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The Arabidopsis RRM domain protein EDM3 mediates race-specific disease resistance by controlling H3K9me2-dependent alternative polyadenylation of RPP7 immune receptor transcripts
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Lai, Yan, Cuzick, Alayne, Lu, Xueqing Maggie, Wang, Jianqiang, Katiyar, Neerja, Tsuchiya, Tokuji, Le Roch, Karine, McDowell, John M., Holub, E. B. and Eulgem, Thomas (2019) The Arabidopsis RRM domain protein EDM3 mediates race-specific disease resistance by controlling H3K9me2-dependent alternative polyadenylation of RPP7 immune receptor transcripts. The Plant Journal, 97 (4). pp. 646-660. doi:10.1111/tpj.14148 ISSN 0960-7412.
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WRAP-Arabidopsis-domain-protein-mediates-race-specific-disease-Holub-2018.pdf - Accepted Version - Requires a PDF viewer. Download (1939Kb) | Preview |
Official URL: http://dx.doi.org/10.1111/tpj.14148
Abstract
The NLR‐receptor RPP7 mediates race‐specific immunity in Arabidopsis. Previous screens for enhanced downy mildew (edm) mutants identified the co‐chaperone SGT1b (EDM1) and the PHD‐finger protein EDM2 as critical regulators of RPP7. Here, we describe a third edm mutant compromised in RPP7 immunity, edm3. EDM3 encodes a nuclear‐localized protein featuring an RNA‐recognition motif. Like EDM2, EDM3 promotes histone H3 lysine 9 dimethylation (H3K9me2) at RPP7. Global profiling of H3K9me2 showed EDM3 to affect this silencing mark at a large set of loci. Importantly, both, EDM3 and EDM2 co‐associate in vivo with H3K9me2‐marked chromatin and transcripts at a critical proximal polyadenyation site of RPP7. Our results highlight the complexity of plant NLR gene regulation and establish a functional and physical link between a histone mark and NLR‐transcript processing.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QK Botany Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | RNA-protein interactions, Arabidopsis -- Disease and pest resistance -- Genetics | |||||||||
| Journal or Publication Title: | The Plant Journal | |||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | |||||||||
| ISSN: | 0960-7412 | |||||||||
| Official Date: | February 2019 | |||||||||
| Dates: |
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| Volume: | 97 | |||||||||
| Number: | 4 | |||||||||
| Page Range: | pp. 646-660 | |||||||||
| DOI: | 10.1111/tpj.14148 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Reuse Statement (publisher, data, author rights): | "This is the peer reviewed version of the following article:Lai, Y. , Cuzick, A. , Lu, X. M., Wang, J. , Katiyar, N. , Tsuchiya, T. , Le Roch, K. , McDowell, J. M., Holub, E. and Eulgem, T. (2018), The Arabidopsis RRM domain protein EDM3 mediates race‐specific disease resistance by controlling H3K9me2‐dependent alternative polyadenylation of RPP7 immune receptor transcripts. Plant J. Accepted Author Manuscript. which has been published in final form at https://doi.org/10.1111/tpj.14148. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | |||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||
| Date of first compliant deposit: | 13 November 2018 | |||||||||
| Date of first compliant Open Access: | 8 November 2019 | |||||||||
| RIOXX Funder/Project Grant: |
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