2020

Bugg, Timothy D. H., Williamson, James J. and Rashid, Goran M. M. (2020) Bacterial enzymes for lignin depolymerisation : new biocatalysts for generation of renewable chemicals from biomass. Current Opinion in Chemical Biology, 55 . pp. 26-33. doi:10.1016/j.cbpa.2019.11.007

Nurika, Irnia, Eastwood, Daniel C., Bugg, Timothy D. H. and Barker, Guy C. (2020) Biochemical characterization of Serpula lacrymans iron-reductase enzymes in lignocellulose breakdown. Journal of Industrial Microbiology & Biotechnology, 47 (1). pp. 145-154. doi:10.1007/s10295-019-02238-7

Tramontina, Robson, Galman, James L., Parmeggiani, Fabio, Derrington, Sasha R., Bugg, Timothy D. H., Turner, Nicholas J., Squina, Fabio M. and Dixon, Neil (2020) Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass. Green Chemistry, 22 (1). pp. 144-152. doi:10.1039/c9gc02359c

Wilkinson, Rachael C., Rahman-Pour, Rahman, Jamshidi, Shirin, Fülöp, Vilmos and Bugg, Timothy D. H. (2020) Extracellular alpha/beta-hydrolase from Paenibacillus species shares structural and functional homology to tobacco salicylic acid binding protein 2. Journal of Structural Biology . (In Press)

2019

Granja-Travez, Rommel Santiago, Persinoti, Gabriela Felix, Squina, Fabio M. and Bugg, Timothy D. H. (2019) Functional genomic analysis of bacterial lignin degraders : diversity in mechanisms of lignin oxidation and metabolism. Applied Microbiology and Biotechnology . (In Press)

Bugg, Tim and Kerr, Rachel V. (2019) Mechanism of action of nucleoside antibacterial natural product antibiotics. Journal of Antibiotics . doi:10.1038/s41429-019-0227-3 (In Press)

Wei, Zhen, Wilkinson, Rachael C., Rashid, Goran M. M., Brown, David, Fülöp, Vilmos and Bugg, Tim (2019) Characterisation of thiamine diphosphate-dependent 4-hydroxybenzoylformate decarboxylase enzymes from Rhodococcus jostii RHA1 and Pseudomonas fluorescens Pf-5 involved in degradation of aryl-C2 lignin degradation fragments. Biochemistry . doi:10.1021/acs.biochem.9b00177 (In Press)

Rahmanpour, Rahman, Ehibhatiomhan, Austine, Huang, Yuling, Ashley, Ben, Rashid, Goran M. M., Mendel-Williams, Sharon and Bugg, Timothy D. H. (2019) Protein engineering of Pseudomonas fluorescens peroxidase Dyp1B for oxidation of phenolic and polymeric lignin substrates. Enzyme and Microbial Technology . doi:10.1016/j.enzmictec.2019.01.002 (In Press)

2018

Granja-Travez, Rommel Santiago and Bugg, Timothy D. H. (2018) Characterization of multicopper oxidase CopA from Pseudomonas putida KT2440 and Pseudomonas fluorescens Pf-5 : Involvement in bacterial lignin oxidation. Archives of Biochemistry and Biophysics, 660 . pp. 97-107. doi:10.1016/j.abb.2018.10.012

Rashid, Goran M. M., Zhang, Xiaoyang, Wilkinson, Rachael C., Fülöp, Vilmos, Cottyn, Betty, Baumberger, Stéphanie and Bugg, Tim (2018) Sphingobacterium sp. T2 manganese superoxide dismutase catalyses the oxidative demethylation of polymeric lignin via generation of hydroxyl radical. ACS Chemical Biology . doi:10.1021/acschembio.8b00557

Persinoti, Gabriela F., Paixão, Douglas A. A., Bugg, Timothy D. H. and Squina, Fabio M. (2018) Genome Sequence of Lysinibacillus sphaericus, a Lignin-Degrading Bacterium Isolated from Municipal Solid Waste Soil. Genome Announcements, 6 (18). e00353-18. doi:10.1128/genomeA.00353-18

Granja-Travez, R. S., Wilkinson, Rachael C., Persinoti, G. F., Squina, F. M., Fülöp, Vilmos and Bugg, Tim (2018) Structural and functional characterisation of multi-copper oxidase CueO from lignin-degrading bacterium Ochrobactrum sp. reveal its activity towards lignin model compounds and lignosulfonate. FEBS Journal, 285 (9). pp. 1684-1700. doi:10.1111/febs.14437

