlos A., Massaguer, Anna and Marchán, Vicente (2012) Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes. Bioconjugate Chemistry, Vol.23 (No.9). pp. 1838-1855. doi:10.1021/bc300173h ISSN 1043-1802.
Barragán, Flavia, López-Senín, Paula, Salassa, Luca, Betanzos-Lara, Soledad, Habtemariam, Abraha, Moreno, Virtudes, Sadler, P. J. and Marchán, Vicente (2011) Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex. Journal of the American Chemical Society, Vol.133 (No.35). pp. 14098-14108. doi:10.1021/ja205235m ISSN 0002-7863.
China. Guo jia ke xue ji shu bu [Ministry of Science and Technology]
Han, Yumiao, Luo, Qun, Hao, Xiang, Li, Xianchan, Wang, Fuyi, Hu, Wenbing, Wu, Kui, Lü, Shuang and Sadler, P. J. (2011) Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide — a model for the active-site cysteine of protein tyrosine phosphatase 1B. Dalton Transactions, Vol.40 (No.43). pp. 11519-11529. doi:10.1039/c1dt11189b ISSN 1477-9226.
Hu, Wenbing, Luo, Qun, Wu, Kui, Li, Xianchan, Wang, Fuyi, Chen, Yi, Ma, Xiaoyan, Wang, Jianping, Liu, Jianan, Xiong, Shaoxiang and Sadler, P. J. (2011) The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin. Chemical Communications, Vol.47 (No.21). pp. 6006-6008. doi:10.1039/c1cc11627d ISSN 1359-7345.
China. Guo jia ke xue ji shu bu [Ministry of Science and Technology] (CMST)
Wu, Kui, Luo, Qun, Hu, Wenbing, Li, Xianchan, Wang, Fuyi, Xiong, Shaoxiang and Sadler, P. J. (2012) Mechanism of interstrand migration of organoruthenium anticancer complexes within a DNA duplex. Metallomics, Vol.4 (No.2). pp. 139-148. doi:10.1039/c2mt00162d ISSN 1756-5901.
Hu, Wenbing, Luo, Qun, Ma, Xiaoyan, Wu, Kui, Liu, Jianan, Chen, Yi, Xiong, Shaoxiang, Wang, Jianping, Sadler, P. J. and Wang, Fuyi (2009) Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes. Chemistry - A European Journal, Vol.15 (No.27). pp. 6586-6594. doi:10.1002/chem.200900699 ISSN 0947-6539.
Chinese Academy of Sciences
Wu, Kui, Luo, Qun, Hu, Wenbing, Li, Xianchan, Wang, Fuyi, Xiong, Shaoxiang and Sadler, P. J. (2012) Mechanism of interstrand migration of organoruthenium anticancer complexes within a DNA duplex. Metallomics, Vol.4 (No.2). pp. 139-148. doi:10.1039/c2mt00162d ISSN 1756-5901.
Consejo Nacional de Ciencia y Tecnología (Mexico) (CONACYT)
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2009) Photocontrolled nucleobase binding to an organometallic Ru-II arene complex. Chemical Communications (No.43). pp. 6622-6624. doi:10.1039/b914153g ISSN 1359-7345.
Consejo Nacional de Ciencia y Tecnología (Mexico) [Mexican Council for Science and Technology] (CONACYT)
Betanzos-Lara, Soledad, Novakova, Olga, Deeth, Robert J., Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor), Sadler, P. J. and Habtemariam, Abraha (2012) Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity. JBIC Journal of Biological Inorganic Chemistry, 17 (7). pp. 1033-1051. doi:10.1007/s00775-012-0917-9 ISSN 0949-8257.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha, Novakova, Olga, Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor) and Sadler, P. J. (2012) Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics, Vol.31 (No.9). pp. 3466-3479. doi:10.1021/om201177y ISSN 0276-7333.
Consejo Nacional de Ciencia y Tecnología (Mexico) [Mexican Council for Science and Technology] (CONACYT)
Betanzos-Lara, Soledad, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic cis-Dichlorido ruthenium(II) ammine complexes. European Journal of Inorganic Chemistry, Volume 2011 (Number 21). pp. 3257-3264. doi:10.1002/ejic.201100250 ISSN 1434-1948.
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Silva Sousa, Eduardo Henrique, Ridnour, Lisa A., Gouveia, Florêncio S., Silva da Silva, Carlos Daniel, Wink, David A., de França Lopes, Luiz Gonzaga and Sadler, P. J. (2016) Thiol-Activated HNO release from a ruthenium antiangiogenesis complex and HIF-1α inhibition for cancer therapy. ACS Chemical Biology, 11 (7). pp. 2057-2065. doi:10.1021/acschembio.6b00222 ISSN 1554-8929.
Czech Republic. Ministerstvo školství, mládeže a tělovýchovy [Czech Republic. Ministry of Education, Youth, and Sport]
Bugarcic, Tijana, Habtemariam, Abraha, Stepankova, Jana, Heringova, Pavla, Kasparkova, Jana, Deeth, Robert J., Johnstone, Russell D. L., Prescimone, Alessandro, Parkin, Andrew, Parsons, S. (Simon), Brabec, V. (Viktor) and Sadler, P. J. (2008) The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes. Inorganic Chemistry, Vol.47 (No.24). pp. 11470-11486. doi:10.1021/ic801361m ISSN 0020-1669.
Bugarcic, Tijana, Novakova, Olga, Halamikova, Anna, Zerzankova, Lenka, Vrana, Oldrich, Kasparkova, Jana, Habtemariam, Abraha, Parsons, S. (Simon), Sadler, P. J. and Brabec, V. (Viktor) (2008) Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes. Journal of Medicinal Chemistry, Vol.51 (No.17). pp. 5310-5319. doi:10.1021/jm8003043 ISSN 0022-2623.
Castellano-Castillo, Maria, Kostrhunova, Hana, Marini, Victoria, Kasparkova, Jana, Sadler, P. J., Malinge, Jean-Marc and Brabec, V. (Viktor) (2008) Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes. Journal of Biological Inorganic Chemistry, Vol.13 (No.6). pp. 993-999. doi:10.1007/s00775-008-0386-3 ISSN 0949-8257.
Kostrhunova, Hana, Florian, Jakub, Novakova, Olga, Peacock, Anna F. A., Sadler, P. J. and Brabec, V. (Viktor) (2008) DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media. Journal of Medicinal Chemistry, Vol.51 (No.12). pp. 3635-3643. doi:10.1021/jm701538w ISSN 0022-2623.
Czech Republic. Ministerstvo školství, mládeže a tělovýchovy [Czech Republic. Ministry of Education, Youth, and Sports]
Kisova, Anna, Zerzankova, Lenka, Habtemariam, Abraha, Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2011) Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Molecular Pharmaceutics, Vol.8 (No.3). pp. 949-957. doi:10.1021/mp200105d ISSN 1543-8384.
Novakova, Olga, Malina, J. (Jaroslav), Suchankova, Tereza, Kasparkova, Jana, Bugarcic, Tijana, Sadler, P. J. and Brabec, V. (Viktor) (2010) Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru-II complexes containing terphenyl arenes. Chemistry - A European Journal, Vol.16 (No.19). pp. 5744-5754. doi:10.1002/chem.200903078 ISSN 0947-6539.
Czech Republic. Ministerstvo školství, mládeže a tělovýchovy [Ministry of Education, Youth, and Sport]
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Czech Republic. National Foundation
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Fletcher, Sally A., Kisova, Anna, Vrana, Oldrich, Salassa, Luca, Bruijnincx, Pieter C. A., Clarkson, Guy J., Brabec, V. (Viktor) and Sadler, P. J. (2011) Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry, Vol.54 (No.8). pp. 3011-3026. doi:10.1021/jm2000932 ISSN 0022-2623.
Czech Science Foundation (CSF)
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Rijt, Sabine H. van, Kostrhunova, Hana, Brabec, V. (Viktor) and Sadler, P. J. (2011) Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity. Bioconjugate Chemistry, Vol.22 (No.2). pp. 218-226. doi:10.1021/bc100369p ISSN 1043-1802.
Delta Biotechnology Ltd (now Novozymes)
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317 ISSN 0300-5127.
Deutsche Forschungsgemeinschaft (DFG)
Liang, Xiangyang, Parkinson, J. A. (John A.), Weishäupl, Michael, Gould, Robert O., Paisey, Stephen J., Park, Hye-seo, Hunter, Tina M., Blindauer, Claudia A., Parsons, S. (Simon) and Sadler, P. J. (2002) Structure and dynamics of metallomacrocycles : recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society, Vol.124 (No.31). pp. 9105-9112. doi:10.1021/ja0260723 ISSN 0002-7863.
Deutscher Akademischer Austauschdienst (DAAD)
Petzold, Holm and Sadler, P. J. (2008) Oxidation induced by the antioxidant glutathione (GSH). Chemical Communications (No.37). pp. 4413-4415. doi:10.1039/b805358h ISSN 1359-7345.
Petzold, Holm, Xu, Jingjing and Sadler, P. J. (2008) Metal and ligand control of sulfenate reactivity : arene ruthenium thiolato-mono-S-oxides. Angewandte Chemie International Edition, Vol.47 (No.16). pp. 3008-3011. doi:10.1002/anie.200705342 ISSN 1433-7851.
Deutscher Akademischer Austauschdienst [German Academic Exchange Council] (DAAD)
Sriskandakumar, Thamayanthy, Petzold, Holm, Bruijnincx, Pieter C. A., Habtemariam, Abraha, Sadler, P. J. and Kennepohl, Pierre (2009) Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT. Journal of the American Chemical Society, Vol.131 (No.37). pp. 13355-13361. doi:10.1021/ja903405z ISSN 0002-7863.
Economic and Social Research Council (Great Britain) (ESRC)
Romero-Canelón, Isolda, Mos, Magdalena and Sadler, P. J. (2015) Enhancement of selectivity of an organometallic anticancer agent by redox modulation. Journal of Medicinal Chemistry, 58 (19). pp. 7874-7880. doi:10.1021/acs.jmedchem.5b00655 ISSN 0022-2623.
Noffke, Anna Louise, Habtemariam, Abraha, Pizarro, Ana M. and Sadler, P. J. (2012) Designing organometallic compounds for catalysis and therapy. Chemical Communications, Vol.48 (No.43). pp. 5219-5246. doi:10.1039/c2cc30678f ISSN 1359-7345.
Edinburgh Protein Interaction Centre
Shi, Yanbo, Harvey, Ian, Campopiano, Dominic and Sadler, P. J. (2010) Niobium uptake and release by bacterial ferric ion binding protein. Bioinorganic Chemistry and Applications . doi:10.1155/2010/307578 ISSN 1565-3633.
Edinburgh Protein Interaction Centre (EPIC)
Liu, Hong-Ke, Parkinson, J. A. (John A.), Bella, Juraj, Wang, Fuyi and Sadler, P. J. (2010) Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene Ru-II anticancer complex. Chemical Science, Vol.1 (No.2). pp. 258-270. doi:10.1039/c0sc00175a ISSN 2041-6520.
Engineering and Physical Sciences Research Council (EPSRC)
Xie, Ming-jin, Zhu, Ming-rong, Lu, Chun-Mei, Jin, Yi, Gao, Li-Hui, Li, Ling, Zhou, Jie, Li, Fan-fang, Zhao, Qi Hua, Liu, Hong-Ke, Sadler, P. J. and Sanchez-Cano, Carlos (2017) Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV. Journal of Inorganic Biochemistry, 175 . pp. 29-35. doi:10.1016/j.jinorgbio.2017.06.014 ISSN 0162-0134.
Smith, Nichola A., Zhang, Pingyu, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2017) Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes. Inorganica Chimica Acta, 454 . pp. 240-246. doi:10.1016/j.ica.2016.06.014 ISSN 00201693.
Fu, Ying, Romero, Maria, Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni and Sadler, P. J. (2016) Os2-Os4 switch controls DNA knotting and anticancer activity. Angewandte Chemie International Edition, 55 (31). pp. 8909-8912. doi:10.1002/anie.201602995 ISSN 1433-7851.
Ude, Ziga, Romero-Canelón, Isolda, Twamley, Brendan, Fitzgerald Hughes, Deirdre, Sadler, P. J. and Marmion, Celine J. (2016) A novel dual-functioning ruthenium(II)–arene complex of an anti-microbial ciprofloxacin derivative — anti-proliferative and anti-microbial activity. Journal of Inorganic Biochemistry, 160 . pp. 210-217. doi:10.1016/j.jinorgbio.2016.02.018 ISSN 0162-0134.
Fu, Ying, Sanchez-Cano, Carlos, Soni, Rina, Romero-Canelón, Isolda, Hearn, Jessica M., Liu, Zhe, Wills, Martin and Sadler, P. J. (2016) The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Transactions, 45 (20). pp. 8367-8378. doi:10.1039/c6dt01242f ISSN 1477-9226.
Pitto-Barry, Anaïs, Sadler, P. J. and Barry, Nicolas P. E. (2016) Dynamics of formation of Ru, Os, Ir and Au metal nanocrystals on doped graphitic surfaces. Chemical Communications, 52 (20). pp. 3895-3898. c5cc09564f. doi:10.1039/c5cc09564f ISSN 1359-7345.
Greenough, Simon E., Horbury, Michael D., Smith, Nichola A., Sadler, P. J., Paterson, Martin J. and Stavros, Vasilios G. (2016) Excited-state dynamics of a two-photon-activatable ruthenium prodrug. ChemPhysChem, 17 (2). pp. 221-224. doi:10.1002/cphc.201501075 ISSN 1439-4235.
Smith, Nichola A., Zhang, Pingyu, Greenough, Simon E., Horbury, Michael D., Clarkson, Guy J., McFeely, Daniel, Habtemariam, Abraha, Salassa, Luca, Stavros, Vasilios G., Dowson, Christopher G. and Sadler, P. J. (2016) Combatting AMR : photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chemical Science, 8 (1). pp. 395-404. doi:10.1039/C6SC03028A ISSN 2041-6520.
Silva Sousa, Eduardo Henrique, Ridnour, Lisa A., Gouveia, Florêncio S., Silva da Silva, Carlos Daniel, Wink, David A., de França Lopes, Luiz Gonzaga and Sadler, P. J. (2016) Thiol-Activated HNO release from a ruthenium antiangiogenesis complex and HIF-1α inhibition for cancer therapy. ACS Chemical Biology, 11 (7). pp. 2057-2065. doi:10.1021/acschembio.6b00222 ISSN 1554-8929.
Soldevila-Barreda, Joan J., Habtemariam, Abraha, Romero-Canelón, Isolda and Sadler, P, J. (2015) Half-sandwich rhodium(III) transfer hydrogenation catalysts : reduction of NAD+ and pyruvate, and antiproliferative activity. Journal of Inorganic Biochemistry, 153 . pp. 322-333. doi:10.1016/j.jinorgbio.2015.10.008 ISSN 0162-0134.
Romero-Canelón, Isolda, Phoenix, Ben, Pitto-Barry, Anaïs, Tran, Johanna, Soldevila-Barreda, Joan J., Kirby, Nigel, Green, Stuart, Sadler, P. J. and Barry, Nicolas P. E. (2015) Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT). Journal of organometallic chemistry, 796 . pp. 17-25. doi:10.1016/j.jorganchem.2015.05.011 ISSN 0022-328X.
Pitto-Barry, Anaïs, Alves Perdigão, Luis M., Walker, Marc, Lawrence, James M., Costantini, Giovanni, Sadler, P. J. and Barry, Nicolas P. E. (2015) Synthesis and controlled growth of osmium nanoparticles by electron irradiation. Dalton Transactions, 44 (47). pp. 20308-20311. doi:10.1039/c5dt03205a ISSN 1477-9226.
Romero-Canelón, Isolda, Mos, Magdalena and Sadler, P. J. (2015) Enhancement of selectivity of an organometallic anticancer agent by redox modulation. Journal of Medicinal Chemistry, 58 (19). pp. 7874-7880. doi:10.1021/acs.jmedchem.5b00655 ISSN 0022-2623.
Zou, Taotao and Sadler, P. J. (2015) Speciation of precious metal anti-cancer complexes by NMR spectroscopy. Drug Discovery Today : Technologies, 16 . pp. 7-15. doi:10.1016/j.ddtec.2015.08.002 ISSN 1740-6749.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Tran, Johanna, Spencer, Simon E. F., Johansen, Adam M., Sanchez, Ana M., Dove, Andrew P., O’Reilly, Rachel K., Deeth, Robert J., Beanland, R. and Sadler, P. J. (2015) Osmium atoms and Os2 molecules move faster on selenium-doped compared to sulfur-doped boronic graphenic surfaces. Chemistry of Materials, 27 (14). pp. 5100-5105. doi:10.1021/acs.chemmater.5b01853 ISSN 0897-4756.
Millett, Adam J., Habtemariam, Abraha, Romero-Canelón, Isolda, Clarkson, Guy J. and Sadler, P. J. (2015) Contrasting anticancer activity of half-sandwich iridium(III) complexes bearing functionally diverse 2-phenylpyridine ligands. Organometallics, Volume 34 (Number 11). pp. 2683-2694. doi:10.1021/acs.organomet.5b00097 ISSN 0276-7333.
Coverdale, James P. C., Sanchez-Cano, Carlos, Clarkson, Guy J., Soni, Rina, Wills, Martin and Sadler, P. J. (2015) Easy to synthesize, robust organo-osmium asymmetric transfer hydrogenation catalysts. Chemistry - A European Journal, 21 (22). pp. 8043-8046. doi:10.1002/chem.201500534 ISSN 0947-6539.
Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2015) Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design. Nature Communications, 6 . pp. 1-9. 6582. doi:10.1038/ncomms7582 ISSN 2041-1723.
Chellan , Prinessa and Sadler, P. J. (2015) The elements of life and medicines. Philosophical Transactions of the Royal Society A : Mathematical, Physical and Engineering Sciences, Volume 373 (Number 2037). Article number 20140182. doi:10.1098/rsta.2014.0182 ISSN 1364-503X.
Soldevila-Barreda, Joan J. and Sadler, P. J. (2015) Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology, Volume 25 . pp. 172-183. doi:10.1016/j.cbpa.2015.01.024 ISSN 1367-5931.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f ISSN 0301-7249.
Li, Huilin, Snelling, Jonathon R., Barrow, Mark P., Scrivens, James H., Sadler, P. J. and O’Connor, Peter B. (2014) Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins. Journal of The American Society for Mass Spectrometry, 25 (7). pp. 1217-1227. doi:10.1007/s13361-014-0877-0 ISSN 1044-0305.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Sánchez, Ana M., Dove, Andrew P., Procter, Richard J., Soldevila-Barreda, Joan J., Kirby, Nigel, Hands-Portman, Ian, Smith, Corinne J., O'Reilly, Rachel K., Beanland, R. and Sadler, P. J. (2014) Fabrication of crystals from single metal atoms. Nature Communications, Volume 5 . Article number 3851 . doi:10.1038/ncomms4851 ISSN 2041-1723.
Rijt, Sabine H. van, Romero-Canelón, Isolda, Fu, Ying, Shnyder, Steve D. and Sadler, P. J. (2014) Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells. Metallomics, 6 (5). pp. 1014-1022. doi:10.1039/c4mt00034j ISSN 1756-5901.
Liu, Zhe and Sadler, P. J. (2014) Organoiridium complexes : anticancer agents and catalysts. Accounts of chemical research, 47 (4). pp. 1174-1185. doi:10.1021/ar400266c ISSN 0001-4842.
