Advantage West Midlands (AWM)

Gerc, Amy J., Song, Lijiang, Challis, Gregory L., Stanley-Wall, Nicola R. and Coulthurst, Sarah J. (2012) The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin. PLoS One, Vol.7 (No.9). e44673. doi:10.1371/journal.pone.0044673 ISSN 1932-6203.

Advantage West Midlands (AWM)

Mahenthiralingam, Eshwar, Song, Lijiang, Sass, Andrea, White, J. (Judith), Wilmot, Ceri, Marchbank, Angela, Boaisha, Othman, Paine, James, Knight, D. (David) and Challis, Gregory L. (2011) Enacyloxins are products of an unusual hybrid modular polyketide synthase encoded by a cryptic burkholderia ambifaria genomic island. Chemistry & Biology, Vol.18 (No.5). pp. 665-677. doi:10.1016/j.chembiol.2011.01.020 ISSN 1074-5521.

Animal Health Trust

Heather, Zoe, Holden, Matthew T. G., Steward, Karen F., Parkhill, Julian, Song, Lijiang, Challis, Gregory L., Robinson, C. (Carl), Davis-Poynter, Nicholas and Waller, Andrew S. (2008) A novel streptococcal integrative conjugative element involved in iron acquisition. Molecular Microbiology, Volume 70 (Number 5). pp. 1274-1292. doi:10.1111/j.1365-2958.2008.06481.x ISSN 0950-382X.

BBSRC

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Füllöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11 . 913-923 . doi:10.1038/s41557-019-0335-5 ISSN 1755-4330.

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Fülöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Data for Structural basis for chain release from the enacyloxin polyketide synthase. [Dataset]

Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)

Jenner, Matthew, Kosol, Simone, Griffiths, Daniel, Prasongpholchai, Panward, Manzi, Lucio, Barrow, Andrew S., Moses, John E., Oldham, Neil J., Lewandowski, Józef R. and Challis, Gregory L. (2018) Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases. Nature Chemical Biology, 14 . pp. 270-275. doi:10.1038/nchembio.2549 ISSN 1552-4450.

Song, Lijiang, Jenner, Matthew, Masschelein, Joleen, Jones, Cerith, Bull, Matthew J., Harris, Simon R., Hartkoorn, Ruben C., Vocat, Anthony, Romero-Canelón, Isolda, Coupland, Paul, Webster, Gordon, Dunn, Matthew, Weiser, Rebecca, Paisey, Christopher, Cole, Stewart T., Parkhill, Julian, Mahenthiralingam, Eshwar and Challis, Gregory L. (2017) Discovery and biosynthesis of Gladiolin : a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. Journal of the American Chemical Society, 139 (23). pp. 7974-7981. doi:10.1021/jacs.7b03382 ISSN 0002-7863.

Inahashi, Yuki, Zhou, Shanshan, Bibb, Maureen J., Song, Lijiang, Al-Bassam, Mahmoud M., Bibb, Mervyn J. and Challis, Gregory L. (2017) Watasemycin biosynthesis in Streptomyces venezuelae : thiazoline C-methylation by a type B radical-SAM methylase homologue. Chemical Science, 8 (4). pp. 2823-2831. doi:10.1039/c6sc03533g ISSN 2041-6520.

Awodi, U. R., Ronan, Jade L., Masschelein, Joleen, Emmanuel de los Santos, L. C. and Challis, Gregory L. (2017) Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis. Chemical Science, 8 (1). pp. 411-415. doi:10.1039/C6SC02803A ISSN 2041-6520.

Ray, Lauren, Valentic, Timothy R., Miyazawa, Takeshi, Withall, David M., Song, Lijiang, Milligan, Jacob C., Osada, Hiroyuki, Takahashi, Shunji, Tsai, Shiou-Chuan and Challis, Gregory L. (2016) A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nature Communications, 7 . 13609. doi:10.1038/ncomms13609 ISSN 2041-1723.

Li, Ning, Song, Lijiang, Liu, Minghao, Shang, Fei, Anderson, Zoe, Fox, David J., Challis, Gregory L. and Huang, Yingping (2015) Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264. Chemical Science, 7 (1). pp. 482-488. doi:10.1039/c5sc03021h ISSN 2041-6520.

Schmelz, Stefan, Botting, Catherine H., Song, Lijiang, Kadi, Nadia, Challis, Gregory L. and Naismith, James H. (2011) Structural basis for acyl acceptor specificity in the achromobactin biosynthetic enzyme AcsD. Journal of Molecular Biology, Vol.412 (No.3). pp. 495-504. doi:10.1016/j.jmb.2011.07.059 ISSN 0022-2836.

