2020

Roscioli, Emanuele, Germanova, Tsvetelina E., Smith, Christopher A., Embacher, Peter A., Erent, Muriel, Thompson, Amelia I., Burroughs, Nigel John and McAinsh, Andrew D. (2020) Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors. Cell Reports, 31 (4). p. 107535. doi:10.1016/j.celrep.2020.107535

Auckland, Philip, Roscioli, Emanuele, Coker, H. L. E. and McAinsh, Andrew D. (2020) CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes. Journal of Cell Biology, 219 (5). e201905018. doi:10.1083/jcb.201905018

2018

Pesenti, Marion E., Prumbaum, Daniel, Auckland, Philip, Smith, Charlotte M., Faesen, Alex C., Petrovic, Arsen, Erent, Muriel, Maffini, Stefano, Pentakota, Satyakrishna, Weir, John R., Lin, Yu-Chih, Raunser, Stefan, McAinsh, Andrew D. and Musacchio, Andrea (2018) Reconstitution of a 26-Subunit human kinetochore reveals cooperative microtubule binding by CENP-OPQUR and NDC80. Molecular Cell, 71 (6). pp. 923-939. doi:10.1016/j.molcel.2018.07.038

Currie, Cerys E., Mora-Santos, Maria, Smith, Chris A., McAinsh, Andrew D. and Millar, Jonathan B.A. (2018) Bub1 is not essential for the checkpoint response to unattached kinetochores in diploid human cells. Current Biology, 28 (17). R929-R930. doi:10.1016/j.cub.2018.07.040

McHugh, Toni, Drechsler, Hauke, McAinsh, Andrew D., Carter, Nicholas J. and Cross, R. A. (2018) Kif15 functions as an active mechanical ratchet. Molecular Biology of the Cell, 29 (4). pp. 1743-1752. doi:10.1091/mbc.E18-03-0151

Dudka, Damian, Noatynska, Anna, Smith, Christopher, A., Liaudet, Nicolas, McAinsh, Andrew D. and Meraldi, Patrick (2018) Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments. Nature Communications, 9 (1). doi:10.1038/s41467-018-04427-x

Hatano, Tomoyuki, Alioto, Salvatore, Roscioli, Emanuele, Palani, Saravanan, Clarke, Scott T., Kamnev, Anton, Hernandez Fernaud, Juan Ramon, Sivashanmugam, Lavanya, Chapa y Lazo, Bernardo, Jones, Alexandra M., Robinson, Robert C., Sampath, Karuna, Mishima, Masanori, McAinsh, Andrew D., Goode, Bruce L. and Balasubramanian, Mohan K. (2018) Rapid production of pure recombinant actin isoforms in Pichia pastoris. Journal of Cell Science, 131 (8). jcs213827. doi:10.1242/jcs.213827

Currie, Cerys E., Mora-Santos, Maria, Smith, Chris, McAinsh, Andrew D. and Millar, Jonathan B. A. (2018) Bub1 is not required for the checkpoint response to unattached kinetochores in diploid human cells. Working Paper. Cold Spring Harbour: BioRXiv.

Smith, Chris A., Burroughs, Nigel John and McAinsh, Andrew D. (2018) Mitotic live-cell imaging at different timescales. In: Maiato, Helder and Schuh, Melina, (eds.) Mitosis and Meiosis Part B. Methods in Cell Biology, 145 . Cambridge, Massachuetts: Elsevier, pp. 1-27. ISBN 9780128141427

2017

Rhys, Alexander D., Monteiro, Pedro, Smith, Christopher Matthew, Vaghela, Malti, Arnandis, Teresa, Kato, Takuya, Leitinger, Birgit, Sahai, Erik, McAinsh, Andrew D., Charras, Guillaume and Godinho, Susana A. (2017) Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells. The Journal of Cell Biology, 217 (1). pp. 195-209. doi:10.1083/jcb.201704102

Sandu, Pamela, Crepin, Valerie F., Drechsler, Hauke, McAinsh, Andrew D., Frankel, Gad and Berger, Cedric N. (2017) The Enterohemorrhagic Escherichia coli effector EspW triggers actin remodeling in a Rac1-dependent manner. Infection and Immunity, 85 (9). e00244-17. doi:10.1128/IAI.00244-17

Auckland, Philip, Clarke, Nicholas I., Royle, Stephen J. and McAinsh, Andrew D. (2017) Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment. The Journal of Cell Biology, 216 (6). pp. 1623-1639. doi:10.1083/jcb.201607096

