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Number of items: 50.

2023

Micelli, Carmina, Dai, Yunfei, Raustad, Nicole, Isberg, Ralph R., Dowson, Christopher G., Lloyd, Adrian J., Geisinger, Edward, Crow, Allister and Roper, David I. (2023) A conserved zinc-binding site in Acinetobacter baumannii PBP2 required for elongasome-directed bacterial cell shape. Proceedings of the National Academy of Sciences of the United States of America, 120 (8). e2215237120. doi:10.1073/pnas.2215237120 ISSN 0027-8424.

2022

Dowson, Amanda J., Lloyd, Adrian J., Cuming, Andrew C., Roper, David I., Frigerio, Lorenzo and Dowson, Christopher G. (2022) Plant peptidoglycan precursor biosynthesis : conservation between moss chloroplasts and Gram-negative bacteria. Plant Physiology, 190 (1). pp. 165-179. doi:10.1093/plphys/kiac176 ISSN 1532-2548.

2021

York, Anna, Lloyd, Adrian J., del Genio, Charo I., Shearer, Jonathan, Hinxman, Karen, Fritz, Konstantin, FΓΌlΓΆp, Vilmos, Dowson, Christopher G., Khalid, Syma and Roper, David I. (2021) Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane. Structure, 29 (7). pp. 731-742. doi:10.1016/j.str.2021.03.001 ISSN 0969-2126.

Aggarwal, Surya D. , Lloyd, Adrian J., Yerneni, Saigopalakrishna S., Narciso, Ana Rita, Shepherd, Jennifer, Roper, David I., Dowson, Christopher G., Filipe, Sergio R and Hiller, N Luisa (2021) A molecular link between cell wall biosynthesis, translation fidelity, and stringent response in Streptococcus pneumoniae. Proceedings of the National Academy of Sciences of the United States of America, 118 (14). e2018089118. doi:10.1073/pnas.2018089118 ISSN 0027-8424.

2020

Catherwood, Anita C., Lloyd, Adrian J., Tod, Julie A., Chauhan, Smita, Slade, Susan E., Walkowiak, Grzegorz P., Galley, Nicola F., Punekar, Avinash S., Smart, Katie, Rea, Dean, Evans, Neil D., Chappell, Michael J., Roper, David I. and Dowson, Christopher G. (2020) Substrate and stereochemical control of peptidoglycan cross-linking by transpeptidation by Escherichia coli PBP1B. Journal of the American Chemical Society, 142 (11). pp. 5034-5048. doi:10.1021/jacs.9b08822 ISSN 0002-7863.

2019

Cain, Ricky, Salimraj, Ramya, Punekar, Avinash S., Bellini, Dom, Fishwick, Colin W. G., Czaplewski, Lloyd, Scott, David J., Harris, Gemma, Dowson, Christopher G., Lloyd, Adrian J. and Roper, David I. (2019) Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase. Journal of Medicinal Chemistry, 62 (21). pp. 9703-9717. doi:10.1021/acs.jmedchem.9b01131 ISSN 0022-2623.

2018

Γ–ster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G. and Lewandowski, JΓ³zef R. (2018) Structural studies suggest aggregation as one of the modes of action for teixobactin. Chemical Science, 9 (47). pp. 8850-8859. doi:10.1039/c8sc03655a ISSN 2041-6520.

Γ–ster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G. and Lewandowski, JΓ³zef R. (2018) Data for Structural studies suggest aggregation as one of the modes of action for teixobactin. [Dataset]

Punekar, Avinash S., Samsudin, Firdaus, Lloyd, Adrian J., Dowson, Christopher G., Scott, David J., Khalid, Syma and Roper, David I. (2018) The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization. The Cell Surface, 2 . pp. 54-66. doi:10.1016/j.tcsw.2018.06.002 ISSN 2468-2330.

