2019

Coverdale, James P. C., Barnett, James P., Adamu, Adamu H., Griffiths, Ellie, Stewart, Alan J. and Blindauer, Claudia A. (2019) A metalloproteomic analysis of interactions between plasma proteins and zinc : elevated fatty acid levels affect zinc distribution. Metallomics . doi:10.1039/c9mt00177h (In Press)

Sobczak, Amélie I. S., Blindauer, Claudia A. and Stewart, Alan (2019) Changes in plasma free fatty acids associated with Type-2 Diabetes. Nutrients, 11 (9). e2022. doi:10.3390/nu11092022

2018

Mierek-Adamska, Agnieszka, Dąbrowskaa, Grażyna B. and Blindauer, Claudia A. (2018) The type 4 metallothionein from Brassica napus seeds folds in a metal-dependent fashion and favours zinc over other metals. Metallomics . doi:10.1039/C8MT00161H (In Press)

Coverdale, James P. C., Katundu, Kondwani G. H., Sobczak, Amélie I. S., Arya, Swati, Blindauer, Claudia A. and Stewart, Alan J. (2018) Ischemia-modified albumin : crosstalk between fatty acid and cobalt binding. Prostaglandins, Leukotrienes and Essential Fatty Acids, 135 . pp. 147-157. doi:10.1016/j.plefa.2018.07.014

Mikhaylina, Alevtina, Ksibe, Amira Z., Scanlan, David J. and Blindauer, Claudia A. (2018) Bacterial zinc uptake regulator proteins and their regulons. BIOCHEMICAL SOCIETY TRANSACTIONS, 46 (4). pp. 983-1001. doi:10.1042/BST20170228

Martin, Esther M., Kondrat, Frances D. L., Stewart, Alan J., Scrivens, James H., Sadler, P. J. and Blindauer, Claudia A. (2018) Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein. Scientific Reports, 8 (1). 8646. doi:10.1038/s41598-018-26924-1

Imam, Hasan T. and Blindauer, Claudia A. (2018) Differential reactivity of closely related zinc(II)-binding metallothioneins from the plant Arabidopsis thaliana. Journal of Biological Inorganic Chemistry, 23 (1). pp. 137-154. doi:10.1007/s00775-017-1516-6

Blindauer, Claudia A., Griesser, Rolf, Holý, Antonín, Operschall, Bert P., Sigel, Astrid, Song, Bin and Sigel, Helmut (2018) Intramolecular π-stacks in mixed-ligand copper(II) complexes formed by heteroaromatic amines and antivirally active acyclic nucleotide analogs carrying a hydroxy-2-(phosphonomethoxy)propyl residue. Journal of Coordination Chemistry, 71 (11-13). pp. 1910-1934. doi:10.1080/00958972.2018.1490019

Chaudhuri, Poulami, Imam, Hasan Tanvir, Essig, Yona, Krasauskas, Jovaras, Webb, Samuel M., Blindauer, Claudia A. and Stürzenbaum, Stephen R. (2018) Molecular genetic and biochemical characterization of a putative family of zinc metalloproteins in Caenorhabditis elegans. Metallomics, 10 (12). pp. 1814-1823. doi:10.1039/c8mt00169c

2017

Gondim, Ana C. S., Romero-Canelón, Isolda, Sousa, Eduardo H.S., Blindauer, Claudia A., Butler, Jennifer S., Romero, Maria, Sanchez-Cano, Carlos, Sousa, Bruno L., Chaves, Renata P., Nagano, Celso S., Cavada, Benildo S. and Sadler, P. J. (2017) The potent anti-cancer activity of Dioclea lasiocarpa lectin. Journal of Inorganic Biochemistry, 175 . pp. 179-189. doi:10.1016/j.jinorgbio.2017.07.011

M'kandawire, Ethel, Mierek-Adamska, Agnieszka, Stürzenbaum, Stephen R., Choongo, Kennedy, Yabe, John, Mwase, Maxwell, Saasa, Ngonda and Blindauer, Claudia A. (2017) Metallothionein from wild populations of the African catfish Clarias gariepinus : from sequence, protein expression and metal binding properties to transcriptional biomarker of metal pollution. International Journal of Molecular Sciences, 18 (7). 1548. doi:10.3390/ijms18071548

