Neef, Nicole E., Müller, Bent, Liebig, Johanna, Schaadt, Gesa, Grigutsch, Maren, Gunter, Thomas C., Wilcke, Arndt, Kirsten, Holger, Skeide, Michael A., Kraft, Indra, Kraus, Nina, Emmrich, Frank, Brauer, Jens, Boltze, Johannes and Friederici, Angela D. (2017) Dyslexia risk gene relates to representation of sound in the auditory brainstem. Developmental Cognitive Neuroscience, 24 . pp. 63-71. doi:10.1016/j.dcn.2017.01.008 ISSN 18789293.
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Abstract
Dyslexia is a reading disorder with strong associations with KIAA0319 and DCDC2. Both genes play a functional role in spike time precision of neurons. Strikingly, poor readers show an imprecise encoding of fast transients of speech in the auditory brainstem. Whether dyslexia risk genes are related to the quality of sound encoding in the auditory brainstem remains to be investigated. Here, we quantified the response consistency of speech-evoked brainstem responses to the acoustically presented syllable [da] in 159 genotyped, literate and preliterate children. When controlling for age, sex, familial risk and intelligence, partial correlation analyses associated a higher dyslexia risk loading with KIAA0319 with noisier responses. In contrast, a higher risk loading with DCDC2 was associated with a trend towards more stable responses. These results suggest that unstable representation of sound, and thus, reduced neural discrimination ability of stop consonants, occurred in genotypes carrying a higher amount of KIAA0319 risk alleles. Current data provide the first evidence that the dyslexia-associated gene KIAA0319 can alter brainstem responses and impair phoneme processing in the auditory brainstem. This brain-gene relationship provides insight into the complex relationships between phenotype and genotype thereby improving the understanding of the dyslexia-inherent complex multifactorial condition.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
| Library of Congress Subject Headings (LCSH): | Dyslexia, Reading disability, Brain stem, Auditory perception |
| Journal or Publication Title: | Developmental Cognitive Neuroscience |
| Publisher: | Elsevier |
| ISSN: | 18789293 |
| Official Date: | April 2017 |
| Dates: | Date Event April 2017 Published 17 January 2017 Available 15 January 2017 Accepted |
| Volume: | 24 |
| Page Range: | pp. 63-71 |
| DOI: | 10.1016/j.dcn.2017.01.008 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 25 June 2019 |
| Date of first compliant Open Access: | 25 June 2019 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID |
| URI: | https://wrap.warwick.ac.uk/119494/ |
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