Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

The economic case for prevention of population vitamin D deficiency : a modelling study using data from England and Wales

Tools
- Tools
+ Tools

Aguiar, M., Andronis, L. (Lazaros) , Pallan, M., Högler , W. and Frew, E. (2020) The economic case for prevention of population vitamin D deficiency : a modelling study using data from England and Wales. European Journal of Clinical Nutrition, 74 . pp. 825-833. doi:10.1038/s41430-019-0486-x ISSN 0954-3007.

[img]
Preview
PDF
WRAP-economic-case-prevention-population-vitamin-D-deficiency-Andronis-2019.pdf - Accepted Version - Requires a PDF viewer.

Download (860Kb) | Preview
Official URL: https://doi.org/10.1038/s41430-019-0486-x

Request Changes to record.

Abstract

Background
Vitamin D deficiency (VDD) affects the health and wellbeing of millions worldwide. In high latitude countries such as the United Kingdom (UK), severe complications disproportionally affect ethnic minority groups.

Objective
To develop a decision-analytic model to estimate the cost effectiveness of population strategies to prevent VDD.

Methods
An individual-level simulation model was used to compare: (I) wheat flour fortification; (II) supplementation of at-risk groups; and (III) combined flour fortification and supplementation; with (IV) a ‘no additional intervention’ scenario, reflecting the current Vitamin D policy in the UK. We simulated the whole population over 90 years. Data from national nutrition surveys were used to estimate the risk of deficiency under the alternative scenarios. Costs incurred by the health care sector, the government, local authorities, and the general public were considered. Results were expressed as total cost and effect of each strategy, and as the cost per ‘prevented case of VDD’ and the ‘cost per Quality Adjusted Life Year (QALY)’.

Results
Wheat flour fortification was cost saving as its costs were more than offset by the cost savings from preventing VDD. The combination of supplementation and fortification was cost effective (£9.5 per QALY gained). The model estimated that wheat flour fortification alone would result in 25% fewer cases of VDD, while the combined strategy would reduce the number of cases by a further 8%.

Conclusion
There is a strong economic case for fortifying wheat flour with Vitamin D, alone or in combination with targeted vitamin D3 supplementation.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Vitamin D deficiency, Vitamin D in human nutrition , Vitamin D in the body , Deficiency diseases , Ethnic groups -- Health aspects
Journal or Publication Title: European Journal of Clinical Nutrition
Publisher: Nature Publishing Group
ISSN: 0954-3007
Official Date: May 2020
Dates:
DateEvent
May 2020Published
20 August 2019Available
15 July 2019Accepted
Volume: 74
Page Range: pp. 825-833
DOI: 10.1038/s41430-019-0486-x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 7 August 2019
Date of first compliant Open Access: 20 February 2020
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
UNSPECIFIEDUniversity Of Birminghamhttp://dx.doi.org/10.13039/501100000855
Related URLs:
  • Publisher

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us