Liu, Zhe , Romero-Canelón, Isolda, Qamar, Bushra, Hearn, Jessica M., Habtemariam, Abraha, Barry, Nicolas P. E., Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2014) The potent oxidant anticancer activity of organoiridium catalysts. Angewandte Chemie International Edition, Volume 53 (Number 15). pp. 3941-3946. doi:10.1002/anie.201311161 ISSN 1433-7851.
Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505 ISSN 1433-7851.
Fu, Ying, Soni, Rina, Romero, Maria, Pizarro, Ana M., Salassa, Luca, Clarkson, Guy J., Hearn, Jessica M., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2013) Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity. Chemistry - A European Journal, Volume 19 (Number 45). pp. 15199-15209. doi:10.1002/chem.201302183 ISSN 0947-6539.
Smith, Nicola A. and Sadler, P. J. (2013) Photoactivatable metal complexes : from theory to applications in biotechnology and medicine. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Volume 371 (Number 1995). p. 20120519. doi:10.1098/rsta.2012.0519 ISSN 1364-503X.
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Li, Huilin, Wells, Stephen A., Jimenez-Roldan, J. Emilio, Römer, Rudolf A., Zhao, Yao, (Researcher in chemistry), Sadler, P. J. and O'Connor, Peter B. (2012) Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Science, Volume 21 (Number 9). pp. 1269-1279. doi:10.1002/pro.2111 ISSN 0961-8368.
Unterkofler, S., McQuitty, Ruth J., Euser, T. G., Farrer, Nicola J., Sadler, P. J. and Russell, P. St.J. (2012) Microfluidic integration of photonic crystal fibers for online photochemical reaction analysis. Optics Letters, Volume 37 (Number 11). pp. 1952-1954. doi:10.1364/OL.37.001952 ISSN 0146-9592.
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) Allosteric inhibition of cobalt binding to albumin by fatty acids : implications for the detection of myocardial ischemia. Journal of Medicinal Chemistry, Vol.55 (No.9). pp. 4425-4430. doi:10.1021/jm3003137 ISSN 0022-2623.
Mukherjee, Arindam, Bilton, Paul R., Mackay, Logan, Janoschka, Adam, Zhu, Haizhong, Rea, Dean, Langridge-Smith, Pat R. R., Campopiano, Dominic J., Teschner, Thomas, Trautwein, Alfred, Schünemann, Volker and Sadler, P. J. (2012) Ferric ion (hydr)oxo clusters in the “Venus flytrap” cleft of FbpA : Mössbauer, calorimetric and mass spectrometric studies. JBIC Journal of Biological Inorganic Chemistry, Vol.17 (No.4). pp. 573-588. doi:10.1007/s00775-012-0878-z ISSN 0949-8257.
Tai, Hui-Chung, Brodbeck, Ralf, Kasparkova, Jana, Farrer, Nicola J., Brabec, V. (Viktor), Sadler, P. J. and Deeth, Robert J. (2012) Combined theoretical and computational study of interstrand DNA guanine–guanine cross-linking bytrans-[Pt(pyridine)2] derived from the photoactivated prodrugtrans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]. Inorganic Chemistry, Vol.51 (No.12). pp. 6830-6841. doi:10.1021/ic3005745 ISSN 0020-1669.
Pracharova, Jitka, Zerzankova, Lenka, Stepankova, Jana, Novakova, Olga, Farrer, Nicola J., Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2012) Interactions of DNA with a new Platinum(IV) Azide Dipyridine complex activated by UVA and visible light : relationship to toxicity in tumor cells. Chemical Research in Toxicology, Vol.25 (No.5). pp. 1099-1111. doi:10.1021/tx300057y ISSN 0893-228X.
Butler, Jennifer S. (Jennifer Suzanne), Woods, Julie A., Farrer, Nicola J., Newton, Mark E. and Sadler, P. J. (2012) Tryptophan switch for a photoactivated platinum anticancer complex. Journal of the American Chemical Society, Vol.134 (No.40). pp. 16508-16511. doi:10.1021/ja3074159 ISSN 0002-7863.
Fu, Y. (Ying), Romero, Maria, Habtemariam, Abraha, Snowden, Michael E., Song, Lijiang, Clarkson, Guy J., Qamar, Bushra, Pizarro, Ana M., Unwin, Patrick R. and Sadler, P. J. (2012) The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes. Chemical Science, Vol.3 (No.8). pp. 2485-2494. doi:10.1039/c2sc20220d ISSN 2041-6520.
Ronconi, Luca, Pizarro, Ana M., McQuitty, Ruth J. and Sadler, P. J. (2011) Insights into the acid-base properties of PtIV-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry - A European Journal, Volume 17 (Number 43). pp. 12051-12058. doi:10.1002/chem.201002792 ISSN 0947-6539.
Farrer, Nicola J., Gierth, Peter and Sadler, P. J. (2011) Probing platinum azido complexes by 14N and 15N NMR spectroscopy. Chemistry - A European Journal, Vol.17 (No.43). pp. 12059-12066. doi:10.1002/chem.201101409 ISSN 0947-6539.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics, Vol.30 (No.17). pp. 4702-4710. doi:10.1021/om2005468 ISSN 0276-7333.
Shnyder, Steve D., Fu, Y. (Ying), Habtemariam, Abraha, Rijt, Sabine H. van, Cooper, Patricia A., Loadman, Paul M. and Sadler, P. J. (2011) Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex. MedChemComm, Vol.2 (No.7). pp. 666-668. doi:10.1039/c1md00075f ISSN 2040-2503.
Liu, Zhe , Salassa, Luca, Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorganic Chemistry, Vol.50 (No.12). pp. 5777-5783. doi:10.1021/ic200607j ISSN 0020-1669.
Li, Huilin, Zhao, Yao, Phillips, Hazel I. A., Qi, Yulin, Lin, Tzu-Yung, Sadler, P. J. and O'Connor, Peter B. (2011) Mass spectrometry evidence for cisplatin as a protein cross-linking reagent. Analytical Chemistry, Vol.83 (No.13). pp. 5369-5376. doi:10.1021/ac200861k ISSN 0003-2700.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Fletcher, Sally A., Kisova, Anna, Vrana, Oldrich, Salassa, Luca, Bruijnincx, Pieter C. A., Clarkson, Guy J., Brabec, V. (Viktor) and Sadler, P. J. (2011) Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry, Vol.54 (No.8). pp. 3011-3026. doi:10.1021/jm2000932 ISSN 0022-2623.
Ronconi, Luca and Sadler, P. J. (2011) Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2]. Dalton Transactions, Vol.40 (No.1). pp. 262-268. doi:10.1039/c0dt00546k ISSN 1477-9226.
Rijt, Sabine H. van, Kostrhunova, Hana, Brabec, V. (Viktor) and Sadler, P. J. (2011) Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity. Bioconjugate Chemistry, Vol.22 (No.2). pp. 218-226. doi:10.1021/bc100369p ISSN 1043-1802.
Liu, Hong-Ke and Sadler, P. J. (2011) Metal complexes as DNA intercalators. Accounts of Chemical Research, Vol.44 (No.5). pp. 349-359. doi:10.1021/ar100140e ISSN 0001-4842.
Fu, Y. (Ying), Habtemariam, Abraha, Basri, Aida M. B. H., Braddick, Darren, Clarkson, Guy J. and Sadler, P. J. (2011) Structure–activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity. Dalton Transactions (No.40). pp. 10553-10562. doi:10.1039/c1dt10937e ISSN 1477-9226.
Li, Huilin, Lin, Tzu-Yung, Van Orden, Steve L., Zhao, Yao, (Researcher in chemistry), Barrow, Mark P., Pizarro, Ana M., Qi, Yulin, Sadler, P. J. and O’Connor, Peter B. (2011) Use of top-down and bottom-up fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs. Analytical Chemistry, Vol.83 (No.24). pp. 9507-9515. doi:10.1021/ac202267g ISSN 0003-2700.
Fu, Y. (Ying), Habtemariam, Abraha, Pizarro, Ana M., Rijt, Sabine H. van, Healey, David J., Cooper, Patricia A., Shnyder, Steven D., Clarkson, Guy J. and Sadler, P. J. (2010) Organometallic osmium arene complexes with potent cancer cell cytotoxicity. Journal of Medicinal Chemistry, Vol.53 (No.22). pp. 8192-8196. doi:10.1021/jm100560f ISSN 0022-2623.
Cubo, Leticia, Pizarro, Ana M., Quiroga, Adoracion G., Salassa, Luca, Navarro-Ranninger, Carmen and Sadler, P. J. (2010) Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides. Journal of Inorganic Biochemistry, Vol.104 (No.9). pp. 909-918. doi:10.1016/j.jinorgbio.2010.04.009 ISSN 0162-0134.
Williams, Jonathan P., Phillips, Hazel I. A., Campuzano, Iain and Sadler, P. J. (2010) Shape changes induced by N-terminal platination of ubiquitin by cisplatin. Journal of The American Society for Mass Spectrometry, Vol.21 (No.7). pp. 1097-1106. doi:10.1016/j.jasms.2010.02.012 ISSN 1044-0305.
Chen, Jocelyn S. Y., Euser, Tijmen G., Farrer, Nicola J., Sadler, P. J., Scharrer, Michael and Russell, Philip St. J. (2010) Photochemistry in photonic crystal fiber nanoreactors. Chemistry - A European Journal, Vol.16 (No.19). pp. 5607-5612. doi:10.1002/chem.201000496 ISSN 0947-6539.
Ross, Allison, Soares, Dinesh C., Covelli, Danielle, Pannecouque, Christophe, Budd, Laura, Collins, Anna, Robertson, N. (Neil), Parsons, S. (Simon), De Clercq, Erik, Kennepohl, Pierre and Sadler, P. J. (2010) Oxovanadium(IV) cyclam and bicyclam complexes : potential CXCR4 receptor antagonists. Inorganic Chemistry, Vol.49 (No.3). pp. 1122-1132. doi:10.1021/ic9020614 ISSN 0020-1669.
Farrer, Nicola J., Woods, Julie A., Munk, Vivienne P., Mackay, Fiona S. and Sadler, P. J. (2010) Photocytotoxic trans-Diam(m)ine platinum(IV) diazido complexes more potent than their cis isomers. Chemical Research in Toxicology, Vol.23 (No.2). pp. 413-421. doi:10.1021/tx900372p ISSN 0893-228X.
Shi, Yanbo, Harvey, Ian, Campopiano, Dominic and Sadler, P. J. (2010) Niobium uptake and release by bacterial ferric ion binding protein. Bioinorganic Chemistry and Applications . doi:10.1155/2010/307578 ISSN 1565-3633.
Farrer, Nicola J., Monk , Nicholas, Heron, Jonathan, Lough, Julie Ann and Sadler, P. J. (2010) (RSC)(2) : chemistry, performance, and pedagogy - an interactive approach to periodic trends. Chemistry Education Research and Practice, Vol.11 (No.4). pp. 308-313. doi:10.1039/c0rp90011g ISSN 1109-4028.
Rijt, Sabine H. van, Hebden, Andrew J., Amaresekera, Thakshila, Deeth, Robert J., Clarkson, Guy J., Parsons, S. (Simon), McGowan, Patrick C. and Sadler, P. J. (2009) Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes. Journal of Medicinal Chemistry, Vol.52 (No.23). pp. 7753-7764. doi:10.1021/jm900731j ISSN 0022-2623.
Rijt, Sabine H. van and Sadler, P. J. (2009) Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discovery Today, Vol.14 (No.23-24). pp. 1089-1097. doi:10.1016/j.drudis.2009.09.003 ISSN 1359-6446.
Salassa, Luca, Phillips, Hazel I. A. and Sadler, P. J. (2009) Decomposition pathways for the photoactivated anticancer complex cis,trans,cis-[Pt(N-3)(2)(OH)(2)(NH3)(2)] : insights from DFT calculations. Physical Chemistry Chemical Physics, Vol.11 (No.44). pp. 10311-10316. doi:10.1039/b912496a ISSN 1463-9076.
Pizarro, Ana M. and Sadler, P. J. (2009) Unusual DNA binding modes for metal anticancer complexes. Biochimie, Vol.91 (No.10). pp. 1198-1211. doi:10.1016/j.biochi.2009.03.017 ISSN 0300-9084.
Mackay, Fiona S., Farrer, Nicola J., Salassa, Luca, Tai, Hui-Chung, Deeth, Robert J., Moggach, Stephen A., Wood, P. A. (Peter A.), Parsons, S. (Simon) and Sadler, P. J. (2009) Synthesis, characterisation and photochemistry of PtIV pyridyl azido acetato complexes. Dalton Transactions, Vol.13 . pp. 2315-2325. doi:10.1039/b820550g ISSN 1477-9226.
Mackay, Fiona S., Moggach, Stephen A., Collins, Anna, Parsons, S. (Simon) and Sadler, P. J. (2009) Photoactive trans ammine/amine diazido platinum(IV) complexes. Inorganica Chimica Acta, Vol.362 (No.3). pp. 811-819. doi:10.1016/j.ica.2008.02.039 ISSN 0020-1693.
Rijt, Sabine H. van, Peacock, Anna F. A., Johnstone, Russell D. L., Parsons, S. (Simon) and Sadler, P. J. (2009) Organometallic osmium(II) arene anticancer complexes containing picolinate derivatives. Inorganic Chemistry, Vol.48 (No.4). pp. 1753-1762. doi:10.1021/ic8020222 ISSN 0020-1669.
Phillips, Hazel I. A., Ronconi, Luca and Sadler, P. J. (2009) Photoinduced reactions of cis,trans,cis-[Pt-IV(N-3)(2)(OH)(2)(NH3)(2)] with 1-methylimidazole. Chemistry: A European Journal, Vol.15 (No.7). pp. 1588-1596. doi:10.1002/chem.200802206 ISSN 0947-6539.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2009) Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design. Advances in Inorganic Chemistry, Vol.61 . pp. 1-62. doi:10.1016/S0898-8838(09)00201-3 ISSN 0898-8838.
Farrer, Nicola J., Salassa, Luca and Sadler, P. J. (2009) Photoactivated chemotherapy (PACT) : the potential of excited-state d-block metals in medicine. Dalton Transactions, Vol.48 . pp. 10690-10701. doi:10.1039/b917753a ISSN 1477-9226.
Kostrhunova, Hana, Florian, Jakub, Novakova, Olga, Peacock, Anna F. A., Sadler, P. J. and Brabec, V. (Viktor) (2008) DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media. Journal of Medicinal Chemistry, Vol.51 (No.12). pp. 3635-3643. doi:10.1021/jm701538w ISSN 0022-2623.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2008) New trends for metal complexes with anticancer activity. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 197-206. doi:10.1016/j.cbpa.2007.11.013 ISSN 1367-5931.
Liang, Xiangyang, Parkinson, J. A. (John A.), Weishäupl, Michael, Gould, Robert O., Paisey, Stephen J., Park, Hye-seo, Hunter, Tina M., Blindauer, Claudia A., Parsons, S. (Simon) and Sadler, P. J. (2002) Structure and dynamics of metallomacrocycles : recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society, Vol.124 (No.31). pp. 9105-9112. doi:10.1021/ja0260723 ISSN 0002-7863.
Engineering and Physical Sciences Research Council (EPSRC)
Farrer, Nicola J., Woods, Julie A., Salassa, Luca, Zhao, Yao, (Researcher in chemistry), Robinson, Kim S., Clarkson, Guy J., Mackay, Fiona S. and Sadler, P. J. (2010) A potent trans-diimine platinum anticancer complex photoactivated by visible light. Angewandte Chemie International Edition, Vol.49 (No.47). pp. 8905-8908. doi:10.1002/anie.201003399 ISSN 1433-7851.
European Commission
Phillips, Hazel I. A., Ronconi, Luca and Sadler, P. J. (2009) Photoinduced reactions of cis,trans,cis-[Pt-IV(N-3)(2)(OH)(2)(NH3)(2)] with 1-methylimidazole. Chemistry: A European Journal, Vol.15 (No.7). pp. 1588-1596. doi:10.1002/chem.200802206 ISSN 0947-6539.
European Commission (EC)
Mukherjee, Arindam, Bilton, Paul R., Mackay, Logan, Janoschka, Adam, Zhu, Haizhong, Rea, Dean, Langridge-Smith, Pat R. R., Campopiano, Dominic J., Teschner, Thomas, Trautwein, Alfred, Schünemann, Volker and Sadler, P. J. (2012) Ferric ion (hydr)oxo clusters in the “Venus flytrap” cleft of FbpA : Mössbauer, calorimetric and mass spectrometric studies. JBIC Journal of Biological Inorganic Chemistry, Vol.17 (No.4). pp. 573-588. doi:10.1007/s00775-012-0878-z ISSN 0949-8257.
Rijt, Sabine H. van, Mukherjee, Arindam, Pizarro, Ana M. and Sadler, P. J. (2010) Cytotoxicity, hydrophobicity, uptake, and distribution of osmium(II) anticancer complexes in ovarian cancer cells. Journal of Medicinal Chemistry, Vol.53 (No.2). pp. 840-849. doi:10.1021/jm901556u ISSN 0022-2623.
Pizarro, Ana M. and Sadler, P. J. (2009) Unusual DNA binding modes for metal anticancer complexes. Biochimie, Vol.91 (No.10). pp. 1198-1211. doi:10.1016/j.biochi.2009.03.017 ISSN 0300-9084.
Mackay, Fiona S., Farrer, Nicola J., Salassa, Luca, Tai, Hui-Chung, Deeth, Robert J., Moggach, Stephen A., Wood, P. A. (Peter A.), Parsons, S. (Simon) and Sadler, P. J. (2009) Synthesis, characterisation and photochemistry of PtIV pyridyl azido acetato complexes. Dalton Transactions, Vol.13 . pp. 2315-2325. doi:10.1039/b820550g ISSN 1477-9226.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2009) Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design. Advances in Inorganic Chemistry, Vol.61 . pp. 1-62. doi:10.1016/S0898-8838(09)00201-3 ISSN 0898-8838.
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317 ISSN 0300-5127.
Liang, Xiangyang, Parkinson, J. A. (John A.), Weishäupl, Michael, Gould, Robert O., Paisey, Stephen J., Park, Hye-seo, Hunter, Tina M., Blindauer, Claudia A., Parsons, S. (Simon) and Sadler, P. J. (2002) Structure and dynamics of metallomacrocycles : recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society, Vol.124 (No.31). pp. 9105-9112. doi:10.1021/ja0260723 ISSN 0002-7863.
European Commission (EC)
Farrer, Nicola J., Woods, Julie A., Salassa, Luca, Zhao, Yao, (Researcher in chemistry), Robinson, Kim S., Clarkson, Guy J., Mackay, Fiona S. and Sadler, P. J. (2010) A potent trans-diimine platinum anticancer complex photoactivated by visible light. Angewandte Chemie International Edition, Vol.49 (No.47). pp. 8905-8908. doi:10.1002/anie.201003399 ISSN 1433-7851.
European Community Marie Curie Fellowship
Blindauer, Claudia A., Harvey, Ian, Bunyan, Kerry E., Stewart, Alan J., Sleep, Darrell, Harrison, David J., Berezenko, Stephen and Sadler, P. J. (2009) Structure, properties, and engineering of the major zinc binding site on human albumin. Journal of Biological Chemistry, Vol.284 (No.34). pp. 23116-23124. doi:10.1074/jbc.M109.003459 ISSN 0021-9258.
European Cooperation in the Field of Scientific and Technical Research (Organization)
Mackay, Fiona S., Moggach, Stephen A., Collins, Anna, Parsons, S. (Simon) and Sadler, P. J. (2009) Photoactive trans ammine/amine diazido platinum(IV) complexes. Inorganica Chimica Acta, Vol.362 (No.3). pp. 811-819. doi:10.1016/j.ica.2008.02.039 ISSN 0020-1693.