Moraes, Eduardo C., Alvarez, Thabata M., Persinoti, Gabriela F., Tomazetto, Geizecler, Brenelli, Livia B., Paixão, Douglas A. A., Ematsu, Gabriela C., Aricetti, Juliana A., Caldana, Camila, Dixon, Neil, Bugg, Tim and Squina, Fabio M. (2018) Lignolytic-consortium omics analyses reveal novel genomes and pathways involved in lignin modification and valorization. Biotechnology for Biofuels, 11 (75). doi:10.1186/s13068-018-1073-4

Eyice, Özge, Myronova, Natalia, Pol, Arjan, Carrion, Ornella, Todd, Jonathan, Smith, Tom J., Gurman, Stephen J., Cuthbertson, Adam, Mazard, Sophie, Mennink-Kersten, Monique A. S. H. , Bugg, Tim, Andersson, K. Kristoffer, Johnston, Andrew W. B., Op Den Camp, Huub J. M. and Schäfer, Hendrik (2018) Bacterial SBP56 identified as a Cu-dependent methanethiol oxidase widely distributed in the biosphere. ISME Journal, 12 . 145-160 . doi:10.1038/ismej.2017.148

2017

Konstantopoulou, Marina, Slator, Paddy J., Taylor, Charles R., Wellington, E. M. H., Allison, Gordon, Harper, Andrea L., Bancroft, Ian and Bugg, Timothy D. H. (2017) Variation in susceptibility to microbial lignin oxidation in a set of wheat straw cultivars : influence of genetic, seasonal and environmental factors. Nordic Pulp and Paper Research Journal, 32 (4). pp. 493-507.

Millar, Robert, Rahmanpour, Rahman, Wei Jia Yuan, Eugenie, White, Catharine and Bugg, Tim (2017) Esterase EstK from Pseudomonas putida mt-2 : an enantioselective acetylesterase with activity for deacetylation of xylan and poly(vinylacetate). Biotechnology and Applied Biochemistry, 64 (6). pp. 803-809.

Rashid, Goran M. M., Duran-Pena, Maria Jesus, Rahmanpour, Rahman , Sapsford, Devin and Bugg, Tim (2017) Delignification and enhanced gas release from soil containing Lignocellulose by treatment with bacterial lignin degraders. Journal of Applied Microbiology, 123 (1). pp. 159-171. doi:10.1111/jam.13470

Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng-Ruh, Linington, Roger G., Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Tim, Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J. and Payne, Richard J. (2017) Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8 . 14414 . doi:10.1038/ncomms14414

Rahmanpour, Rahman, King, Lloyd D. W and Bugg, Tim (2017) Identification of an extracellular bacterial flavoenzyme that can prevent re-polymerisation of lignin fragments. Biochemical and Biophysical Research Communications, 482 (1). pp. 57-61. doi:10.1016/j.bbrc.2016.10.144

Awan, Sajjad Zahoor, Chandler, Jake Owen, Harrison, Peter J., Sergeant, Martin J., Bugg, Tim and Thompson, Andrew David (2017) Promotion of germination using hydroxamic acid inhibitors of 9-cis-epoxycarotenoid dioxygenase. Frontiers in Plant Science, 8 . 357. doi:10.3389/fpls.2017.00357

2016

Zhu, Yijun , Ksibe, Amira Z., Schäfer, Hendrik, Blindauer, Claudia A., Bugg, Tim and Chen, Yin (2016) O2-independent demethylation of trimethylamine N-oxide by Tdm of Methylocella silvestris. FEBS Journal, 283 (21). pp. 3979-3993. doi:10.1111/febs.13902

Lancefield, Christopher S., Rashid, Goran M. M., Bouxin, Florent, Wasak, Agata, Tu, Wei-Chien, Hallett, Jason P., Zein, Sharif, Rodriguez, Jaime, Jackson, S. David, Westwood, Nicholas J. and Bugg, Timothy D. H. (2016) An investigation of the chemocatalytic and biocatalytic valorisation of a range of different lignin preparations : the importance of β-O-4 content. ACS Sustainable Chemistry & Engineering . doi:10.1021/acssuschemeng.6b01855