Davis, Carol, Carberry, Stephen, Schrettl, Markus, Singh, Ishwar, Stephens, John C., Barry, Sarah M., Kavanagh, Kevin, Challis, Gregory L., Brougham, Dermot and Doyle, S. (Sean) (2011) The role of glutathione S-transferase GliG in gliotoxin biosynthesis in aspergillus fumigatus. Chemistry & Biology, Vol.18 (No.4). pp. 542-552. doi:10.1016/j.chembiol.2010.12.022 ISSN 1074-5521.

Corre, Christophe, Haynes, Stuart W., Malet, Nicolas, Song, Lijiang and Challis, Gregory L. (2011) A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically C-13-labelled glycerols. Chemical Communications, Vol.46 (No.23). pp. 4079-4081. doi:10.1039/c000496k ISSN 1359-7345.

(2010) The Scottish Structural Proteomics Facility : targets, methods and outputs. Journal of Structural and Functional Genomics, Vol.11 (No.2). pp. 167-180. doi:10.1007/s10969-010-9090-y

Corre, Christophe and Challis, Gregory L. (2009) New natural product biosynthetic chemistry discovered by genome mining. Natural Product Reports, Vol.26 (No.8). pp. 977-986. doi:10.1039/b713024b

(2009) Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biology (Online), Vol.10 (No.5). R51. doi:10.1186/gb-2009-10-5-r51 ISSN 1474-760X.

Oves-Costales, Daniel, Song, Lijiang and Challis, Gregory L. (2009) Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA. Chemical Communications (No.11). pp. 1389-1391. doi:10.1039/b823147h ISSN 1359-7345.

Zerikly, Malek and Challis, Gregory L. (2009) Strategies for the discovery of new natural products by genome mining. Chembiochem, Vol.10 (No.4). pp. 625-633. doi:10.1002/cbic.200800389 ISSN 1439-4227.

Schmelz, Stefan, Kadi, Nadia, McMahon, Stephen A., Song, Lijiang, Oves-Costales, Daniel, Oke, Muse, Liu, Huanting, Johnson, K. A. (Kenneth A.), Carter, Lester G., Botting, Catherine H., White, Malcolm F., Challis, Gregory L. and Naismith, James H. (2009) AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. Nature Chemical Biology, Vol.5 (No.3). pp. 174-182. doi:10.1038/nchembio.145 ISSN 1552-4450.

Oves-Costales, Daniel, Kadi, Nadia and Challis, Gregory L. (2009) The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis. Chemical Communications (No.43). pp. 6530-6541. doi:10.1039/b913092f

Corre, Christophe, Song, Lijiang, O'Rourke, S. (Sean), Chater, K. F. and Challis, Gregory L. (2008) 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proceedings of the National Academy of Sciences of the United States of America, Vol.105 (No.45). pp. 17510-17515. doi:10.1073/pnas.0805530105 ISSN 0027-8424.

Kadi, Nadia, Song, Lijiang and Challis, Gregory L. (2008) Bisucaberin biosynthesis : an adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy-N-succinylcadaverine. Chemical Communications (No.41). pp. 5119-5121. doi:10.1039/b813029a ISSN 1359-7345.

McMahon, Stephen A., Oke, Muse, Liu, Huanting, Johnson, K. A. (Kenneth A.), Carter, Lester, Kadi, Nadia, White, Malcolm F., Challis, Gregory L. and Naismith, James H. (2008) Purification, crystallization and data collection of Pectobacterium chrysanthemi AcsD, a type A siderophore synthetase. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, Vol.64 (Pt.11). pp. 1052-1055. doi:10.1107/S1744309108032132 ISSN 1744-3091.

Oves-Costales, Daniel, Kadi, Nadia, Fogg, Mark J., Song, Lijiang, Wilson, Keith S. and Challis, Gregory L. (2008) Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N-8-citryl-spermidine and its N-1-(3,4-dihydroxybenzoyl) derivative. Chemical Communications (No.34). pp. 4034-4036. doi:10.1039/b809353a ISSN 1359-7345.

Kadi, Nadia, Arbache, Simon, Song, Lijiang, Oves-Costales, Daniel and Challis, Gregory L. (2008) Identification of a gene cluster that directs putrebactin biosynthesis in Shewanella species : PubC catalyzes cyclodimerization of N-hydroxy-N-succinyiputrescine. Journal of the American Chemical Society, Vol.130 (No.32). pp. 10458-10459. doi:10.1021/ja8027263 ISSN 0002-7863.

Challis, Gregory L. (2008) Genome mining for novel natural product discovery. Journal of Medicinal Chemistry, Vol.51 (No.9). pp. 2618-2628. doi:10.1021/jm700948z ISSN 0022-2623.