European Cooperation in the Field of Scientific and Technical Research (Organization) (COST)
Ragazzon, Giulio, Bratsos, Ioannis, Alessio, E. (Enzo), Salassa, Luca, Habtemariam, Abraha, McQuitty, Ruth J., Clarkson, Guy J. and Sadler, P. J. (2012) Design of photoactivatable metallodrugs : selective and rapid light-induced ligand dissociation from half-sandwich [Ru([9]aneS3)(N–N′)(py)]2+ complexes. Inorganica Chimica Acta, Vol.393 . pp. 230-238. doi:10.1016/j.ica.2012.06.031 ISSN 0020-1693.
Rijt, Sabine H. van and Sadler, P. J. (2009) Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discovery Today, Vol.14 (No.23-24). pp. 1089-1097. doi:10.1016/j.drudis.2009.09.003 ISSN 1359-6446.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2008) New trends for metal complexes with anticancer activity. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 197-206. doi:10.1016/j.cbpa.2007.11.013 ISSN 1367-5931.
European Regional Development Fund (ERDF)
Fu, Ying, Romero, Maria, Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni and Sadler, P. J. (2016) Os2-Os4 switch controls DNA knotting and anticancer activity. Angewandte Chemie International Edition, 55 (31). pp. 8909-8912. doi:10.1002/anie.201602995 ISSN 1433-7851.
Fu, Ying, Sanchez-Cano, Carlos, Soni, Rina, Romero-Canelón, Isolda, Hearn, Jessica M., Liu, Zhe, Wills, Martin and Sadler, P. J. (2016) The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Transactions, 45 (20). pp. 8367-8378. doi:10.1039/c6dt01242f ISSN 1477-9226.
Romero-Canelón, Isolda, Mos, Magdalena and Sadler, P. J. (2015) Enhancement of selectivity of an organometallic anticancer agent by redox modulation. Journal of Medicinal Chemistry, 58 (19). pp. 7874-7880. doi:10.1021/acs.jmedchem.5b00655 ISSN 0022-2623.
Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2015) Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design. Nature Communications, 6 . pp. 1-9. 6582. doi:10.1038/ncomms7582 ISSN 2041-1723.
Soldevila-Barreda, Joan J. and Sadler, P. J. (2015) Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology, Volume 25 . pp. 172-183. doi:10.1016/j.cbpa.2015.01.024 ISSN 1367-5931.
Liu, Zhe , Romero-Canelón, Isolda, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2014) Potent half-sandwich iridium(III) anticancer complexes containing C∧N-Chelated and pyridine ligands. Organometallics, 33 (19). pp. 5324-5333. doi:10.1021/om500644f ISSN 0276-7333.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Sánchez, Ana M., Dove, Andrew P., Procter, Richard J., Soldevila-Barreda, Joan J., Kirby, Nigel, Hands-Portman, Ian, Smith, Corinne J., O'Reilly, Rachel K., Beanland, R. and Sadler, P. J. (2014) Fabrication of crystals from single metal atoms. Nature Communications, Volume 5 . Article number 3851 . doi:10.1038/ncomms4851 ISSN 2041-1723.
Rijt, Sabine H. van, Romero-Canelón, Isolda, Fu, Ying, Shnyder, Steve D. and Sadler, P. J. (2014) Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells. Metallomics, 6 (5). pp. 1014-1022. doi:10.1039/c4mt00034j ISSN 1756-5901.
Liu, Zhe and Sadler, P. J. (2014) Organoiridium complexes : anticancer agents and catalysts. Accounts of chemical research, 47 (4). pp. 1174-1185. doi:10.1021/ar400266c ISSN 0001-4842.
Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505 ISSN 1433-7851.
Fu, Ying, Soni, Rina, Romero, Maria, Pizarro, Ana M., Salassa, Luca, Clarkson, Guy J., Hearn, Jessica M., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2013) Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity. Chemistry - A European Journal, Volume 19 (Number 45). pp. 15199-15209. doi:10.1002/chem.201302183 ISSN 0947-6539.
Smith, Nicola A. and Sadler, P. J. (2013) Photoactivatable metal complexes : from theory to applications in biotechnology and medicine. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Volume 371 (Number 1995). p. 20120519. doi:10.1098/rsta.2012.0519 ISSN 1364-503X.
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Betanzos-Lara, Soledad, Novakova, Olga, Deeth, Robert J., Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor), Sadler, P. J. and Habtemariam, Abraha (2012) Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity. JBIC Journal of Biological Inorganic Chemistry, 17 (7). pp. 1033-1051. doi:10.1007/s00775-012-0917-9 ISSN 0949-8257.
Unterkofler, S., McQuitty, Ruth J., Euser, T. G., Farrer, Nicola J., Sadler, P. J. and Russell, P. St.J. (2012) Microfluidic integration of photonic crystal fibers for online photochemical reaction analysis. Optics Letters, Volume 37 (Number 11). pp. 1952-1954. doi:10.1364/OL.37.001952 ISSN 0146-9592.
Noffke, Anna Louise, Habtemariam, Abraha, Pizarro, Ana M. and Sadler, P. J. (2012) Designing organometallic compounds for catalysis and therapy. Chemical Communications, Vol.48 (No.43). pp. 5219-5246. doi:10.1039/c2cc30678f ISSN 1359-7345.
Mukherjee, Arindam, Bilton, Paul R., Mackay, Logan, Janoschka, Adam, Zhu, Haizhong, Rea, Dean, Langridge-Smith, Pat R. R., Campopiano, Dominic J., Teschner, Thomas, Trautwein, Alfred, Schünemann, Volker and Sadler, P. J. (2012) Ferric ion (hydr)oxo clusters in the “Venus flytrap” cleft of FbpA : Mössbauer, calorimetric and mass spectrometric studies. JBIC Journal of Biological Inorganic Chemistry, Vol.17 (No.4). pp. 573-588. doi:10.1007/s00775-012-0878-z ISSN 0949-8257.
Romero-Canelón, Isolda, Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2012) Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes. Metallomics, Volume 4 (Number 12). pp. 1271-1279. doi:10.1039/c2mt20189e ISSN 1756-5901.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha, Novakova, Olga, Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor) and Sadler, P. J. (2012) Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics, Vol.31 (No.9). pp. 3466-3479. doi:10.1021/om201177y ISSN 0276-7333.
Fu, Y. (Ying), Romero, Maria, Habtemariam, Abraha, Snowden, Michael E., Song, Lijiang, Clarkson, Guy J., Qamar, Bushra, Pizarro, Ana M., Unwin, Patrick R. and Sadler, P. J. (2012) The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes. Chemical Science, Vol.3 (No.8). pp. 2485-2494. doi:10.1039/c2sc20220d ISSN 2041-6520.
Ronconi, Luca, Pizarro, Ana M., McQuitty, Ruth J. and Sadler, P. J. (2011) Insights into the acid-base properties of PtIV-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry - A European Journal, Volume 17 (Number 43). pp. 12051-12058. doi:10.1002/chem.201002792 ISSN 0947-6539.
Farrer, Nicola J., Gierth, Peter and Sadler, P. J. (2011) Probing platinum azido complexes by 14N and 15N NMR spectroscopy. Chemistry - A European Journal, Vol.17 (No.43). pp. 12059-12066. doi:10.1002/chem.201101409 ISSN 0947-6539.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics, Vol.30 (No.17). pp. 4702-4710. doi:10.1021/om2005468 ISSN 0276-7333.
Shnyder, Steve D., Fu, Y. (Ying), Habtemariam, Abraha, Rijt, Sabine H. van, Cooper, Patricia A., Loadman, Paul M. and Sadler, P. J. (2011) Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex. MedChemComm, Vol.2 (No.7). pp. 666-668. doi:10.1039/c1md00075f ISSN 2040-2503.
Betanzos-Lara, Soledad, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic cis-Dichlorido ruthenium(II) ammine complexes. European Journal of Inorganic Chemistry, Volume 2011 (Number 21). pp. 3257-3264. doi:10.1002/ejic.201100250 ISSN 1434-1948.
Liu, Zhe , Salassa, Luca, Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorganic Chemistry, Vol.50 (No.12). pp. 5777-5783. doi:10.1021/ic200607j ISSN 0020-1669.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Fletcher, Sally A., Kisova, Anna, Vrana, Oldrich, Salassa, Luca, Bruijnincx, Pieter C. A., Clarkson, Guy J., Brabec, V. (Viktor) and Sadler, P. J. (2011) Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry, Vol.54 (No.8). pp. 3011-3026. doi:10.1021/jm2000932 ISSN 0022-2623.
Kisova, Anna, Zerzankova, Lenka, Habtemariam, Abraha, Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2011) Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Molecular Pharmaceutics, Vol.8 (No.3). pp. 949-957. doi:10.1021/mp200105d ISSN 1543-8384.
Rijt, Sabine H. van, Kostrhunova, Hana, Brabec, V. (Viktor) and Sadler, P. J. (2011) Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity. Bioconjugate Chemistry, Vol.22 (No.2). pp. 218-226. doi:10.1021/bc100369p ISSN 1043-1802.
Liu, Hong-Ke and Sadler, P. J. (2011) Metal complexes as DNA intercalators. Accounts of Chemical Research, Vol.44 (No.5). pp. 349-359. doi:10.1021/ar100140e ISSN 0001-4842.
Fu, Y. (Ying), Habtemariam, Abraha, Basri, Aida M. B. H., Braddick, Darren, Clarkson, Guy J. and Sadler, P. J. (2011) Structure–activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity. Dalton Transactions (No.40). pp. 10553-10562. doi:10.1039/c1dt10937e ISSN 1477-9226.
Salassa, Luca, Ruiu, Tiziana, Garino, Claudio, Pizarro, Ana M., Bardelli, Fabrizio, Gianolio, Diego, Westendorf, Aron, Bednarski, Patrick J., Lamberti, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) EXAFS, DFT, light-induced nucleobase binding, and cytotoxicity of the photoactive complex cis-[Ru(bpy)2(CO)Cl]+. Organometallics, Vol.29 (No.4). pp. 6703-6710. doi:10.1021/om100734y ISSN 0276-7333.
Fu, Y. (Ying), Habtemariam, Abraha, Pizarro, Ana M., Rijt, Sabine H. van, Healey, David J., Cooper, Patricia A., Shnyder, Steven D., Clarkson, Guy J. and Sadler, P. J. (2010) Organometallic osmium arene complexes with potent cancer cell cytotoxicity. Journal of Medicinal Chemistry, Vol.53 (No.22). pp. 8192-8196. doi:10.1021/jm100560f ISSN 0022-2623.
Ruiu, Tiziana, Garino, Claudio, Salassa, Luca, Pizarro, Ana M., Nervi, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) Spectroscopic and computational study of ligand photodissociation from [Ru(dipyrido[3,2-a:2',3'-c]phenazine)(4-aminopyridine)(4)](2+). European Journal of Inorganic Chemistry, Vol.2010 (No.8). pp. 1186-1195. doi:10.1002/ejic.200900990 ISSN 1434-1948.
Rijt, Sabine H. van, Mukherjee, Arindam, Pizarro, Ana M. and Sadler, P. J. (2010) Cytotoxicity, hydrophobicity, uptake, and distribution of osmium(II) anticancer complexes in ovarian cancer cells. Journal of Medicinal Chemistry, Vol.53 (No.2). pp. 840-849. doi:10.1021/jm901556u ISSN 0022-2623.
Rijt, Sabine H. van and Sadler, P. J. (2009) Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discovery Today, Vol.14 (No.23-24). pp. 1089-1097. doi:10.1016/j.drudis.2009.09.003 ISSN 1359-6446.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2009) Photocontrolled nucleobase binding to an organometallic Ru-II arene complex. Chemical Communications (No.43). pp. 6622-6624. doi:10.1039/b914153g ISSN 1359-7345.
European Research Council (ERC)
Xie, Ming-jin, Zhu, Ming-rong, Lu, Chun-Mei, Jin, Yi, Gao, Li-Hui, Li, Ling, Zhou, Jie, Li, Fan-fang, Zhao, Qi Hua, Liu, Hong-Ke, Sadler, P. J. and Sanchez-Cano, Carlos (2017) Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV. Journal of Inorganic Biochemistry, 175 . pp. 29-35. doi:10.1016/j.jinorgbio.2017.06.014 ISSN 0162-0134.
Smith, Nichola A., Zhang, Pingyu, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2017) Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes. Inorganica Chimica Acta, 454 . pp. 240-246. doi:10.1016/j.ica.2016.06.014 ISSN 00201693.
Fu, Ying, Romero, Maria, Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni and Sadler, P. J. (2016) Os2-Os4 switch controls DNA knotting and anticancer activity. Angewandte Chemie International Edition, 55 (31). pp. 8909-8912. doi:10.1002/anie.201602995 ISSN 1433-7851.
Ude, Ziga, Romero-Canelón, Isolda, Twamley, Brendan, Fitzgerald Hughes, Deirdre, Sadler, P. J. and Marmion, Celine J. (2016) A novel dual-functioning ruthenium(II)–arene complex of an anti-microbial ciprofloxacin derivative — anti-proliferative and anti-microbial activity. Journal of Inorganic Biochemistry, 160 . pp. 210-217. doi:10.1016/j.jinorgbio.2016.02.018 ISSN 0162-0134.
Fu, Ying, Sanchez-Cano, Carlos, Soni, Rina, Romero-Canelón, Isolda, Hearn, Jessica M., Liu, Zhe, Wills, Martin and Sadler, P. J. (2016) The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Transactions, 45 (20). pp. 8367-8378. doi:10.1039/c6dt01242f ISSN 1477-9226.
Pitto-Barry, Anaïs, Sadler, P. J. and Barry, Nicolas P. E. (2016) Dynamics of formation of Ru, Os, Ir and Au metal nanocrystals on doped graphitic surfaces. Chemical Communications, 52 (20). pp. 3895-3898. c5cc09564f. doi:10.1039/c5cc09564f ISSN 1359-7345.
Greenough, Simon E., Horbury, Michael D., Smith, Nichola A., Sadler, P. J., Paterson, Martin J. and Stavros, Vasilios G. (2016) Excited-state dynamics of a two-photon-activatable ruthenium prodrug. ChemPhysChem, 17 (2). pp. 221-224. doi:10.1002/cphc.201501075 ISSN 1439-4235.
Smith, Nichola A., Zhang, Pingyu, Greenough, Simon E., Horbury, Michael D., Clarkson, Guy J., McFeely, Daniel, Habtemariam, Abraha, Salassa, Luca, Stavros, Vasilios G., Dowson, Christopher G. and Sadler, P. J. (2016) Combatting AMR : photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chemical Science, 8 (1). pp. 395-404. doi:10.1039/C6SC03028A ISSN 2041-6520.
Silva Sousa, Eduardo Henrique, Ridnour, Lisa A., Gouveia, Florêncio S., Silva da Silva, Carlos Daniel, Wink, David A., de França Lopes, Luiz Gonzaga and Sadler, P. J. (2016) Thiol-Activated HNO release from a ruthenium antiangiogenesis complex and HIF-1α inhibition for cancer therapy. ACS Chemical Biology, 11 (7). pp. 2057-2065. doi:10.1021/acschembio.6b00222 ISSN 1554-8929.
Soldevila-Barreda, Joan J., Habtemariam, Abraha, Romero-Canelón, Isolda and Sadler, P, J. (2015) Half-sandwich rhodium(III) transfer hydrogenation catalysts : reduction of NAD+ and pyruvate, and antiproliferative activity. Journal of Inorganic Biochemistry, 153 . pp. 322-333. doi:10.1016/j.jinorgbio.2015.10.008 ISSN 0162-0134.
Romero-Canelón, Isolda, Phoenix, Ben, Pitto-Barry, Anaïs, Tran, Johanna, Soldevila-Barreda, Joan J., Kirby, Nigel, Green, Stuart, Sadler, P. J. and Barry, Nicolas P. E. (2015) Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT). Journal of organometallic chemistry, 796 . pp. 17-25. doi:10.1016/j.jorganchem.2015.05.011 ISSN 0022-328X.
Pitto-Barry, Anaïs, Alves Perdigão, Luis M., Walker, Marc, Lawrence, James M., Costantini, Giovanni, Sadler, P. J. and Barry, Nicolas P. E. (2015) Synthesis and controlled growth of osmium nanoparticles by electron irradiation. Dalton Transactions, 44 (47). pp. 20308-20311. doi:10.1039/c5dt03205a ISSN 1477-9226.
Romero-Canelón, Isolda, Mos, Magdalena and Sadler, P. J. (2015) Enhancement of selectivity of an organometallic anticancer agent by redox modulation. Journal of Medicinal Chemistry, 58 (19). pp. 7874-7880. doi:10.1021/acs.jmedchem.5b00655 ISSN 0022-2623.
Zou, Taotao and Sadler, P. J. (2015) Speciation of precious metal anti-cancer complexes by NMR spectroscopy. Drug Discovery Today : Technologies, 16 . pp. 7-15. doi:10.1016/j.ddtec.2015.08.002 ISSN 1740-6749.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Tran, Johanna, Spencer, Simon E. F., Johansen, Adam M., Sanchez, Ana M., Dove, Andrew P., O’Reilly, Rachel K., Deeth, Robert J., Beanland, R. and Sadler, P. J. (2015) Osmium atoms and Os2 molecules move faster on selenium-doped compared to sulfur-doped boronic graphenic surfaces. Chemistry of Materials, 27 (14). pp. 5100-5105. doi:10.1021/acs.chemmater.5b01853 ISSN 0897-4756.
Millett, Adam J., Habtemariam, Abraha, Romero-Canelón, Isolda, Clarkson, Guy J. and Sadler, P. J. (2015) Contrasting anticancer activity of half-sandwich iridium(III) complexes bearing functionally diverse 2-phenylpyridine ligands. Organometallics, Volume 34 (Number 11). pp. 2683-2694. doi:10.1021/acs.organomet.5b00097 ISSN 0276-7333.
Coverdale, James P. C., Sanchez-Cano, Carlos, Clarkson, Guy J., Soni, Rina, Wills, Martin and Sadler, P. J. (2015) Easy to synthesize, robust organo-osmium asymmetric transfer hydrogenation catalysts. Chemistry - A European Journal, 21 (22). pp. 8043-8046. doi:10.1002/chem.201500534 ISSN 0947-6539.
Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2015) Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design. Nature Communications, 6 . pp. 1-9. 6582. doi:10.1038/ncomms7582 ISSN 2041-1723.
Chellan , Prinessa and Sadler, P. J. (2015) The elements of life and medicines. Philosophical Transactions of the Royal Society A : Mathematical, Physical and Engineering Sciences, Volume 373 (Number 2037). Article number 20140182. doi:10.1098/rsta.2014.0182 ISSN 1364-503X.
Soldevila-Barreda, Joan J. and Sadler, P. J. (2015) Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology, Volume 25 . pp. 172-183. doi:10.1016/j.cbpa.2015.01.024 ISSN 1367-5931.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f ISSN 0301-7249.
Liu, Zhe , Romero-Canelón, Isolda, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2014) Potent half-sandwich iridium(III) anticancer complexes containing C∧N-Chelated and pyridine ligands. Organometallics, 33 (19). pp. 5324-5333. doi:10.1021/om500644f ISSN 0276-7333.
Li, Huilin, Snelling, Jonathon R., Barrow, Mark P., Scrivens, James H., Sadler, P. J. and O’Connor, Peter B. (2014) Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins. Journal of The American Society for Mass Spectrometry, 25 (7). pp. 1217-1227. doi:10.1007/s13361-014-0877-0 ISSN 1044-0305.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Sánchez, Ana M., Dove, Andrew P., Procter, Richard J., Soldevila-Barreda, Joan J., Kirby, Nigel, Hands-Portman, Ian, Smith, Corinne J., O'Reilly, Rachel K., Beanland, R. and Sadler, P. J. (2014) Fabrication of crystals from single metal atoms. Nature Communications, Volume 5 . Article number 3851 . doi:10.1038/ncomms4851 ISSN 2041-1723.