Rahmanpour, Rahman , Rea, Dean, Jamshidi, Shirin, Fülöp, Vilmos and Bugg, Tim (2016) Structure of thermobifida fusca DyP-type peroxidase and activity towards kraft lignin and lignin model compounds. Archives of Biochemistry and Biophysics, 594 . pp. 54-60. doi:10.1016/j.abb.2016.02.019

Bugg, Tim, Rodolis, Maria T., Mihalyi, Agnes and Jamshidi, Shirin (2016) Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage <phi>X174 lysis protein E, and cationic antibacterial peptides. Bioorganic and Medicinal Chemistry . doi:10.1016/j.bmc.2016.03.018

2015

Mycroft, Zoe, Gomis, Maria, Mine, Paul, Law, Paul and Bugg, Tim (2015) Biocatalytic conversion of lignin to aromatic dicarboxylic acids in Rhodococcus jostii RHA1 by re-routing aromatic degradation pathways. Green chemistry, 17 (11). pp. 4974-4979. doi:10.1039/c5gc01347j

Harrison, Peter J., Newgas, Sophie A., Descombes, Flora, Shepherd, Sarah A., Thompson, Andrew J. and Bugg, Tim (2015) Biochemical characterization and selective inhibition of β-carotenecis-transisomerase D27 and carotenoid cleavage dioxygenase CCD8 on the strigolactone biosynthetic pathway. FEBS Journal . doi:10.1111/febs.13400

Rashid, Goran M. M., Taylor, Charles R. (Charles Robert), Liu, Yangqingxu, Zhang, Xiaoyang, Rea, Dean, Fülöp, Vilmos and Bugg, Tim (2015) Identification of manganese superoxide dismutase from Sphingobacterium sp. T2 as a novel bacterial enzyme for lignin oxidation. ACS chemical biology, 10 (10). pp. 2286-2294. doi:10.1021/acschembio.5b00298

2014

Rodolis, Maria T., Mihalyi, Agnes, Ducho, Christian, Eitel, Kornelia, Gust, Bertolt, Goss, Rebecca J. M. and Bugg, Tim (2014) Mechanism of action of the uridyl peptide antibiotics: an unexpected link to a protein–protein interaction site in translocase MraY. Chemical Communications, 50 (86). pp. 13023-13025. doi:10.1039/c4cc06516f

Braddick, Darren, Sandhu, Sandeep, Roper, David I., Chappell, M. J. (Michael J.) and Bugg, Tim (2014) Observation of the time-course for peptidoglycan lipid intermediate II polymerization by Staphylococcus aureus monofunctional transglycosylase. Microbiology, Volume 160 (Part 8). pp. 1628-1636. doi:10.1099/mic.0.079442-0

Rodolis, Maria T., Mihalyi, Agnes, O'Reilly, Amy M., Slikas, Justinas, Roper, David I., Hancock, Robert E. W. and Bugg, Tim (2014) Identification of a novel inhibition site in Translocase MraY based upon the site of interaction with Lysis Protein E from Bacteriophage ϕX174. Chembiochem, Volume 15 (Number 9). pp. 1300-1308. doi:10.1002/cbic.201402064

Van Norman, Jaimie M., Zhang, Jingyuan, Cazzonelli, Christopher I., Pogson, Barry J., Harrison, Peter J. , Bugg, Tim, Chan, Kai Xun, Thompson, Andrew J. and Benfey, Philip N. (2014) Periodic root branching inArabidopsis requires synthesis of an uncharacterized carotenoid derivative. Proceedings of the National Academy of Sciences of the United States of America, Volume 111 (Number 13). E1300-E1309. doi:10.1073/pnas.1403016111

Zhu, Yijun , Jameson, Eleanor, Cosatti, Marialuisa , Schäfer, Hendrik, Rajakumar, Kumar , Bugg, Tim and Chen, Yin (2014) Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. Proceedings of the National Academy of Sciences of the United States of America, 111 (11). pp. 4268-4273. doi:10.1073/pnas.1316569111

Bugg, Tim (2014) How to break the rules of dioxygen activation. Chemistry & Biology, Volume 21 (Number 2). pp. 168-169. doi:10.1016/j.chembiol.2014.01.007