2017

Batson, Sarah, de Chiara, Cesira, Majce, Vita, Lloyd, Adrian J., Gobec, Stanislav, Rea, Dean, FΓΌlΓΆp, Vilmos, Thoroughgood, Christopher W., Simmons, Katie J., Dowson, Christopher G., Fishwick, Colin W. G., de Carvalho, Luiz Pedro S. and Roper, David I. (2017) Inhibition of D-Ala : D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nature Communications, 8 (1). 1939 . doi:10.1038/s41467-017-02118-7 ISSN 2041-1723.

Vajs, Jure, Proud, Conor, Brozovic, Anamaria, Gazvoda, Martin, Lloyd, Adrian J., Roper, David I., Osmak, Maja, KoΕ‘mrlj, Janez and Dowson, Christopher G. (2017) Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. European Journal of Medicinal Chemistry, 127 . pp. 223-234. doi:10.1016/j.ejmech.2016.12.060 ISSN 0223-5234.

2016

Usha, Veeraraghavan, Lloyd, Adrian J., Roper, David I., Dowson, Christopher G., Kozlov, Guennadi, Gehring, Kalle, Chauhan, Smita, Imam, Hasan T., Blindauer, Claudia A. and Besra, Gurdyal S. (2016) Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase. Scientific Reports, 6 . 23191. doi:10.1038/srep23191 ISSN 2045-2322.

2015

Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Thanh, Giang Le, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X. et al.
(2015) Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6 . pp. 1-11. 7719. doi:10.1038/ncomms8719 ISSN 2041-1723.

2014

Gurcha, Sudagar S., Usha, Veeraraghavan, Cox, Jonathan A. G., FΓΌtterer, Klaus, Abrahams, Katherine A., Bhatt, Apoorva, Alderwick, Luke J., Reynolds, Robert C., Loman, Nicholas J., Nataraj, VijayaShankar, Alemparte, Carlos, Barros, David, Lloyd, Adrian J., Ballell, Lluis, Hobrath, Judith V. and Besra, Gurdyal S. (2014) Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target. PLoS One, Volume 9 (Number 11). Article number e113568. doi:10.1371/journal.pone.0113568 ISSN 1932-6203.

2013

Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I. and Dowson, Christopher G. (2013) Adenosine Tetraphosphoadenosine drives a continuous ATP-release assay for Aminoacyl-tRNA synthetases and other Adenylate-forming enzymes. ACS Chemical Biology, 8 (10). pp. 2157-2163. doi:10.1021/cb400248f ISSN 1554-8929.

Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I. and Dowson, Christopher G. (2013) Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes. ACS Chemical Biology, 8 (10). pp. 2157-2163. doi:10.1021/cb400248f ISSN 1554-8929.

ValegΓ₯rd, Karin, Iqbal, Aman, Kershaw, Nadia J., Ivison, David, GΓ©nΓ©reux, Catherine, Dubus, Alain, Blikstad, Cecilia, Demetriades, Marina, Hopkinson, Richard J., Lloyd, Adrian J., Roper, David I., Schofield, Christopher J., Andersson, Inger and McDonough, Michael A. (2013) Structural and mechanistic studies of theorf12 gene product from the clavulanic acid biosynthesis pathway. Acta Crystallographica Section D Biological Crystallography, Volume 69 (Number 8). pp. 1567-1579. doi:10.1107/S0907444913011013 ISSN 0907-4449.

Ruane, Karen M., Lloyd, Adrian J., Fülâp, Vilmos, Dowson, Christopher G., Barreteau, Hélène, Boniface, Audrey, Dementin, Sébastien, Blanot, Didier, Mengin-Lecreulx, Dominique, Gobec, Stanislav, Dessen, Andréa and Roper, David I. (2013) Specificity determinants for lysine incorporation in staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex. Journal of Biological Chemistry, Volume 288 (Number 46). Article number 33439. doi:10.1074/jbc.M113.508135 ISSN 0021-9258.