Rijt, Sabine H. van, Romero-Canelón, Isolda, Fu, Ying, Shnyder, Steve D. and Sadler, P. J. (2014) Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells. Metallomics, 6 (5). pp. 1014-1022. doi:10.1039/c4mt00034j ISSN 1756-5901.
Liu, Zhe and Sadler, P. J. (2014) Organoiridium complexes : anticancer agents and catalysts. Accounts of chemical research, 47 (4). pp. 1174-1185. doi:10.1021/ar400266c ISSN 0001-4842.
Liu, Zhe , Romero-Canelón, Isolda, Qamar, Bushra, Hearn, Jessica M., Habtemariam, Abraha, Barry, Nicolas P. E., Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2014) The potent oxidant anticancer activity of organoiridium catalysts. Angewandte Chemie International Edition, Volume 53 (Number 15). pp. 3941-3946. doi:10.1002/anie.201311161 ISSN 1433-7851.
Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505 ISSN 1433-7851.
Barnett, James P., Dr., Blindauer, Claudia A., Kassaar, Omar, Khazaipoul, Siavash, Martin, Esther M., Sadler, P. J. and Stewart, Alan J. S. (2013) Allosteric modulation of zinc speciation by fatty acids. Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 830 (Number 12). doi:10.1016/j.bbagen.2013.05.028 ISSN 0304-4165.
Fu, Ying, Soni, Rina, Romero, Maria, Pizarro, Ana M., Salassa, Luca, Clarkson, Guy J., Hearn, Jessica M., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2013) Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity. Chemistry - A European Journal, Volume 19 (Number 45). pp. 15199-15209. doi:10.1002/chem.201302183 ISSN 0947-6539.
Smith, Nicola A. and Sadler, P. J. (2013) Photoactivatable metal complexes : from theory to applications in biotechnology and medicine. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Volume 371 (Number 1995). p. 20120519. doi:10.1098/rsta.2012.0519 ISSN 1364-503X.
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Hearn, Jessica M., Romero-Canelón, Isolda, Qamar, Bushra, Liu, Zhe , Hands-Portman, Ian and Sadler, P. J. (2013) Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis. ACS Chemical Biology, Volume 8 (Number 6). pp. 1335-1343. doi:10.1021/cb400070a ISSN 1554-8929.
Liu, Zhe , Deeth, Robert J., Butler, Jennifer S. (Jennifer Suzanne), Habtemariam, Abraha, Newton, Mark E. and Sadler, P. J. (2013) Reduction of quinones by NADH catalyzed by organoiridium complexes. Angewandte Chemie International Edition, Volume 52 (Number 15). pp. 4194-4197. doi:10.1002/anie.201300747 ISSN 1433-7851.
Garino, Claudio, Gallo, Erik, Smolentsev, Nikolay, Glatzel, Pieter, Gobetto, Roberto, Lamberti, Carlo, Sadler, P. J. and Salassa, Luca (2012) Resonant X-ray emission spectroscopy reveals d–d ligand-field states involved in the self-assembly of a square-planar platinum complex. Physical Chemistry Chemical Physics, Vol.14 (No.44). pp. 15278-15281. doi:10.1039/c2cp42451g ISSN 1463-9076.
Betanzos-Lara, Soledad, Novakova, Olga, Deeth, Robert J., Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor), Sadler, P. J. and Habtemariam, Abraha (2012) Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity. JBIC Journal of Biological Inorganic Chemistry, 17 (7). pp. 1033-1051. doi:10.1007/s00775-012-0917-9 ISSN 0949-8257.
Li, Huilin, Wells, Stephen A., Jimenez-Roldan, J. Emilio, Römer, Rudolf A., Zhao, Yao, (Researcher in chemistry), Sadler, P. J. and O'Connor, Peter B. (2012) Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Science, Volume 21 (Number 9). pp. 1269-1279. doi:10.1002/pro.2111 ISSN 0961-8368.
Barragán, Flavia, Carrion-Salip, Dolors, Gómez-Pinto, Irene, González-Cantó, Alejandro, Sadler, P. J., de Llorens, Rafael, Moreno, Virtudes, González, Carlos A., Massaguer, Anna and Marchán, Vicente (2012) Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes. Bioconjugate Chemistry, Vol.23 (No.9). pp. 1838-1855. doi:10.1021/bc300173h ISSN 1043-1802.
Unterkofler, S., McQuitty, Ruth J., Euser, T. G., Farrer, Nicola J., Sadler, P. J. and Russell, P. St.J. (2012) Microfluidic integration of photonic crystal fibers for online photochemical reaction analysis. Optics Letters, Volume 37 (Number 11). pp. 1952-1954. doi:10.1364/OL.37.001952 ISSN 0146-9592.
Noffke, Anna Louise, Habtemariam, Abraha, Pizarro, Ana M. and Sadler, P. J. (2012) Designing organometallic compounds for catalysis and therapy. Chemical Communications, Vol.48 (No.43). pp. 5219-5246. doi:10.1039/c2cc30678f ISSN 1359-7345.
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) Allosteric inhibition of cobalt binding to albumin by fatty acids : implications for the detection of myocardial ischemia. Journal of Medicinal Chemistry, Vol.55 (No.9). pp. 4425-4430. doi:10.1021/jm3003137 ISSN 0022-2623.
Mukherjee, Arindam, Bilton, Paul R., Mackay, Logan, Janoschka, Adam, Zhu, Haizhong, Rea, Dean, Langridge-Smith, Pat R. R., Campopiano, Dominic J., Teschner, Thomas, Trautwein, Alfred, Schünemann, Volker and Sadler, P. J. (2012) Ferric ion (hydr)oxo clusters in the “Venus flytrap” cleft of FbpA : Mössbauer, calorimetric and mass spectrometric studies. JBIC Journal of Biological Inorganic Chemistry, Vol.17 (No.4). pp. 573-588. doi:10.1007/s00775-012-0878-z ISSN 0949-8257.
Booyjzsen, Claire, Scarff, Charlotte A., Moreton, Ben, Portman, Ian J., Scrivens, James H., Costantini, Giovanni and Sadler, P. J. (2012) Fibrillation of transferrin. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1820 (No.3). pp. 427-436. doi:10.1016/j.bbagen.2011.11.004 ISSN 0304-4165.
Tai, Hui-Chung, Brodbeck, Ralf, Kasparkova, Jana, Farrer, Nicola J., Brabec, V. (Viktor), Sadler, P. J. and Deeth, Robert J. (2012) Combined theoretical and computational study of interstrand DNA guanine–guanine cross-linking bytrans-[Pt(pyridine)2] derived from the photoactivated prodrugtrans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]. Inorganic Chemistry, Vol.51 (No.12). pp. 6830-6841. doi:10.1021/ic3005745 ISSN 0020-1669.
Romero-Canelón, Isolda, Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2012) Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes. Metallomics, Volume 4 (Number 12). pp. 1271-1279. doi:10.1039/c2mt20189e ISSN 1756-5901.
Ragazzon, Giulio, Bratsos, Ioannis, Alessio, E. (Enzo), Salassa, Luca, Habtemariam, Abraha, McQuitty, Ruth J., Clarkson, Guy J. and Sadler, P. J. (2012) Design of photoactivatable metallodrugs : selective and rapid light-induced ligand dissociation from half-sandwich [Ru([9]aneS3)(N–N′)(py)]2+ complexes. Inorganica Chimica Acta, Vol.393 . pp. 230-238. doi:10.1016/j.ica.2012.06.031 ISSN 0020-1693.
Barry, Nicolas P. E. and Sadler, P. J. (2012) Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium : biological relevance and synthetic strategies. Chemical Society Reviews, Vol.41 (No.8). pp. 3264-3279. doi:10.1039/c2cs15300a ISSN 0306-0012.
Pracharova, Jitka, Zerzankova, Lenka, Stepankova, Jana, Novakova, Olga, Farrer, Nicola J., Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2012) Interactions of DNA with a new Platinum(IV) Azide Dipyridine complex activated by UVA and visible light : relationship to toxicity in tumor cells. Chemical Research in Toxicology, Vol.25 (No.5). pp. 1099-1111. doi:10.1021/tx300057y ISSN 0893-228X.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha, Novakova, Olga, Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor) and Sadler, P. J. (2012) Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics, Vol.31 (No.9). pp. 3466-3479. doi:10.1021/om201177y ISSN 0276-7333.
Butler, Jennifer S. (Jennifer Suzanne), Woods, Julie A., Farrer, Nicola J., Newton, Mark E. and Sadler, P. J. (2012) Tryptophan switch for a photoactivated platinum anticancer complex. Journal of the American Chemical Society, Vol.134 (No.40). pp. 16508-16511. doi:10.1021/ja3074159 ISSN 0002-7863.
Fu, Y. (Ying), Romero, Maria, Habtemariam, Abraha, Snowden, Michael E., Song, Lijiang, Clarkson, Guy J., Qamar, Bushra, Pizarro, Ana M., Unwin, Patrick R. and Sadler, P. J. (2012) The contrasting chemical reactivity of potent isoelectronic iminopyridine and azopyridine osmium(ii) arene anticancer complexes. Chemical Science, Vol.3 (No.8). pp. 2485-2494. doi:10.1039/c2sc20220d ISSN 2041-6520.
Han, Yumiao, Luo, Qun, Hao, Xiang, Li, Xianchan, Wang, Fuyi, Hu, Wenbing, Wu, Kui, Lü, Shuang and Sadler, P. J. (2011) Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide — a model for the active-site cysteine of protein tyrosine phosphatase 1B. Dalton Transactions, Vol.40 (No.43). pp. 11519-11529. doi:10.1039/c1dt11189b ISSN 1477-9226.
Ronconi, Luca, Pizarro, Ana M., McQuitty, Ruth J. and Sadler, P. J. (2011) Insights into the acid-base properties of PtIV-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry - A European Journal, Volume 17 (Number 43). pp. 12051-12058. doi:10.1002/chem.201002792 ISSN 0947-6539.
Farrer, Nicola J., Gierth, Peter and Sadler, P. J. (2011) Probing platinum azido complexes by 14N and 15N NMR spectroscopy. Chemistry - A European Journal, Vol.17 (No.43). pp. 12059-12066. doi:10.1002/chem.201101409 ISSN 0947-6539.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics, Vol.30 (No.17). pp. 4702-4710. doi:10.1021/om2005468 ISSN 0276-7333.
Shnyder, Steve D., Fu, Y. (Ying), Habtemariam, Abraha, Rijt, Sabine H. van, Cooper, Patricia A., Loadman, Paul M. and Sadler, P. J. (2011) Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex. MedChemComm, Vol.2 (No.7). pp. 666-668. doi:10.1039/c1md00075f ISSN 2040-2503.
Betanzos-Lara, Soledad, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic cis-Dichlorido ruthenium(II) ammine complexes. European Journal of Inorganic Chemistry, Volume 2011 (Number 21). pp. 3257-3264. doi:10.1002/ejic.201100250 ISSN 1434-1948.
Liu, Zhe , Salassa, Luca, Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorganic Chemistry, Vol.50 (No.12). pp. 5777-5783. doi:10.1021/ic200607j ISSN 0020-1669.
Li, Huilin, Zhao, Yao, Phillips, Hazel I. A., Qi, Yulin, Lin, Tzu-Yung, Sadler, P. J. and O'Connor, Peter B. (2011) Mass spectrometry evidence for cisplatin as a protein cross-linking reagent. Analytical Chemistry, Vol.83 (No.13). pp. 5369-5376. doi:10.1021/ac200861k ISSN 0003-2700.
Westendorf, Aron, Zerzankova, Lenka, Salassa, Luca, Sadler, P. J., Brabec, V. (Viktor) and Bednarski, Patrick J. (2011) Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]. Journal of Inorganic Biochemistry, Vol.105 (No.5). pp. 652-662. doi:10.1016/j.jinorgbio.2011.01.003 ISSN 01620134.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Fletcher, Sally A., Kisova, Anna, Vrana, Oldrich, Salassa, Luca, Bruijnincx, Pieter C. A., Clarkson, Guy J., Brabec, V. (Viktor) and Sadler, P. J. (2011) Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry, Vol.54 (No.8). pp. 3011-3026. doi:10.1021/jm2000932 ISSN 0022-2623.
Kisova, Anna, Zerzankova, Lenka, Habtemariam, Abraha, Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2011) Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Molecular Pharmaceutics, Vol.8 (No.3). pp. 949-957. doi:10.1021/mp200105d ISSN 1543-8384.
Rijt, Sabine H. van, Kostrhunova, Hana, Brabec, V. (Viktor) and Sadler, P. J. (2011) Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity. Bioconjugate Chemistry, Vol.22 (No.2). pp. 218-226. doi:10.1021/bc100369p ISSN 1043-1802.
Liu, Hong-Ke and Sadler, P. J. (2011) Metal complexes as DNA intercalators. Accounts of Chemical Research, Vol.44 (No.5). pp. 349-359. doi:10.1021/ar100140e ISSN 0001-4842.
Fu, Y. (Ying), Habtemariam, Abraha, Basri, Aida M. B. H., Braddick, Darren, Clarkson, Guy J. and Sadler, P. J. (2011) Structure–activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity. Dalton Transactions (No.40). pp. 10553-10562. doi:10.1039/c1dt10937e ISSN 1477-9226.
Li, Huilin, Lin, Tzu-Yung, Van Orden, Steve L., Zhao, Yao, (Researcher in chemistry), Barrow, Mark P., Pizarro, Ana M., Qi, Yulin, Sadler, P. J. and O’Connor, Peter B. (2011) Use of top-down and bottom-up fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs. Analytical Chemistry, Vol.83 (No.24). pp. 9507-9515. doi:10.1021/ac202267g ISSN 0003-2700.
Salassa, Luca, Borfecchia, Elisa, Ruiu, Tiziana, Garino, Claudio, Gianolio, Diego, Gobetto, Roberto, Sadler, P. J., Cammarata, Marco, Wulff, Michael and Lamberti, Carlo (2010) Photo-induced pyridine substitution in cis-[Ru(bpy)(2)(py)(2)]Cl-2 : a snapshot by time-resolved X-ray solution scattering. Inorganic Chemistry, Vol.49 (No.23). pp. 11240-11248. doi:10.1021/ic102021k ISSN 0020-1669.
Salassa, Luca, Ruiu, Tiziana, Garino, Claudio, Pizarro, Ana M., Bardelli, Fabrizio, Gianolio, Diego, Westendorf, Aron, Bednarski, Patrick J., Lamberti, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) EXAFS, DFT, light-induced nucleobase binding, and cytotoxicity of the photoactive complex cis-[Ru(bpy)2(CO)Cl]+. Organometallics, Vol.29 (No.4). pp. 6703-6710. doi:10.1021/om100734y ISSN 0276-7333.
European Research Council under the European Community/ERC
Wu, Kui, Luo, Qun, Hu, Wenbing, Li, Xianchan, Wang, Fuyi, Xiong, Shaoxiang and Sadler, P. J. (2012) Mechanism of interstrand migration of organoruthenium anticancer complexes within a DNA duplex. Metallomics, Vol.4 (No.2). pp. 139-148. doi:10.1039/c2mt00162d ISSN 1756-5901.
European Synchrotron Radiation Facility (ESRF)
Garino, Claudio, Gallo, Erik, Smolentsev, Nikolay, Glatzel, Pieter, Gobetto, Roberto, Lamberti, Carlo, Sadler, P. J. and Salassa, Luca (2012) Resonant X-ray emission spectroscopy reveals d–d ligand-field states involved in the self-assembly of a square-planar platinum complex. Physical Chemistry Chemical Physics, Vol.14 (No.44). pp. 15278-15281. doi:10.1039/c2cp42451g ISSN 1463-9076.
Salassa, Luca, Ruiu, Tiziana, Garino, Claudio, Pizarro, Ana M., Bardelli, Fabrizio, Gianolio, Diego, Westendorf, Aron, Bednarski, Patrick J., Lamberti, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) EXAFS, DFT, light-induced nucleobase binding, and cytotoxicity of the photoactive complex cis-[Ru(bpy)2(CO)Cl]+. Organometallics, Vol.29 (No.4). pp. 6703-6710. doi:10.1021/om100734y ISSN 0276-7333.
European Union (EU)
Shnyder, Steve D., Fu, Y. (Ying), Habtemariam, Abraha, Rijt, Sabine H. van, Cooper, Patricia A., Loadman, Paul M. and Sadler, P. J. (2011) Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex. MedChemComm, Vol.2 (No.7). pp. 666-668. doi:10.1039/c1md00075f ISSN 2040-2503.
Westendorf, Aron, Zerzankova, Lenka, Salassa, Luca, Sadler, P. J., Brabec, V. (Viktor) and Bednarski, Patrick J. (2011) Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]. Journal of Inorganic Biochemistry, Vol.105 (No.5). pp. 652-662. doi:10.1016/j.jinorgbio.2011.01.003 ISSN 01620134.
Fondazione Beneficentia Stiftung
Ragazzon, Giulio, Bratsos, Ioannis, Alessio, E. (Enzo), Salassa, Luca, Habtemariam, Abraha, McQuitty, Ruth J., Clarkson, Guy J. and Sadler, P. J. (2012) Design of photoactivatable metallodrugs : selective and rapid light-induced ligand dissociation from half-sandwich [Ru([9]aneS3)(N–N′)(py)]2+ complexes. Inorganica Chimica Acta, Vol.393 . pp. 230-238. doi:10.1016/j.ica.2012.06.031 ISSN 0020-1693.
Fondazione CRTrieste
Bergamo, A., Masi, A., Peacock, Anna F. A., Habtemariam, Abraha, Sadler, P. J. and Sava, G. (2010) In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model. Journal of Inorganic Biochemistry, Vol.104 (No.1). pp. 79-86. doi:10.1016/j.jinorgbio.2009.10.005 ISSN 0162-0134.
Friedrich-Alexander-Universität Erlangen-Nürnberg
Chen, Jocelyn S. Y., Euser, Tijmen G., Farrer, Nicola J., Sadler, P. J., Scharrer, Michael and Russell, Philip St. J. (2010) Photochemistry in photonic crystal fiber nanoreactors. Chemistry - A European Journal, Vol.16 (No.19). pp. 5607-5612. doi:10.1002/chem.201000496 ISSN 0947-6539.
Friuli-Venezia Giulia (Italy)
Bergamo, A., Masi, A., Peacock, Anna F. A., Habtemariam, Abraha, Sadler, P. J. and Sava, G. (2010) In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model. Journal of Inorganic Biochemistry, Vol.104 (No.1). pp. 79-86. doi:10.1016/j.jinorgbio.2009.10.005 ISSN 0162-0134.
Fundación "Pedro Barrié de la Maza, Conde de Fenosa"
Fu, Ying, Soni, Rina, Romero, Maria, Pizarro, Ana M., Salassa, Luca, Clarkson, Guy J., Hearn, Jessica M., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2013) Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity. Chemistry - A European Journal, Volume 19 (Number 45). pp. 15199-15209. doi:10.1002/chem.201302183 ISSN 0947-6539.
Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP)
Silva Sousa, Eduardo Henrique, Ridnour, Lisa A., Gouveia, Florêncio S., Silva da Silva, Carlos Daniel, Wink, David A., de França Lopes, Luiz Gonzaga and Sadler, P. J. (2016) Thiol-Activated HNO release from a ruthenium antiangiogenesis complex and HIF-1α inhibition for cancer therapy. ACS Chemical Biology, 11 (7). pp. 2057-2065. doi:10.1021/acschembio.6b00222 ISSN 1554-8929.
