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Functional connectivity of the human amygdala in health and in depression

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Cheng, Wei, Rolls, Edmund T., Qiu, Jiang, Xie, Xiongfei, Lyu, Wujun, Li, Yu, Huang, Chu-Chung, Yang, Albert C, Tsai, Shih-Jen, Lyu, Fajin, Zhuang, Kaixiang, Lin, Ching-Po, Xie, Peng and Feng, Jianfeng (2018) Functional connectivity of the human amygdala in health and in depression. Social Cognitive and Affective Neuroscience . nsy032. doi:10.1093/scan/nsy032 (In Press)

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Official URL: https://doi.org/10.1093/scan/nsy032

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Abstract

To analyze the functioning of the amygdala in depression, we performed the first voxel-level resting state functional-connectivity neuroimaging analysis of depression of voxels in the amygdala with all other voxels in the brain, with 336 patients with major depressive disorder and 350 controls. Amygdala voxels had decreased functional connectivity with the orbitofrontal cortex, temporal lobe areas, including the temporal pole, inferior temporal gyrus, and the parahippocampal gyrus. The reductions in the strengths of the functional connectivity of the amygdala voxels with the medial orbitofrontal cortex and temporal lobe voxels were correlated with increases in the Beck Depression Inventory score and in the duration of illness measures of depression. Parcellation analysis in 350 healthy controls based on voxel-level functional connectivity showed that the basal division of the amygdala has high functional connectivity with medial orbitofrontal cortex areas, and the dorsolateral amygdala has strong functional connectivity with the lateral orbitofrontal cortex and related ventral parts of the inferior frontal gyrus. In depression, the basal amygdala division had especially reduced functional connectivity with the medial orbitofrontal cortex which is involved in reward; and the dorsolateral amygdala subdivision had relatively reduced functional connectivity with the lateral orbitofrontal cortex which is involved in non-reward.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science > Computer Science
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Amygdaloid body, Temporal lobes, Cognitive neuroscience, Depression, Mental
Journal or Publication Title: Social Cognitive and Affective Neuroscience
Publisher: Oxford University Press
ISSN: 1749-5024
Official Date: 14 May 2018
Dates:
DateEvent
14 May 2018Published
3 May 2018Accepted
Date of first compliant deposit: 30 May 2018
Article Number: nsy032
DOI: 10.1093/scan/nsy032
Status: Peer Reviewed
Publication Status: In Press
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
Wolfson Research Merit AwardRoyal Societyhttp://dx.doi.org/10.13039/501100000288
2015AA020507Ministry of Science and Technology of the People's Republic of Chinahttp://dx.doi.org/10.13039/501100002855
15JC1400101Shanghai Association for Science and Technologyhttp://dx.doi.org/10.13039/100010098
91630314Chinese Academy of Scienceshttp://dx.doi.org/10.13039/501100002367
91630314National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
15692106604Ministry of Science and Technology of the People's Republic of Chinahttp://dx.doi.org/10.13039/501100002855
81701773National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
11771010National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
11471081National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
11101429 National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
71661167002National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
17YF1426200Shanghai University of Sporthttp://dx.doi.org/10.13039/501100002397
2017M610226Ministry of Science and Technology of the People's Republic of Chinahttp://dx.doi.org/10.13039/501100002855
NSC100-2911-I-010-010Ministry of Science and Technology, Taiwanhttp://dx.doi.org/10.13039/501100004663
NSC101-2911-I-010-009Ministry of Science and Technology, Taiwanhttp://dx.doi.org/10.13039/501100004663
NSC100-2628-E-010-002-MY3Ministry of Science and Technology, Taiwanhttp://dx.doi.org/10.13039/501100004663
NSC102-2321-B-010-023Ministry of Science and Technology, Taiwanhttp://dx.doi.org/10.13039/501100004663
NSC103-2911-I-010-501Ministry of Science and Technology, Taiwanhttp://dx.doi.org/10.13039/501100004663
NHRI-EX103-10310EINational Health Research Instituteshttp://dx.doi.org/10.13039/501100004737
DOH102-TD-PB-111-NSC006Ministry of Health and Welfarehttp://dx.doi.org/10.13039/100008903
UNSPECIFIEDAcademia Sinicahttp://dx.doi.org/10.13039/501100001869
31271087National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
31470981National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
31571137National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
31500885National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
UNSPECIFIEDNational Outstanding young people planUNSPECIFIED
UNSPECIFIEDProgram for New Century Excellent Talents in Universityhttp://dx.doi.org/10.13039/501100004602
SWU1509383Ministry of Education of the People's Republic of Chinahttp://dx.doi.org/10.13039/501100002338
cstc2015jcyjA10106National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
2015M572423China Postdoctoral Science Foundationhttp://dx.doi.org/10.13039/501100002858
2017YFA0505700Ministry of Science and Technology of the People's Republic of Chinahttp://dx.doi.org/10.13039/501100002855

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