2016

Handing, Katarzyna B., Shabalin, Ivan G., Kassaar, Omar, Khazaipoul, Siavash, Blindauer, Claudia A., Stewart, Alan, Chruszch, Maksymilian and Minor, Wladek (2016) Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins. Chemical Science, 2016 (7). pp. 6635-6648. doi:10.1039/C6SC02267G

Zhu, Yijun , Ksibe, Amira Z., Schäfer, Hendrik, Blindauer, Claudia A., Bugg, Tim and Chen, Yin (2016) O2-independent demethylation of trimethylamine N-oxide by Tdm of Methylocella silvestris. FEBS Journal, 283 (21). pp. 3979-3993. doi:10.1111/febs.13902

Sklepari, Meropi, Rodger, Alison, Reason, A., Jamshidi, Shirin, Prokes, Ivan and Blindauer, Claudia A. (2016) Biophysical characterization of a protein for structure comparison : methods for identifying insulin structural changes. Analytical Methods, 8 (41). pp. 7460-7471. doi:10.1039/c6ay01573e

Usha, Veeraraghavan, Lloyd, Adrian J., Roper, David I., Dowson, Christopher G., Kozlov, Guennadi, Gehring, Kalle, Chauhan, Smita, Imam, Hasan T., Blindauer, Claudia A. and Besra, Gurdyal S. (2016) Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase. Scientific Reports, 6 . 23191. doi:10.1038/srep23191

Blindauer, Claudia A., Khazaipoul , S., Yu, R. and Stewart, A. J. (2016) Fatty acid-mediated inhibition of metal binding to the multi-metal site on serum albumin : implications for cardiovascular disease. Current Trends in Medicinal Chemistry, 16 . doi:10.2174/1568026616666160216155927

Acharya, Celin and Blindauer, Claudia A. (2016) Unexpected interactions of the cyanobacterial metallothionein SmtA with uranium. Inorganic Chemistry, 55 (4). pp. 1505-1515. doi:10.1021/acs.inorgchem.5b02327

Kowald, Gregory R., Sturzenbaum, Stephen R. and Blindauer, Claudia A. (2016) Earthworm Lumbricus rubellus MT-2 : metal binding and protein folding of a true Cadmium-MT. International Journal of Molecular Sciences, 17 (1). pp. 1-16. 65. doi:10.3390/ijms17010065

Blindauer, Claudia A., Sigel, Astrid, Operschall, Bert P. , Griesser, Rolf, Holý, Antonín and Sigel, Helmut (2016) Extent of intramolecular π stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and the anticancer and antivirally active 9-[2-phosphonomethoxy)ethyl]guanine (PMEG).✩ a comparison with related acyclic nucleotide analogues. Polyhedron, 103 (Part B). pp. 248-260. doi:10.1016/j.poly.2015.02.022

Collins, Jennifer, Kempe, Kristian, Wilson, Paul, Blindauer, Claudia A., McIntosh, Michelle P., Davis, Thomas P., Whittaker, Michael R. and Haddleton, David M. (2016) Stability enhancing N-Terminal PEGylation of oxytocin exploiting different polymer architectures and conjugation approaches. Biomacromolecules, 17 (8). pp. 2755-2766. doi:10.1021/acs.biomac.6b00919

2015

Heal, Jack W., Wells, Stephen A., Blindauer, Claudia A., Freedman, R. B. and Römer, Rudolf A. (2015) Characterization of folding cores in the cyclophilin A-cyclosporin A complex. Biophysical Journal, Volume 108 (Number 7). pp. 1739-1746. doi:10.1016/j.bpj.2015.02.017

Blindauer, Claudia A. (2015) Advances in the molecular understanding of biological zinc transport. Chemical Communications, 51 (22). pp. 4544-4563. doi:10.1039/c4cc10174j

Kassaar, Omar, Schwarz-Linek, Ulrich, Blindauer, Claudia A. and Stewart, Alan J. (2015) Plasma free fatty acid levels influence Zn2+-dependent histidine-rich glycoprotein-heparin interactions via an allosteric switch on serum albumin. Journal of Thrombosis and Haemostasis, 13 (1). pp. 101-110. doi:10.1111/jth.12771

2014

Barnett, James P., Scanlan, David J. and Blindauer, Claudia A. (2014) Identification of major zinc-binding proteins from a marine cyanobacterium : insight into metal uptake in oligotrophic environments. Metallomics, Volume 6 (Number 7). pp. 1254-1268. doi:10.1039/c4mt00048j