Grantová agentura České republiky [Czech Science Foundation] (GACR)
Kisova, Anna, Zerzankova, Lenka, Habtemariam, Abraha, Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2011) Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand. Molecular Pharmaceutics, Vol.8 (No.3). pp. 949-957. doi:10.1021/mp200105d ISSN 1543-8384.
Grantová agentura České republiky [Grant Agency of the Czech Republic]
Novakova, Olga, Malina, J. (Jaroslav), Suchankova, Tereza, Kasparkova, Jana, Bugarcic, Tijana, Sadler, P. J. and Brabec, V. (Viktor) (2010) Energetics, conformation, and recognition of DNA duplexes modified by monodentate Ru-II complexes containing terphenyl arenes. Chemistry - A European Journal, Vol.16 (No.19). pp. 5744-5754. doi:10.1002/chem.200903078 ISSN 0947-6539.
Grantová agentura České republiky [Grant Agency of the Czech Republic] (GACR)
Betanzos-Lara, Soledad, Novakova, Olga, Deeth, Robert J., Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor), Sadler, P. J. and Habtemariam, Abraha (2012) Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity. JBIC Journal of Biological Inorganic Chemistry, 17 (7). pp. 1033-1051. doi:10.1007/s00775-012-0917-9 ISSN 0949-8257.
Tai, Hui-Chung, Brodbeck, Ralf, Kasparkova, Jana, Farrer, Nicola J., Brabec, V. (Viktor), Sadler, P. J. and Deeth, Robert J. (2012) Combined theoretical and computational study of interstrand DNA guanine–guanine cross-linking bytrans-[Pt(pyridine)2] derived from the photoactivated prodrugtrans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]. Inorganic Chemistry, Vol.51 (No.12). pp. 6830-6841. doi:10.1021/ic3005745 ISSN 0020-1669.
Pracharova, Jitka, Zerzankova, Lenka, Stepankova, Jana, Novakova, Olga, Farrer, Nicola J., Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2012) Interactions of DNA with a new Platinum(IV) Azide Dipyridine complex activated by UVA and visible light : relationship to toxicity in tumor cells. Chemical Research in Toxicology, Vol.25 (No.5). pp. 1099-1111. doi:10.1021/tx300057y ISSN 0893-228X.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha, Novakova, Olga, Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor) and Sadler, P. J. (2012) Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics, Vol.31 (No.9). pp. 3466-3479. doi:10.1021/om201177y ISSN 0276-7333.
Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation (China)] (NSFC)
Hu, Wenbing, Luo, Qun, Ma, Xiaoyan, Wu, Kui, Liu, Jianan, Chen, Yi, Xiong, Shaoxiang, Wang, Jianping, Sadler, P. J. and Wang, Fuyi (2009) Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes. Chemistry - A European Journal, Vol.15 (No.27). pp. 6586-6594. doi:10.1002/chem.200900699 ISSN 0947-6539.
Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC)
Xie, Ming-jin, Zhu, Ming-rong, Lu, Chun-Mei, Jin, Yi, Gao, Li-Hui, Li, Ling, Zhou, Jie, Li, Fan-fang, Zhao, Qi Hua, Liu, Hong-Ke, Sadler, P. J. and Sanchez-Cano, Carlos (2017) Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV. Journal of Inorganic Biochemistry, 175 . pp. 29-35. doi:10.1016/j.jinorgbio.2017.06.014 ISSN 0162-0134.
Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505 ISSN 1433-7851.
Wu, Kui, Luo, Qun, Hu, Wenbing, Li, Xianchan, Wang, Fuyi, Xiong, Shaoxiang and Sadler, P. J. (2012) Mechanism of interstrand migration of organoruthenium anticancer complexes within a DNA duplex. Metallomics, Vol.4 (No.2). pp. 139-148. doi:10.1039/c2mt00162d ISSN 1756-5901.
Han, Yumiao, Luo, Qun, Hao, Xiang, Li, Xianchan, Wang, Fuyi, Hu, Wenbing, Wu, Kui, Lü, Shuang and Sadler, P. J. (2011) Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide — a model for the active-site cysteine of protein tyrosine phosphatase 1B. Dalton Transactions, Vol.40 (No.43). pp. 11519-11529. doi:10.1039/c1dt11189b ISSN 1477-9226.
Hu, Wenbing, Luo, Qun, Wu, Kui, Li, Xianchan, Wang, Fuyi, Chen, Yi, Ma, Xiaoyan, Wang, Jianping, Liu, Jianan, Xiong, Shaoxiang and Sadler, P. J. (2011) The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin. Chemical Communications, Vol.47 (No.21). pp. 6006-6008. doi:10.1039/c1cc11627d ISSN 1359-7345.
Higher Education Funding Council for England (HEFCE)
Farrer, Nicola J., Monk , Nicholas, Heron, Jonathan, Lough, Julie Ann and Sadler, P. J. (2010) (RSC)(2) : chemistry, performance, and pedagogy - an interactive approach to periodic trends. Chemistry Education Research and Practice, Vol.11 (No.4). pp. 308-313. doi:10.1039/c0rp90011g ISSN 1109-4028.
Institute of Advanced Studies (IAS)
Hearn, Jessica M., Romero-Canelón, Isolda, Qamar, Bushra, Liu, Zhe , Hands-Portman, Ian and Sadler, P. J. (2013) Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis. ACS Chemical Biology, Volume 8 (Number 6). pp. 1335-1343. doi:10.1021/cb400070a ISSN 1554-8929.
Instituto de Salud Carlos III
Barragán, Flavia, Carrion-Salip, Dolors, Gómez-Pinto, Irene, González-Cantó, Alejandro, Sadler, P. J., de Llorens, Rafael, Moreno, Virtudes, González, Carlos A., Massaguer, Anna and Marchán, Vicente (2012) Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes. Bioconjugate Chemistry, Vol.23 (No.9). pp. 1838-1855. doi:10.1021/bc300173h ISSN 1043-1802.
JSSF
Liu, Hong-Ke, Parkinson, J. A. (John A.), Bella, Juraj, Wang, Fuyi and Sadler, P. J. (2010) Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene Ru-II anticancer complex. Chemical Science, Vol.1 (No.2). pp. 258-270. doi:10.1039/c0sc00175a ISSN 2041-6520.
Japan Securities Scholarship Foundation (JSSF)
Liu, Hong-Ke and Sadler, P. J. (2011) Metal complexes as DNA intercalators. Accounts of Chemical Research, Vol.44 (No.5). pp. 349-359. doi:10.1021/ar100140e ISSN 0001-4842.
Körber-Stiftung
Chen, Jocelyn S. Y., Euser, Tijmen G., Farrer, Nicola J., Sadler, P. J., Scharrer, Michael and Russell, Philip St. J. (2010) Photochemistry in photonic crystal fiber nanoreactors. Chemistry - A European Journal, Vol.16 (No.19). pp. 5607-5612. doi:10.1002/chem.201000496 ISSN 0947-6539.
Ronconi, Luca and Sadler, P. J. (2008) Applications of heteronuclear NMR spectroscopy in biological and medicinal inorganic chemistry. Coordination Chemistry Reviews, Vol.252 (No.21-22). pp. 2239-2277. ISSN 0010-8545 doi:10.1016/j.ccr.2008.01.016
Euser, T. G., Chen, J. S. Y., Scharrer, M., Russell, Philip St. J., Farrer, Nicola J. and Sadler, P. J. (2008) Quantitative broadband chemical sensing in air-suspended solid-core fibers. Journal of Applied Physics, Vol.103 (No.10). p. 103108. doi:10.1063/1.2924408 ISSN 0021-8979.
Ronconi, Luca and Sadler, P. J. (2008) Unprecedented carbon–carbon bond formation induced by photoactivation of a platinum(iv)-diazido complex. Chemical Communications (2). pp. 235-237. doi:10.1039/b714216a ISSN 1359-7345.
Körber-Stiftung (KS)
Unterkofler, S., McQuitty, Ruth J., Euser, T. G., Farrer, Nicola J., Sadler, P. J. and Russell, P. St.J. (2012) Microfluidic integration of photonic crystal fibers for online photochemical reaction analysis. Optics Letters, Volume 37 (Number 11). pp. 1952-1954. doi:10.1364/OL.37.001952 ISSN 0146-9592.
Pizarro, Ana M. and Sadler, P. J. (2009) Unusual DNA binding modes for metal anticancer complexes. Biochimie, Vol.91 (No.10). pp. 1198-1211. doi:10.1016/j.biochi.2009.03.017 ISSN 0300-9084.
Leverhulme Trust (LT)
Pitto-Barry, Anaïs, Sadler, P. J. and Barry, Nicolas P. E. (2016) Dynamics of formation of Ru, Os, Ir and Au metal nanocrystals on doped graphitic surfaces. Chemical Communications, 52 (20). pp. 3895-3898. c5cc09564f. doi:10.1039/c5cc09564f ISSN 1359-7345.
Romero-Canelón, Isolda, Phoenix, Ben, Pitto-Barry, Anaïs, Tran, Johanna, Soldevila-Barreda, Joan J., Kirby, Nigel, Green, Stuart, Sadler, P. J. and Barry, Nicolas P. E. (2015) Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT). Journal of organometallic chemistry, 796 . pp. 17-25. doi:10.1016/j.jorganchem.2015.05.011 ISSN 0022-328X.
Pitto-Barry, Anaïs, Alves Perdigão, Luis M., Walker, Marc, Lawrence, James M., Costantini, Giovanni, Sadler, P. J. and Barry, Nicolas P. E. (2015) Synthesis and controlled growth of osmium nanoparticles by electron irradiation. Dalton Transactions, 44 (47). pp. 20308-20311. doi:10.1039/c5dt03205a ISSN 1477-9226.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Tran, Johanna, Spencer, Simon E. F., Johansen, Adam M., Sanchez, Ana M., Dove, Andrew P., O’Reilly, Rachel K., Deeth, Robert J., Beanland, R. and Sadler, P. J. (2015) Osmium atoms and Os2 molecules move faster on selenium-doped compared to sulfur-doped boronic graphenic surfaces. Chemistry of Materials, 27 (14). pp. 5100-5105. doi:10.1021/acs.chemmater.5b01853 ISSN 0897-4756.
Coverdale, James P. C., Sanchez-Cano, Carlos, Clarkson, Guy J., Soni, Rina, Wills, Martin and Sadler, P. J. (2015) Easy to synthesize, robust organo-osmium asymmetric transfer hydrogenation catalysts. Chemistry - A European Journal, 21 (22). pp. 8043-8046. doi:10.1002/chem.201500534 ISSN 0947-6539.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f ISSN 0301-7249.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Sánchez, Ana M., Dove, Andrew P., Procter, Richard J., Soldevila-Barreda, Joan J., Kirby, Nigel, Hands-Portman, Ian, Smith, Corinne J., O'Reilly, Rachel K., Beanland, R. and Sadler, P. J. (2014) Fabrication of crystals from single metal atoms. Nature Communications, Volume 5 . Article number 3851 . doi:10.1038/ncomms4851 ISSN 2041-1723.
Li, Huilin, Wells, Stephen A., Jimenez-Roldan, J. Emilio, Römer, Rudolf A., Zhao, Yao, (Researcher in chemistry), Sadler, P. J. and O'Connor, Peter B. (2012) Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Science, Volume 21 (Number 9). pp. 1269-1279. doi:10.1002/pro.2111 ISSN 0961-8368.
Marie Curie Integration Grant
Smith, Nichola A., Zhang, Pingyu, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2017) Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes. Inorganica Chimica Acta, 454 . pp. 240-246. doi:10.1016/j.ica.2016.06.014 ISSN 00201693.
Marie Curie Intra-European Fellowship (IEF)
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Ronconi, Luca, Pizarro, Ana M., McQuitty, Ruth J. and Sadler, P. J. (2011) Insights into the acid-base properties of PtIV-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry - A European Journal, Volume 17 (Number 43). pp. 12051-12058. doi:10.1002/chem.201002792 ISSN 0947-6539.
Medical Research Council (Great Britain) (MRC)
Ronconi, Luca and Sadler, P. J. (2011) Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2]. Dalton Transactions, Vol.40 (No.1). pp. 262-268. doi:10.1039/c0dt00546k ISSN 1477-9226.
Fu, Y. (Ying), Habtemariam, Abraha, Pizarro, Ana M., Rijt, Sabine H. van, Healey, David J., Cooper, Patricia A., Shnyder, Steven D., Clarkson, Guy J. and Sadler, P. J. (2010) Organometallic osmium arene complexes with potent cancer cell cytotoxicity. Journal of Medicinal Chemistry, Vol.53 (No.22). pp. 8192-8196. doi:10.1021/jm100560f ISSN 0022-2623.
Cubo, Leticia, Pizarro, Ana M., Quiroga, Adoracion G., Salassa, Luca, Navarro-Ranninger, Carmen and Sadler, P. J. (2010) Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides. Journal of Inorganic Biochemistry, Vol.104 (No.9). pp. 909-918. doi:10.1016/j.jinorgbio.2010.04.009 ISSN 0162-0134.
Chen, Jocelyn S. Y., Euser, Tijmen G., Farrer, Nicola J., Sadler, P. J., Scharrer, Michael and Russell, Philip St. J. (2010) Photochemistry in photonic crystal fiber nanoreactors. Chemistry - A European Journal, Vol.16 (No.19). pp. 5607-5612. doi:10.1002/chem.201000496 ISSN 0947-6539.
Ruiu, Tiziana, Garino, Claudio, Salassa, Luca, Pizarro, Ana M., Nervi, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) Spectroscopic and computational study of ligand photodissociation from [Ru(dipyrido[3,2-a:2',3'-c]phenazine)(4-aminopyridine)(4)](2+). European Journal of Inorganic Chemistry, Vol.2010 (No.8). pp. 1186-1195. doi:10.1002/ejic.200900990 ISSN 1434-1948.
Farrer, Nicola J., Woods, Julie A., Munk, Vivienne P., Mackay, Fiona S. and Sadler, P. J. (2010) Photocytotoxic trans-Diam(m)ine platinum(IV) diazido complexes more potent than their cis isomers. Chemical Research in Toxicology, Vol.23 (No.2). pp. 413-421. doi:10.1021/tx900372p ISSN 0893-228X.
Rijt, Sabine H. van, Mukherjee, Arindam, Pizarro, Ana M. and Sadler, P. J. (2010) Cytotoxicity, hydrophobicity, uptake, and distribution of osmium(II) anticancer complexes in ovarian cancer cells. Journal of Medicinal Chemistry, Vol.53 (No.2). pp. 840-849. doi:10.1021/jm901556u ISSN 0022-2623.
Rijt, Sabine H. van and Sadler, P. J. (2009) Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discovery Today, Vol.14 (No.23-24). pp. 1089-1097. doi:10.1016/j.drudis.2009.09.003 ISSN 1359-6446.
Pizarro, Ana M. and Sadler, P. J. (2009) Unusual DNA binding modes for metal anticancer complexes. Biochimie, Vol.91 (No.10). pp. 1198-1211. doi:10.1016/j.biochi.2009.03.017 ISSN 0300-9084.
Mackay, Fiona S., Farrer, Nicola J., Salassa, Luca, Tai, Hui-Chung, Deeth, Robert J., Moggach, Stephen A., Wood, P. A. (Peter A.), Parsons, S. (Simon) and Sadler, P. J. (2009) Synthesis, characterisation and photochemistry of PtIV pyridyl azido acetato complexes. Dalton Transactions, Vol.13 . pp. 2315-2325. doi:10.1039/b820550g ISSN 1477-9226.
Farrer, Nicola J., Salassa, Luca and Sadler, P. J. (2009) Photoactivated chemotherapy (PACT) : the potential of excited-state d-block metals in medicine. Dalton Transactions, Vol.48 . pp. 10690-10701. doi:10.1039/b917753a ISSN 1477-9226.
Medical Research Council (Great Britain) (MRC)
Farrer, Nicola J., Woods, Julie A., Salassa, Luca, Zhao, Yao, (Researcher in chemistry), Robinson, Kim S., Clarkson, Guy J., Mackay, Fiona S. and Sadler, P. J. (2010) A potent trans-diimine platinum anticancer complex photoactivated by visible light. Angewandte Chemie International Edition, Vol.49 (No.47). pp. 8905-8908. doi:10.1002/anie.201003399 ISSN 1433-7851.
Ministerstvo zdravotnictví České republiky [Ministry of Health of the Czech Republic] (MZCR)
Bugarcic, Tijana, Habtemariam, Abraha, Stepankova, Jana, Heringova, Pavla, Kasparkova, Jana, Deeth, Robert J., Johnstone, Russell D. L., Prescimone, Alessandro, Parkin, Andrew, Parsons, S. (Simon), Brabec, V. (Viktor) and Sadler, P. J. (2008) The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes. Inorganic Chemistry, Vol.47 (No.24). pp. 11470-11486. doi:10.1021/ic801361m ISSN 0020-1669.
Bugarcic, Tijana, Novakova, Olga, Halamikova, Anna, Zerzankova, Lenka, Vrana, Oldrich, Kasparkova, Jana, Habtemariam, Abraha, Parsons, S. (Simon), Sadler, P. J. and Brabec, V. (Viktor) (2008) Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes. Journal of Medicinal Chemistry, Vol.51 (No.17). pp. 5310-5319. doi:10.1021/jm8003043 ISSN 0022-2623.
Kostrhunova, Hana, Florian, Jakub, Novakova, Olga, Peacock, Anna F. A., Sadler, P. J. and Brabec, V. (Viktor) (2008) DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media. Journal of Medicinal Chemistry, Vol.51 (No.12). pp. 3635-3643. doi:10.1021/jm701538w ISSN 0022-2623.
National Center for Research Resources (U.S.) (NCRR)
Ross, Allison, Soares, Dinesh C., Covelli, Danielle, Pannecouque, Christophe, Budd, Laura, Collins, Anna, Robertson, N. (Neil), Parsons, S. (Simon), De Clercq, Erik, Kennepohl, Pierre and Sadler, P. J. (2010) Oxovanadium(IV) cyclam and bicyclam complexes : potential CXCR4 receptor antagonists. Inorganic Chemistry, Vol.49 (No.3). pp. 1122-1132. doi:10.1021/ic9020614 ISSN 0020-1669.
National Center for Research Resources (U.S.). Biomedical Technology
Ross, Allison, Soares, Dinesh C., Covelli, Danielle, Pannecouque, Christophe, Budd, Laura, Collins, Anna, Robertson, N. (Neil), Parsons, S. (Simon), De Clercq, Erik, Kennepohl, Pierre and Sadler, P. J. (2010) Oxovanadium(IV) cyclam and bicyclam complexes : potential CXCR4 receptor antagonists. Inorganic Chemistry, Vol.49 (No.3). pp. 1122-1132. doi:10.1021/ic9020614 ISSN 0020-1669.
National Institutes of Health (NIH)
Li, Huilin, Snelling, Jonathon R., Barrow, Mark P., Scrivens, James H., Sadler, P. J. and O’Connor, Peter B. (2014) Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins. Journal of The American Society for Mass Spectrometry, 25 (7). pp. 1217-1227. doi:10.1007/s13361-014-0877-0 ISSN 1044-0305.
National Institutes of Health (U.S.) (NIH)
Silva Sousa, Eduardo Henrique, Ridnour, Lisa A., Gouveia, Florêncio S., Silva da Silva, Carlos Daniel, Wink, David A., de França Lopes, Luiz Gonzaga and Sadler, P. J. (2016) Thiol-Activated HNO release from a ruthenium antiangiogenesis complex and HIF-1α inhibition for cancer therapy. ACS Chemical Biology, 11 (7). pp. 2057-2065. doi:10.1021/acschembio.6b00222 ISSN 1554-8929.