2012

Usha, Veeraraghavan, Lloyd, Adrian, Lovering, Andrew L. and Besra, Gurdyal S. (2012) Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes. FEMS Microbiology Letters, Vol.330 (No.1). pp. 10-16. doi:10.1111/j.1574-6968.2012.02527.x ISSN 0378-1097.

2011

Alderwick, Luke J., Lloyd, Georgina S., Lloyd, Adrian, Lovering, Andrew L., Eggeling, L. and Besra, Gurdyal S. (2011) Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase. Glycobiology, Vol.21 (No.4). pp. 410-425. doi:10.1093/glycob/cwq173 ISSN 1460-2423.

Usha, Veeraraghavan, Gurcha, Sudagar S., Lovering, Andrew L., Lloyd, Adrian, Papaemmanouil, A., Reynolds, Robert C. and Besra, Gurdyal S. (2011) Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis. Microbiology, Vol.157 (No.1). pp. 290-299. doi:10.1099/mic.0.042549-0 ISSN 1350-0872.

Lloyd, Amanda J., William Allwood, J., Winder, Catherine L., Dunn, Warwick B., Heald, James K., Cristescu, Simona M., Sivakumaran, Anushen, Harren, Frans J. M., Mulema, Joseph M. K., Denby, Katherine J., Goodacre, Royston, Smith, Aileen R. and Mur, Luis A. J. (2011) Metabolomic approaches reveal that cell wall modifications play a major role in ethylene-mediated resistance against Botrytis cinerea. The Plant Journal, Vol.67 (No.5). pp. 852-868. doi:10.1111/j.1365-313X.2011.04639.x ISSN 09607412.

2010

Coker, Shu-Fen, Lloyd, Adrian J., Mitchell, Edward, Lewis, Gareth R., Coker, Alun R. and Shoolingin-Jordan, Peter M. (2010) The high-resolution structure of pig heart succinyl-CoA:3-oxoacid coenzyme A transferase. Acta Crystallographica Section D Biological Crystallography, Vol.66 (No.7). pp. 797-805. doi:10.1107/S0907444910018366 ISSN 0907-4449.

2009

Paradis-Bleau, Catherine, Lloyd, Adrian, Sanschagrin, Francois, Maaroufi, Halim, Clarke, Thomas B., Blewett, Ann, Dowson, Christopher G., Roper, David I., Bugg, Tim and Levesque, Roger C. (2009) Pseudomonas aeruginosa MurE amide ligase : enzyme kinetics and peptide inhibitor. Biochemical Journal, Vol.421 (No. 2). pp. 263-272. doi:10.1042/BJ20081395 ISSN 0264-6021.

Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Mok, B. James, Caddick, Stephen, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2009) Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors. Bioorganic & Medicinal Chemistry, Vol.17 (No.9). pp. 3443-3455. doi:10.1016/j.bmc.2009.03.028 ISSN 0968-0896.

Sova, Matej, Cadez, Gasper, Turk, Samo, Majce, Vita, Polanc, Slovenko, Batson, Sarah, Lloyd, Adrian, Roper, David I., Fishwick, Colin W. G. and Gobec, Stanislav (2009) Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB). Bioorganic & Medicinal Chemistry Letters, Vol.19 (No.5). pp. 1376-1379. doi:10.1016/j.bmcl.2009.01.034 ISSN 0960-894X.

2008

Paradis-Bleau , Catherine, Lloyd, Adrian, Sanschagrin, François, Clark, Tom, Blewett, Ann, Bugg, Tim and Levesque, Roger C. (2008) Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF. BMC Biochemistry, Vol.9 (No.33). doi:10.1186/1471-2091-9-33 ISSN 1471-2091.

De Pascale, Gianfranco, Lloyd, Adrian J., Schouten, James A., Gilbey, Andrea M., Roper, David I., Dowson, Christopher G. and Bugg, Tim (2008) Kinetic characterization of lipid II-Ala:Alanyl-tRNA ligase (MurN) from streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates. Journal of Biological Chemistry, Vol.283 (No.50). pp. 34571-34579. doi:10.1074/jbc.M805807200 ISSN 0021-9258.