Haynes, Stuart W., Sydor, Paulina K., Stanley, Anna E., Song, Lijiang and Challis, Gregory L. (2008) Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis. Chemical Communications (No.16). pp. 1865-1867. doi:10.1039/b801677a ISSN 1359-7345.

Mo, SangJoon, Sydor, Paulina K., Corre, Christophe, Alhamadsheh, Mamoun M., Stanley, Anna E., Haynes, Stuart W., Song, Lijiang, Reynolds, Kevin A. and Challis, Gregory L. (2008) Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chemistry & Biology, Vol.15 (No.2). pp. 137-148. doi:10.1016/j.chembiol.2007.11.015 ISSN 1074-5521.

Challis, Gregory L. (2008) Mining microbial genomes for new natural products and biosynthetic pathways. Microbiology, Vol.154 (No.6). pp. 1555-1569. doi:10.1099/mic.0.2008/018523-0 ISSN 1350-0872.

Kadi, Nadia, Oves-Costales, Daniel, Barona-Gomez, Francisco and Challis, Gregory L. (2007) A new family of ATP-dependent oligomerization-macrocyclization biocatalysts. Nature, Vol.3 (No.10). pp. 652-656. doi:10.1038/nchembio.2007.23 ISSN 0028-0836.

Biotica Technology Ltd

Ray, Lauren, Valentic, Timothy R., Miyazawa, Takeshi, Withall, David M., Song, Lijiang, Milligan, Jacob C., Osada, Hiroyuki, Takahashi, Shunji, Tsai, Shiou-Chuan and Challis, Gregory L. (2016) A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nature Communications, 7 . 13609. doi:10.1038/ncomms13609 ISSN 2041-1723.

Cystic Fibrosis Foundation

Mahenthiralingam, Eshwar, Song, Lijiang, Sass, Andrea, White, J. (Judith), Wilmot, Ceri, Marchbank, Angela, Boaisha, Othman, Paine, James, Knight, D. (David) and Challis, Gregory L. (2011) Enacyloxins are products of an unusual hybrid modular polyketide synthase encoded by a cryptic burkholderia ambifaria genomic island. Chemistry & Biology, Vol.18 (No.5). pp. 665-677. doi:10.1016/j.chembiol.2011.01.020 ISSN 1074-5521.

EPSRC

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Füllöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11 . 913-923 . doi:10.1038/s41557-019-0335-5 ISSN 1755-4330.

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Fülöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Data for Structural basis for chain release from the enacyloxin polyketide synthase. [Dataset]

ERC

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Fülöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Data for Structural basis for chain release from the enacyloxin polyketide synthase. [Dataset]

Engineering and Physical Sciences Research Council (EPSRC)

Sidda, John D., Song, Lijiang, Poon, Vincent, Al-Bassam, Mahmoud, Lazos, Orestis, Buttner, Mark J., Challis, Gregory L. and Corre, Christophe (2014) Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chemical Science, Volume 5 . pp. 86-89. doi:10.1039/c3sc52536h ISSN 2041-6520.

Sydor, Paulina K., Barry, Sarah M., Odulate, Olanipekun M., Barona-Gomez, Francisco, Haynes, Stuart W., Corre, Christophe, Song, Lijiang and Challis, Gregory L. (2011) Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nature Chemistry, Vol.3 (No.5). pp. 388-392. doi:10.1038/nchem.1024 ISSN 1755-4330.

Patel, Prakash, Song, Lijiang and Challis, Gregory L. (2010) Distinct extracytoplasmic siderophore binding proteins recognize ferrioxamines and ferricoelichelin in streptomyces coelicolor A3(2). Biochemistry, Vol.49 (No.37). pp. 8033-8042. doi:10.1021/bi100451k ISSN 0006-2960.

Montgomery, Laura J. and Challis, Gregory L. (2008) Concise synthesis of key 3-polyenoyl-5-methylenefuran-2,4-dione putative intermediates in quartromicin biosynthesis. Synlett (No.14). pp. 2164-2168. doi:10.1055/s-2008-1078247 ISSN 0936-5214.

European Commission (EC)

Davis, Carol, Carberry, Stephen, Schrettl, Markus, Singh, Ishwar, Stephens, John C., Barry, Sarah M., Kavanagh, Kevin, Challis, Gregory L., Brougham, Dermot and Doyle, S. (Sean) (2011) The role of glutathione S-transferase GliG in gliotoxin biosynthesis in aspergillus fumigatus. Chemistry & Biology, Vol.18 (No.4). pp. 542-552. doi:10.1016/j.chembiol.2010.12.022 ISSN 1074-5521.

(2010) The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics, Vol.11 (Article 10). doi:10.1186/1471-2164-11-10 ISSN 1471-2164.

