2015

Spooner, Robert A. and Lord, Mike (2015) Ricin trafficking in cells. Toxins, Volume 7 (Number 1). pp. 49-65. doi:10.3390/toxins7010049

2013

Pietroni, Paola, Vasisht, Nishi, Cook, Jonathan P., Roberts, David M., Lord, Mike, Hartmann-Petersen, Rasmus, Roberts, L. M. (Lynne M.) and Spooner, Robert A. (2013) The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain. Biochemical Journal, Volume 453 (Number 3). pp. 435-445. doi:10.1042/BJ20130133

2012

Li, Shuyu, Spooner, Robert A. , Hampton, Randolph Y., Lord, Mike and Roberts, L. M. (Lynne M.) (2012) Cytosolic entry of Shiga-like toxin A chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p. PLoS ONE, Vol.7 (No.7). e41119. doi:10.1371/journal.pone.0041119

Spooner, Robert A. and Lord, Mike (2012) How ricin and shiga toxin reach the cytosol of target cells : retrotranslocation from the endoplasmic reticulum. Current Topics in Microbiology and Immunology, Vol.357 . pp. 19-40. doi:1007/82_2011_154

2011

Sorieul, Mathias, Langhans, Markus, Guetzoyan, Lucie J., Hillmer, Stefan, Clarkson, Guy J., Lord, Mike, Roberts, L. M. (Lynne M.), Robinson, David G., Spooner, Robert A. and Frigerio, Lorenzo (2011) An Exo2 derivative affects ER and Golgi morphology and vacuolar sorting in a tissue-specific manner in arabidopsis. Traffic, Vol.12 (No.11). pp. 1552-1562. doi:10.1111/j.1600-0854.2011.01258.x

Aletrari, Mina-Olga , McKibbin, Craig, Williams, Helen, Pawar, Vidya, Pietroni, Paola, Lord, Mike, Flitsch, Sabine L., Whitehead, Roger C., Swanton, Eileithyia, High, Stephen and Spooner, Robert A. (2011) Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways. PLoS One, Vol.6 (No.7). e22713. doi:10.1371/journal.pone.0022713

Lord, Mike and Spooner, Robert A. (2011) Ricin trafficking in plant and mammalian cells. Toxins, Volume 3 (Number 7). pp. 787-801. doi:10.3390/toxins3070787

Redmann, V., Oresic, K., Tortorella, L. L., Cook, Jonathan P., Lord, Mike and Tortorella, D. (2011) Dislocation of ricin toxin A chains in human cells utilizes selective cellular factors. Journal of Biological Chemistry, Vol.286 (No.24). pp. 21231-21238. doi:10.1074/jbc.M111.234708

Pawar, Vidya, De, Antara, Briggs, Laura, Omar, Mahmoud M., Sweeney, Sean T., Lord, Mike, Roberts, L. M. (Lynne M.), Spooner, Robert A. and Moffat, Kevin G. (2011) RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance. Journal of Biomolecular Screening, Vol.16 (No.4). pp. 436-442. doi:10.1177/1087057110397890

2010

Boal, Frederic, Guetzoyan, Lucie, Sessions, Richard B., Zeghouf, Mahel, Spooner, Robert A. , Lord, Mike, Cherfils, Jacqueline, Clarkson, Guy J., Roberts, L. M. (Lynne M.) and Stephens, David J. (2010) LG186: an inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells. Traffic, Vol.11 (No.12). pp. 1537-1551. doi:10.1111/j.1600-0854.2010.01122.x

Li, Shuyu, Spooner, Robert A. , Allen, Stuart C. H., Guise, Christopher P., Ladds, Graham, Schnöder, Tina, Schmitt, Manfred J., Lord, Mike and Roberts, L. M. (Lynne M.) (2010) Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum. Molecular Biology of the Cell, Vol.21 (No.15). pp. 2543-2554. doi:10.1091/mbc.E09-08-0743

Guetzoyan, Lucie J., Spooner, Robert A. , Lord, Mike, Roberts, L. M. (Lynne M.) and Clarkson, Guy J. (2010) Simple oxidation of pyrimidinylhydrazones to triazolopyrimidines and their inhibition of Shiga toxin trafficking. European Journal of Medicinal Chemistry, Vol.45 (No.1). pp. 275-283. doi:10.1016/j.ejmech.2009.10.007