Lloyd, Adrian J., Gilbey, Andrea M., Blewett, Anne M., De Pascale, Gianfranco, El Zoeiby, Ahmed, Levesque, Roger C., Catherwood, Anita C., Tomasz, Alexander, Bugg, Tim, Roper, David I. and Dowson, Christopher G. (2008) Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan. Journal of Biological Chemistry, Vol.283 (No.10). pp. 6402-6417. doi:10.1074/jbc.M708105200 ISSN 0021-9258.

Lloyd, Adrian (2008) Making resistance futile - targeting penicillin resistant super-bug infections. Warwick University: University of Warwick, Communications Office. (Vision 2015).

2007

Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2007) Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry Letters, Vol.17 (No.16). pp. 4654-4656. doi:10.1016/j.bmcl.2007.05.071 ISSN 0960-894X.

2006

Schouten, James A., Bagga, Sangeev, Lloyd, Adrian J., De Pascale, Gianfranco, Dowson, Christopher G., Roper, David I. and Bugg, Timothy D. H. (2006) Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5. Molecular BioSystems, 2 (10). pp. 484-491. doi:10.1039/b607908c ISSN 1742-206X.

Usha, Veeraraghavan, Dover, Lynn G., Roper, David I., Lloyd, Adrian J. and Besra, Gurdyal S. (2006) Use of a codon alteration strategy in a novel approach to cloning the Mycobacterium tuberculosis diaminopimelic acid epimerase. FEMS Microbiology Letters, Volume 262 (Number 1). pp. 39-47. doi:10.1111/j.1574-6968.2006.00356.x ISSN 0378-1097.

Bugg, Timothy D. H., Lloyd, Adrian J. and Roper, David I. (2006) Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins. Infectious Disorders - Drug Targets, 6 (2). pp. 85-106. doi:10.2174/187152606784112128 ISSN 1871-5265.

TΓΆtemeyer, Sabine, Sheppard, Mark, Lloyd, Adrian, Roper, David I., Dowson, Christopher G., Underhill, David, Murray, Peter, Maskell, Duncan and Bryant, Clare (2006) IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2. Journal of Immunology, Vol.176 (No.8). pp. 4804-4810. ISSN 0022-1767.

Paradis-Bleau , Catherine, Beaumont, Mélanie , Boudreault, Lydia , Lloyd, Adrian, Sanschagrina, François , Bugg, Tim and Levesquea, Roger C. (2006) Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme. Peptides, Volume 27 (Number 7). pp. 1693-1700. doi:10.1016/j.peptides.2006.01.017 ISSN 0196-9781.

Kishida, H., Unzai, Satoru, Roper, David I., Lloyd, A, Park, S.Y. and Tame, Jeremy R. H. (2006) Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics. Biochemistry, Vol.45 (No.3). pp. 783-792. doi:10.1021/bi051533t ISSN 0006-2960.

2005

Besong, Gilbert E., Bostock, Julieanne M., Stubbings, Will, Chopra, Ian, Roper, David I., Lloyd, Adrian J., Fishwick, Colin W. G. and Johnson, A. Peter (2005) A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli. Angewandte Chemie (International Edition), 44 (39). pp. 6403-6406. doi:10.1002/anie.200501662 ISSN 1433-7851.

2004

Lloyd, Adrian J., Brandish, Philip E., Gilbey, Andrea M. and Bugg, Timothy D. H. (2004) Phospho-N-acetyl-muramyl-pentapeptide translocase from Escherichia coli : catalytic role of conserved aspartic acid residues. Journal of bacteriology, 186 (6). pp. 1747-57. doi:10.1128/JB.186.6.1747-1757.2004 ISSN 0021-9193.