European Regional Development Fund (EDRF)

Mahenthiralingam, Eshwar, Song, Lijiang, Sass, Andrea, White, J. (Judith), Wilmot, Ceri, Marchbank, Angela, Boaisha, Othman, Paine, James, Knight, D. (David) and Challis, Gregory L. (2011) Enacyloxins are products of an unusual hybrid modular polyketide synthase encoded by a cryptic burkholderia ambifaria genomic island. Chemistry & Biology, Vol.18 (No.5). pp. 665-677. doi:10.1016/j.chembiol.2011.01.020 ISSN 1074-5521.

European Regional Development Fund (ERDF)

Gerc, Amy J., Song, Lijiang, Challis, Gregory L., Stanley-Wall, Nicola R. and Coulthurst, Sarah J. (2012) The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin. PLoS One, Vol.7 (No.9). e44673. doi:10.1371/journal.pone.0044673 ISSN 1932-6203.

European Regional Development Fund (ERDF)

Bunet, R., Song, Lijiang, Mendes, M. V., Corre, Christophe, Hotel, L., Rouhier, N., Framboisier, X., Leblond, Pierre, Challis, Gregory L. and Aigle, B. (2011) Characterization and manipulation of the pathway-specific late regulator AlpW reveals streptomyces ambofaciens as a new producer of kinamycins. Journal of Bacteriology, Vol.193 (No.5). pp. 1142-1153. doi:10.1128/JB.01269-10 ISSN 0021-9193.

European Research Area Network (ERA-NET)

(2010) The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics, 11 . p. 10. doi:DOI: 10.1186/1471-2164-11-10 ISSN 1471-2164.

European Research Council

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Füllöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11 . 913-923 . doi:10.1038/s41557-019-0335-5 ISSN 1755-4330.

European Union

Corre, Christophe and Challis, Gregory L. (2009) New natural product biosynthetic chemistry discovered by genome mining. Natural Product Reports, Vol.26 (No.8). pp. 977-986. doi:10.1039/b713024b

European Union (EU)

Sydor, Paulina K., Barry, Sarah M., Odulate, Olanipekun M., Barona-Gomez, Francisco, Haynes, Stuart W., Corre, Christophe, Song, Lijiang and Challis, Gregory L. (2011) Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nature Chemistry, Vol.3 (No.5). pp. 388-392. doi:10.1038/nchem.1024 ISSN 1755-4330.

(2010) The Scottish Structural Proteomics Facility : targets, methods and outputs. Journal of Structural and Functional Genomics, Vol.11 (No.2). pp. 167-180. doi:10.1007/s10969-010-9090-y

Zerikly, Malek and Challis, Gregory L. (2009) Strategies for the discovery of new natural products by genome mining. Chembiochem, Vol.10 (No.4). pp. 625-633. doi:10.1002/cbic.200800389 ISSN 1439-4227.

Chen, Kan, Rannulu, Nalaka S., Cai, Yang, Lane, P., Liebl, Andrea L., Rees, Bernard B., Corre, Christophe, Challis, Gregory L. and Cole, Richard B. (2008) Unusual odd-electron fragments from even-electron protonated prodiginine precursors using positive-ion electrospray tandem mass spectrometry. Journal of The American Society for Mass Spectrometry, Vol.19 (No.12). pp. 1856-1866. doi:10.1016/j.jasms.2008.08.002 ISSN 1044-0305.

Corre, Christophe, Song, Lijiang, O'Rourke, S. (Sean), Chater, K. F. and Challis, Gregory L. (2008) 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proceedings of the National Academy of Sciences of the United States of America, Vol.105 (No.45). pp. 17510-17515. doi:10.1073/pnas.0805530105 ISSN 0027-8424.

Challis, Gregory L. (2008) Genome mining for novel natural product discovery. Journal of Medicinal Chemistry, Vol.51 (No.9). pp. 2618-2628. doi:10.1021/jm700948z ISSN 0022-2623.

Haynes, Stuart W., Sydor, Paulina K., Stanley, Anna E., Song, Lijiang and Challis, Gregory L. (2008) Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis. Chemical Communications (No.16). pp. 1865-1867. doi:10.1039/b801677a ISSN 1359-7345.

Mo, SangJoon, Sydor, Paulina K., Corre, Christophe, Alhamadsheh, Mamoun M., Stanley, Anna E., Haynes, Stuart W., Song, Lijiang, Reynolds, Kevin A. and Challis, Gregory L. (2008) Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chemistry & Biology, Vol.15 (No.2). pp. 137-148. doi:10.1016/j.chembiol.2007.11.015 ISSN 1074-5521.