Harrison, Peter J. and Bugg, Tim (2014) Enzymology of the carotenoid cleavage dioxygenases : Reaction mechanisms, inhibition and biochemical roles. Archives of Biochemistry and Biophysics, Volume 544 . pp. 105-111. doi:10.1016/j.abb.2013.10.005

Williams, Allison H., Boneca, Ivo G., Burrows, Lori L. and Bugg, Tim (2014) The dynamics of peptidoglycan structure and function : conference report on the 3rd Great Wall Symposium. Research in Microbiology, Volume 165 (Number 1). pp. 60-67. doi:10.1016/j.resmic.2013.11.002

2013

Brown, Kieron, Vial, Sarah C. M., Dedi, Neesha, Westcott, James, Scally, Stephen, Bugg, Tim, Charlton, Peter A. and Cheetham, Graham M. T. (2013) Crystal structure of the Pseudomonas aeruginosa MurG : UDP-GlcNAc substrate complex. Protein and Peptide Letters, Volume 20 (Number 9). pp. 1002-1008. doi:10.2174/0929866511320090006

Rahmanpour, Rahman and Bugg, Tim (2013) Assembly in vitro of rhodococcus jostii RHA1 encapsulin and peroxidase DypB to form a nano-compartment. FEBS Journal, Volume 280 (Issue 9). pp. 2097-2104. doi:10.1111/febs.12234

2012

Sandhu, Sandeep, Schouten, James A., Thompson, Julie, Davis, Mark and Bugg, Tim (2012) Detection of Staphylococcus aureus cell walls by enzyme-linked immunoassay using antibodies prepared from a semi-synthetic peptidoglycan precursor. The Analyst, Vol.137 (No.5). pp. 1130-1136. doi:10.1039/c2an16036f

Bugg, Tim (2012) Biosynthesis : imaging cell-wall biosynthesis live. Nature Chemistry, Vol.5 (No.1). pp. 10-12. doi:10.1038/nchem.1538

Taylor, C. R. (Charles R.), Hardiman, E. M., Ahmad, Mussawar, Sainsbury, P. D., Norris, Paul R. and Bugg, Tim (2012) Isolation of bacterial strains able to metabolize lignin from screening of environmental samples. Journal of Applied Microbiology, Volume 113 (Number 3). pp. 521-530. doi:10.1111/j.1365-2672.2012.05352.x

Coles, Stuart R., Ahmad, Mark, Barker, Guy C., Bugg, Tim, Clark, Andrew J., Collis, Alana and Kirwan, Kerry (2012) Wealth out of waste. In: 19th Annual Meeting of the BioEnvironmental Polymer Society - BEPS, Vienna, Austria, 28-30 Sep 2012 (Unpublished)

2011

Bugg, Tim, Braddick, Darren, Dowson, Christopher G. and Roper, David I. (2011) Bacterial cell wall assembly : still an attractive antibacterial target. Trends in Biotechnology, Vol.29 (No.4). pp. 167-173. doi:10.1016/j.tibtech.2010.12.006

Roberts, Joseph N., Singh, Rahul, Grigg, Jason C., Murphy, Michael E. P., Bugg, Tim and Eltis, Lindsay D. (2011) Characterization of dye-decolorizing peroxidases from Rhodococcus jostii RHA1. Biochemistry, Vol.50 (No.23). pp. 5108-5119. doi:10.1021/bi200427h

Ahmad, Mark, Roberts, Joseph N., Hardiman, Elizabeth M, Singh, Rahul, Eltis, Lindsay D. and Bugg, Tim (2011) Identification of DypB from Rhodococcus jostii RHA1 as a lignin peroxidase. Biochemistry, Vol.50 (No.23). pp. 5096-5107. doi:10.1021/bi101892z

Hattersley, John G., Pérez-Velázquez, J., Chappell, M. J. (Michael J.), Bearup, Daniel James, Roper, David I., Dowson, Christopher G., Bugg, Tim and Evans, Neil D. (2011) Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 70-80. doi:10.1016/j.cmpb.2010.07.009

Bugg, Tim, Ahmad, Mark, Hardiman, Elizabeth M. and Rahmanpour, Rahman (2011) Pathways for degradation of lignin in bacteria and fungi. Natural Product Reports, Vol.28 (No.12). pp. 1883-1896. doi:10.1039/c1np00042j