Heal, Jack W., Römer, Rudolf A., Blindauer, Claudia A. and Freedman, R. B. (2014) Characterising the folding core of the cyclophilin A — cyclosporin A complex I : hydrogen exchange data and rigidity analysis. Biophysical Journal . (Submitted)

Irvine, Alistair, Wallis, A. Katrine, Sanghera, Narinder, Rowe, Michelle L., Ruddock, Lloyd W., Howard, Mark J., Williamson, Richard A., Blindauer, Claudia A. and Freedman, R. B. (2014) Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway. PLoS One, Volume 9 (Number 1). Article number e82511. doi:10.1371/journal.pone.0082511

2013

Barnett, James P., Dr., Blindauer, Claudia A., Kassaar, Omar, Khazaipoul, Siavash, Martin, Esther M., Sadler, P. J. and Stewart, Alan J. S. (2013) Allosteric modulation of zinc speciation by fatty acids. Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 830 (Number 12). doi:10.1016/j.bbagen.2013.05.028

Blindauer, Claudia A. (2013) Erratum to “Lessons on the critical interplay between zinc binding and protein structure and dynamics” [JIB 121C (2013) 145–155]. Journal of Inorganic Biochemistry, Volume 123 . p. 88. doi:10.1016/j.jinorgbio.2013.04.001

Blindauer, Claudia A., Sigel, Astrid, Operschall, Bert P., Holý, Antonín and Sigel, Helmut (2013) Extent of intramolecular pi stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and 1-[2-(Phosphonomethoxy)ethyl]cytosine (PMEC), a relative of antivirally active acyclic nucleotide analogues (Part 72)[1, 2]. Zeitschrift fuer anorganische und allgemeine Chemie, Volume 639 (Number 8-9). pp. 1661-1673. doi:10.1002/zaac.201300095

Blindauer, Claudia A. (2013) Lessons on the critical interplay between zinc binding and protein structure and dynamics. Journal of Inorganic Biochemistry, Volume 121 . pp. 145-155. doi:10.1016/j.jinorgbio.2013.01.005

2012

Kondrat, Frances D. L., Kowald, Gregory R., Scarff, Charlotte A., Scrivens, James H. and Blindauer, Claudia A. (2012) Resolution of a paradox by native mass spectrometry : facile occupation of all four metal binding sites in the dimeric zinc sensor SmtB. Chemical Communications, Volume 49 (Number 8). pp. 813-815. doi:10.1039/c2cc38387j

Gómez-Coca, Raquel B., Blindauer, Claudia A., Sigel, Astrid, Operschall, Bert P., Holý, Antonín and Sigel, Helmut (2012) Extent of intramolecular π-stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and several 2-aminopurine derivatives of the antivirally active nucleotide analog 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA). Chemistry & Biodiversity, Vol.9 (No.9). pp. 2008-2034. doi:10.1002/cbdv.201200022

Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) Allosteric inhibition of cobalt binding to albumin by fatty acids : implications for the detection of myocardial ischemia. Journal of Medicinal Chemistry, Vol.55 (No.9). pp. 4425-4430. doi:10.1021/jm3003137

Jones, Mathew W., Mantovani, Giuseppe, Blindauer, Claudia A., Ryan, Sinead M., Wang, Xuexuan, Brayden, David J. and Haddleton, David M. (2012) Direct peptide bioconjugation/PEGylation at tyrosine with linear and branched polymeric diazonium salts. Journal of the American Chemical Society, 134 (17). pp. 7406-7413. doi:10.1021/ja211855q

Barnett, James P., Scanlan, David J. and Blindauer, Claudia A. (2012) Protein fractionation and detection for metalloproteomics : challenges and approaches. Analytical and Bioanalytical Chemistry, Vol.402 (No.10). pp. 3311-3322. doi:10.1007/s00216-012-5743-y

Lu, Jin, Stewart, Alan J, Sleep, Darrell, Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2012) A molecular mechanism for modulating plasma Zn speciation by fatty acids. Journal of the American Chemical Society, Vol.134 (No.3). pp. 1454-1457. doi:10.1021/ja210496n

Barnett, James P., Scanlan, David J. and Blindauer, Claudia A. (2012) Fractionation and identification of metalloproteins from a marine cyanobacterium. Analytical and Bioanalytical Chemistry, Vol.402 (No.10). pp. 3371-3377. doi:10.1007/s00216-011-5708-6