Challis, Gregory L. (2008) Mining microbial genomes for new natural products and biosynthetic pathways. Microbiology, Vol.154 (No.6). pp. 1555-1569. doi:10.1099/mic.0.2008/018523-0 ISSN 1350-0872.

Foundation for Research, Science & Technology (N.Z.) (FRST)

(2009) Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biology (Online), Vol.10 (No.5). R51. doi:10.1186/gb-2009-10-5-r51 ISSN 1474-760X.

Gates Foundation

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Füllöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11 . 913-923 . doi:10.1038/s41557-019-0335-5 ISSN 1755-4330.

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Fülöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Data for Structural basis for chain release from the enacyloxin polyketide synthase. [Dataset]

Great Britain. Horserace Betting Levy Board

Heather, Zoe, Holden, Matthew T. G., Steward, Karen F., Parkhill, Julian, Song, Lijiang, Challis, Gregory L., Robinson, C. (Carl), Davis-Poynter, Nicholas and Waller, Andrew S. (2008) A novel streptococcal integrative conjugative element involved in iron acquisition. Molecular Microbiology, Volume 70 (Number 5). pp. 1274-1292. doi:10.1111/j.1365-2958.2008.06481.x ISSN 0950-382X.

Horse Trust

Heather, Zoe, Holden, Matthew T. G., Steward, Karen F., Parkhill, Julian, Song, Lijiang, Challis, Gregory L., Robinson, C. (Carl), Davis-Poynter, Nicholas and Waller, Andrew S. (2008) A novel streptococcal integrative conjugative element involved in iron acquisition. Molecular Microbiology, Volume 70 (Number 5). pp. 1274-1292. doi:10.1111/j.1365-2958.2008.06481.x ISSN 0950-382X.

John Innes Foundation

O'Rourke, S. (Sean), Wietzorrek, Andreas, Fowler, Kay, Corre, Christophe, Challis, Gregory L. and Chater, K. F. (2009) Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor. Molecular Microbiology, Vol.71 (No.3). pp. 763-778. doi:10.1111/j.1365-2958.2008.06560.x ISSN 0950-382X.

Lawrence Berkeley National Laboratory (LBNL)

(2009) Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biology (Online), Vol.10 (No.5). R51. doi:10.1186/gb-2009-10-5-r51 ISSN 1474-760X.

Lawrence Livermore Laboratory (LLL)

(2009) Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biology (Online), Vol.10 (No.5). R51. doi:10.1186/gb-2009-10-5-r51 ISSN 1474-760X.

Los Alamos National Laboratory (LANL)

(2009) Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biology (Online), Vol.10 (No.5). R51. doi:10.1186/gb-2009-10-5-r51 ISSN 1474-760X.

Louisiana Board of Regents. Health Excellence Fund (HEF)

Chen, Kan, Rannulu, Nalaka S., Cai, Yang, Lane, P., Liebl, Andrea L., Rees, Bernard B., Corre, Christophe, Challis, Gregory L. and Cole, Richard B. (2008) Unusual odd-electron fragments from even-electron protonated prodiginine precursors using positive-ion electrospray tandem mass spectrometry. Journal of The American Society for Mass Spectrometry, Vol.19 (No.12). pp. 1856-1866. doi:10.1016/j.jasms.2008.08.002 ISSN 1044-0305.

Marie Curie Cancer Care

Challis, Gregory L. (2008) Mining microbial genomes for new natural products and biosynthetic pathways. Microbiology, Vol.154 (No.6). pp. 1555-1569. doi:10.1099/mic.0.2008/018523-0 ISSN 1350-0872.

Marie Curie Individual Fellowship

Song, Lijiang, Jenner, Matthew, Masschelein, Joleen, Jones, Cerith, Bull, Matthew J., Harris, Simon R., Hartkoorn, Ruben C., Vocat, Anthony, Romero-Canelón, Isolda, Coupland, Paul, Webster, Gordon, Dunn, Matthew, Weiser, Rebecca, Paisey, Christopher, Cole, Stewart T., Parkhill, Julian, Mahenthiralingam, Eshwar and Challis, Gregory L. (2017) Discovery and biosynthesis of Gladiolin : a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. Journal of the American Chemical Society, 139 (23). pp. 7974-7981. doi:10.1021/jacs.7b03382 ISSN 0002-7863.

Awodi, U. R., Ronan, Jade L., Masschelein, Joleen, Emmanuel de los Santos, L. C. and Challis, Gregory L. (2017) Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis. Chemical Science, 8 (1). pp. 411-415. doi:10.1039/C6SC02803A ISSN 2041-6520.

