Dyson, Louise, Holmes, Alexander, Li, Ang and Kulesa, Paul M. (2018) A chemotactic model of trunk neural crest cell migration. Genesis: The Journal of Genetics and Development, 56 (9). e23239. doi:10.1002/dvg.23239 ISSN 1526-954X.
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Abstract
Trunk neural crest cells follow a common ventral migratory pathway but are distributed into two distinct locations to form discrete sympathetic and dorsal root ganglia along the vertebrate axis. Although fluorescent cell labeling and time‐lapse studies have recorded complex trunk neural crest cell migratory behaviors, the signals that underlie this dynamic patterning remain unclear. The absence of molecular information has led to a number of mechanistic hypotheses for trunk neural crest cell migration. Here, we review recent data in support of three distinct mechanisms of trunk neural crest cell migration and develop and simulate a computational model based on chemotactic signaling. We show that by integrating the timing and spatial location of multiple chemotactic signals, trunk neural crest cells may be accurately positioned into two distinct targets that correspond to the sympathetic and dorsal root ganglia. In doing so, we honor the contributions of Wilhelm His to his identification of the neural crest and extend the observations of His and others to better understand a complex question in neural crest cell biology.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QA Mathematics Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics |
| Library of Congress Subject Headings (LCSH): | Neural crest -- Cytology, Cell migration -- Mathematical models, Chemotaxis |
| Journal or Publication Title: | Genesis: The Journal of Genetics and Development |
| Publisher: | John Wiley & Sons Ltd. |
| ISSN: | 1526-954X |
| Official Date: | September 2018 |
| Dates: | Date Event September 2018 Published 21 August 2018 Available 14 July 2018 Accepted |
| Volume: | 56 |
| Number: | 9 |
| Article Number: | e23239 |
| DOI: | 10.1002/dvg.23239 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Re-use Statement: | "This is the pre-peer reviewed version of the following article: Dyson L, Holmes A, Li A, Kulesa PM. A chemotactic model of trunk neural crest cell migration. genesis. 2018; e23239. https://doi.org/10.1002/dvg.23239 which has been published in final form. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." |
| Access rights to Published version: | Restricted or Subscription Access |
| Date of first compliant deposit: | 28 August 2018 |
| Date of first compliant Open Access: | 21 August 2019 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID |
| URI: | https://wrap.warwick.ac.uk/107727/ |
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