Guetzoyan, Lucie J., Spooner, Robert A. , Boal, Frédéric, Stephens, David J., Lord, Mike, Roberts, L. M. (Lynne M.) and Clarkson, Guy J. (2010) Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells. Molecular BioSystems, Vol.6 (No.10). pp. 2030-2038. doi:10.1039/c0mb00035c

Spooner, Robert A., Cook, Jonathan P., Li, Shuyu, Pietroni, Paula and Lord, Mike (2010) How Ricin Reaches its Target in the Cytosol of Mammalian Cells. In: Toxic Plant Proteins. Plant Cell Monographs, Vol.18 . Springer, pp. 207-224. ISBN 1861-1370

2009

Crispin, Max, Chang, Veronica T., Harvey, David J., Dwek, Raymond A., Evans, Edward J., Stuart, David I., Jones, E. Yvonne, Lord, Mike, Spooner, Robert A. and Davis, Simon J. (2009) A human embryonic kidney 293T cell line mutated at the Golgi alpha-mannosidase II locus. Journal of Biological Chemistry, Vol.284 (No.32). pp. 21684-21695. doi:10.1074/jbc.M109.006254

Marshall, Richard S., Jolliffe, Nicholas A., Ceriotti, Aldo, Snowden, Christopher J., Lord, Mike, Frigerio, Lorenzo and Roberts, L. M. (Lynne M.) (2009) The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells. Journal of Biological Chemistry, Vol.283 . pp. 15869-15877. doi:10.1074/jbc.M709316200

Crispin, Max, Chang, Veronica T., Harvey, David J., Dwek, Raymond A., Evans, Edward J., Stuart, David I., Jones, E. Yvonne, Lord, Mike, Spooner, Robert A. and Davis, Simon J. (2009) A human embryonic kidney 293T cell line mutated at the Golgi -mannosidase II locus. Journal of Biological Chemistry . doi:10.1074/jbc.M109.006254

Mayerhofer, Peter U., Cook, Jonathan P., Wahlman, Judit, Pinheiro, Teresa J. T., Moore, Katherine A. H., Lord, Mike, Johnson, Arthur E. and Roberts, L. M. (Lynne M.) (2009) Ricin A chain insertion into endoplasmic reticulum membranes is triggered by a temperature increase to 37 degrees C. Journal of Biological Chemistry, Vol.284 (No.15). pp. 10232-10242. doi:10.1074/jbc.M808387200

2008

Chamberlain, Kerry L., Marshall, Richard S., Jolliffe, Nicholas A., Frigerio, Lorenzo, Ceriotti, Aldo, Lord, Mike and Roberts, L. M. (Lynne M.) (2008) Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism. Journal of Biological Chemistry, Vol.283 (No.48). pp. 33276-33286. doi:10.1074/jbc.M805222200

Spooner, Robert A., Harte, Philip J. , Cook, Jonathan P., Pietroni, Paola, Rogon, Christian, Höhfeld, Jörg, Roberts, L. M. (Lynne M.) and Lord, Mike (2008) Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America, Vol.105 (No.45). pp. 17408-17413. doi:10.1073/pnas.0809013105

Spooner, Robert A., Watson, Peter, Smith, Daniel C., Boal, Frédéric, Amessou, Mohammed, Mohammed, Ludger, Clarkson, Guy J., Lord, Mike, Stephens, David J. and Roberts, L. M. (Lynne M.) (2008) The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Biochemical Journal, Vol.414 (No.3). pp. 471-484. doi:10.1042/BJ20080149

2007

Allen, Stuart C. H., Moore, Katherine A. H., Marsden, Catherine J., Fülöp, Vilmos, Moffat, Kevin G., Lord, Mike, Ladds, Graham and Roberts, L. M. (Lynne M.) (2007) The isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae. FEBS JOURNAL, 274 (21). pp. 5586-5599. doi:10.1111/j.1742-4658.2007.06080.x