NSFC

Li, Ning, Song, Lijiang, Liu, Minghao, Shang, Fei, Anderson, Zoe, Fox, David J., Challis, Gregory L. and Huang, Yingping (2015) Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal peptides from Streptomyces sp. FXJ1.264. Chemical Science, 7 (1). pp. 482-488. doi:10.1039/c5sc03021h ISSN 2041-6520.

National Institutes of Health (U.S.) (NIH)

Ray, Lauren, Valentic, Timothy R., Miyazawa, Takeshi, Withall, David M., Song, Lijiang, Milligan, Jacob C., Osada, Hiroyuki, Takahashi, Shunji, Tsai, Shiou-Chuan and Challis, Gregory L. (2016) A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nature Communications, 7 . 13609. doi:10.1038/ncomms13609 ISSN 2041-1723.

Papireddy, Kancharla, Smilkstein, Martin, Kelly, Jane Xu, Salem, Shaimaa M., Alhamadsheh, Mamoun, Haynes, Stuart W., Challis, Gregory L. and Reynolds, Kevin A. (2011) Antimalarial activity of natural and synthetic prodiginines. Journal of Medicinal Chemistry, Volume 54 (Number 15). pp. 5296-5306. doi:10.1021/jm200543y ISSN 0022-2623.

Whicher, J. R., Florova, G., Sydor, Paulina K., Singh, R., Alhamadsheh, M., Challis, Gregory L., Reynolds, Kevin A. and Smith, Janet Louise (2011) Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in streptomyces coelicolor. Journal of Biological Chemistry, Vol.286 (No.25). pp. 22558-22569. doi:10.1074/jbc.M110.213512 ISSN 0021-9258.

Sydor, Paulina K., Barry, Sarah M., Odulate, Olanipekun M., Barona-Gomez, Francisco, Haynes, Stuart W., Corre, Christophe, Song, Lijiang and Challis, Gregory L. (2011) Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nature Chemistry, Vol.3 (No.5). pp. 388-392. doi:10.1038/nchem.1024 ISSN 1755-4330.

Haynes, Stuart W., Sydor, Paulina K., Stanley, Anna E., Song, Lijiang and Challis, Gregory L. (2008) Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis. Chemical Communications (No.16). pp. 1865-1867. doi:10.1039/b801677a ISSN 1359-7345.

Mo, SangJoon, Sydor, Paulina K., Corre, Christophe, Alhamadsheh, Mamoun M., Stanley, Anna E., Haynes, Stuart W., Song, Lijiang, Reynolds, Kevin A. and Challis, Gregory L. (2008) Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chemistry & Biology, Vol.15 (No.2). pp. 137-148. doi:10.1016/j.chembiol.2007.11.015 ISSN 1074-5521.

National Science Foundation (U.S.) (NSF)

Chen, Kan, Rannulu, Nalaka S., Cai, Yang, Lane, P., Liebl, Andrea L., Rees, Bernard B., Corre, Christophe, Challis, Gregory L. and Cole, Richard B. (2008) Unusual odd-electron fragments from even-electron protonated prodiginine precursors using positive-ion electrospray tandem mass spectrometry. Journal of The American Society for Mass Spectrometry, Vol.19 (No.12). pp. 1856-1866. doi:10.1016/j.jasms.2008.08.002 ISSN 1044-0305.

Nihon Gakujutsu Shinkōkai [Japan Society for the Promotion of Science] (NGS)

Ray, Lauren, Valentic, Timothy R., Miyazawa, Takeshi, Withall, David M., Song, Lijiang, Milligan, Jacob C., Osada, Hiroyuki, Takahashi, Shunji, Tsai, Shiou-Chuan and Challis, Gregory L. (2016) A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nature Communications, 7 . 13609. doi:10.1038/ncomms13609 ISSN 2041-1723.

Norges forskningsråd [Norwegian Research Council]

(2010) The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics, Vol.11 (Article 10). doi:10.1186/1471-2164-11-10 ISSN 1471-2164.

Norges forskningsråd [Research Council of Norway] (NF)

(2010) The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics, 11 . p. 10. doi:DOI: 10.1186/1471-2164-11-10 ISSN 1471-2164.

Programme for Research in Third-Level Institutions (PRTLI)

Davis, Carol, Carberry, Stephen, Schrettl, Markus, Singh, Ishwar, Stephens, John C., Barry, Sarah M., Kavanagh, Kevin, Challis, Gregory L., Brougham, Dermot and Doyle, S. (Sean) (2011) The role of glutathione S-transferase GliG in gliotoxin biosynthesis in aspergillus fumigatus. Chemistry & Biology, Vol.18 (No.4). pp. 542-552. doi:10.1016/j.chembiol.2010.12.022 ISSN 1074-5521.

Royal Society

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Füllöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11 . 913-923 . doi:10.1038/s41557-019-0335-5 ISSN 1755-4330.

Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Fülöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L. and Lewandowski, Józef R. (2019) Data for Structural basis for chain release from the enacyloxin polyketide synthase. [Dataset]

Royal Society (Great Britain)

Sidda, John D., Song, Lijiang, Poon, Vincent, Al-Bassam, Mahmoud, Lazos, Orestis, Buttner, Mark J., Challis, Gregory L. and Corre, Christophe (2014) Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chemical Science, Volume 5 . pp. 86-89. doi:10.1039/c3sc52536h ISSN 2041-6520.

Royal Society of Chemistry (Great Britain)

Ray, Lauren, Valentic, Timothy R., Miyazawa, Takeshi, Withall, David M., Song, Lijiang, Milligan, Jacob C., Osada, Hiroyuki, Takahashi, Shunji, Tsai, Shiou-Chuan and Challis, Gregory L. (2016) A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nature Communications, 7 . 13609. doi:10.1038/ncomms13609 ISSN 2041-1723.

Royal Society of Edinburgh

Gerc, Amy J., Song, Lijiang, Challis, Gregory L., Stanley-Wall, Nicola R. and Coulthurst, Sarah J. (2012) The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin. PLoS One, Vol.7 (No.9). e44673. doi:10.1371/journal.pone.0044673 ISSN 1932-6203.

Science Foundation Ireland (SFI)

Davis, Carol, Carberry, Stephen, Schrettl, Markus, Singh, Ishwar, Stephens, John C., Barry, Sarah M., Kavanagh, Kevin, Challis, Gregory L., Brougham, Dermot and Doyle, S. (Sean) (2011) The role of glutathione S-transferase GliG in gliotoxin biosynthesis in aspergillus fumigatus. Chemistry & Biology, Vol.18 (No.4). pp. 542-552. doi:10.1016/j.chembiol.2010.12.022 ISSN 1074-5521.

Scotland

Gerc, Amy J., Song, Lijiang, Challis, Gregory L., Stanley-Wall, Nicola R. and Coulthurst, Sarah J. (2012) The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin. PLoS One, Vol.7 (No.9). e44673. doi:10.1371/journal.pone.0044673 ISSN 1932-6203.

Scottish Funding Council (SFC)

(2010) The Scottish Structural Proteomics Facility : targets, methods and outputs. Journal of Structural and Functional Genomics, Vol.11 (No.2). pp. 167-180. doi:10.1007/s10969-010-9090-y

Schmelz, Stefan, Kadi, Nadia, McMahon, Stephen A., Song, Lijiang, Oves-Costales, Daniel, Oke, Muse, Liu, Huanting, Johnson, K. A. (Kenneth A.), Carter, Lester G., Botting, Catherine H., White, Malcolm F., Challis, Gregory L. and Naismith, James H. (2009) AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. Nature Chemical Biology, Vol.5 (No.3). pp. 174-182. doi:10.1038/nchembio.145 ISSN 1552-4450.

Scottish Higher Education Funding Council (SHEFC)

McMahon, Stephen A., Oke, Muse, Liu, Huanting, Johnson, K. A. (Kenneth A.), Carter, Lester, Kadi, Nadia, White, Malcolm F., Challis, Gregory L. and Naismith, James H. (2008) Purification, crystallization and data collection of Pectobacterium chrysanthemi AcsD, a type A siderophore synthetase. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, Vol.64 (Pt.11). pp. 1052-1055. doi:10.1107/S1744309108032132 ISSN 1744-3091.

Sixth Framework Programme (European Commission) (FP6)

Laureti, L., Song, Lijiang, Huang, S., Corre, Christophe, Leblond, Pierre, Challis, Gregory L. and Aigle, B. (2011) Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proceedings of the National Academy of Sciences of the United States of America, Vol.108 (No.15). pp. 6258-6263. doi:10.1073/pnas.1019077108 ISSN 0027-8424.

Bunet, R., Song, Lijiang, Mendes, M. V., Corre, Christophe, Hotel, L., Rouhier, N., Framboisier, X., Leblond, Pierre, Challis, Gregory L. and Aigle, B. (2011) Characterization and manipulation of the pathway-specific late regulator AlpW reveals streptomyces ambofaciens as a new producer of kinamycins. Journal of Bacteriology, Vol.193 (No.5). pp. 1142-1153. doi:10.1128/JB.01269-10 ISSN 0021-9193.

United States. Cooperative State Research, Education, and Extension Service (CSREES)

Seipke, R. F., Song, Lijiang, Bicz, Joanna, Laskaris, Paris, Yaxley, Alice M., Challis, Gregory L. and Loria, Rosemary (2011) The plant pathogen Streptomyces scabies 87-22 has a functional pyochelin biosynthetic pathway that is regulated by TetR- and AfsR-family proteins. Microbiology, Vol.157 (No.9). pp. 2681-2693. doi:10.1099/mic.0.047977-0 ISSN 1350-0872.