Barnett, James P., Millard, Andrew D., Ksibe, Amira Z., Scanlan, David J., Schmid, Ralf and Blindauer, Claudia A. (2012) Mining genomes of marine cyanobacteria for elements of zinc homeostasis. Frontiers in Microbiology, Volume 3 . Article number 142. doi:10.3389/fmicb.2012.00142

2011

Blindauer, Claudia A. (2011) Bacterial metallothioneins: past, present, and questions for the future. JBIC Journal of Biological Inorganic Chemistry, Vol.16 (No.7). pp. 1011-1024. doi:10.1007/s00775-011-0790-y

Zeitoun-Ghandour, Sukaina, Leszczyszyn, Oksana I., Blindauer, Claudia A., Geier, Florian M., Bundy, Jacob G. and Stürzenbaum, Stephen R. (2011) C. elegans metallothioneins : response to and defence against ROS toxicity. Molecular BioSystems, Vol.7 (No.8). pp. 2397-2406. doi:10.1039/c1mb05114h

Barnett, James P., Robinson, Colin, Scanlan, David J. and Blindauer, Claudia A. (2011) The Tat protein export pathway and its role in cyanobacterial metalloprotein biosynthesis. FEMS Microbiology Letters, Vol.325 (No.1). pp. 1-9. doi:10.1111/j.1574-6968.2011.02391.x

Leszczyszyn, Oksana I., Zeitoun-Ghandour, Sukaina, Stuerzenbaum, Stephen R. and Blindauer, Claudia A. (2011) Tools for metal ion sorting : in vitro evidence for partitioning of zinc and cadmium in C. elegans metallothionein isoforms. Chemical Communications, Vol.47 (No.1). pp. 448-450. doi:10.1039/c0cc02188a

2010

Blindauer, Claudia A. and Schmid, R. (Ralf) (2010) Cytosolic metal handling in plants : determinants for zinc specificity in metal transporters and metallothioneins. Metallomics, Vol.2 (No.8). pp. 510-529. doi:10.1039/c004880a

Zeitoun-Ghandour, Sukaina, Charnock, John M., Hodson, Mark E., Leszczyszyn, Oksana I., Blindauer, Claudia A. and Sturzenbaum, Stephen R. (2010) The two Caenorhabditis elegans metallothioneins (CeMT-1 and CeMT-2) discriminate between essential zinc and toxic cadmium. The FEBS Journal, Vol.277 (No.11). pp. 2531-2542. doi:10.1111/j.1742-4658.2010.07667.x

Blindauer, Claudia A. and Leszczyszyn, Oksana I. (2010) Metallothioneins : unparalleled diversity in structures and functions for metal ion homeostasis and more. Natural Product Reports, Vol.27 (No.5). pp. 720-741. doi:10.1039/b906685n

Leszczyszyn, Oksana I. and Blindauer, Claudia A. (2010) Zinc transfer from the embryo-specific metallothionein E-C from wheat : a case study. Physical Chemistry Chemical Physics, Vol.12 (No.41). pp. 13408-13418. doi:10.1039/c0cp00680g

Leszczyszyn, Oksana I., White, Craig Roy J. and Blindauer, Claudia A. (2010) The isolated Cys(2)His(2) site in EC metallothionein mediates metal-specific protein folding. Molecular BioSystems, Vol.6 (No.9). pp. 1592-1603. doi:10.1039/c002348e

2009

Stewart, Alan J., Blindauer, Claudia A. and Sadler, P. J. (2009) Plasma fatty acid levels may regulate the Zn2+-dependent activities of histidine-rich glycoprotein. Biochimie, Vol.91 (No.11-12). pp. 1518-1522. doi:10.1016/j.biochi.2009.08.002

Blindauer, Claudia A., Harvey, Ian, Bunyan, Kerry E., Stewart, Alan J., Sleep, Darrell, Harrison, David J., Berezenko, Stephen and Sadler, P. J. (2009) Structure, properties, and engineering of the major zinc binding site on human albumin. Journal of Biological Chemistry, Vol.284 (No.34). pp. 23116-23124. doi:10.1074/jbc.M109.003459

Blindauer, Claudia A. (2009) Bacterial metallothioneins. In: Sigel, Astrid and Sigel, Helmut and Sigel, Roland K. O., (eds.) Metallothioneins and Related Chelators. Metal Ions in Life Sciences, Vol.5 . Cambridge: Royal Society of Chemistry, pp. 51-81. ISBN 9781847558992