Bugg, Tim, Ahmad, Mark, Hardiman, Elizabeth M. and Singh, Rahul (2011) The emerging role for bacteria in lignin degradation and bio-product formation. Current Opinion in Biotechnology, Vol.22 (No.3). pp. 394-400. doi:10.1016/j.copbio.2010.10.009

2010

López-Ráez, Juan A., Kohlen, Wouter, Charnikhova, Tatsiana, Mulder, Patrick, Undas, Anna K., Sergeant, Martin J., Verstappen, Francel, Bugg, Tim, Thompson, Andrew J., Ruyter-Spira, Carolien and Bouwmeester, Harro (2010) Does abscisic acid affect strigolactone biosynthesis? New Phytologist, Vol.87 (No.2). pp. 343-354. doi:10.1111/j.1469-8137.2010.03291.x

Ahmad, Mark, Taylor, C. R. (Charles R.), Pink, David, Burton, Kerry S., Eastwood, Daniel C., Bending, G. D. and Bugg, Tim (2010) Development of novel assays for lignin degradation : comparative analysis of bacterial and fungal lignin degraders. Molecular BioSystems, Vol.6 (No.5). pp. 815-821. doi:10.1039/b908966g

Trunkfield, Amy E., Gurcha, Sudagar S., Besra, Gurdyal S. and Bugg, Tim (2010) Inhibition of escherichia coli glycosyltransferase MurG and mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics. Bioorganic & Medicinal Chemistry, Vol.18 (No.7). pp. 2651-2663. doi:10.1016/j.bmc.2010.02.026

Xin, Meite and Bugg, Tim (2010) Biomimetic formation of 2-tropolones by dioxygenase-catalysed ring expansion of substituted 2,4-cyclohexadienones. ChemBioChem, Vol.11 (No.2). pp. 272-276. doi:10.1002/cbic.200900631

Winn, M. (Michael), Goss, Rebecca J. M., Kimura, Ken-ichi and Bugg, Tim (2010) Antimicrobial nucleoside antibiotics targeting cell wall assembly : recent advances in structure-function studies and nucleoside biosynthesis. Natural Product Reports, Vol.27 (No.2). pp. 279-304. doi:10.1039/b816215h

Ahmad, Mark, Bugg, Tim, Clark, Andrew J., Coles, Stuart R., Collis, Alana, Kirwan, Kerry, Koncsag, Claudia I., Barker, Guy C., Burton, Kerry S., Eastwood, Daniel C. and Pink, David (2010) Wealth out of waste. In: 3rd International IUPAC Conference on Green Chemistry, Ottawa, Ontario, Canada, Aug 15-18, 2010

2009

Bugg, Tim (2009) Oxygenases get to grips with polypeptides. Structure, Vol.17 (No.7). pp. 913-914. doi:10.1016/j.str.2009.06.004

Paradis-Bleau, Catherine, Lloyd, Adrian, Sanschagrin, Francois, Maaroufi, Halim, Clarke, Thomas B., Blewett, Ann, Dowson, Christopher G., Roper, David I., Bugg, Tim and Levesque, Roger C. (2009) Pseudomonas aeruginosa MurE amide ligase : enzyme kinetics and peptide inhibitor. Biochemical Journal, Vol.421 (No. 2). pp. 263-272. doi:10.1042/BJ20081395

Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Mok, B. James, Caddick, Stephen, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2009) Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors. Bioorganic & Medicinal Chemistry, Vol.17 (No.9). pp. 3443-3455. doi:10.1016/j.bmc.2009.03.028

Sergeant, Martin J., Li, J.J., Fox, C., Brookbank, N., Rea, Dean, Bugg, Tim and Thompson, Andrew J. (2009) Selective inhibition of carotenoid cleavage dioxygenases : phenotypic effects on shoot branching. Journal of Biological Chemistry, Vol.284 (No.8). pp. 5257-5264. doi:10.1074/jbc.M805453200

Vinatier, Virginie, Blakey, Carl B., Braddick, Darren, Johnson, Benjamin R. G., Evans, Stephen D. and Bugg, Tim (2009) In vitro biosynthesis of bacterial peptidoglycan using D-Cys-containing precursors : fluorescent detection of transglycosylation and transpeptidation. Chemical Communications (No.27). pp. 4037-4039. doi:10.1039/b819869a