Maciejowski, John, Drechsler, Hauke, Grundner-Culemann, Kathrin, Ballister, Edward R., Rodriguez-Rodriguez, Jose-Antonio, Rodriguez-Bravo, Veronica, Jones, Mathew J. K., Foley, Emily, Lampson, Michael A., Daub, Henrik, McAinsh, Andrew D. and Jallepalli, Prasad V. (2017) Mps1 regulates kinetochore-microtubule attachment stability via the ska complex to ensure error-free chromosome segregation. Developmental Cell, 41 (2). 143-156.e6. doi:10.1016/j.devcel.2017.03.025

2016

Smith, Chris A., McAinsh, Andrew D. and Burroughs, Nigel John (2016) Human kinetochores are swivel joints that mediate microtubule attachments. eLife, 5 . e16159. doi:10.7554/eLife.16159

Armond, Jonathan W., Vladimirou, Elina, McAinsh, Andrew D. and Burroughs, Nigel John (2016) KiT : a MATLAB package for kinetochore tracking. Bioinformatics, 32 (12). pp. 1917-1919. doi:10.1093/bioinformatics/btw087

Drechsler, Hauke and McAinsh, Andrew D. (2016) Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles. Proceedings of the National Academy of Sciences of the United States of America, 113 (12). E1635-E1644. doi:10.1073/pnas.1516370113

Patel, Jessica, Tan, S. L., Hartshorne, Geraldine M. and McAinsh, Andrew D. (2016) Unique geometry of sister kinetochores in human oocytes during meiosis I may explain maternal age-associated increases in chromosomal abnormalities. Biology Open, 5 (2). pp. 178-184. doi:10.1242/bio.016394

2015

Silió, Virginia, McAinsh, Andrew D. and Millar, Jonathan B. A. (2015) KNL1-Bubs and RZZ provide two separable pathways for checkpoint activation at human kinetochores. Developmental Cell, 35 (5). pp. 600-613. doi:10.1016/j.devcel.2015.11.012

Armond, Jonathan W., Harry, Edward, McAinsh, Andrew D. and Burroughs, Nigel John (2015) Inferring the forces controlling metaphase kinetochore oscillations by reverse engineering system dynamics. PLoS Computational Biology, 11 (11). e1004607. doi:10.1371/journal.pcbi.1004607

Burroughs, Nigel John, Harry, Edward and McAinsh, Andrew D. (2015) Super-resolution kinetochore tracking reveals the mechanisms of human sister kinetochore directional switching. eLife, 4 . e09500. doi:10.7554/eLife.09500

Auckland, Philip and McAinsh, Andrew D. (2015) Building an integrated model of chromosome congression. Journal of Cell Science, 128 (18). pp. 3363-3374. doi:10.1242/jcs.169367

Armond, Jonathan W., Vladimirou, Elina, Erent, Muriel, McAinsh, Andrew D. and Burroughs, Nigel John (2015) Probing microtubule polymerisation state at single kinetochores during metaphase chromosome motion. Journal of Cell Science, Volume 128 (Number 10). pp. 1991-2001. doi:10.1242/jcs.168682

Bancroft, James M., Auckland, Philip, Samora, C. P. and McAinsh, Andrew D. (2015) Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways. Journal of Cell Science, 128 (1). pp. 171-184. doi:10.1242/jcs.163659

2014

McAinsh, Andrew D. (2014) How kinetochores CCAN resist force. Developmental Cell, Volume 30 (Number 6). pp. 637-638. doi:10.1016/j.devcel.2014.09.007

Drechsler, Hauke, McHugh, Toni, Singleton, Martin R., Carter, Nicholas J. and McAinsh, Andrew D. (2014) The kinesin-12 Kif15 is a processive track-switching tetramer. eLife, Volume 3 . Article number e01724. doi:10.7554/eLife.01724

Cross, R. A. and McAinsh, Andrew D. (2014) Prime movers : mechanochemistry of mitotic kinesins. Nature Reviews Molecular Cell Biology, Volume 15 . pp. 257-271. doi:10.1038/nrm3768

Vázquez-Novelle, María Dolores, Sansregret, Laurent, Dick, Amalie E., Smith, Christopher A., McAinsh, Andrew D., Gerlich, Daniel W. and Petronczki, Mark (2014) Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase. Current Biology, Volume 24 (Number 6). pp. 638-645. doi:10.1016/j.cub.2014.01.034

2013

Vladimirou, Elina , Mchedlishvili, Nunu, Gasic, Ivana, Armond, Jonathan W., Samora, Catarina P., Meraldi, Patrick and McAinsh, Andrew D. (2013) Nonautonomous movement of chromosomes in mitosis. Developmental Cell, Volume 27 (Number 1). pp. 60-71. doi:10.1016/j.devcel.2013.08.004