Li, Huilin, Wells, Stephen A., Jimenez-Roldan, J. Emilio, Römer, Rudolf A., Zhao, Yao, (Researcher in chemistry), Sadler, P. J. and O'Connor, Peter B. (2012) Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Science, Volume 21 (Number 9). pp. 1269-1279. doi:10.1002/pro.2111 ISSN 0961-8368.
Li, Huilin, Zhao, Yao, Phillips, Hazel I. A., Qi, Yulin, Lin, Tzu-Yung, Sadler, P. J. and O'Connor, Peter B. (2011) Mass spectrometry evidence for cisplatin as a protein cross-linking reagent. Analytical Chemistry, Vol.83 (No.13). pp. 5369-5376. doi:10.1021/ac200861k ISSN 0003-2700.
Li, Huilin, Lin, Tzu-Yung, Van Orden, Steve L., Zhao, Yao, (Researcher in chemistry), Barrow, Mark P., Pizarro, Ana M., Qi, Yulin, Sadler, P. J. and O’Connor, Peter B. (2011) Use of top-down and bottom-up fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs. Analytical Chemistry, Vol.83 (No.24). pp. 9507-9515. doi:10.1021/ac202267g ISSN 0003-2700.
Ross, Allison, Soares, Dinesh C., Covelli, Danielle, Pannecouque, Christophe, Budd, Laura, Collins, Anna, Robertson, N. (Neil), Parsons, S. (Simon), De Clercq, Erik, Kennepohl, Pierre and Sadler, P. J. (2010) Oxovanadium(IV) cyclam and bicyclam complexes : potential CXCR4 receptor antagonists. Inorganic Chemistry, Vol.49 (No.3). pp. 1122-1132. doi:10.1021/ic9020614 ISSN 0020-1669.
National Research Foundation (South Africa) (NRF)
Chellan , Prinessa and Sadler, P. J. (2015) The elements of life and medicines. Philosophical Transactions of the Royal Society A : Mathematical, Physical and Engineering Sciences, Volume 373 (Number 2037). Article number 20140182. doi:10.1098/rsta.2014.0182 ISSN 1364-503X.
National Science Foundation (U.S.) (NSF)
Liu, Hong-Ke and Sadler, P. J. (2011) Metal complexes as DNA intercalators. Accounts of Chemical Research, Vol.44 (No.5). pp. 349-359. doi:10.1021/ar100140e ISSN 0001-4842.
Liu, Hong-Ke, Parkinson, J. A. (John A.), Bella, Juraj, Wang, Fuyi and Sadler, P. J. (2010) Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene Ru-II anticancer complex. Chemical Science, Vol.1 (No.2). pp. 258-270. doi:10.1039/c0sc00175a ISSN 2041-6520.
Natural Sciences and Engineering Research Council Canada (NSERC)
Sriskandakumar, Thamayanthy, Petzold, Holm, Bruijnincx, Pieter C. A., Habtemariam, Abraha, Sadler, P. J. and Kennepohl, Pierre (2009) Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT. Journal of the American Chemical Society, Vol.131 (No.37). pp. 13355-13361. doi:10.1021/ja903405z ISSN 0002-7863.
Nederlandse Organisatie voor Wetenschappelijk Onderzoek [Nederlands Organization for Scientific Research] (NWO)
Sriskandakumar, Thamayanthy, Petzold, Holm, Bruijnincx, Pieter C. A., Habtemariam, Abraha, Sadler, P. J. and Kennepohl, Pierre (2009) Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT. Journal of the American Chemical Society, Vol.131 (No.37). pp. 13355-13361. doi:10.1021/ja903405z ISSN 0002-7863.
Nederlandse Organisatie voor Wetenschappelijk Onderzoek [Netherlands Organisation for Scientific Research] (NWO)
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Fletcher, Sally A., Kisova, Anna, Vrana, Oldrich, Salassa, Luca, Bruijnincx, Pieter C. A., Clarkson, Guy J., Brabec, V. (Viktor) and Sadler, P. J. (2011) Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry, Vol.54 (No.8). pp. 3011-3026. doi:10.1021/jm2000932 ISSN 0022-2623.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2009) Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design. Advances in Inorganic Chemistry, Vol.61 . pp. 1-62. doi:10.1016/S0898-8838(09)00201-3 ISSN 0898-8838.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2008) New trends for metal complexes with anticancer activity. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 197-206. doi:10.1016/j.cbpa.2007.11.013 ISSN 1367-5931.
Novozymes Biopharma, Ltd
Blindauer, Claudia A., Harvey, Ian, Bunyan, Kerry E., Stewart, Alan J., Sleep, Darrell, Harrison, David J., Berezenko, Stephen and Sadler, P. J. (2009) Structure, properties, and engineering of the major zinc binding site on human albumin. Journal of Biological Chemistry, Vol.284 (No.34). pp. 23116-23124. doi:10.1074/jbc.M109.003459 ISSN 0021-9258.
ORS
Petzold, Holm, Xu, Jingjing and Sadler, P. J. (2008) Metal and ligand control of sulfenate reactivity : arene ruthenium thiolato-mono-S-oxides. Angewandte Chemie International Edition, Vol.47 (No.16). pp. 3008-3011. doi:10.1002/anie.200705342 ISSN 1433-7851.
Oncosence Ltd.
Bugarcic, Tijana, Habtemariam, Abraha, Deeth, Robert J., Fabbiani, Francesca P. A., Parsons, S. (Simon) and Sadler, P. J. (2009) Ruthenium(II) arene anticancer complexes with redox-active diamine ligands. Inorganic Chemistry, Vol.48 (No.19). pp. 9444-9453. doi:10.1021/ic9013366 ISSN 0020-1669.
Oncosense Ltd.
Liu, Hong-Ke, Parkinson, J. A. (John A.), Bella, Juraj, Wang, Fuyi and Sadler, P. J. (2010) Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene Ru-II anticancer complex. Chemical Science, Vol.1 (No.2). pp. 258-270. doi:10.1039/c0sc00175a ISSN 2041-6520.
Wang, Fuyi, Habtemariam, Abraha, van der Geer, Erwin P. L., Deeth, Robert J., Gould, Robert O., Parsons, Simon and Sadler, P. J. (2009) Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex. Journal of Biological Inorganic Chemistry, Vol.14 (No.7). pp. 1065-1076. doi:10.1007/s00775-009-0549-x ISSN 0949-8257.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2009) Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design. Advances in Inorganic Chemistry, Vol.61 . pp. 1-62. doi:10.1016/S0898-8838(09)00201-3 ISSN 0898-8838.
Dougan, Sarah J., Habtemariam, Abraha, McHale, Sarah E., Parsons, S. (Simon) and Sadler, P. J. (2008) Catalytic organometallic anticancer complexes. Proceedings of the National Academy of Sciences of the United States of America, Vol.105 (No.33). pp. 11628-11633. doi:10.1073/pnas.0800076105 ISSN 0027-8424.
Castellano-Castillo, Maria, Kostrhunova, Hana, Marini, Victoria, Kasparkova, Jana, Sadler, P. J., Malinge, Jean-Marc and Brabec, V. (Viktor) (2008) Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes. Journal of Biological Inorganic Chemistry, Vol.13 (No.6). pp. 993-999. doi:10.1007/s00775-008-0386-3 ISSN 0949-8257.
Wang, Fuyi, Weidt, Stefan, Xu, Jingjing, Mackay, C. Logan, Langridge-Smith, Pat R. R. and Sadler, P. J. (2008) Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography fourier transform ion cyclotron mass spectrometry combined with 18O-labeling. Journal of The American Society for Mass Spectrometry, Vol.19 (No.4). pp. 544-549. doi:10.1016/j.jasms.2007.12.002 ISSN 1044-0305.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2008) New trends for metal complexes with anticancer activity. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 197-206. doi:10.1016/j.cbpa.2007.11.013 ISSN 1367-5931.
Overseas Research Students Award Scheme (ORSAS)
Bugarcic, Tijana, Habtemariam, Abraha, Deeth, Robert J., Fabbiani, Francesca P. A., Parsons, S. (Simon) and Sadler, P. J. (2009) Ruthenium(II) arene anticancer complexes with redox-active diamine ligands. Inorganic Chemistry, Vol.48 (No.19). pp. 9444-9453. doi:10.1021/ic9013366 ISSN 0020-1669.
Overseas Research Students Awards Scheme (ORSAS)
Liu, Zhe and Sadler, P. J. (2014) Organoiridium complexes : anticancer agents and catalysts. Accounts of chemical research, 47 (4). pp. 1174-1185. doi:10.1021/ar400266c ISSN 0001-4842.
Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505 ISSN 1433-7851.
Betanzos-Lara, Soledad, Novakova, Olga, Deeth, Robert J., Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor), Sadler, P. J. and Habtemariam, Abraha (2012) Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity. JBIC Journal of Biological Inorganic Chemistry, 17 (7). pp. 1033-1051. doi:10.1007/s00775-012-0917-9 ISSN 0949-8257.
Tai, Hui-Chung, Brodbeck, Ralf, Kasparkova, Jana, Farrer, Nicola J., Brabec, V. (Viktor), Sadler, P. J. and Deeth, Robert J. (2012) Combined theoretical and computational study of interstrand DNA guanine–guanine cross-linking bytrans-[Pt(pyridine)2] derived from the photoactivated prodrugtrans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]. Inorganic Chemistry, Vol.51 (No.12). pp. 6830-6841. doi:10.1021/ic3005745 ISSN 0020-1669.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha, Novakova, Olga, Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor) and Sadler, P. J. (2012) Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics, Vol.31 (No.9). pp. 3466-3479. doi:10.1021/om201177y ISSN 0276-7333.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics, Vol.30 (No.17). pp. 4702-4710. doi:10.1021/om2005468 ISSN 0276-7333.
Betanzos-Lara, Soledad, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic cis-Dichlorido ruthenium(II) ammine complexes. European Journal of Inorganic Chemistry, Volume 2011 (Number 21). pp. 3257-3264. doi:10.1002/ejic.201100250 ISSN 1434-1948.
Liu, Zhe , Salassa, Luca, Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorganic Chemistry, Vol.50 (No.12). pp. 5777-5783. doi:10.1021/ic200607j ISSN 0020-1669.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Fletcher, Sally A., Kisova, Anna, Vrana, Oldrich, Salassa, Luca, Bruijnincx, Pieter C. A., Clarkson, Guy J., Brabec, V. (Viktor) and Sadler, P. J. (2011) Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry, Vol.54 (No.8). pp. 3011-3026. doi:10.1021/jm2000932 ISSN 0022-2623.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2009) Photocontrolled nucleobase binding to an organometallic Ru-II arene complex. Chemical Communications (No.43). pp. 6622-6624. doi:10.1039/b914153g ISSN 1359-7345.
Piedmont (Italy)
Salassa, Luca, Ruiu, Tiziana, Garino, Claudio, Pizarro, Ana M., Bardelli, Fabrizio, Gianolio, Diego, Westendorf, Aron, Bednarski, Patrick J., Lamberti, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) EXAFS, DFT, light-induced nucleobase binding, and cytotoxicity of the photoactive complex cis-[Ru(bpy)2(CO)Cl]+. Organometallics, Vol.29 (No.4). pp. 6703-6710. doi:10.1021/om100734y ISSN 0276-7333.
Ruiu, Tiziana, Garino, Claudio, Salassa, Luca, Pizarro, Ana M., Nervi, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) Spectroscopic and computational study of ligand photodissociation from [Ru(dipyrido[3,2-a:2',3'-c]phenazine)(4-aminopyridine)(4)](2+). European Journal of Inorganic Chemistry, Vol.2010 (No.8). pp. 1186-1195. doi:10.1002/ejic.200900990 ISSN 1434-1948.
Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Liu, Hong-Ke and Sadler, P. J. (2011) Metal complexes as DNA intercalators. Accounts of Chemical Research, Vol.44 (No.5). pp. 349-359. doi:10.1021/ar100140e ISSN 0001-4842.
Research Councils UK (RCUK)
Petzold, Holm and Sadler, P. J. (2008) Oxidation induced by the antioxidant glutathione (GSH). Chemical Communications (No.37). pp. 4413-4415. doi:10.1039/b805358h ISSN 1359-7345.
Petzold, Holm, Xu, Jingjing and Sadler, P. J. (2008) Metal and ligand control of sulfenate reactivity : arene ruthenium thiolato-mono-S-oxides. Angewandte Chemie International Edition, Vol.47 (No.16). pp. 3008-3011. doi:10.1002/anie.200705342 ISSN 1433-7851.
Wang, Fuyi, Weidt, Stefan, Xu, Jingjing, Mackay, C. Logan, Langridge-Smith, Pat R. R. and Sadler, P. J. (2008) Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography fourier transform ion cyclotron mass spectrometry combined with 18O-labeling. Journal of The American Society for Mass Spectrometry, Vol.19 (No.4). pp. 544-549. doi:10.1016/j.jasms.2007.12.002 ISSN 1044-0305.
Research Councils UK (RCUK)
Scotcher, Jenna, Clarke, D. J., Weidt, Stefan K., Mackay, C. Logan, Hupp, Theodore, Sadler, P. J. and Langridge-Smith, Pat R. R. (2011) Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry. Journal of The American Society for Mass Spectrometry, Vol.22 (No.5). pp. 888-897. doi:10.1007/s13361-011-0088-x ISSN 1044-0305.
Royal Society (Great Britain)
Greenough, Simon E., Horbury, Michael D., Smith, Nichola A., Sadler, P. J., Paterson, Martin J. and Stavros, Vasilios G. (2016) Excited-state dynamics of a two-photon-activatable ruthenium prodrug. ChemPhysChem, 17 (2). pp. 221-224. doi:10.1002/cphc.201501075 ISSN 1439-4235.
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) Allosteric inhibition of cobalt binding to albumin by fatty acids : implications for the detection of myocardial ischemia. Journal of Medicinal Chemistry, Vol.55 (No.9). pp. 4425-4430. doi:10.1021/jm3003137 ISSN 0022-2623.
Stewart, Alan J., Blindauer, Claudia A. and Sadler, P. J. (2009) Plasma fatty acid levels may regulate the Zn2+-dependent activities of histidine-rich glycoprotein. Biochimie, Vol.91 (No.11-12). pp. 1518-1522. doi:10.1016/j.biochi.2009.08.002 ISSN 0300-9084.
Blindauer, Claudia A., Harvey, Ian, Bunyan, Kerry E., Stewart, Alan J., Sleep, Darrell, Harrison, David J., Berezenko, Stephen and Sadler, P. J. (2009) Structure, properties, and engineering of the major zinc binding site on human albumin. Journal of Biological Chemistry, Vol.284 (No.34). pp. 23116-23124. doi:10.1074/jbc.M109.003459 ISSN 0021-9258.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2009) Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design. Advances in Inorganic Chemistry, Vol.61 . pp. 1-62. doi:10.1016/S0898-8838(09)00201-3 ISSN 0898-8838.
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317 ISSN 0300-5127.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2008) New trends for metal complexes with anticancer activity. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 197-206. doi:10.1016/j.cbpa.2007.11.013 ISSN 1367-5931.
Liang, Xiangyang, Parkinson, J. A. (John A.), Weishäupl, Michael, Gould, Robert O., Paisey, Stephen J., Park, Hye-seo, Hunter, Tina M., Blindauer, Claudia A., Parsons, S. (Simon) and Sadler, P. J. (2002) Structure and dynamics of metallomacrocycles : recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society, Vol.124 (No.31). pp. 9105-9112. doi:10.1021/ja0260723 ISSN 0002-7863.
Royal Society of Chemistry
Li, Huilin, Snelling, Jonathon R., Barrow, Mark P., Scrivens, James H., Sadler, P. J. and O’Connor, Peter B. (2014) Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins. Journal of The American Society for Mass Spectrometry, 25 (7). pp. 1217-1227. doi:10.1007/s13361-014-0877-0 ISSN 1044-0305.
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [Swiss National Science Foundation] (SNSF)
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f ISSN 0301-7249.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Sánchez, Ana M., Dove, Andrew P., Procter, Richard J., Soldevila-Barreda, Joan J., Kirby, Nigel, Hands-Portman, Ian, Smith, Corinne J., O'Reilly, Rachel K., Beanland, R. and Sadler, P. J. (2014) Fabrication of crystals from single metal atoms. Nature Communications, Volume 5 . Article number 3851 . doi:10.1038/ncomms4851 ISSN 2041-1723.
Liu, Zhe , Romero-Canelón, Isolda, Qamar, Bushra, Hearn, Jessica M., Habtemariam, Abraha, Barry, Nicolas P. E., Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2014) The potent oxidant anticancer activity of organoiridium catalysts. Angewandte Chemie International Edition, Volume 53 (Number 15). pp. 3941-3946. doi:10.1002/anie.201311161 ISSN 1433-7851.
Barry, Nicolas P. E. and Sadler, P. J. (2012) Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium : biological relevance and synthetic strategies. Chemical Society Reviews, Vol.41 (No.8). pp. 3264-3279. doi:10.1039/c2cs15300a ISSN 0306-0012.
Science City Research Alliance
Millett, Adam J., Habtemariam, Abraha, Romero-Canelón, Isolda, Clarkson, Guy J. and Sadler, P. J. (2015) Contrasting anticancer activity of half-sandwich iridium(III) complexes bearing functionally diverse 2-phenylpyridine ligands. Organometallics, Volume 34 (Number 11). pp. 2683-2694. doi:10.1021/acs.organomet.5b00097 ISSN 0276-7333.
Liu, Zhe , Romero-Canelón, Isolda, Qamar, Bushra, Hearn, Jessica M., Habtemariam, Abraha, Barry, Nicolas P. E., Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2014) The potent oxidant anticancer activity of organoiridium catalysts. Angewandte Chemie International Edition, Volume 53 (Number 15). pp. 3941-3946. doi:10.1002/anie.201311161 ISSN 1433-7851.
Fu, Ying, Soni, Rina, Romero, Maria, Pizarro, Ana M., Salassa, Luca, Clarkson, Guy J., Hearn, Jessica M., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2013) Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity. Chemistry - A European Journal, Volume 19 (Number 45). pp. 15199-15209. doi:10.1002/chem.201302183 ISSN 0947-6539.
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Ronconi, Luca, Pizarro, Ana M., McQuitty, Ruth J. and Sadler, P. J. (2011) Insights into the acid-base properties of PtIV-diazidodiam(m)inedihyroxido complexes from multinuclear NMR spectroscopy. Chemistry - A European Journal, Volume 17 (Number 43). pp. 12051-12058. doi:10.1002/chem.201002792 ISSN 0947-6539.
Betanzos-Lara, Soledad, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic cis-Dichlorido ruthenium(II) ammine complexes. European Journal of Inorganic Chemistry, Volume 2011 (Number 21). pp. 3257-3264. doi:10.1002/ejic.201100250 ISSN 1434-1948.
Science Foundation Ireland (SFI)
Ude, Ziga, Romero-Canelón, Isolda, Twamley, Brendan, Fitzgerald Hughes, Deirdre, Sadler, P. J. and Marmion, Celine J. (2016) A novel dual-functioning ruthenium(II)–arene complex of an anti-microbial ciprofloxacin derivative — anti-proliferative and anti-microbial activity. Journal of Inorganic Biochemistry, 160 . pp. 210-217. doi:10.1016/j.jinorgbio.2016.02.018 ISSN 0162-0134.