Allen, Stuart C. H., Moore, Katherine A. H., Marsden, Catherine J., Fülöp, Vilmos, Moffat, Kevin G., Lord, Mike, Ladds, Graham and Roberts, L. M. (Lynne M.) (2007) The isolation and characterisation of temperature-dependent Ricin A chain molecules in Saccharomyces cerevisiae. FEBS Journal, Vol.274 (No.21). pp. 5586-5599. doi:10.1111/j.1742-4658.2007.06080.x

Fuchs, Evelyn, Haas, Alexander K., Spooner, Robert A. , Yoshimura, Shin-Ichiro, Lord, Mike and Barr, Francis A. (2007) Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. Journal of Cell Biology, Vol.177 (No.6). pp. 1133-1143. doi:10.1083/jcb.200612068

Fuchs, Evelyn, Hass, Alexander K., Spooner, Robert A. , Yoshimura, Shin-ichiro , Lord, Mike and Barr, Francis A. (2007) Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. Journal of Cell Biology, Vol.177 (No.6). pp. 1133-1143. doi:10.1083/jcb.200612068

Jarvis, Rosemary M., Chamba, Anita, Holder, Michelle J., Challa, Anita, Smith, Daniel C., Hodgkin, Matthew N., Lord, Mike and Gordon, John (2007) Dynamic interplay between the neutral glycosphingolipid CD77/Gb3 and the therapeutic antibody target CD20 within the lipid bilayer of model B lymphoma cells. Biochemical and Biophysical Research Communications, Vol.355 (No.4). pp. 944-949. doi:10.1016/j.bbrc.2007.02.053

Amessou, Mohamed, Fradagrada, Alexandre, Falguières, Thomas, Lord, Mike, Smith, Daniel C., Roberts, L. M. (Lynne M.), Lamaze, Christophe and Johannes, Ludger (2007) Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins. Journal of Cell Science, Vol.120 (No.8). pp. 1457-1468. doi:10.1242/jcs.03436

Grimaldi, Elizabeth, Claassen, Erwin A. W., Lord, Mike, Smith, Daniel C. and Easton, A. J. (Andrew J.) (2007) Stimulation of pneumovirus-specific CD8(+) T-cells using a non-toxic recombinant ricin delivery system. Molecular Immunology, Vol.44 (No.5). pp. 993-998. doi:10.1016/j.molimm.2006.03.008

2006

Stirling, Colin J. and Lord, Mike (2006) Quality control: Linking retrotranslocation and degradation. CURRENT BIOLOGY, 16 (24). R1035-R1037. doi:10.1016/j.cub.2006.11.013

Jolliffe, Nicholas A., Di Cola, Alessandra, Marsden, Catherine J., Lord, Mike, Ceriotti, Aldo, Frigerio, Lorenzo and Roberts, L. M. (Lynne M.) (2006) The N-terminal ricin propeptide influences the fate of ricin A-chain in tobacco protoplasts. JOURNAL OF BIOLOGICAL CHEMISTRY, 281 (33). pp. 23377-23385. doi:10.1074/jbc.M602678200

Spooner, Robert A. , Smith, Daniel C., Easton, A. J. (Andrew J.), Roberts, L. M. (Lynne M.) and Lord, Mike (2006) Retrograde transport pathways utilised by viruses and protein toxins. Virology Journal, Vol.3 . p. 26. doi:10.1186/1743-422X-3-26

Smith, Daniel C. , Sillence, Daniel J., Falguières, Thomas, Jarvis, Rosemary M., Johannes, Ludger, Lord, Mike, Platt, Frances M. and Roberts, L. M. (Lynne M.) (2006) The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect. Molecular Biology of the Cell, Vol.17 (No.3). pp. 1375-1387. doi:10.1091/mbc.E05-11-1035

2004

Spooner, Robert A. , Watson, Peter, Marsden, Catherine J., Smith, Daniel C., Moore, Katherine A. H., Cook, Jonathan P., Lord, Mike and Roberts, L. M. (Lynne M.) (2004) Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum. Biochemical Journal, Vol.383 (No.2). pp. 285-293. doi:10.1042/BJ20040742