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The Arabidopsis RRM domain protein EDM3 mediates race-specific disease resistance by controlling H3K9me2-dependent alternative polyadenylation of RPP7 immune receptor transcripts

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Lai, Yan, Cuzick, Alayne, Lu, Xueqing Maggie, Wang, Jianqiang, Katiyar, Neerja, Tsuchiya, Tokuji, Le Roch, Karine, McDowell, John M., Holub, E. B. and Eulgem, Thomas (2019) The Arabidopsis RRM domain protein EDM3 mediates race-specific disease resistance by controlling H3K9me2-dependent alternative polyadenylation of RPP7 immune receptor transcripts. The Plant Journal, 97 (4). pp. 646-660. doi:10.1111/tpj.14148 ISSN 0960-7412.

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Official URL: http://dx.doi.org/10.1111/tpj.14148

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Abstract

The NLR‐receptor RPP7 mediates race‐specific immunity in Arabidopsis. Previous screens for enhanced downy mildew (edm) mutants identified the co‐chaperone SGT1b (EDM1) and the PHD‐finger protein EDM2 as critical regulators of RPP7. Here, we describe a third edm mutant compromised in RPP7 immunity, edm3. EDM3 encodes a nuclear‐localized protein featuring an RNA‐recognition motif. Like EDM2, EDM3 promotes histone H3 lysine 9 dimethylation (H3K9me2) at RPP7. Global profiling of H3K9me2 showed EDM3 to affect this silencing mark at a large set of loci. Importantly, both, EDM3 and EDM2 co‐associate in vivo with H3K9me2‐marked chromatin and transcripts at a critical proximal polyadenyation site of RPP7. Our results highlight the complexity of plant NLR gene regulation and establish a functional and physical link between a histone mark and NLR‐transcript processing.

Item Type: Journal Article
Subjects: Q Science > QK Botany
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): RNA-protein interactions, Arabidopsis -- Disease and pest resistance -- Genetics
Journal or Publication Title: The Plant Journal
Publisher: Wiley-Blackwell Publishing Ltd.
ISSN: 0960-7412
Official Date: February 2019
Dates:
DateEvent
February 2019Published
8 November 2018Available
26 October 2018Accepted
Volume: 97
Number: 4
Page Range: pp. 646-660
DOI: 10.1111/tpj.14148
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): "This is the peer reviewed version of the following article:Lai, Y. , Cuzick, A. , Lu, X. M., Wang, J. , Katiyar, N. , Tsuchiya, T. , Le Roch, K. , McDowell, J. M., Holub, E. and Eulgem, T. (2018), The Arabidopsis RRM domain protein EDM3 mediates race‐specific disease resistance by controlling H3K9me2‐dependent alternative polyadenylation of RPP7 immune receptor transcripts. Plant J. Accepted Author Manuscript. which has been published in final form at https://doi.org/10.1111/tpj.14148. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 13 November 2018
Date of first compliant Open Access: 8 November 2019
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
207/ICR07554[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
IOS-1457329 National Science Foundationhttp://dx.doi.org/10.13039/100000001

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