Scottish Enterprise
Farrer, Nicola J., Woods, Julie A., Munk, Vivienne P., Mackay, Fiona S. and Sadler, P. J. (2010) Photocytotoxic trans-Diam(m)ine platinum(IV) diazido complexes more potent than their cis isomers. Chemical Research in Toxicology, Vol.23 (No.2). pp. 413-421. doi:10.1021/tx900372p ISSN 0893-228X.
Mackay, Fiona S., Moggach, Stephen A., Collins, Anna, Parsons, S. (Simon) and Sadler, P. J. (2009) Photoactive trans ammine/amine diazido platinum(IV) complexes. Inorganica Chimica Acta, Vol.362 (No.3). pp. 811-819. doi:10.1016/j.ica.2008.02.039 ISSN 0020-1693.
Phillips, Hazel I. A., Ronconi, Luca and Sadler, P. J. (2009) Photoinduced reactions of cis,trans,cis-[Pt-IV(N-3)(2)(OH)(2)(NH3)(2)] with 1-methylimidazole. Chemistry: A European Journal, Vol.15 (No.7). pp. 1588-1596. doi:10.1002/chem.200802206 ISSN 0947-6539.
Ronconi, Luca and Sadler, P. J. (2008) Unprecedented carbon–carbon bond formation induced by photoactivation of a platinum(iv)-diazido complex. Chemical Communications (2). pp. 235-237. doi:10.1039/b714216a ISSN 1359-7345.
Scottish Enterprise (SE)
Mackay, Fiona S., Farrer, Nicola J., Salassa, Luca, Tai, Hui-Chung, Deeth, Robert J., Moggach, Stephen A., Wood, P. A. (Peter A.), Parsons, S. (Simon) and Sadler, P. J. (2009) Synthesis, characterisation and photochemistry of PtIV pyridyl azido acetato complexes. Dalton Transactions, Vol.13 . pp. 2315-2325. doi:10.1039/b820550g ISSN 1477-9226.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2009) Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design. Advances in Inorganic Chemistry, Vol.61 . pp. 1-62. doi:10.1016/S0898-8838(09)00201-3 ISSN 0898-8838.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2008) New trends for metal complexes with anticancer activity. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 197-206. doi:10.1016/j.cbpa.2007.11.013 ISSN 1367-5931.
Seventh Framework Programme (European Commission) (FP6)
Salassa, Luca, Phillips, Hazel I. A. and Sadler, P. J. (2009) Decomposition pathways for the photoactivated anticancer complex cis,trans,cis-[Pt(N-3)(2)(OH)(2)(NH3)(2)] : insights from DFT calculations. Physical Chemistry Chemical Physics, Vol.11 (No.44). pp. 10311-10316. doi:10.1039/b912496a ISSN 1463-9076.
Seventh Framework Programme (European Commission) (FP7)
Greenough, Simon E., Horbury, Michael D., Smith, Nichola A., Sadler, P. J., Paterson, Martin J. and Stavros, Vasilios G. (2016) Excited-state dynamics of a two-photon-activatable ruthenium prodrug. ChemPhysChem, 17 (2). pp. 221-224. doi:10.1002/cphc.201501075 ISSN 1439-4235.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha, Novakova, Olga, Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor) and Sadler, P. J. (2012) Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics, Vol.31 (No.9). pp. 3466-3479. doi:10.1021/om201177y ISSN 0276-7333.
Westendorf, Aron, Zerzankova, Lenka, Salassa, Luca, Sadler, P. J., Brabec, V. (Viktor) and Bednarski, Patrick J. (2011) Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]. Journal of Inorganic Biochemistry, Vol.105 (No.5). pp. 652-662. doi:10.1016/j.jinorgbio.2011.01.003 ISSN 01620134.
Barragán, Flavia, López-Senín, Paula, Salassa, Luca, Betanzos-Lara, Soledad, Habtemariam, Abraha, Moreno, Virtudes, Sadler, P. J. and Marchán, Vicente (2011) Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex. Journal of the American Chemical Society, Vol.133 (No.35). pp. 14098-14108. doi:10.1021/ja205235m ISSN 0002-7863.
Salassa, Luca, Borfecchia, Elisa, Ruiu, Tiziana, Garino, Claudio, Gianolio, Diego, Gobetto, Roberto, Sadler, P. J., Cammarata, Marco, Wulff, Michael and Lamberti, Carlo (2010) Photo-induced pyridine substitution in cis-[Ru(bpy)(2)(py)(2)]Cl-2 : a snapshot by time-resolved X-ray solution scattering. Inorganic Chemistry, Vol.49 (No.23). pp. 11240-11248. doi:10.1021/ic102021k ISSN 0020-1669.
Salassa, Luca, Ruiu, Tiziana, Garino, Claudio, Pizarro, Ana M., Bardelli, Fabrizio, Gianolio, Diego, Westendorf, Aron, Bednarski, Patrick J., Lamberti, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) EXAFS, DFT, light-induced nucleobase binding, and cytotoxicity of the photoactive complex cis-[Ru(bpy)2(CO)Cl]+. Organometallics, Vol.29 (No.4). pp. 6703-6710. doi:10.1021/om100734y ISSN 0276-7333.
Cubo, Leticia, Pizarro, Ana M., Quiroga, Adoracion G., Salassa, Luca, Navarro-Ranninger, Carmen and Sadler, P. J. (2010) Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides. Journal of Inorganic Biochemistry, Vol.104 (No.9). pp. 909-918. doi:10.1016/j.jinorgbio.2010.04.009 ISSN 0162-0134.
Ruiu, Tiziana, Garino, Claudio, Salassa, Luca, Pizarro, Ana M., Nervi, Carlo, Gobetto, Roberto and Sadler, P. J. (2010) Spectroscopic and computational study of ligand photodissociation from [Ru(dipyrido[3,2-a:2',3'-c]phenazine)(4-aminopyridine)(4)](2+). European Journal of Inorganic Chemistry, Vol.2010 (No.8). pp. 1186-1195. doi:10.1002/ejic.200900990 ISSN 1434-1948.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2009) Photocontrolled nucleobase binding to an organometallic Ru-II arene complex. Chemical Communications (No.43). pp. 6622-6624. doi:10.1039/b914153g ISSN 1359-7345.
Salassa, Luca, Garino, Claudio, Salassa, Giovanni, Nervi, Carlo, Gobetto, Roberto, Lamberti, Carlo, Gianolio, Diego, Bizzarri, Ranieri and Sadler, P. J. (2009) Ligand-selective photodissociation from [Ru(bpy)(4AP)(4)](2+) : a spectroscopic and computational study. Inorganic Chemistry, Vol.48 (No.4). pp. 1469-1481. doi:10.1021/ic8015436 ISSN 0020-1669.
Ronconi, Luca and Sadler, P. J. (2008) Applications of heteronuclear NMR spectroscopy in biological and medicinal inorganic chemistry. Coordination Chemistry Reviews, Vol.252 (No.21-22). pp. 2239-2277. ISSN 0010-8545 doi:10.1016/j.ccr.2008.01.016
Ronconi, Luca and Sadler, P. J. (2008) Unprecedented carbon–carbon bond formation induced by photoactivation of a platinum(iv)-diazido complex. Chemical Communications (2). pp. 235-237. doi:10.1039/b714216a ISSN 1359-7345.
Spain. Instituto de Ciencias Matemáticas (ICMAT)
Smith, Nichola A., Zhang, Pingyu, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2017) Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes. Inorganica Chimica Acta, 454 . pp. 240-246. doi:10.1016/j.ica.2016.06.014 ISSN 00201693.
Spain. Ministerio de Ciencia e Innovación (MICINN)
Fu, Ying, Soni, Rina, Romero, Maria, Pizarro, Ana M., Salassa, Luca, Clarkson, Guy J., Hearn, Jessica M., Habtemariam, Abraha, Wills, Martin and Sadler, P. J. (2013) Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity. Chemistry - A European Journal, Volume 19 (Number 45). pp. 15199-15209. doi:10.1002/chem.201302183 ISSN 0947-6539.
Garino, Claudio, Gallo, Erik, Smolentsev, Nikolay, Glatzel, Pieter, Gobetto, Roberto, Lamberti, Carlo, Sadler, P. J. and Salassa, Luca (2012) Resonant X-ray emission spectroscopy reveals d–d ligand-field states involved in the self-assembly of a square-planar platinum complex. Physical Chemistry Chemical Physics, Vol.14 (No.44). pp. 15278-15281. doi:10.1039/c2cp42451g ISSN 1463-9076.
Spain. Ministerio de Economía y Competitividad [Ministry of Economy and Competitiveness] (MINECO)
Smith, Nichola A., Zhang, Pingyu, Salassa, Luca, Habtemariam, Abraha and Sadler, P. J. (2017) Synthesis, characterisation and dynamic behavior of photoactive bipyridyl ruthenium(II)-nicotinamide complexes. Inorganica Chimica Acta, 454 . pp. 240-246. doi:10.1016/j.ica.2016.06.014 ISSN 00201693.
Fu, Ying, Romero, Maria, Salassa, Luca, Cheng, Xi, Habtemariam, Abraha, Clarkson, Guy J., Prokes, Ivan, Rodger, Alison, Costantini, Giovanni and Sadler, P. J. (2016) Os2-Os4 switch controls DNA knotting and anticancer activity. Angewandte Chemie International Edition, 55 (31). pp. 8909-8912. doi:10.1002/anie.201602995 ISSN 1433-7851.
Spain. Ministerio de Educación y Ciencia (MEC)
Barragán, Flavia, Carrion-Salip, Dolors, Gómez-Pinto, Irene, González-Cantó, Alejandro, Sadler, P. J., de Llorens, Rafael, Moreno, Virtudes, González, Carlos A., Massaguer, Anna and Marchán, Vicente (2012) Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes. Bioconjugate Chemistry, Vol.23 (No.9). pp. 1838-1855. doi:10.1021/bc300173h ISSN 1043-1802.
Barragán, Flavia, López-Senín, Paula, Salassa, Luca, Betanzos-Lara, Soledad, Habtemariam, Abraha, Moreno, Virtudes, Sadler, P. J. and Marchán, Vicente (2011) Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex. Journal of the American Chemical Society, Vol.133 (No.35). pp. 14098-14108. doi:10.1021/ja205235m ISSN 0002-7863.
Cubo, Leticia, Pizarro, Ana M., Quiroga, Adoracion G., Salassa, Luca, Navarro-Ranninger, Carmen and Sadler, P. J. (2010) Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides. Journal of Inorganic Biochemistry, Vol.104 (No.9). pp. 909-918. doi:10.1016/j.jinorgbio.2010.04.009 ISSN 0162-0134.
Spain. Ministerio de Educación, Cultura y Deporte [Spain. Ministry of Education, Culture, and Sports]
Castellano-Castillo, Maria, Kostrhunova, Hana, Marini, Victoria, Kasparkova, Jana, Sadler, P. J., Malinge, Jean-Marc and Brabec, V. (Viktor) (2008) Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes. Journal of Biological Inorganic Chemistry, Vol.13 (No.6). pp. 993-999. doi:10.1007/s00775-008-0386-3 ISSN 0949-8257.
United States. Dept. of Energy
Ross, Allison, Soares, Dinesh C., Covelli, Danielle, Pannecouque, Christophe, Budd, Laura, Collins, Anna, Robertson, N. (Neil), Parsons, S. (Simon), De Clercq, Erik, Kennepohl, Pierre and Sadler, P. J. (2010) Oxovanadium(IV) cyclam and bicyclam complexes : potential CXCR4 receptor antagonists. Inorganic Chemistry, Vol.49 (No.3). pp. 1122-1132. doi:10.1021/ic9020614 ISSN 0020-1669.
Universidad Autónoma de Madrid (UAM)
Cubo, Leticia, Pizarro, Ana M., Quiroga, Adoracion G., Salassa, Luca, Navarro-Ranninger, Carmen and Sadler, P. J. (2010) Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides. Journal of Inorganic Biochemistry, Vol.104 (No.9). pp. 909-918. doi:10.1016/j.jinorgbio.2010.04.009 ISSN 0162-0134.
Universidad de los Andes (Mérida, Venezuela)
Romero-Canelón, Isolda, Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2012) Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes. Metallomics, Volume 4 (Number 12). pp. 1271-1279. doi:10.1039/c2mt20189e ISSN 1756-5901.
Universitat de Barcelona
Barragán, Flavia, Carrion-Salip, Dolors, Gómez-Pinto, Irene, González-Cantó, Alejandro, Sadler, P. J., de Llorens, Rafael, Moreno, Virtudes, González, Carlos A., Massaguer, Anna and Marchán, Vicente (2012) Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes. Bioconjugate Chemistry, Vol.23 (No.9). pp. 1838-1855. doi:10.1021/bc300173h ISSN 1043-1802.
University of Birmingham
Romero-Canelón, Isolda, Phoenix, Ben, Pitto-Barry, Anaïs, Tran, Johanna, Soldevila-Barreda, Joan J., Kirby, Nigel, Green, Stuart, Sadler, P. J. and Barry, Nicolas P. E. (2015) Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT). Journal of organometallic chemistry, 796 . pp. 17-25. doi:10.1016/j.jorganchem.2015.05.011 ISSN 0022-328X.
University of British Columbia
Sriskandakumar, Thamayanthy, Petzold, Holm, Bruijnincx, Pieter C. A., Habtemariam, Abraha, Sadler, P. J. and Kennepohl, Pierre (2009) Influence of oxygenation on the reactivity of ruthenium-thiolato bonds in arene anticancer complexes: insights from XAS and DFT. Journal of the American Chemical Society, Vol.131 (No.37). pp. 13355-13361. doi:10.1021/ja903405z ISSN 0002-7863.
University of Edinburgh
Bugarcic, Tijana, Habtemariam, Abraha, Deeth, Robert J., Fabbiani, Francesca P. A., Parsons, S. (Simon) and Sadler, P. J. (2009) Ruthenium(II) arene anticancer complexes with redox-active diamine ligands. Inorganic Chemistry, Vol.48 (No.19). pp. 9444-9453. doi:10.1021/ic9013366 ISSN 0020-1669.
Newstead, Simon, Fowler, Philip W., Bilton, Paul R., Carpenter, Elisabeth P., Sadler, P. J., Campopiano, Dominic J., Sansom, M. S. P. (Mark S. P.) and Iwata, So (2009) Insights into how nucleotide-binding domains power ABC transport. Structure, Vol.17 (NO.9). pp. 1213-1222. doi:10.1016/j.str.2009.07.009 ISSN 0969-2126.
University of Manchester
Ross, Allison, Soares, Dinesh C., Covelli, Danielle, Pannecouque, Christophe, Budd, Laura, Collins, Anna, Robertson, N. (Neil), Parsons, S. (Simon), De Clercq, Erik, Kennepohl, Pierre and Sadler, P. J. (2010) Oxovanadium(IV) cyclam and bicyclam complexes : potential CXCR4 receptor antagonists. Inorganic Chemistry, Vol.49 (No.3). pp. 1122-1132. doi:10.1021/ic9020614 ISSN 0020-1669.
University of Sydney
Diakos, Connie I., Messerle, Barbara A., del Socorro Murdoch, P., Parkinson, J. A. (John A.), Sadler, P. J., Fenton, Ronald R. and Hambley, Trevor W. (2009) Identification by NMR spectroscopy of the two stereoisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz=3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A.T-rich 14-mer DNA duplex. Inorganic Chemistry, Vol.48 (No.7). pp. 3047-3056. doi:10.1021/ic802207m ISSN 0020-1669.
University of Warwick
Romero-Canelón, Isolda, Phoenix, Ben, Pitto-Barry, Anaïs, Tran, Johanna, Soldevila-Barreda, Joan J., Kirby, Nigel, Green, Stuart, Sadler, P. J. and Barry, Nicolas P. E. (2015) Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT). Journal of organometallic chemistry, 796 . pp. 17-25. doi:10.1016/j.jorganchem.2015.05.011 ISSN 0022-328X.
Pitto-Barry, Anaïs, Alves Perdigão, Luis M., Walker, Marc, Lawrence, James M., Costantini, Giovanni, Sadler, P. J. and Barry, Nicolas P. E. (2015) Synthesis and controlled growth of osmium nanoparticles by electron irradiation. Dalton Transactions, 44 (47). pp. 20308-20311. doi:10.1039/c5dt03205a ISSN 1477-9226.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Tran, Johanna, Spencer, Simon E. F., Johansen, Adam M., Sanchez, Ana M., Dove, Andrew P., O’Reilly, Rachel K., Deeth, Robert J., Beanland, R. and Sadler, P. J. (2015) Osmium atoms and Os2 molecules move faster on selenium-doped compared to sulfur-doped boronic graphenic surfaces. Chemistry of Materials, 27 (14). pp. 5100-5105. doi:10.1021/acs.chemmater.5b01853 ISSN 0897-4756.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f ISSN 0301-7249.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Sánchez, Ana M., Dove, Andrew P., Procter, Richard J., Soldevila-Barreda, Joan J., Kirby, Nigel, Hands-Portman, Ian, Smith, Corinne J., O'Reilly, Rachel K., Beanland, R. and Sadler, P. J. (2014) Fabrication of crystals from single metal atoms. Nature Communications, Volume 5 . Article number 3851 . doi:10.1038/ncomms4851 ISSN 2041-1723.
Zhao, Yao, (Researcher in chemistry), Farrer, Nicola J., Li, Huilin, Butler, Jennifer S. (Jennifer Suzanne), McQuitty, Ruth J., Habtemariam, Abraha, Wang, Fuyi and Sadler, P. J. (2013) De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex. Angewandte Chemie International Edition, Volume 52 (Number 51). pp. 13633-13637. doi:10.1002/anie.201307505 ISSN 1433-7851.
Hearn, Jessica M., Romero-Canelón, Isolda, Qamar, Bushra, Liu, Zhe , Hands-Portman, Ian and Sadler, P. J. (2013) Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis. ACS Chemical Biology, Volume 8 (Number 6). pp. 1335-1343. doi:10.1021/cb400070a ISSN 1554-8929.
Liu, Zhe , Deeth, Robert J., Butler, Jennifer S. (Jennifer Suzanne), Habtemariam, Abraha, Newton, Mark E. and Sadler, P. J. (2013) Reduction of quinones by NADH catalyzed by organoiridium complexes. Angewandte Chemie International Edition, Volume 52 (Number 15). pp. 4194-4197. doi:10.1002/anie.201300747 ISSN 1433-7851.
Booyjzsen, Claire, Scarff, Charlotte A., Moreton, Ben, Portman, Ian J., Scrivens, James H., Costantini, Giovanni and Sadler, P. J. (2012) Fibrillation of transferrin. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1820 (No.3). pp. 427-436. doi:10.1016/j.bbagen.2011.11.004 ISSN 0304-4165.
Romero-Canelón, Isolda, Pizarro, Ana M., Habtemariam, Abraha and Sadler, P. J. (2012) Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes. Metallomics, Volume 4 (Number 12). pp. 1271-1279. doi:10.1039/c2mt20189e ISSN 1756-5901.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics, Vol.30 (No.17). pp. 4702-4710. doi:10.1021/om2005468 ISSN 0276-7333.
Liu, Zhe , Salassa, Luca, Habtemariam, Abraha, Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2011) Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorganic Chemistry, Vol.50 (No.12). pp. 5777-5783. doi:10.1021/ic200607j ISSN 0020-1669.
Li, Huilin, Zhao, Yao, Phillips, Hazel I. A., Qi, Yulin, Lin, Tzu-Yung, Sadler, P. J. and O'Connor, Peter B. (2011) Mass spectrometry evidence for cisplatin as a protein cross-linking reagent. Analytical Chemistry, Vol.83 (No.13). pp. 5369-5376. doi:10.1021/ac200861k ISSN 0003-2700.