Brivio, Michela, Schlosrich, Janne, Ahmad, Mark, Tolond, Caroline and Bugg, Tim (2009) Investigation of acid-base catalysis in the extradiol and intradiol catechol dioxygenase reactions using a broad specificity mutant enzyme and model chemistry. Organic & Biomolecular Chemistry, Vol.7 (No.7). pp. 1368-1373. doi:10.1039/b821559f

2008

Paradis-Bleau , Catherine, Lloyd, Adrian, Sanschagrin, François, Clark, Tom, Blewett, Ann, Bugg, Tim and Levesque, Roger C. (2008) Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF. BMC Biochemistry, Vol.9 (No.33). doi:10.1186/1471-2091-9-33

De Pascale, Gianfranco, Lloyd, Adrian J., Schouten, James A., Gilbey, Andrea M., Roper, David I., Dowson, Christopher G. and Bugg, Tim (2008) Kinetic characterization of lipid II-Ala:Alanyl-tRNA ligase (MurN) from streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates. Journal of Biological Chemistry, Vol.283 (No.50). pp. 34571-34579. doi:10.1074/jbc.M805807200

Rea, Dean, Hovington, Rebecca, Rakus, John F., Gerlt, John A., Fülöp, Vilmos, Bugg, Tim and Roper, David I. (2008) Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12. Biochemistry, Vol.47 (No.38). pp. 9955-9965. doi:10.1021/bi800943g

Dodd, Charlotte E., Johnson, Benjamin R. G., Vinatier, Virginie, Bugg, Tim, Bushby, Richard J., Jeuken, Lars J. C. and Evans, Stephen D. (2008) COLL 53-Peptidoglycan biosynthesis on lipid bilayers. In: 236th National Meeting of the American-Chemical-Society, Philadelphia, PA, Aug 17-21, 2008. Published in: Abstracts of papers of the American Chemical Society, Vol.236 ISSN 0065-7727.

Xin, Meite and Bugg, Tim (2008) Evidence from mechanistic probes for distinct hydroperoxide rearrangement mechanisms in the intradiol and extradiol catechol dioxygenases. Journal of the American Chemical Society, Vol.130 (No.31). pp. 10422-10430. doi:10.1021/ja8029569

Dodd, Charlotte E., Johnson, Benjamin R. G., Jeuken, Lars J. C., Bugg, Tim, Bushby, Richard J. and Evans, Stephen D. (2008) Native E. coli inner membrane incorporation in solid-supported lipid bilayer membranes. Biointerphases, Vol.3 (No.2). FA59-FA67. doi:10.1116/1.2896113

Bugg, Tim and Ramaswamy, S. (2008) Non-heme iron-dependent dioxygenases : unravelling catalytic mechanisms for complex enzymatic oxidations. Current Opinion in Chemical Biology, Vol.12 (No.2). pp. 134-140. doi:10.1016/j.cbpa.2007.12.007

Lloyd, Adrian J., Gilbey, Andrea M., Blewett, Anne M., De Pascale, Gianfranco, El Zoeiby, Ahmed, Levesque, Roger C., Catherwood, Anita C., Tomasz, Alexander, Bugg, Tim, Roper, David I. and Dowson, Christopher G. (2008) Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan. Journal of Biological Chemistry, Vol.283 (No.10). pp. 6402-6417. doi:10.1074/jbc.M708105200

Mainardi, Jean-Luc, Villet, Regis, Bugg, Tim, Mayer, Claudine and Arthur, Michel (2008) Evolution of peptidoglycan biosynthesis under the selective pressure of antibiotics in Gram-positive bacteria. FEMS Microbiology Reviews, Vol.32 (No.2). pp. 386-408. doi:10.1111/j.1574-6976.2007.00097.x

Bouhss, Ahmed, Trunkfield, Amy E., Bugg, Tim and Mengin-Lecreulx, Dominique (2008) The biosynthesis of peptidoglycan lipid-linked intermediates. FEMS Microbiology Reviews, Vol.32 (No.2). pp. 208-233. doi:10.1111/j.1574-6976.2007.00089.x

Li, C. (Chen), Hassler, Melanie and Bugg, Tim (2008) Catalytic promiscuity in the alpha/beta-hydrolase superfamily: Hydroxamic acid formation, C-C bondformation, ester and thioester hydrolysis in the C-C hydrolase family. Chembiochem, Vol.9 (No.1). pp. 71-76. doi:10.1002/cbic.200700428