(2013) Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Research, Volume 21 (Number 2). pp. 101-106. doi:10.1007/s10577-013-9347-y

Cheeseman, L. P., Harry, Edward, McAinsh, Andrew D., Prior, I. A. and Royle, Stephen J. (2013) Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. Journal of Cell Science, Volume 126 (Number 9). pp. 2102-2113. doi:10.1242/jcs.124834

2012

Drechsler, Hauke and McAinsh, Andrew D. (2012) Exotic mitotic mechanisms. Open Biology, Vol.2 . Article number 120140. doi:10.1098/rsob.120140

Eskat, Anja, Deng, Wen, Hofmeister, Antje, Rudolphi, Sven, Emmerth, Stephan, Hellwig, Daniela, Ulbricht, Tobias, Döring, Volker, Bancroft, James M., McAinsh, Andrew D., Cardoso, M. Cristina, Meraldi, Patrick, Hoischen, Christian, Leonhardt, Heinrich and Diekmann, Stephan (2012) Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex. PLoS One, Vol.7 (No.9). e44717. doi:10.1371/journal.pone.0044717

Kaseda, Kuniyoshi, McAinsh, Andrew D. and Cross, R. A. (2012) Dual pathway spindle assembly increases both the speed and the fidelity of mitosis. Biology Open, Vol.1 (No.1). pp. 12-18. doi:10.1242/bio.2011012

2011

McAinsh, Andrew D. and Meraldi, Patrick (2011) The CCAN complex : linking centromere specification to control of kinetochore–microtubule dynamics. Seminars in Cell & Developmental Biology, Vol.22 (No.9). pp. 946-952. doi:10.1016/j.semcdb.2011.09.016

Cross, R. A., McAinsh, Andrew D. and Straube, Anne (2011) Mechanochemical cell biology. Seminars in Cell & Developmental Biology, Vol.22 (No.9). pp. 913-915. doi:10.1016/j.semcdb.2011.10.002

Samora, Catarina P., Mogessie, Binyam, Conway, Leslie, Ross, Jennifer L., Straube, Anne and McAinsh, Andrew D. (2011) MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis. Nature Cell Biology, Vol.13 (No.9). pp. 1040-1050. doi:10.1038/ncb2297

Vladimirou, Elina, Harry, Edward, Burroughs, Nigel John and McAinsh, Andrew D. (2011) Springs, clutches and motors : driving forward kinetochore mechanism by modelling. Chromosome Research, Volume 19 (Number 3). pp. 409-421. doi:10.1007/s10577-011-9191-x

Samora, Catarina P. and McAinsh, Andrew D. (2011) Photoactivatable-GFP-α-tubulin as a tool to study microtubule plus-end turnover in living human cells. In: Straube, Anne, (ed.) Microtubule Dynamics. Methods in Molecular Biology, Vol.777 . Humana Press, pp. 223-233. ISBN 9781617792519

2010

Amaro, Ana C., Samora, Catarina P., Holtackers, Rene, Wang, Enxiu, Kingston, Isabel J., Alonso, M. (Maria), Lampson, Michael, McAinsh, Andrew D. and Meraldi, Patrick (2010) Molecular control of kinetochore-microtubule dynamics and chromosome oscillations. Nature Cell Biology, Vol.12 (No.4). 319-U42. doi:10.1038/ncb2033

Jaqaman, K., King, E. M., Amaro, A. C., Winter, J. R., Dorn, J. F., Elliott, Hunter L., Mchedlishvili, N., McClelland, S. E., Porter, I. M., Posch, M., Toso, A., Danuser, G., McAinsh, Andrew D., Meraldi, P. and Swedlow, Jason (2010) Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases. Journal of Cell Biology, Vol.188 (No.5). pp. 665-679. doi:10.1083/jcb.200909005

2009

Braun, Marcus, Drummond, Douglas R., Cross, R. A. and McAinsh, Andrew D. (2009) The kinesin-14 Klp2 organizes microtubules into parallel bundles by an ATP-dependent sorting mechanism. Nature Cell Biology, Vol.11 (No.6). pp. 724-730. doi:10.1038/ncb1878

Toso, Alberto, Winter, Jennifer R., Garrod, Ainslie J., Amaro, Ana C., Meraldi, Patrick and McAinsh, Andrew D. (2009) Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly. Journal of Cell Biology, Vol.184 (No.3). pp. 365-372. doi:10.1083/jcb.200809055

McClelland, Sarah E. and McAinsh, Andrew D. (2009) Hydrodynamic analysis of human kinetochore complexes during mitosis. In: McAinsh, Andrew D., (ed.) Mitosis. Methods in Molecular Biology, Vol.545 . Humana Press, pp. 81-98. ISBN 9781603279925