Liu, Zhe , Habtemariam, Abraha, Pizarro, Ana M., Fletcher, Sally A., Kisova, Anna, Vrana, Oldrich, Salassa, Luca, Bruijnincx, Pieter C. A., Clarkson, Guy J., Brabec, V. (Viktor) and Sadler, P. J. (2011) Organometallic half-sandwich iridium anticancer complexes. Journal of Medicinal Chemistry, Vol.54 (No.8). pp. 3011-3026. doi:10.1021/jm2000932 ISSN 0022-2623.
Williams, Jonathan P., Phillips, Hazel I. A., Campuzano, Iain and Sadler, P. J. (2010) Shape changes induced by N-terminal platination of ubiquitin by cisplatin. Journal of The American Society for Mass Spectrometry, Vol.21 (No.7). pp. 1097-1106. doi:10.1016/j.jasms.2010.02.012 ISSN 1044-0305.
Williams, Jonathan P., Lough, Julie Ann, Campuzano, Iain, Richardson, K. (Keith) and Sadler, P. J. (2009) Use of ion mobility mass spectrometry and a collision cross-section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide. Rapid Communications in Mass Spectrometry, Vol.23 (No.22). pp. 3563-3569. doi:10.1002/rcm.4285 ISSN 09514198.
Bugarcic, Tijana, Habtemariam, Abraha, Deeth, Robert J., Fabbiani, Francesca P. A., Parsons, S. (Simon) and Sadler, P. J. (2009) Ruthenium(II) arene anticancer complexes with redox-active diamine ligands. Inorganic Chemistry, Vol.48 (No.19). pp. 9444-9453. doi:10.1021/ic9013366 ISSN 0020-1669.
Phillips, Hazel I. A., Ronconi, Luca and Sadler, P. J. (2009) Photoinduced reactions of cis,trans,cis-[Pt-IV(N-3)(2)(OH)(2)(NH3)(2)] with 1-methylimidazole. Chemistry: A European Journal, Vol.15 (No.7). pp. 1588-1596. doi:10.1002/chem.200802206 ISSN 0947-6539.
University of Warwick Postgraduate Research Scholarship
Fu, Ying, Sanchez-Cano, Carlos, Soni, Rina, Romero-Canelón, Isolda, Hearn, Jessica M., Liu, Zhe, Wills, Martin and Sadler, P. J. (2016) The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Transactions, 45 (20). pp. 8367-8378. doi:10.1039/c6dt01242f ISSN 1477-9226.
Li, Huilin, Snelling, Jonathon R., Barrow, Mark P., Scrivens, James H., Sadler, P. J. and O’Connor, Peter B. (2014) Mass spectrometric strategies to improve the identification of Pt(II)-modification sites on peptides and proteins. Journal of The American Society for Mass Spectrometry, 25 (7). pp. 1217-1227. doi:10.1007/s13361-014-0877-0 ISSN 1044-0305.
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Hearn, Jessica M., Romero-Canelón, Isolda, Qamar, Bushra, Liu, Zhe , Hands-Portman, Ian and Sadler, P. J. (2013) Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis. ACS Chemical Biology, Volume 8 (Number 6). pp. 1335-1343. doi:10.1021/cb400070a ISSN 1554-8929.
Betanzos-Lara, Soledad, Novakova, Olga, Deeth, Robert J., Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor), Sadler, P. J. and Habtemariam, Abraha (2012) Bipyrimidine ruthenium(II) arene complexes : structure, reactivity and cytotoxicity. JBIC Journal of Biological Inorganic Chemistry, 17 (7). pp. 1033-1051. doi:10.1007/s00775-012-0917-9 ISSN 0949-8257.
Li, Huilin, Wells, Stephen A., Jimenez-Roldan, J. Emilio, Römer, Rudolf A., Zhao, Yao, (Researcher in chemistry), Sadler, P. J. and O'Connor, Peter B. (2012) Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Science, Volume 21 (Number 9). pp. 1269-1279. doi:10.1002/pro.2111 ISSN 0961-8368.
Tai, Hui-Chung, Brodbeck, Ralf, Kasparkova, Jana, Farrer, Nicola J., Brabec, V. (Viktor), Sadler, P. J. and Deeth, Robert J. (2012) Combined theoretical and computational study of interstrand DNA guanine–guanine cross-linking bytrans-[Pt(pyridine)2] derived from the photoactivated prodrugtrans,trans,trans-[Pt(N3)2(OH)2(pyridine)2]. Inorganic Chemistry, Vol.51 (No.12). pp. 6830-6841. doi:10.1021/ic3005745 ISSN 0020-1669.
Betanzos-Lara, Soledad, Salassa, Luca, Habtemariam, Abraha, Novakova, Olga, Pizarro, Ana M., Clarkson, Guy J., Liskova, Barbora, Brabec, V. (Viktor) and Sadler, P. J. (2012) Photoactivatable organometallic pyridyl ruthenium(II) arene complexes. Organometallics, Vol.31 (No.9). pp. 3466-3479. doi:10.1021/om201177y ISSN 0276-7333.
Betanzos-Lara, Soledad, Habtemariam, Abraha, Clarkson, Guy J. and Sadler, P. J. (2011) Organometallic cis-Dichlorido ruthenium(II) ammine complexes. European Journal of Inorganic Chemistry, Volume 2011 (Number 21). pp. 3257-3264. doi:10.1002/ejic.201100250 ISSN 1434-1948.
University of Warwick Research Development Fund
Williams, Jonathan P., Brown, Jeffery M., Campuzano, Iain and Sadler, P. J. (2010) Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS). Chemical Communications, Vol.46 (No.30). pp. 5458-5460. doi:10.1039/c0cc00358a ISSN 1359-7345.
Williams, Jonathan P., Phillips, Hazel I. A., Campuzano, Iain and Sadler, P. J. (2010) Shape changes induced by N-terminal platination of ubiquitin by cisplatin. Journal of The American Society for Mass Spectrometry, Vol.21 (No.7). pp. 1097-1106. doi:10.1016/j.jasms.2010.02.012 ISSN 1044-0305.
University of Warwick. Dept. of Chemistry
Li, Huilin, Wells, Stephen A., Jimenez-Roldan, J. Emilio, Römer, Rudolf A., Zhao, Yao, (Researcher in chemistry), Sadler, P. J. and O'Connor, Peter B. (2012) Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Science, Volume 21 (Number 9). pp. 1269-1279. doi:10.1002/pro.2111 ISSN 0961-8368.
University of Warwick. Institute of Advanced Study (IAS)
Greenough, Simon E., Horbury, Michael D., Smith, Nichola A., Sadler, P. J., Paterson, Martin J. and Stavros, Vasilios G. (2016) Excited-state dynamics of a two-photon-activatable ruthenium prodrug. ChemPhysChem, 17 (2). pp. 221-224. doi:10.1002/cphc.201501075 ISSN 1439-4235.
Soldevila-Barreda, Joan J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, P. J. (2015) Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design. Nature Communications, 6 . pp. 1-9. 6582. doi:10.1038/ncomms7582 ISSN 2041-1723.
Soldevila-Barreda, Joan J. and Sadler, P. J. (2015) Approaches to the design of catalytic metallodrugs. Current Opinion in Chemical Biology, Volume 25 . pp. 172-183. doi:10.1016/j.cbpa.2015.01.024 ISSN 1367-5931.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f ISSN 0301-7249.
Rijt, Sabine H. van, Romero-Canelón, Isolda, Fu, Ying, Shnyder, Steve D. and Sadler, P. J. (2014) Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells. Metallomics, 6 (5). pp. 1014-1022. doi:10.1039/c4mt00034j ISSN 1756-5901.
Liu, Zhe , Romero-Canelón, Isolda, Qamar, Bushra, Hearn, Jessica M., Habtemariam, Abraha, Barry, Nicolas P. E., Pizarro, Ana M., Clarkson, Guy J. and Sadler, P. J. (2014) The potent oxidant anticancer activity of organoiridium catalysts. Angewandte Chemie International Edition, Volume 53 (Number 15). pp. 3941-3946. doi:10.1002/anie.201311161 ISSN 1433-7851.
University of Warwick. Molecular Organisation and Assembly in Cells
Unterkofler, S., McQuitty, Ruth J., Euser, T. G., Farrer, Nicola J., Sadler, P. J. and Russell, P. St.J. (2012) Microfluidic integration of photonic crystal fibers for online photochemical reaction analysis. Optics Letters, Volume 37 (Number 11). pp. 1952-1954. doi:10.1364/OL.37.001952 ISSN 0146-9592.
University of Warwick. Protein Biology and Biophysics Network
Li, Huilin, Wells, Stephen A., Jimenez-Roldan, J. Emilio, Römer, Rudolf A., Zhao, Yao, (Researcher in chemistry), Sadler, P. J. and O'Connor, Peter B. (2012) Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Science, Volume 21 (Number 9). pp. 1269-1279. doi:10.1002/pro.2111 ISSN 0961-8368.
Univerzita Palackého v Olomouci [Palacky University]
Zhao, Yao, (Researcher in chemistry), Woods, Julie A., Farrer, Nicola J., Robinson, Kim S., Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M., Clarkson, Guy J., Song, Lijiang, Brabec, V. (Viktor) and Sadler, P. J. (2013) Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts. Chemistry - A European Journal, Volume 19 (Number 29). pp. 9578-9591. doi:10.1002/chem.201300374 ISSN 0947-6539.
Univerzita Palackého v Olomouci
Pracharova, Jitka, Zerzankova, Lenka, Stepankova, Jana, Novakova, Olga, Farrer, Nicola J., Sadler, P. J., Brabec, V. (Viktor) and Kasparkova, Jana (2012) Interactions of DNA with a new Platinum(IV) Azide Dipyridine complex activated by UVA and visible light : relationship to toxicity in tumor cells. Chemical Research in Toxicology, Vol.25 (No.5). pp. 1099-1111. doi:10.1021/tx300057y ISSN 0893-228X.
Warwick Collaborative Postgraduate Research Scholarship (WCPRS)
Coverdale, James P. C., Sanchez-Cano, Carlos, Clarkson, Guy J., Soni, Rina, Wills, Martin and Sadler, P. J. (2015) Easy to synthesize, robust organo-osmium asymmetric transfer hydrogenation catalysts. Chemistry - A European Journal, 21 (22). pp. 8043-8046. doi:10.1002/chem.201500534 ISSN 0947-6539.
Warwick Collaborative Postgraduate Research Scholarships
Wootton, Christopher, Millett, Adam J., Lopez-Clavijo, Andrea F., Chiu, Cookson, Barrow, Mark P., Clarkson, Guy J., Sadler, P. J. and O'Connor, Peter B. (2019) Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation. Analyst, 144 (5). pp. 1575-1581. doi:10.1039/C8AN02094A ISSN 0003-2654.
Warwick Research Development Fund
Williams, Jonathan P., Bugarcic, Tijana, Habtemariam, Abraha, Giles, K. (Kevin), Campuzano, Iain, Rodger, P. Mark and Sadler, P. J. (2009) Isomer separation and gas-phase configurations of organoruthenium anticancer complexes : ion mobility mass spectrometry and modeling. Journal of The American Society for Mass Spectrometry, Vol.20 (No.6). pp. 1119-1122. doi:10.1016/j.jasms.2009.02.016 ISSN 1044-0305.
Warwick University
Rijt, Sabine H. van, Peacock, Anna F. A., Johnstone, Russell D. L., Parsons, S. (Simon) and Sadler, P. J. (2009) Organometallic osmium(II) arene anticancer complexes containing picolinate derivatives. Inorganic Chemistry, Vol.48 (No.4). pp. 1753-1762. doi:10.1021/ic8020222 ISSN 0020-1669.
Waters Corporation
Booyjzsen, Claire, Scarff, Charlotte A., Moreton, Ben, Portman, Ian J., Scrivens, James H., Costantini, Giovanni and Sadler, P. J. (2012) Fibrillation of transferrin. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1820 (No.3). pp. 427-436. doi:10.1016/j.bbagen.2011.11.004 ISSN 0304-4165.
Wellcome Trust
Lu, Jin, Stewart, Alan J, Sleep, Darrell, Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) A molecular mechanism for modulating plasma Zn speciation by fatty acids. Journal of the American Chemical Society, Vol.134 (No.3). pp. 1454-1457. doi:10.1021/ja210496n ISSN 1520-5126.
Wellcome Trust (London, England)
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Romero-Canelón, Isolda, Tran, Johanna, Soldevila-Barreda, Joan J., Hands-Portman, Ian, Smith, Corinne J., Kirby, Nigel, Dove, Andrew P., O'Reilly, Rachel K. and Sadler, P. J. (2014) Precious metal carborane polymer nanoparticles : characterisation of micellar formulations and anticancer activity. Faraday Discussions, 175 . pp. 229-240. doi:10.1039/c4fd00098f ISSN 0301-7249.
Barry, Nicolas P. E., Pitto-Barry, Anaïs, Sánchez, Ana M., Dove, Andrew P., Procter, Richard J., Soldevila-Barreda, Joan J., Kirby, Nigel, Hands-Portman, Ian, Smith, Corinne J., O'Reilly, Rachel K., Beanland, R. and Sadler, P. J. (2014) Fabrication of crystals from single metal atoms. Nature Communications, Volume 5 . Article number 3851 . doi:10.1038/ncomms4851 ISSN 2041-1723.
Liu, Hong-Ke, Parkinson, J. A. (John A.), Bella, Juraj, Wang, Fuyi and Sadler, P. J. (2010) Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene Ru-II anticancer complex. Chemical Science, Vol.1 (No.2). pp. 258-270. doi:10.1039/c0sc00175a ISSN 2041-6520.
Shi, Yanbo, Harvey, Ian, Campopiano, Dominic and Sadler, P. J. (2010) Niobium uptake and release by bacterial ferric ion binding protein. Bioinorganic Chemistry and Applications . doi:10.1155/2010/307578 ISSN 1565-3633.
Newstead, Simon, Fowler, Philip W., Bilton, Paul R., Carpenter, Elisabeth P., Sadler, P. J., Campopiano, Dominic J., Sansom, M. S. P. (Mark S. P.) and Iwata, So (2009) Insights into how nucleotide-binding domains power ABC transport. Structure, Vol.17 (NO.9). pp. 1213-1222. doi:10.1016/j.str.2009.07.009 ISSN 0969-2126.
Blindauer, Claudia A., Harvey, Ian, Bunyan, Kerry E., Stewart, Alan J., Sleep, Darrell, Harrison, David J., Berezenko, Stephen and Sadler, P. J. (2009) Structure, properties, and engineering of the major zinc binding site on human albumin. Journal of Biological Chemistry, Vol.284 (No.34). pp. 23116-23124. doi:10.1074/jbc.M109.003459 ISSN 0021-9258.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2009) Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design. Advances in Inorganic Chemistry, Vol.61 . pp. 1-62. doi:10.1016/S0898-8838(09)00201-3 ISSN 0898-8838.
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317 ISSN 0300-5127.
Kostrhunova, Hana, Florian, Jakub, Novakova, Olga, Peacock, Anna F. A., Sadler, P. J. and Brabec, V. (Viktor) (2008) DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media. Journal of Medicinal Chemistry, Vol.51 (No.12). pp. 3635-3643. doi:10.1021/jm701538w ISSN 0022-2623.
Bruijnincx, Pieter C. A. and Sadler, P. J. (2008) New trends for metal complexes with anticancer activity. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 197-206. doi:10.1016/j.cbpa.2007.11.013 ISSN 1367-5931.
Liang, Xiangyang, Parkinson, J. A. (John A.), Weishäupl, Michael, Gould, Robert O., Paisey, Stephen J., Park, Hye-seo, Hunter, Tina M., Blindauer, Claudia A., Parsons, S. (Simon) and Sadler, P. J. (2002) Structure and dynamics of metallomacrocycles : recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society, Vol.124 (No.31). pp. 9105-9112. doi:10.1021/ja0260723 ISSN 0002-7863.
Wolfson Foundation
Blindauer, Claudia A., Harvey, Ian, Bunyan, Kerry E., Stewart, Alan J., Sleep, Darrell, Harrison, David J., Berezenko, Stephen and Sadler, P. J. (2009) Structure, properties, and engineering of the major zinc binding site on human albumin. Journal of Biological Chemistry, Vol.284 (No.34). pp. 23116-23124. doi:10.1074/jbc.M109.003459 ISSN 0021-9258.
Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317 ISSN 0300-5127.
Liang, Xiangyang, Parkinson, J. A. (John A.), Weishäupl, Michael, Gould, Robert O., Paisey, Stephen J., Park, Hye-seo, Hunter, Tina M., Blindauer, Claudia A., Parsons, S. (Simon) and Sadler, P. J. (2002) Structure and dynamics of metallomacrocycles : recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society, Vol.124 (No.31). pp. 9105-9112. doi:10.1021/ja0260723 ISSN 0002-7863.
Yunnan Sheng (China)
Xie, Ming-jin, Zhu, Ming-rong, Lu, Chun-Mei, Jin, Yi, Gao, Li-Hui, Li, Ling, Zhou, Jie, Li, Fan-fang, Zhao, Qi Hua, Liu, Hong-Ke, Sadler, P. J. and Sanchez-Cano, Carlos (2017) Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV. Journal of Inorganic Biochemistry, 175 . pp. 29-35. doi:10.1016/j.jinorgbio.2017.06.014 ISSN 0162-0134.
Zhongguo ke xue yuan [Chinese Academy of Sciences]
Wang, Fuyi, Habtemariam, Abraha, van der Geer, Erwin P. L., Deeth, Robert J., Gould, Robert O., Parsons, Simon and Sadler, P. J. (2009) Synthesis, characterization, and reaction pathways for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex. Journal of Biological Inorganic Chemistry, Vol.14 (No.7). pp. 1065-1076. doi:10.1007/s00775-009-0549-x ISSN 0949-8257.
Hu, Wenbing, Luo, Qun, Ma, Xiaoyan, Wu, Kui, Liu, Jianan, Chen, Yi, Xiong, Shaoxiang, Wang, Jianping, Sadler, P. J. and Wang, Fuyi (2009) Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes. Chemistry - A European Journal, Vol.15 (No.27). pp. 6586-6594. doi:10.1002/chem.200900699 ISSN 0947-6539.
Wang, Fuyi, Weidt, Stefan, Xu, Jingjing, Mackay, C. Logan, Langridge-Smith, Pat R. R. and Sadler, P. J. (2008) Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography fourier transform ion cyclotron mass spectrometry combined with 18O-labeling. Journal of The American Society for Mass Spectrometry, Vol.19 (No.4). pp. 544-549. doi:10.1016/j.jasms.2007.12.002 ISSN 1044-0305.
Zhongguo ke xue yuan [Chinese Academy of Sciences] (CAS)
Han, Yumiao, Luo, Qun, Hao, Xiang, Li, Xianchan, Wang, Fuyi, Hu, Wenbing, Wu, Kui, Lü, Shuang and Sadler, P. J. (2011) Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide — a model for the active-site cysteine of protein tyrosine phosphatase 1B. Dalton Transactions, Vol.40 (No.43). pp. 11519-11529. doi:10.1039/c1dt11189b ISSN 1477-9226.
Hu, Wenbing, Luo, Qun, Wu, Kui, Li, Xianchan, Wang, Fuyi, Chen, Yi, Ma, Xiaoyan, Wang, Jianping, Liu, Jianan, Xiong, Shaoxiang and Sadler, P. J. (2011) The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin. Chemical Communications, Vol.47 (No.21). pp. 6006-6008. doi:10.1039/c1cc11627d ISSN 1359-7345.
This list was generated on Fri Apr 19 07:41:46 2024 BST.