Lam, Wai-Ho, Rychli, Kathrin and Bugg, Tim (2008) Cation of a novel beta-replacement reaction in the biosynthesis of 2,3-diaminobutyric acid in peptidylnucleoside mureidomycin A. Organic & Biomolecular Chemistry, Vol.6 (No.11). pp. 1912-1917. doi:10.1039/b802585a

Lam, Wai-Ho, Rychli, Kathrin and Bugg, Tim (2008) Identification of a novel β-replacement reaction in the biosynthesis of 2,3-diaminobutyric acid in peptidylnucleoside mureidomycin A. Organic & Biomolecular Chemistry, Vol.6 (No.11). pp. 1912-1917. doi:10.1039/b802585a

Xu, Xiu-Hua, Trunkfield, Amy E., Bugg, Tim and Qing, Feng-Ling (2008) Synthesis of gem-difluorinated nucleoside analogues of the liposidomycins and evaluation as MraY inhibitors. Organic & Biomolecular Chemistry, Vol.6 (No.1). pp. 157-161. doi:10.1039/b713068f

2007

Rea, Dean, Fülöp, Vilmos, Bugg, Tim and Roper, David I. (2007) Structure and mechanism of HpcH : a metal ion dependent class II aldolase from the homoprotocatechuate degradation pathway of Escherichia coli. Journal of Molecular Biology, Vol.373 (No.4). pp. 866-876. doi:10.1016/j.jmb.2007.06.048

Xin, Meite and Bugg, Tim (2007) BIOL 223-Mechanistic studies of the intradiol catechol dioxygenases. In: UNSPECIFIED. Published in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 234 ISSN 0065-7727.

Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2007) Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry Letters, Vol.17 (No.16). pp. 4654-4656. doi:10.1016/j.bmcl.2007.05.071

Li, Jian-Jun and Bugg, Tim (2007) Investigation of a general base mechanism for ester hydrolysis in C-C hydrolase enzymes of the alpha/beta-hydrolase superfamily : a novel mechanism for the serine catalytic triad. Organic & Biomolecular Chemistry, Volume 5 (Number 3). pp. 507-513. doi:10.1039/b615605c

2006

Schlosrich, Janne, Eley, Kirstin L., Crowley, Patrick J. and Bugg, Tim (2006) Directed evolution of a non-heme-iron-dependent extradiol catechol dioxygenase: Identification of mutants with intradiol oxidative cleavage activity. CHEMBIOCHEM, 7 (12). pp. 1899-1908. doi:10.1002/cbic.200600296

Li, Chen, Li, Jian-Jun, Montgomery, Mark G., Wood, Stephen P. and Bugg, Tim (2006) Catalytic role for Arginine 188 in the C-C hydrolase catalytic mechanism for Escherichia coli MhpC and Burkholderia xenovorans LB400 BphD. BIOCHEMISTRY, 45 (41). pp. 12470-12479. doi:10.1021/bi061253t

Li, Jian-Jun, Li, Chen, Blindauer, Claudia A. and Bugg, Tim (2006) Evidence for a gem-diol reaction intermediate in bacterial C-C hydrolase enzymes BphD and MhpC from C-13 NMR spectroscopy. BIOCHEMISTRY, 45 (41). pp. 12461-12469. doi:10.1021/bi0612519

Schouten, James A., Bagga, Sangeev, Lloyd, Adrian J., de Pascale, Gianfranco, Dowson, Christopher G., Roper, David I. and Bugg, Tim (2006) Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing D-cysteine at position 4 or 5. MOLECULAR BIOSYSTEMS, 2 (10). pp. 484-491. doi:10.1039/b607908c

Mendel, Sharon, Holbourn, Joanne M., Schouten, James A. and Bugg, Tim (2006) Interaction of the transmembrane domain of lysis protein E from bacteriophage phi X174 with bacterial translocase MraY and peptidyi-prolyl isomerase SlyD. MICROBIOLOGY-SGM, 152 (Part 10). pp. 2959-2967. doi:10.1099/mic.0.28776-0

Paradis-Bleau , Catherine, Beaumont, Mélanie , Boudreault, Lydia , Lloyd, Adrian, Sanschagrina, François , Bugg, Tim and Levesquea, Roger C. (2006) Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme. Peptides, Volume 27 (Number 7). pp. 1693-1700. doi:10.1016/j.peptides.2006.01.017