Lloyd, Adrian J., Huyton, Trevor, Turkenburg, Johan and Roper, David I. (2004) Refinement of Haemophilus influenzae diaminopimelic acid epimerase (DapF) at 1.75 A resolution suggests a mechanism for stereocontrol during catalysis. Acta crystallographica. Section D, Biological crystallography, 60 (2). pp. 397-400. doi:10.1107/S0907444903027999

2001

Lloyd, Adrian J. and Shoolingin-Jordan, P. M. (2001) Dimeric pig heart succinate-coenzyme A transferase uses only one subunit to support catalysis. Biochemistry, 40 (8). pp. 2455-2467. doi:10.1021/bi002169v ISSN 0006-2960.

1997

Shoolingin-Jordan, Peter M., LeLean, Jeremy E. and Lloyd, Adrian J. (1997) Continuous coupled assay for 5-aminolevulinate synthase. Methods in Enzymology, 281 . pp. 309-316. doi:10.1016/S0076-6879(97)81037-3 ISSN 00766879.

1995

Lloyd, Adrian J., Thomann, H. U., Ibba, M. and SΓΆll, D. (1995) A broadly applicable continuous spectrophotometric assay for measuring aminoacyl-tRNA synthetase activity. Nucleic Acids Research, 23 (15). pp. 2886-2892. doi:10.1093/nar/23.15.2886 ISSN 0305-1048.

1994

Verkamp, Elizabeth, Kumar, A. Madan, Lloyd, Adrian J. and Martins, Orlando (1994) Glutamyl-tRNA as an intermediate in Glutamate conversions. In: SΓΆll, Dieter and RajBhandary, Uttam L., (eds.) tRNA: Structure, Biosynthesis, and Function. Washington DC: ASM Press, pp. 545-550. ISBN 9781555810733

Stange-Thomann, N., Thomann, H. U., Lloyd, Adrian J., Lyman, H. and SΓΆll, D. (1994) A point mutation in Euglena gracilis chloroplast tRNA(Glu) uncouples protein and chlorophyll biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 91 (17). pp. 7947-7951. doi:10.1073/pnas.91.17.7947 ISSN 0027-8424.

Lloyd, Adrian J., Gray, R. G. and Green, A (1994) Tyrosinaemia type 1 and glutathione synthetase deficiency : two disorders with reduced hepatic thiol group concentrations and a liver 4-fumarylacetoacetate hydrolase deficiency. Journal of Inherited Metabolic Disease, 18 (1). pp. 48-55. doi:10.1007/BF00711372 ISSN 0141-8955.

1993

Lloyd, Adrian J., Weitzman, P. D. and Soll, D. (1993) Incomplete citric acid cycle obliges aminolevulinic acid synthesis via the C5 pathway in a methylotroph. Journal of General Microbiology, 139 (12). pp. 2931-2938. doi:10.1099/00221287-139-12-2931 ISSN 0022-1287.

1991

Griffiths, E. J., Lloyd, Adrian J. and Brunt, R. V. (1991) Effect of ischaemia and reperfusion on lipid metabolism and glycogenolysis in hearts from normal and diabetic rats. In: Nagano, M. and Dhalla, N., (eds.) The Diabetic Heart. New York: Raven Press. ISBN 9780881677430

1988

Lloyd, Adrian J. and Weitzman, P. D. J. (1988) Purification and characterization of NAD-linked isocitrate dehydrogenase from Methylophilus methylotrophus. Biochemical Society Transactions, 16 (5). pp. 871-872. doi:10.1042/bst0160871 ISSN 0300-5127.

1987

Lloyd, Adrian J. and Weitzman , P. D. J. (1987) Modification of the regulatory properties of Acinetobacter citrate synthase by cross-linking. Biochemical Society Transactions, 15 (5). p. 840. doi:10.1042/bst0150840 ISSN 0300-5127.

This list was generated on Fri Dec 8 12:27:41 2023 GMT.