Lutton, E. Josiah, Lammers, Wim J. E. P., James, Sean G., Berg, Hugo van den and Blanks, Andrew M. (2018) Identification of uterine pacemaker regions at the myometrial-placental interface in the rat. The Journal of Physiology, 596 (14). pp. 2841-2852. doi:10.1113/JP275688 ISSN 0022-3751.
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Abstract
Coordinated uterine contractions are essential for delivering viable offspring in mammals. In contrast to other visceral smooth muscles, it is not known where excitation within the uterus is initiated, and no defined pace‐making region has hitherto been identified. Using multi‐electrode array recordings and high‐resolution computational reconstruction of the three‐dimensional micro‐structure of late pregnant rat uterus, we demonstrate that electrical potentials are initiated in distinct structures within the placental bed of individual implantation sites. These previously unidentified structures represent modified smooth muscle bundles that are derived from bridges between the longitudinal and circular layers. Coordinated implantation and encapsulation by invading trophoblast give rise to isolated placental/myometrial interface bundles that directly connect to the overlying longitudinal smooth muscle layer. Taken together, these observations imply that the anatomical structure of the uterus, combined with site‐specific implantation, gives rise to emergent patterns of electrical activity that drive effective contractility during parturition.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QP Physiology |
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Science > Mathematics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Library of Congress Subject Headings (LCSH): | Uterus -- Contraction, Myometrium, Rats -- Parturition, Excitation (Physiology) |
| Journal or Publication Title: | The Journal of Physiology |
| Publisher: | Blackwell |
| ISSN: | 0022-3751 |
| Official Date: | 15 July 2018 |
| Dates: | Date Event 15 July 2018 Published 28 April 2018 Available 19 April 2018 Accepted |
| Volume: | 596 |
| Number: | 14 |
| Page Range: | pp. 2841-2852 |
| DOI: | 10.1113/JP275688 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 2 May 2018 |
| Date of first compliant Open Access: | 28 April 2019 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID |
| URI: | https://wrap.warwick.ac.uk/101736/ |
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