United States. Department of Energy. Office of Basic Energy Sciences (OBES)

Ray, Lauren, Valentic, Timothy R., Miyazawa, Takeshi, Withall, David M., Song, Lijiang, Milligan, Jacob C., Osada, Hiroyuki, Takahashi, Shunji, Tsai, Shiou-Chuan and Challis, Gregory L. (2016) A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nature Communications, 7 . 13609. doi:10.1038/ncomms13609 ISSN 2041-1723.

United States. Dept. of Agriculture

(2009) Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biology (Online), Vol.10 (No.5). R51. doi:10.1186/gb-2009-10-5-r51 ISSN 1474-760X.

United States. Dept. of Energy. Office of Biological and Environmental Research

(2009) Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biology (Online), Vol.10 (No.5). R51. doi:10.1186/gb-2009-10-5-r51 ISSN 1474-760X.

University of Warwick

Sydor, Paulina K., Barry, Sarah M., Odulate, Olanipekun M., Barona-Gomez, Francisco, Haynes, Stuart W., Corre, Christophe, Song, Lijiang and Challis, Gregory L. (2011) Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nature Chemistry, Vol.3 (No.5). pp. 388-392. doi:10.1038/nchem.1024 ISSN 1755-4330.

Mo, SangJoon, Sydor, Paulina K., Corre, Christophe, Alhamadsheh, Mamoun M., Stanley, Anna E., Haynes, Stuart W., Song, Lijiang, Reynolds, Kevin A. and Challis, Gregory L. (2008) Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chemistry & Biology, Vol.15 (No.2). pp. 137-148. doi:10.1016/j.chembiol.2007.11.015 ISSN 1074-5521.

University of Warwick Chancellor's Scholarship

Awodi, U. R., Ronan, Jade L., Masschelein, Joleen, Emmanuel de los Santos, L. C. and Challis, Gregory L. (2017) Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis. Chemical Science, 8 (1). pp. 411-415. doi:10.1039/C6SC02803A ISSN 2041-6520.

University of Warwick Chancellor’s Interational Scholarship

Inahashi, Yuki, Zhou, Shanshan, Bibb, Maureen J., Song, Lijiang, Al-Bassam, Mahmoud M., Bibb, Mervyn J. and Challis, Gregory L. (2017) Watasemycin biosynthesis in Streptomyces venezuelae : thiazoline C-methylation by a type B radical-SAM methylase homologue. Chemical Science, 8 (4). pp. 2823-2831. doi:10.1039/c6sc03533g ISSN 2041-6520.

Awodi, U. R., Ronan, Jade L., Masschelein, Joleen, Emmanuel de los Santos, L. C. and Challis, Gregory L. (2017) Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis. Chemical Science, 8 (1). pp. 411-415. doi:10.1039/C6SC02803A ISSN 2041-6520.

Wellcome Trust (London, England)

Gerc, Amy J., Song, Lijiang, Challis, Gregory L., Stanley-Wall, Nicola R. and Coulthurst, Sarah J. (2012) The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin. PLoS One, Vol.7 (No.9). e44673. doi:10.1371/journal.pone.0044673 ISSN 1932-6203.

(2009) Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biology (Online), Vol.10 (No.5). R51. doi:10.1186/gb-2009-10-5-r51 ISSN 1474-760X.

Challis, Gregory L. (2008) Mining microbial genomes for new natural products and biosynthetic pathways. Microbiology, Vol.154 (No.6). pp. 1555-1569. doi:10.1099/mic.0.2008/018523-0 ISSN 1350-0872.

(2006) The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081. PLOS Genetics, Vol.2 (No.12). pp. 2039-2051. doi:10.1371/journal.pgen.0020206 ISSN 1553-7390.

Welsh Assembly. Life Sciences Bridging Fund (WALSBF)

Song, Lijiang, Jenner, Matthew, Masschelein, Joleen, Jones, Cerith, Bull, Matthew J., Harris, Simon R., Hartkoorn, Ruben C., Vocat, Anthony, Romero-Canelón, Isolda, Coupland, Paul, Webster, Gordon, Dunn, Matthew, Weiser, Rebecca, Paisey, Christopher, Cole, Stewart T., Parkhill, Julian, Mahenthiralingam, Eshwar and Challis, Gregory L. (2017) Discovery and biosynthesis of Gladiolin : a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis. Journal of the American Chemical Society, 139 (23). pp. 7974-7981. doi:10.1021/jacs.7b03382 ISSN 0002-7863.