The Library
Data for Photoactivatable cell-selective dinuclear trans-diazidoplatinum(IV) anticancer prodrugs
Tools
Shi, Huayun, Romero-Canelón, Isolda, Hreusova, Monika, Novakova, Olga, Venkatesh, V., Habtemariam, Abraha, Clarkson, Guy J., Song, Ji-Inn, Brabec, Viktor and Sadler, Peter J. (2018) Data for Photoactivatable cell-selective dinuclear trans-diazidoplatinum(IV) anticancer prodrugs. [Dataset]
Other
ch-071118-wrap--ms_and_nmr.rar - Unspecified Version Available under License Creative Commons Attribution. Download (4Mb) |
|
Other (Supporting information)
ic-2018-02599g_SI_Photoactivatable Cell-selective Dinuclear Trans Diazido Plati-num(IV) Anticancer Prodrugs.docx - Updated Version Available under License Creative Commons Attribution. Download (2247Kb) |
Official URL: https://wrap.warwick.ac.uk/110768/
Abstract
Novel all-trans dinuclear PtIV complexes bridged by a dicarboxylate linker, highly stable in the dark, generate azidyl and hydroxyl radicals upon irradiation with blue light. They are photocytotoxic to human cancer cells, whereas cisplatin was inactive under these conditions and more photoactive toward cisplatin-resistant ovarian cancer cells compared to wild-type cells. Remarkably, the dinuclear complexes were relatively nontoxic toward normal human cells. Cell cycle and DNA binding experiments suggested that DNA is a target.
Item Type: | Dataset | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry | |||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||||||||||||||
Type of Data: | ns and nmr | |||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Antineoplastic agents -- Development, Platinum compounds -- Therapeutic use, Cisplatin, Azides, Photochemistry | |||||||||||||||||||||||||||
Journal or Publication Title: | Inorganic Chemistry | |||||||||||||||||||||||||||
Publisher: | University of Warwick, Department of Chemistry | |||||||||||||||||||||||||||
ISSN: | 0020-1669 | |||||||||||||||||||||||||||
Official Date: | 2018 | |||||||||||||||||||||||||||
Dates: |
|
|||||||||||||||||||||||||||
Status: | Not Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Media of Output (format): | .rar | |||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
Copyright Holders: | University of Warwick | |||||||||||||||||||||||||||
Date of first compliant deposit: | 12 November 2018 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
|
|||||||||||||||||||||||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year