Sayers, Claire T., Mantovani, Giuseppe, Ryan, Sinead M., Randev, Rajan K., Keiper, Odin, Leszczyszyn, Oksana I., Blindauer, Claudia A., Brayden, David J. and Haddleton, David M. (2009) Site-specific N-terminus conjugation of poly(mPEG(1100)) methacrylates to salmon calcitonin : synthesis and preliminary biological evaluation. Soft Matter, Vol.5 (No.16). pp. 3038-3046. doi:10.1039/b905335b

2008

Lu, Jin, Stewart, Alan J., Sadler, P. J., Pinheiro, Teresa J. T. and Blindauer, Claudia A. (2008) Albumin as a zinc carrier : properties of its high-affinity zinc-binding site. Biochemical Society Transactions, Vol.36 (No.6). pp. 1317-1321. doi:10.1042/BST0361317

Randev, Rajan, Sayers, Claire, Ryan, Sinead, Mantovani, G. (Giuseppe), Keiper, Odin, Blindauer, Claudia A., Brayden, David J. and Haddleton, David M. (2008) POLY 433-site-specific conjugation of a well-defined functional poly(mPEG1100) methacrylate to salmon calcitonin : design, synthesis, characterization and investigation via NMR. In: 236th National Meeting of the American-Chemical-Society, Philadelphia, PA, 17-21 Aug 2008. Published in: Abstracts of papers of the American Chemical Society, Vol.236 433-POLY. ISSN 0065-7727.

Blindauer, Claudia A., Harrison, Mark D., Parkinson, J. A. (John A.), Robinson, N. J. (Nigel J.) and Sadler, P. J. (2008) Isostructural replacement of zinc by cadmium in bacterial metallothionein. In: 10th International Symposium on Metal Ions in Biology and Medicine, Bastia, France, 19-22 May 2008. Published in: Metal Ions in Biology and Medicine, Vol.10 pp. 167-173. ISBN 978-2-7420-0714-1. ISSN 1257-2535.

Blindauer, Claudia A. (2008) Metallothioneins with unusual residues : histidines as modulators of zinc affinity and reactivity. In: 1st Georgian Bay International Conference on Bioinorganic Chemistry, Parry Sound, Canada, 22-25 May 2007. Published in: Journal of Inorganic Biochemistry, Vol.102 (No.3). pp. 507-521. ISSN 0162-0134. doi:10.1016/j.jinorgbio.2007.10.032

Blindauer, Claudia A. (2008) Zinc-handling in Cyanobacteria : an update. Chemistry & Biodiversity, Vol.5 (No.10). pp. 1990-2013. doi:10.1002/cbdv.200890183

2007

Leszczyszyn, Oksana I., Schmid, Ralf and Blindauer, Claudia A. (2007) Toward a property/function relationship for metallothioneins: Histidine coordination and unusual cluster composition in a zinc-metallothionein from plants. Proteins, Vol.68 (No.4). pp. 922-935. doi:10.1002/prot.21463

Blindauer, Claudia A., Razi, M. Tahir, Campopiano, Dominic J. and Sadler, P. J. (2007) Histidine ligands in bacterial metallothionein enhance cluster stability. Journal of Biological Inorganic Chemistry, Vol.12 (No.3). pp. 393-405. doi:10.1007/s00775-006-0196-4

Leszczyszyn, Oksana I., Evans, Christine D., Keiper, Stella E., Warren, Gernma Z. L. and Blindauer, Claudia A. (2007) Differential reactivity of individual zinc ions in clusters from bacterial metallothioneins. Inorganica Chimica Acta, Volume 360 (Number 1). pp. 3-13. doi:10.1016/j.ica.2006.08.015

2002

Liang, Xiangyang, Parkinson, J. A. (John A.), Weishäupl, Michael, Gould, Robert O., Paisey, Stephen J., Park, Hye-seo, Hunter, Tina M., Blindauer, Claudia A., Parsons, S. (Simon) and Sadler, P. J. (2002) Structure and dynamics of metallomacrocycles : recognition of zinc xylyl-bicyclam by an HIV coreceptor. Journal of the American Chemical Society, Vol.124 (No.31). pp. 9105-9112. doi:10.1021/ja0260723